GO:0000302

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Name response to reactive oxygen species
Categary Process
Go Slim No
Go Link GO:0000302
Unique Molecular Interactions 309
Total Molecular Interactions 406
Total Single Events 4324
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to reactive oxygen species. They are ordered first by their pain relevance and then by number of times they were reported for response to reactive oxygen species. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
3 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
4 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
5 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
6 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
7 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
8 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
9 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
10 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
11 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
12 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
13 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
14 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
15 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
16 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
17 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
18 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
19 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
20 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
21 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
22 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
23 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
24 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
25 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
26 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
27 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
28 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
29 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
30 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
31 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
32 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
33 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
34 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
35 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
36 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
37 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
38 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
39 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
40 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
41 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
42 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
43 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
44 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
45 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
46 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
47 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
48 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
49 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
50 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
51 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
52 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
53 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
54 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
55 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
56 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
57 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
58 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
59 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
60 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
61 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
62 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
63 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
64 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
65 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
66 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
67 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
68 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
69 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
70 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
71 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
72 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
73 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
74 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
75 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
76 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
77 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 0.10 0.06 0.39
78 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
79 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
80 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
81 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
82 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
83 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36
84 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35
85 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
86 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
87 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
88 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
89 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
90 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
91 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
92 INT307215 Negative_regulation of Prkca Negative_regulation of Ppara 1 0.09 0.21 0.3
93 INT296473 Prkca Regulation of Serac1 1 0.00 0.14 0.3
94 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
95 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
96 INT185144 Prkca Positive_regulation of Snrpd1 1 0.00 0.16 0.29
97 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29
98 INT137684 Binding of Cyp27b1 and Prkca 1 0.02 0 0.29
99 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
100 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
