GO:0000186

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Name activation of MAPKK activity
Categary Process
Go Slim No
Go Link GO:0000186
Unique Molecular Interactions 1101
Total Molecular Interactions 1533
Total Single Events 9782
Pain Genes Associated 60

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of MAPKK activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of MAPKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
2 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
3 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
4 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
5 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
6 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
7 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
8 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
9 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
10 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
11 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
12 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
13 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
14 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
15 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
16 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
17 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
18 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
19 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
20 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
21 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
22 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
23 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
24 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
25 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
26 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
27 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
28 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
29 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
30 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
31 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
32 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
33 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
34 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
35 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
36 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
37 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
38 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
39 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
40 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
41 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
42 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
43 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
44 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
45 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
46 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
47 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
48 INT253827 Cck Regulation of Cartpt 1 0.41 0 1.16
49 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
50 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
51 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
52 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
53 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
54 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
55 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
56 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
57 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
58 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
59 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
60 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
61 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
62 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
63 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
64 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
65 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
66 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
67 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
68 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
69 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
70 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
71 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
72 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
73 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
74 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
75 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
76 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
77 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
78 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
79 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
80 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
81 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
82 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
83 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
84 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
85 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
86 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
87 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
88 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
89 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
90 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
91 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
92 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
93 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
94 INT66333 Fgf2 Negative_regulation of Positive_regulation of Npy 1 0.20 0.17 0.85
95 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
96 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
97 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
98 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
99 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
100 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
101 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
102 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
103 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
104 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
105 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
106 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
107 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
108 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
109 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
110 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
111 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
112 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
113 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
114 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
115 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
116 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72
117 INT253829 Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72
118 INT253833 Positive_regulation of Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72
119 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
120 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
121 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
122 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
123 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
124 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
125 INT282139 Grm1 Regulation of Grip2 1 0.00 0.62 0.69
126 INT253831 Cck Positive_regulation of Gene_expression of Cartpt 1 0.48 0.23 0.69
127 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
128 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
129 INT169215 Binding of OPRM1 and CARTPT 1 0.00 0.22 0.67
130 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
131 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
132 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
133 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
134 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
135 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
136 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
137 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
138 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
139 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62
140 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
141 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
142 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61
143 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
144 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
145 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
146 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
147 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
148 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
149 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
150 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
151 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
152 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
153 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
154 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56
155 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
156 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
157 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
158 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
159 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
160 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
161 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
162 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
163 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
164 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
165 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
166 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
167 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
168 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
169 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
170 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
171 INT164970 Binding of Rgs8 and Gnai2 1 0.01 0 0.53
172 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
173 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
174 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
175 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
176 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
177 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
178 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
179 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
180 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
181 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
182 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
183 INT140841 Il24 Positive_regulation of Gene_expression of GADD45G 1 0.25 1.21 0.51
184 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
185 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
186 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
187 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
188 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
189 INT66336 Fgf2 Regulation of Gene_expression of Npy 1 0.12 0.09 0.5
190 INT210878 Binding of FLT1 and HBM 1 0.06 0.83 0.5
191 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
192 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
193 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
194 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
195 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
