GO:0000185

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Name activation of MAPKKK activity
Categary Process
Go Slim No
Go Link GO:0000185
Unique Molecular Interactions 1073
Total Molecular Interactions 1480
Total Single Events 15919
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of MAPKKK activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of MAPKKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
3 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
4 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
5 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
6 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
7 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
8 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
9 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
10 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
11 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
12 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
13 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
14 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
15 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
16 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
17 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
18 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
19 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
20 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
21 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
22 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
23 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
24 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
25 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
26 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
27 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
28 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
29 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
30 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
31 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
32 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
33 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
34 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
35 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
36 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
37 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
38 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
39 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
40 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
41 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
42 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
43 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
44 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
45 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
46 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
47 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
48 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
49 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
50 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
51 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
52 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
53 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
54 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
55 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
56 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
57 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
58 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
59 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
60 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
61 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
62 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
63 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
64 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
65 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
66 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
67 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
68 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
69 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
70 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
71 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
72 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
73 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
74 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
75 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
76 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
77 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
78 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
79 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
80 INT162250 Binding of TRPV1 and Grm5 1 0.01 0.8 1.03
81 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
82 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
83 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
84 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
85 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
86 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
87 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
88 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
89 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
90 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
91 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
92 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
93 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
94 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
95 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
96 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
97 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
98 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
99 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
100 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
101 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
102 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
103 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
104 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
105 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
106 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
107 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
108 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
109 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
110 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
111 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
112 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
113 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
114 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
115 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
116 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
117 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
118 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
119 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
120 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
121 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
122 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
123 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
124 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
125 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
126 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
127 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79
128 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
129 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
130 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
131 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
132 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
133 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
134 INT130138 TNF Negative_regulation of Gene_expression of S100A10 1 0.06 1.32 0.78
135 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
136 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
137 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77
138 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
139 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
140 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
141 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76
142 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
143 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
144 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
145 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75
146 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
147 INT301141 Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
148 INT301142 Negative_regulation of Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
149 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
150 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
151 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
152 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
153 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
154 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
155 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
156 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
157 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
158 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
159 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
160 INT113499 TNF Positive_regulation of Gene_expression of BHLHE23 1 0.25 0.1 0.71
161 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
162 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
163 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
164 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
165 INT117533 TNF Positive_regulation of Positive_regulation of SETBP1 1 0.34 0.29 0.7
166 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7
167 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
168 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
169 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69