101 INT221236 Ros1 Positive_regulation of Localization of Prkca 1 0.01 0.15 0.27
102 INT351391 Binding of Sod2 and Gtf3a 1 0.00 0.18 0.27
103 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
104 INT241911 Binding of Cat and Ros1 1 0.03 0.85 0.27
105 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
106 INT196880 Binding of Ly6 and Prkca 1 0.01 0.18 0.25
107 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
108 INT207641 Positive_regulation of Prkca Positive_regulation of Mapk1 1 0.08 0.09 0.24
109 INT356098 Prkca Regulation of Prkaca 1 0.01 0.11 0.24
110 INT207632 Prkca Positive_regulation of Phosphorylation of Mapk1 1 0.08 0 0.23
111 INT120583 Gsta4 Regulation of Cat 1 0.03 0 0.23
112 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
113 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22
114 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
115 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
116 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 0.02 0.28 0.22
117 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
118 INT334379 Ros1 Regulation of Cat 1 0.04 0.08 0.21
119 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
120 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2
121 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
122 INT226720 Binding of Prkca and Il27ra 1 0.00 0.52 0.2
123 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
124 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
125 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2
126 INT226756 Positive_regulation of Binding of Prkca and Il27ra 1 0.00 0.52 0.2
127 INT226738 Binding of Cd4 and Prkca 1 0.02 0.52 0.2
128 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
129 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
130 INT338043 F2 Positive_regulation of Localization of Prkca 1 0.04 0.1 0.2
131 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
132 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
133 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
134 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 0.08 0 0.19
135 INT301083 Binding of BCS1L and MYH7 1 0.36 1.53 0.19
136 INT226727 Positive_regulation of Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.46 0.19
137 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
138 INT226761 Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.45 0.19
139 INT191890 Pbsn Negative_regulation of Binding of Prkca 1 0.03 0.29 0.18
140 INT191881 Pbsn Negative_regulation of Prkca 1 0.03 0.29 0.18
141 INT328923 Car2 Positive_regulation of Prkca 1 0.00 0 0.18
142 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
143 INT266899 Binding of Prkca and Plat 1 0.02 0.57 0.17
144 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
145 INT112133 Gast Positive_regulation of Prkca 1 0.18 0.13 0.16
146 INT241177 Abl2 Regulation of Cat 1 0.14 0.3 0.15
147 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
148 INT180671 Binding of Plat and Regulation of Serpine1 1 0.16 0.06 0.14
149 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
150 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
151 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
152 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
153 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
154 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
155 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
156 INT99737 Serpinf2 Negative_regulation of Localization of SERPINE1 1 0.00 0.24 0.12
157 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12
158 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
159 INT310695 Binding of Btk and Pla2g6 1 0.18 0.16 0.12
160 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
161 INT338054 Par2 Positive_regulation of Localization of Prkca 1 0.06 0 0.11
162 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
163 INT211921 Gene_expression of Nek1 Positive_regulation of Cat 1 0.01 0.26 0.1
164 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
165 INT22670 PLAT Positive_regulation of SERPINE1 1 0.03 0.1 0.1
166 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1
167 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1
168 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1
169 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
170 INT22672 Positive_regulation of Binding of SERPINE1 and PLAT 1 0.03 0.1 0.1
171 INT241913 AAVS1 Positive_regulation of Cat 1 0.04 0.46 0.1
172 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
173 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08
174 INT23896 Positive_regulation of Rtcd1 Positive_regulation of Cat 1 0.25 0 0.08
175 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
176 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
177 INT201736 Nfkb1 Positive_regulation of Transcription of Sod2 1 0.01 0.93 0.08
178 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07
179 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
180 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07
181 INT166919 Binding of CAT and GSTK1 1 0.09 0.16 0.07
182 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07
183 INT57268 SERPINE1 Positive_regulation of SERPINC1 1 0.07 0.94 0.07
184 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07
185 INT227353 Binding of Cat and Mpo 1 0.18 0.56 0.07
186 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
187 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
188 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06
189 INT281879 Cat Negative_regulation of Fig4 1 0.01 0.96 0.06
190 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06
191 INT229419 Atp6v0a2 Regulation of Cat 1 0.01 1.73 0.06
192 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
193 INT272734 Prkaca Positive_regulation of Gene_expression of Prkca 1 0.00 0 0.06
194 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
195 INT191893 Pbsn Regulation of Gene_expression of Prkca 1 0.03 0.13 0.05
196 INT245369 Gpm6a Negative_regulation of Phosphorylation of Prkca 1 0.20 0.08 0.05
197 INT191891 Prkca Regulation of Gene_expression of Mapk3 1 0.03 0.13 0.05
198 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