196 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
197 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
198 INT110300 Cartpt Regulation of Adarb1 1 0.14 0 0.49
199 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
200 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of MAPKK activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of MAPKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
3 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
4 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
5 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
6 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
7 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
8 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
9 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
10 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
11 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
12 INT11157 Binding of EGF 88 0.48 53.73 21.25
13 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
14 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
15 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
16 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
17 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
18 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
19 INT20216 Localization of NGF 40 0.80 18.16 16.61
20 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
21 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
22 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
23 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
24 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
25 INT71150 Binding of NGF 22 0.46 13.67 14.81
26 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
27 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
28 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
29 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
30 INT82984 Gene_expression of Cartpt 27 0.78 3.93 11.55
31 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
32 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
33 INT19155 Binding of Adora1 25 0.47 6.41 10.72
34 INT85048 Regulation of NGF 19 0.62 11.61 10.5
35 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82
36 INT2036 Localization of EGF 42 0.77 21.5 9.74
37 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
38 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
39 INT68133 Localization of Fgf2 36 0.81 15.37 9.14
40 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
41 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
42 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
43 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
44 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
45 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
46 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
47 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
48 INT214106 Gene_expression of Cartpt 21 0.73 3.68 7.84
49 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
50 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
51 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
52 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
53 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
54 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
55 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
56 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
57 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
58 INT9167 Binding of Adora1 6 0.40 0.53 6.9
59 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
60 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
61 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58
62 INT13822 Localization of Egf 30 0.81 13.79 6.4
63 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
64 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
65 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2
66 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
67 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
68 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
69 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
70 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
71 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
72 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
73 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
74 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
75 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
76 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
77 INT37227 Regulation of EGF 19 0.45 11.16 5.17
78 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
79 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
80 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
81 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
82 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
83 INT128069 Localization of Cartpt 6 0.81 0.65 4.75
84 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
85 INT100520 Regulation of Grm1 8 0.44 1.3 4.48
86 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
87 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
88 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
89 INT20981 Binding of HRAS 42 0.48 24.49 4.23
90 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
91 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
92 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
93 INT23653 Binding of Egf 22 0.36 11.34 4.12
94 INT74814 Binding of Grm1 5 0.45 2.69 4.1
95 INT100372 Gene_expression of Flt1 47 0.71 24.33 4.09
96 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
97 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
98 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
99 INT169475 Localization of HRAS 14 0.73 9.02 3.9
100 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
101 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
102 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
103 INT84925 Transcription of NGF 11 0.65 4.13 3.65
104 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
105 INT18920 Binding of Egf 24 0.48 9.43 3.57
106 INT88197 Binding of ZAK 9 0.46 6.23 3.54
107 INT215604 Localization of Adora1 10 0.78 1.47 3.49
108 INT253819 Negative_regulation of Cartpt 1 0.40 0.34 3.49
109 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
110 INT168003 Localization of Fgf2 24 0.80 12.52 3.31
111 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
112 INT95785 Positive_regulation of Positive_regulation of Grm1 6 0.49 3.59 3.3
113 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
114 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24
115 INT46754 Localization of F2r 7 0.78 2.36 3.24
116 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
117 INT101083 Binding of Fgf2 14 0.42 4.12 3.14
118 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
119 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
120 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
121 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
122 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
123 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
124 INT115317 Transcription of FGF2 14 0.62 12.79 3
125 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
126 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
127 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
128 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
129 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94
130 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
131 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
132 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
133 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
134 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
135 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
136 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
137 INT11283 Negative_regulation of Grm1 5 0.57 0.8 2.63
138 INT82653 Regulation of F2r 8 0.36 3.78 2.62
139 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
140 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
141 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
142 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
143 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
144 INT64688 Negative_regulation of Gene_expression of Fgf2 5 0.59 5.07 2.56
145 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
146 INT24672 Localization of FGF2 27 0.71 14.59 2.48
147 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
148 INT72013 Negative_regulation of Gnai2 5 0.35 0.09 2.44
149 INT163544 Binding of Psen1 40 0.36 15.28 2.42
150 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39
151 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
152 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
153 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
154 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
155 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
156 INT300587 Negative_regulation of Gene_expression of Cartpt 3 0.36 0.58 2.19
157 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
158 INT85464 Positive_regulation of Cartpt 5 0.70 0.62 2.18
159 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
160 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
161 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
162 INT97898 Regulation of FGF2 8 0.60 3.85 2.09
163 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08
164 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
165 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
166 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03
167 INT100371 Positive_regulation of Flt1 11 0.63 6.42 2.02
168 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
169 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
170 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
171 INT99636 Negative_regulation of Localization of Fgf2 4 0.41 1.32 1.97
172 INT98927 Localization of Grm1 4 0.71 0.42 1.97
173 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
174 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
175 INT67237 Binding of Grm1 7 0.00 1.49 1.94
176 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
177 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93
178 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92
179 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
180 INT253822 Binding of Cartpt 1 0.35 0.16 1.92
181 INT64687 Regulation of Gene_expression of Fgf2 7 0.62 2.29 1.89
182 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88
183 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
184 INT82983 Transcription of Cartpt 2 0.66 0.17 1.86
185 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
186 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
187 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
188 INT172961 Localization of Egf 26 0.71 16.74 1.81
189 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
190 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
191 INT214096 Localization of Cartpt 3 0.76 0.62 1.8
192 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
193 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
194 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
195 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
196 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
197 INT19747 Regulation of Egf 14 0.46 4.67 1.68
198 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68
199 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
200 INT255663 Binding of Flt1 11 0.32 6.92 1.64
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