GO:0000165

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Name MAPK cascade
Categary Process
Go Slim No
Go Link GO:0000165
Unique Molecular Interactions 3392
Total Molecular Interactions 4570
Total Single Events 41206
Pain Genes Associated 101

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
8 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
9 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
10 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
11 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
12 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
13 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
14 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
15 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
16 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
17 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
18 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
19 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
20 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
21 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
22 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
23 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
24 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
25 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
26 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
27 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
28 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
29 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
30 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
31 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
32 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
33 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
34 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
35 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
36 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
37 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
38 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
39 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
40 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
41 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
42 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
43 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1 0.72 1.54 2.16
44 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
45 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
46 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
47 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
48 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
49 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
50 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
51 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
52 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
53 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
54 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
55 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
56 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
57 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
58 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
59 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
60 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
61 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
62 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
63 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
64 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
65 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
66 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
67 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
68 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
69 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
70 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
71 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
72 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
73 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
74 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
75 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
76 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
77 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
78 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
79 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
80 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
81 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
82 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
83 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
84 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
85 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
86 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
87 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
88 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
89 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
90 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
91 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
92 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
93 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
94 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
95 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
96 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
97 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
98 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
99 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
100 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
101 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
102 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
103 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
104 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
105 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
106 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
107 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
108 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
109 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
110 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
111 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
112 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
113 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
114 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
115 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
116 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
117 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
118 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27
119 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
120 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
121 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
122 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
123 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
124 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
125 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
126 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
127 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
128 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
129 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
130 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
131 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
132 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
133 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
134 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
135 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
136 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
137 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
138 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
139 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
140 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
141 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
142 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
143 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
144 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
145 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
146 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
147 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
148 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
149 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
150 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
151 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
152 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
153 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
154 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
155 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
156 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
157 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
158 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
159 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
160 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
161 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
162 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
163 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
164 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
165 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
166 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
167 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
168 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
169 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
170 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
171 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
172 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
173 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
174 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
175 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
176 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
177 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
178 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
179 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
180 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
181 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
182 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
183 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
184 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
185 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
186 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
187 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
188 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
189 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
190 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
191 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
192 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
193 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
194 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
195 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
196 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
197 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
198 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
199 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
200 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
7 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
8 INT6481 Binding of TNF 624 0.48 510.2 214.82
9 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
10 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
11 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
12 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
13 INT812 Localization of INS 1026 0.81 515.6 145.31
14 INT9660 Regulation of TNF 363 0.62 312.94 139.99
15 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
16 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
17 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
18 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35
19 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
20 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
21 INT10166 Localization of Tnf 237 0.81 153.95 88.64
22 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
23 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
24 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
25 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
26 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
27 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
28 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
29 INT6849 Localization of IL1B 229 0.81 112.56 69.63
30 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
31 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41
32 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
33 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
34 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
35 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
36 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
37 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
38 INT251 Regulation of INS 398 0.62 232.47 55.04
39 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
40 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
41 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
42 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
43 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
44 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
45 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
46 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
47 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
48 INT13354 Transcription of TNF 108 0.72 85.81 42.32
49 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27
50 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
51 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
52 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
53 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
54 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
55 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
56 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
57 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
58 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
59 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95
60 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
61 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
62 INT6484 Binding of IL1B 122 0.47 75.84 35.07
63 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
64 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
65 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
66 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
67 INT65698 Localization of CCL2 118 0.81 77.54 32.69
68 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43
69 INT35406 Localization of Tnf 94 0.81 64.63 31.65
70 INT9347 Localization of Il1b 58 0.81 26.13 31.53
71 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
72 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
73 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
74 INT82882 Localization of Ccl2 61 0.80 41.96 28
75 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
76 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
77 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
78 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
79 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
80 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
81 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
82 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
83 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
84 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
85 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
86 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
87 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
88 INT48081 Localization of Il1b 46 0.80 21.59 22.4
89 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
90 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
91 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
92 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
93 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
94 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
95 INT78901 Localization of CCL5 67 0.78 40.79 20.59
96 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
97 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
98 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58
99 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
100 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
101 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
102 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
103 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42
104 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
105 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28
106 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
107 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
108 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
109 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
110 INT113602 Positive_regulation of Gene_expression of Ccl2 48 0.70 48.71 17.85
111 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48
112 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
113 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
114 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
115 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
116 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
117 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
118 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
119 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
120 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
121 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
122 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
123 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
124 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
125 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
126 INT10173 Binding of Tnf 45 0.48 35.6 14.32
127 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
128 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
129 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
130 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
131 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
132 INT14572 Binding of INS 205 0.48 175.43 13.38
133 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
134 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3
135 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
136 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
137 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
138 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
139 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
140 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
141 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
142 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
143 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
144 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
145 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
146 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
147 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
148 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
149 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
150 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
151 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
152 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
153 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
154 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
155 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
156 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
157 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
158 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
159 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
160 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
161 INT106200 Binding of Ccl2 22 0.42 16.7 9.75
162 INT113667 Positive_regulation of Mapk7 15 0.70 12.24 9.72
163 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53
164 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
165 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
166 INT135407 Negative_regulation of Ccl2 33 0.57 32.74 9.45
167 INT140224 Localization of Ccl2 32 0.72 26.91 9.39
168 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
169 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1
170 INT138700 Negative_regulation of Gene_expression of Ccl2 27 0.57 24.1 9.08
171 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
172 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
173 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
174 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
175 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
176 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
177 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
178 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
179 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
180 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
181 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
182 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
183 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
184 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
185 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
186 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
187 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
188 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
189 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
190 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
191 INT68299 Binding of Tnf 17 0.39 12.55 7.49
192 INT94127 Positive_regulation of Il18 14 0.69 14 7.47
193 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
194 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
195 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
196 INT82881 Regulation of Ccl2 19 0.57 15.29 7.19
197 INT153271 Localization of Ccl3 7 0.81 11.29 7.14
198 INT91758 Binding of CCR5 28 0.45 20.16 7.07
199 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
200 INT56285 Localization of SCG2 10 0.81 1.65 6.92
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