GO:0000247

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Name C-8 sterol isomerase activity
Categary Function
Go Slim No
Go Link GO:0000247
Unique Molecular Interactions 73
Total Molecular Interactions 90
Total Single Events 611
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for C-8 sterol isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported for C-8 sterol isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
2 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
3 INT29554 Ebp Positive_regulation of LH 2 0.40 0.12 1.41
4 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
5 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
6 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
7 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
8 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
9 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
10 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
11 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
12 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
13 INT52195 Sigmar1 Positive_regulation of Positive_regulation of Grin1 1 0.15 0 0.87
14 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
15 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
16 INT106691 Ngf Positive_regulation of SIGMAR1 1 0.04 0 0.74
17 INT65426 Sigmar1 Regulation of Gpi1 1 0.21 0 0.7
18 INT55919 Binding of Sigmar1 and Ap2s1 1 0.02 0.84 0.6
19 INT77379 Tmie Negative_regulation of Ebp 1 0.03 0 0.59
20 INT95895 Sigmar1 Regulation of Positive_regulation of Npy 1 0.18 0 0.55
21 INT21372 Binding of pcp and Sigmar1 1 0.01 0 0.53
22 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
23 INT151222 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Adrbk1 1 0.00 0.13 0.51
24 INT151223 Negative_regulation of SIGMAR1 Negative_regulation of Adrbk1 1 0.00 0.13 0.51
25 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
26 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
27 INT12453 Sigmar1 Regulation of Gene_expression of Penk 2 0.35 0 0.43
28 INT37270 Negative_regulation of Ebp Positive_regulation of LH 1 0.37 0 0.38
29 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36
30 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35
31 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35
32 INT28327 Binding of Sigmar1 and Abat 1 0.15 0.14 0.35
33 INT214987 Binding of FANCC and Sigmar1 1 0.06 0.34 0.32
34 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3
35 INT158621 Binding of SIGMAR1 and Sphk1 1 0.01 0 0.25
36 INT214977 Binding of Jun and Sigmar1 1 0.01 0.27 0.24
37 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24
38 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22
39 INT136492 Binding of Adarb1 and Sigmar1 1 0.03 0.1 0.21
40 INT72325 Binding of Sigmar1 and WWOX 1 0.26 0 0.18
41 INT18043 Binding of SIGMAR1 and Pgr 1 0.00 0.06 0.16
42 INT214978 Positive_regulation of Sigmar1 Positive_regulation of Positive_regulation of Fosl2 1 0.01 0.23 0.16
43 INT145207 Binding of Sigmar1 and Ctdspl2 1 0.00 0 0.12
44 INT145214 Binding of Sigmar1 and Herc1 1 0.00 0 0.11
45 INT66109 SIGMAR1 Regulation of Localization of Pomc 1 0.00 0 0.1
46 INT102636 Binding of Sigmar1 and Mir377 1 0.05 0.19 0.07
47 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
48 INT252823 Binding of TNF and SIGMAR1 1 0.01 0.95 0.05
49 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0
50 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0
51 INT214980 Binding of Cav2 and Sigmar1 1 0.02 0.07 0
52 INT339709 HMGCR Positive_regulation of Gene_expression of SREBF2 1 0.05 0.54 0
53 INT339699 LDLR Positive_regulation of SREBF2 1 0.08 1.08 0
54 INT339694 LDLR Positive_regulation of Gene_expression of SREBF2 1 0.08 1.08 0
55 INT209986 Binding of HSD11B1 and SIGMAR1 1 0.00 0.1 0
56 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0
57 INT190051 Binding of Ebp and Mrc1 1 0.04 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for C-8 sterol isomerase activity. They are ordered first by their pain relevance and then by number of times they were reported in C-8 sterol isomerase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49
2 INT20715 Binding of Sigmar1 45 0.48 4.03 13.17
3 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35
4 INT60148 Regulation of Sigmar1 20 0.43 7.23 7.76
