GO:0000166

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Name nucleotide binding
Categary Function
Go Slim No
Go Link GO:0000166
Unique Molecular Interactions 9378
Total Molecular Interactions 12451
Total Single Events 94672
Pain Genes Associated 1189

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported for nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
3 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
4 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
5 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
6 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
7 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
8 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
9 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
10 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
11 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
12 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
13 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
14 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
15 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
16 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
17 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
18 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
19 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
20 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
21 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
22 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
23 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
24 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
25 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
26 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
27 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
28 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
29 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
30 INT138961 Dbi Positive_regulation of Chkb 1 0.00 3.05 3.99
31 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
32 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
33 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
34 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
35 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
36 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
37 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
38 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
39 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
40 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
41 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
42 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
43 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
44 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
45 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
46 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
47 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
48 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
49 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
50 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
51 INT85042 Binding of CCT6A and MAX 1 0.00 0 3.13
52 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
53 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
54 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
55 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
56 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
57 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
58 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
59 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
60 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
61 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
62 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
63 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
64 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
65 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
66 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
67 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
68 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
69 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
70 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
71 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
72 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
73 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
74 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
75 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
76 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
77 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
78 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
79 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
80 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
81 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
82 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
83 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
84 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
85 INT92182 Mir702 Negative_regulation of Adk 1 0.07 1.29 2.47
86 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47
87 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
88 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
89 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
90 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
91 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
92 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
93 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
94 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
95 INT284860 Binding of Pdzd2 and Nav1 9 0.29 2.33 2.34
96 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
97 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
98 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
99 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
100 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
101 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
102 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
103 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
104 INT128778 Binding of Mcam and Nav1 1 0.03 0.51 2.28
105 INT128777 Binding of Cntn1 and Nav1 1 0.48 0.51 2.28
106 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
107 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26
108 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
109 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
110 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
111 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
112 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
113 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
114 INT334136 Binding of IFNA1 and Acsm3 1 0.01 4.52 2.19
115 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
116 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
117 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
118 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
119 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
120 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
121 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
122 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
123 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
124 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
125 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
126 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
127 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
128 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
129 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
130 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
131 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
132 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
133 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
134 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
135 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
136 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
137 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
138 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
139 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
140 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
141 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
142 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
143 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
144 INT125348 Decr1 Regulation of Gene_expression of Fos 1 0.00 0.1 1.92
145 INT6320 Binding of Rbm39 and Scq1 1 0.03 0 1.92
146 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
147 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9
148 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
149 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
150 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
151 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
152 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
153 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
154 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
155 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88
156 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
157 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
158 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
159 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
160 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85
161 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
162 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
163 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
164 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
165 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
166 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
167 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
168 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
169 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
170 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
171 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
172 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
173 INT104710 Em Positive_regulation of Rbm39 1 0.02 0.07 1.76
174 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76
175 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
176 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
177 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
178 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
179 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
180 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73
181 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
182 INT282398 Binding of Mefv and Nlrp3 1 0.40 6.8 1.72
183 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
184 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
185 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
186 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
187 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
188 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
189 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
190 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
191 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
192 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
193 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
194 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
195 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
196 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
197 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
198 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
199 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
200 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65

Single Events

The table below shows the top 100 pain related interactions that have been reported for nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported in nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
2 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
3 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
4 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
5 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75
6 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
7 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
8 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
9 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46
10 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
11 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
12 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
13 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
14 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
15 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
16 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
17 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
18 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
19 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
20 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
21 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
22 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
23 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
24 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
25 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
26 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
27 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
28 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28
29 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
30 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
31 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
32 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
33 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
34 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
35 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
36 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
37 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
38 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
39 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
40 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
41 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
42 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
43 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
44 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
45 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
46 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
47 INT4153 Binding of Insrr 109 0.40 17.99 72.15
48 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
49 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
50 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
51 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
52 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
53 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66
54 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44
55 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
56 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
57 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
58 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
59 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
60 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
61 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45
62 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
63 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
64 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
65 INT5770 Binding of Rbm39 88 0.41 13.23 55.5
66 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
67 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
68 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
69 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
70 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
71 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
72 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
73 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
74 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
75 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33
76 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
77 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
78 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
79 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27
80 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
81 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
82 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
83 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
84 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
85 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
86 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
87 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
88 INT9298 Positive_regulation of Gtpbp4 64 0.69 12.29 41.97
89 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
90 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
91 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
92 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38
93 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
94 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
95 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
96 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
97 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27
98 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
99 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
100 INT116321 Regulation of Nav1 38 0.62 26.62 37.97
101 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
102 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
103 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83
104 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
105 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
106 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
107 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
108 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48
109 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28
110 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
111 INT1163 Negative_regulation of Rbm39 64 0.29 16.8 34.74
112 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
113 INT103262 Localization of Nav1 53 0.81 19.23 34.44
114 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
115 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
116 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
117 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
118 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
119 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
120 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
121 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
122 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
123 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
124 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
125 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
126 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
127 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43
128 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
129 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
130 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
131 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
132 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
133 INT8691 Localization of Insr 85 0.80 9.27 30.32
134 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
135 INT6762 Binding of Srms 56 0.31 6.62 30.27
136 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
137 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
138 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
139 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3
140 INT15296 Regulation of Rbm39 45 0.29 10.66 29.27
141 INT5300 Regulation of Insr 54 0.60 11.33 29.26
142 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
143 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
144 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11
145 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
146 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
147 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
148 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
149 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
150 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
151 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
152 INT123419 Binding of NAV1 37 0.48 7.09 26.43
153 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
154 INT136268 Localization of NAV1 22 0.75 2.84 26.23
155 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86
156 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
157 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74
158 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
159 INT116226 Regulation of NAV1 20 0.51 14.32 25.61
160 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6
161 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
162 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
163 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
164 INT103320 Positive_regulation of Positive_regulation of Trpv1 44 0.70 27.73 25.28
165 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27
166 INT9781 Binding of INSRR 64 0.31 19.1 25.2
167 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01
168 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
169 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
170 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47
171 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
172 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
173 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
174 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
175 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
176 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
177 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
178 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2
179 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
180 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89
181 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
182 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
183 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
184 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
185 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
186 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
187 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
188 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19
189 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16
190 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
191 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
192 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
193 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39
194 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
195 INT117527 Binding of Prkca 25 0.48 6.43 21.05
196 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99
197 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91
198 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
199 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
200 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
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