199 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
200 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to reactive oxygen species. They are ordered first by their pain relevance and then by number of times they were reported in response to reactive oxygen species. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
4 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
5 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
6 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
7 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
8 INT117527 Binding of Prkca 25 0.48 6.43 21.05
9 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
10 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
11 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
12 INT79458 Localization of Prkca 30 0.81 11.13 15.78
13 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
14 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
15 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
16 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
17 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
18 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
19 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
20 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
21 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
22 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
23 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
24 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
25 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
26 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
27 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64
28 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
29 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
30 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
31 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
32 INT38366 Regulation of Cat 45 0.62 23.45 5.34
33 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2
34 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
35 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
36 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
37 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
38 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
39 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
40 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
41 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
42 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
43 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
44 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92
45 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
46 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
47 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71
48 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
49 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
50 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
51 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
52 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
53 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
54 INT12948 Positive_regulation of Gene_expression of Cat 17 0.67 6.46 3.12
55 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
56 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
57 INT79722 Regulation of Cat 14 0.62 5.88 2.86
58 INT50080 Binding of APOE 38 0.45 29.61 2.67
59 INT113892 Binding of Cat 6 0.48 3.95 2.65
60 INT91899 Binding of Sod1 17 0.47 11.56 2.63
61 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
62 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37
63 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
64 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
65 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
66 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
67 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
68 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
69 INT123873 Positive_regulation of Negative_regulation of Cat 7 0.50 2.86 1.86
70 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
71 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
72 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
73 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
74 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
75 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
76 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
77 INT163666 Localization of Cat 8 0.80 5.84 1.57
78 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
79 INT124299 Negative_regulation of Gene_expression of Sod2 15 0.53 13.8 1.51
80 INT91900 Localization of Sod1 12 0.77 6.62 1.51
81 INT154763 Gene_expression of Nox1 3 0.67 1.83 1.48
82 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
83 INT154764 Localization of Nox1 1 0.65 1.07 1.47
84 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
85 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
86 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
87 INT91122 Localization of CAT 6 0.78 4.13 1.19
88 INT134061 Transcription of Sod2 5 0.68 3.46 1.19
89 INT148228 Positive_regulation of Regulation of Cat 1 0.49 1.16 1.19
90 INT20100 Binding of Serpine1 16 0.29 6.78 1.18
91 INT15919 Positive_regulation of Gene_expression of Serpine1 6 0.41 4.5 1.15
92 INT12952 Negative_regulation of Gene_expression of Cat 16 0.57 7.44 1.14
93 INT125356 Negative_regulation of Negative_regulation of Cat 4 0.42 2.66 1.06
94 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
95 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97
96 INT12945 Negative_regulation of Positive_regulation of Cat 3 0.41 2.61 0.97
97 INT53682 Regulation of Gene_expression of CAT 2 0.60 0.36 0.96
98 INT55052 Binding of Cat 10 0.36 5.46 0.92
99 INT42504 Negative_regulation of Nox1 5 0.43 0.55 0.91
100 INT66314 Negative_regulation of Positive_regulation of CAT 4 0.42 0.8 0.91
101 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9
102 INT142919 Regulation of Gene_expression of Cat 2 0.32 0.33 0.89
103 INT93747 Localization of Cat 9 0.56 4.25 0.88
104 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