170 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
171 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
172 INT113959 TNF Positive_regulation of Gene_expression of IK 1 0.02 0.66 0.69
173 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68
174 INT119107 Negative_regulation of Binding of LTBR and TNF 1 0.17 1.16 0.68
175 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
176 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67
177 INT119105 Binding of FCGR1A and TNF 1 0.03 1.16 0.67
178 INT119106 Negative_regulation of Binding of FCGR1A and TNF 1 0.03 1.16 0.67
179 INT264338 Binding of IL-17 and Positive_regulation of Localization of TNF 1 0.04 1.71 0.67
180 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
181 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
182 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
183 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
184 INT252293 Binding of TNF and Positive_regulation of Gene_expression of Ccl20 1 0.04 0.54 0.66
185 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
186 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 0.40 0.86 0.66
187 INT120145 seb Positive_regulation of Tnf 1 0.40 0.85 0.65
188 INT254230 Ik Negative_regulation of Gene_expression of TNF 1 0.00 1.29 0.65
189 INT132689 Tnf Regulation of Dnajc13 1 0.01 1.27 0.65
190 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
191 INT295705 Binding of IK and TNF 1 0.00 0.27 0.64
192 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63
193 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
194 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
195 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
196 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
197 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
198 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
199 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
200 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of MAPKKK activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of MAPKKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
10 INT9660 Regulation of TNF 363 0.62 312.94 139.99
11 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
12 INT10166 Localization of Tnf 237 0.81 153.95 88.64
13 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
14 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
15 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
16 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
17 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
18 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
19 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
20 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
21 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
22 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
23 INT13354 Transcription of TNF 108 0.72 85.81 42.32
24 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
25 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
26 INT35406 Localization of Tnf 94 0.81 64.63 31.65
27 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
28 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
29 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
30 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
31 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
32 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
33 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
34 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
35 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
36 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
37 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
38 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
39 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
40 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82
41 INT10173 Binding of Tnf 45 0.48 35.6 14.32
42 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
43 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
44 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
45 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
46 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
47 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
48 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
49 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
50 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
51 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
52 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
53 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
54 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
55 INT68299 Binding of Tnf 17 0.39 12.55 7.49
56 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
57 INT147498 Gene_expression of GRM5 10 0.75 3.16 7.12
58 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
59 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
60 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
61 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
62 INT119132 Regulation of Grm5 8 0.48 2.66 5.46
63 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
64 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
65 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
66 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
67 INT107390 Negative_regulation of Grm5 11 0.45 6 4.42
68 INT74815 Binding of Grm5 11 0.36 3.62 4.25
69 INT95784 Positive_regulation of Positive_regulation of Grm5 8 0.11 3.48 4.01
70 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
71 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
72 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
73 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
74 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
75 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
76 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
77 INT140206 Binding of GRM5 6 0.36 1.85 2.52
78 INT123713 Binding of Grm5 7 0.31 2.96 2.38
79 INT107656 Regulation of Gene_expression of Grm5 4 0.26 0.84 2.38
80 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
81 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
82 INT157529 Positive_regulation of GRM5 3 0.48 0.59 2.07
83 INT152025 Negative_regulation of Positive_regulation of Grm5 4 0.14 2.21 2.06
84 INT101945 Regulation of Gene_expression of Grm5 2 0.48 0.96 1.98
85 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
86 INT51603 Localization of Grm5 5 0.73 0.33 1.87
87 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
88 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
89 INT147384 Regulation of Positive_regulation of Grm5 2 0.11 0.41 1.65
90 INT117607 Localization of Grm5 12 0.50 1.31 1.56
91 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
92 INT100523 Regulation of GRM5 2 0.26 0.49 1.51
93 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
94 INT128391 Positive_regulation of Regulation of Grm5 1 0.37 0 1.49
95 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
96 INT168906 Positive_regulation of Gene_expression of Grm5 4 0.39 1.75 1.38
97 INT107658 Regulation of Positive_regulation of Grm5 1 0.26 0.84 1.17
98 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
99 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
100 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
101 INT157528 Regulation of Gene_expression of GRM5 1 0.43 0 0.96
102 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
103 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
104 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
105 INT223653 Transcription of Grm5 4 0.69 1.4 0.83
106 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
107 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
108 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
109 INT157526 Regulation of Binding of GRM5 1 0.43 0 0.73
110 INT168907 Negative_regulation of Negative_regulation of Grm5 1 0.14 1.01 0.65
111 INT51263 Regulation of Phosphorylation of TNF 2 0.26 1.06 0.63
112 INT235079 Negative_regulation of Phosphorylation of TNF 2 0.41 1.16 0.6
113 INT140837 Negative_regulation of Transcription of GADD45G 1 0.41 1.14 0.51
114 INT140830 Transcription of GADD45G 1 0.69 1.13 0.5
115 INT140834 Negative_regulation of GADD45G 1 0.18 1.14 0.5
116 INT140833 Positive_regulation of Gene_expression of GADD45G 1 0.45 1.18 0.5
117 INT140832 Gene_expression of GADD45G 1 0.75 1.18 0.49
118 INT210972 Positive_regulation of Localization of Grm5 3 0.06 0.24 0.48
119 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47
120 INT163205 Transcription of Grm5 1 0.00 0.73 0.47
121 INT128595 Negative_regulation of Gene_expression of Grm5 2 0.38 0.51 0.43
122 INT138003 Positive_regulation of Negative_regulation of Tnf 2 0.49 2.07 0.43
123 INT347792 Regulation of Regulation of Grm5 1 0.35 0.12 0.42
124 INT72086 Regulation of Regulation of Tnf 1 0.45 0.3 0.4
125 INT159782 Phosphorylation of Tnf 2 0.79 1.51 0.36
126 INT143535 Protein_catabolism of Tnf 2 0.86 3.43 0.33
127 INT147500 Positive_regulation of Gene_expression of GRM5 1 0.67 0.25 0.33
128 INT116034 Negative_regulation of Transcription of Tnf 2 0.41 0.17 0.29
129 INT147499 Negative_regulation of Gene_expression of GRM5 1 0.41 0.29 0.26
130 INT194643 Positive_regulation of Regulation of TNF 2 0.28 2.4 0.21
131 INT81351 Negative_regulation of Regulation of TNF 1 0.33 0.23 0.21
132 INT159783 Positive_regulation of Phosphorylation of Tnf 1 0.12 0.39 0.19
133 INT251578 Positive_regulation of Protein_catabolism of TNF 1 0.41 0.26 0.16
134 INT170142 Regulation of Protein_catabolism of Tnf 1 0.44 1.53 0.13
135 INT295324 Regulation of Binding of Tnf 2 0.44 1.11 0.09
136 INT170678 Negative_regulation of Gene_expression of Grm5 1 0.41 0.07 0.09
137 INT223648 Negative_regulation of Transcription of Grm5 1 0.41 0.65 0.08
138 INT347712 Positive_regulation of Binding of Grm5 1 0.13 0 0.05
139 INT159591 Positive_regulation of Binding of Tnf 1 0.43 0.06 0
140 INT170708 Protein_catabolism of Grm5 1 0.02 0.08 0
141 INT170703 Positive_regulation of Regulation of Grm5 1 0.01 0 0
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