5 INT12838 Gene_expression of SIGMAR1 30 0.78 3.52 6.81
6 INT25242 Positive_regulation of Sigmar1 17 0.66 3.93 5.65
7 INT55917 Binding of Sigmar1 26 0.45 12.65 5.58
8 INT5978 Positive_regulation of SIGMAR1 13 0.42 0.72 5.35
9 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26
10 INT64668 Regulation of SIGMAR1 13 0.60 0.54 3.91
11 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54
12 INT114571 Gene_expression of Sigmar1 39 0.77 36.78 3.4
13 INT29064 Gene_expression of Sigmar1 9 0.77 2.48 2.65
14 INT61907 Negative_regulation of Ebp 9 0.37 4.77 2.49
15 INT40479 Negative_regulation of SIGMAR1 6 0.52 1.26 1.88
16 INT107332 Negative_regulation of Regulation of Sigmar1 1 0.19 0 1.86
17 INT97073 Positive_regulation of Ebp 6 0.42 2.68 1.8
18 INT61890 Localization of SIGMAR1 6 0.40 0.3 1.52
19 INT25241 Negative_regulation of Sigmar1 10 0.56 2.97 1.5
20 INT26153 Localization of Sigmar1 4 0.80 0.1 1.26
21 INT156804 Transcription of Ebp 1 0.41 0.49 1.13
22 INT156805 Gene_expression of Ebp 6 0.40 6.09 1.07
23 INT106690 Positive_regulation of Gene_expression of SIGMAR1 5 0.61 0.12 1.03
24 INT167 Regulation of Ebp 3 0.44 0.77 1.03
25 INT70604 Positive_regulation of Positive_regulation of Sigmar1 2 0.50 0 0.98
26 INT26326 Regulation of Binding of Sigmar1 4 0.27 0.66 0.9
27 INT107333 Regulation of Regulation of Sigmar1 1 0.27 0 0.9
28 INT167761 Phosphorylation of Sigmar1 1 0.46 0.22 0.88
29 INT167762 Positive_regulation of Phosphorylation of Sigmar1 1 0.34 0.22 0.88
30 INT1011 Positive_regulation of Ebp 3 0.50 1.59 0.86
31 INT96012 Gene_expression of EBP 3 0.67 0.8 0.85
32 INT77375 Phosphorylation of Ebp 1 0.13 0 0.81
33 INT151217 Phosphorylation of SIGMAR1 2 0.04 0.41 0.72
34 INT167760 Positive_regulation of Positive_regulation of Sigmar1 2 0.32 0.42 0.68
35 INT140711 Positive_regulation of EBP 1 0.29 0.72 0.68
36 INT103199 Positive_regulation of Positive_regulation of SIGMAR1 2 0.13 0.15 0.62
37 INT63458 Negative_regulation of Binding of Sigmar1 2 0.36 0.39 0.52
38 INT147919 Regulation of Ebp 1 0.08 0.94 0.48
39 INT110278 Negative_regulation of Sigmar1 3 0.32 0.35 0.47
40 INT147918 Positive_regulation of Negative_regulation of Ebp 1 0.14 0.88 0.42
41 INT90553 Positive_regulation of Regulation of Sigmar1 1 0.39 0 0.41
42 INT61891 Positive_regulation of Binding of SIGMAR1 2 0.32 0.34 0.39
43 INT214974 Positive_regulation of Gene_expression of Sigmar1 2 0.52 1.92 0.38
44 INT84110 Negative_regulation of Ebp 5 0.42 0.32 0.35
45 INT214965 Positive_regulation of Localization of Sigmar1 1 0.44 0.42 0.31
46 INT84109 Binding of Ebp 2 0.34 0.27 0.23
47 INT63457 Positive_regulation of Gene_expression of Sigmar1 1 0.36 0.09 0.23
48 INT110279 Regulation of Localization of Sigmar1 1 0.01 0 0.21
49 INT150306 Negative_regulation of Positive_regulation of Ebp 1 0.15 0.07 0.2
50 INT255393 Regulation of SREBF2 1 0.27 0.78 0.17
51 INT214971 Protein_catabolism of Sigmar1 1 0.56 0.45 0.16
52 INT59959 Positive_regulation of Binding of Sigmar1 1 0.47 0.16 0.14
53 INT255398 Regulation of Localization of SREBF2 1 0.45 0.81 0.13
54 INT18042 Negative_regulation of Binding of SIGMAR1 1 0.12 0 0.13
55 INT255391 Localization of SREBF2 1 0.74 0.8 0.11
56 INT211344 Regulation of Binding of Sigmar1 2 0.41 0.65 0.1
57 INT266951 Negative_regulation of Binding of Sigmar1 1 0.32 0.48 0.1
58 INT341313 Regulation of EBP 1 0.45 0.1 0.1
59 INT180293 Binding of EBP 3 0.37 0.06 0.09
60 INT66203 Regulation of Binding of SIGMAR1 1 0.44 0.19 0.09
61 INT255389 Gene_expression of SREBF2 3 0.77 1.67 0.08
62 INT84943 Regulation of Transcription of SIGMAR1 1 0.03 0.08 0.08
63 INT84942 Transcription of SIGMAR1 1 0.06 0.08 0.08
64 INT226027 Positive_regulation of Gene_expression of Ebp 1 0.13 2.46 0.06
65 INT190030 Binding of Ebp 1 0.09 0.72 0.03
66 INT339734 Positive_regulation of SREBF2 1 0.11 0.56 0.03
67 INT339773 Negative_regulation of SREBF2 1 0.11 0.57 0.03
68 INT304992 Regulation of Binding of EBP 1 0.26 0 0.03
69 INT155520 Regulation of Gene_expression of SIGMAR1 1 0.24 0.16 0
70 INT341312 Regulation of Gene_expression of EBP 1 0.45 0 0
71 INT169262 Negative_regulation of Binding of Ebp 1 0.39 0 0
72 INT180292 Localization of EBP 1 0.62 0 0
73 INT77301 Positive_regulation of Regulation of Sigmar1 1 0.43 0 0
74 INT341311 Positive_regulation of Gene_expression of EBP 1 0.50 0 0
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