105 INT130188 Positive_regulation of Negative_regulation of Cat 5 0.45 2.26 0.86
106 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83
107 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
108 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
109 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
110 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
111 INT89801 Positive_regulation of Positive_regulation of Cat 2 0.49 0.21 0.71
112 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
113 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69
114 INT266894 Positive_regulation of Positive_regulation of Sod2 5 0.41 3.26 0.67
115 INT94211 Positive_regulation of Negative_regulation of Prkca 1 0.43 0 0.67
116 INT66783 Positive_regulation of Negative_regulation of Nox1 1 0.63 0.81 0.66
117 INT175580 Localization of APOE 10 0.76 18.84 0.65
118 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
119 INT270033 Regulation of Gene_expression of Sod2 5 0.45 2.34 0.63
120 INT66903 Positive_regulation of Nox1 3 0.25 1.1 0.62
121 INT107417 Regulation of CAT 8 0.60 2.4 0.61
122 INT147440 Gene_expression of Nox1 3 0.57 1.61 0.6
123 INT79459 Protein_catabolism of Prkca 2 1.00 0.09 0.6
124 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
125 INT111960 Binding of Sod2 4 0.37 2.03 0.59
126 INT70971 Negative_regulation of Positive_regulation of SERPINE1 3 0.40 2.65 0.58
127 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
128 INT266893 Negative_regulation of Gene_expression of Cat 4 0.58 3.76 0.55
129 INT130387 Binding of CAT 4 0.36 2.39 0.55
130 INT79725 Regulation of Sod2 8 0.61 4.95 0.54
131 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
132 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53
133 INT20099 Regulation of Positive_regulation of Serpine1 2 0.40 1.75 0.52
134 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
135 INT58015 Regulation of Gene_expression of Serpine1 3 0.41 2.61 0.47
136 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47
137 INT35435 Negative_regulation of Positive_regulation of Serpine1 5 0.42 2.26 0.46
138 INT96816 Regulation of APOE 8 0.45 6.62 0.44
139 INT136205 Positive_regulation of Regulation of Cat 1 0.38 0.51 0.43
140 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38
141 INT124298 Localization of Sod2 8 0.74 3.5 0.37
142 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37
143 INT325423 Localization of Gstp1 1 0.06 0.85 0.37
144 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37
145 INT187606 Negative_regulation of Gene_expression of Serpine1 3 0.05 1.78 0.36
146 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
147 INT84981 Negative_regulation of Gene_expression of CAT 3 0.41 0.35 0.35
148 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
149 INT163803 Regulation of Gene_expression of Cat 3 0.61 1.51 0.33
150 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33
151 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33
152 INT144475 Protein_catabolism of Sod2 1 0.17 0.58 0.33
153 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32
154 INT314342 Positive_regulation of Localization of Cat 2 0.04 1.05 0.31
155 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
156 INT144868 Transcription of Cat 3 0.62 1.23 0.29
157 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
158 INT211917 Positive_regulation of Positive_regulation of Cat 1 0.62 0.97 0.29
159 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
160 INT129632 Negative_regulation of Transcription of Sod1 1 0.43 0.69 0.28
161 INT129631 Transcription of Sod1 1 0.52 0.69 0.28
162 INT158564 Negative_regulation of Positive_regulation of Cat 2 0.37 1.27 0.27
163 INT48719 Negative_regulation of Transcription of SERPINE1 1 0.42 0.17 0.26
164 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
165 INT88003 Gene_expression of MYH7 3 0.57 0.65 0.24
166 INT180280 Positive_regulation of Phosphorylation of SERPINE1 2 0.48 0 0.24
167 INT180281 Phosphorylation of SERPINE1 2 0.78 0 0.24
168 INT202186 Negative_regulation of Phosphorylation of SERPINE1 1 0.41 0 0.24
169 INT58442 Transcription of Cat 3 0.67 0.28 0.22
170 INT100870 Positive_regulation of Binding of SERPINE1 2 0.49 1.24 0.21
171 INT284147 Positive_regulation of MYH7 1 0.12 0.52 0.21
172 INT238309 Negative_regulation of Gene_expression of Sod1 3 0.38 1.09 0.2
173 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
174 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
175 INT48723 Regulation of Transcription of SERPINE1 1 0.27 0.26 0.2
176 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19
177 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19
178 INT25009 Regulation of Localization of Serpine1 2 0.36 0.15 0.17
179 INT270426 Regulation of Binding of SERPINE1 1 0.06 0.42 0.17
180 INT257835 Negative_regulation of Btk 6 0.41 2.41 0.16
181 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
182 INT55051 Negative_regulation of Binding of Cat 2 0.35 0.61 0.16
183 INT82636 Negative_regulation of Localization of Serpine1 1 0.29 1.01 0.16
184 INT238306 Regulation of Gene_expression of Sod1 1 0.39 0.46 0.16
185 INT124301 Negative_regulation of Localization of Sod2 1 0.38 1.25 0.16
186 INT355976 Negative_regulation of Transcription of Cat 1 0.51 0.31 0.15
187 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
188 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14
189 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
190 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
191 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
192 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
193 INT278171 Positive_regulation of Transcription of GSTP1 1 0.50 1.86 0.13
194 INT229429 Localization of Sod1 2 0.65 0.8 0.12
195 INT270029 Negative_regulation of Phosphorylation of Sod2 1 0.26 1.3 0.12
196 INT270035 Phosphorylation of Sod2 1 0.50 1.29 0.12
197 INT181919 Protein_catabolism of CAT 1 0.15 0.54 0.12
198 INT266895 Positive_regulation of Negative_regulation of Sod2 2 0.46 1.36 0.11
199 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
200 INT305016 Positive_regulation of Negative_regulation of SERPINE1 1 0.10 1.13 0.11
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