GO:0000307

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Name cyclin-dependent protein kinase holoenzyme complex
Categary Component
Go Slim No
Go Link GO:0000307
Unique Molecular Interactions 274
Total Molecular Interactions 373
Total Single Events 2878
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase holoenzyme complex. They are ordered first by their pain relevance and then by number of times they were reported for cyclin-dependent protein kinase holoenzyme complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
3 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
4 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
5 INT116107 CDK4 Positive_regulation of Phosphorylation of EID1 1 0.01 0.32 0.86
6 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
7 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
8 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
9 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
10 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
11 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
12 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
13 INT164263 TGM7 Negative_regulation of CCND3 1 0.04 1.08 0.54
14 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
15 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
16 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
17 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
18 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34
19 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
20 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
21 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
22 INT304280 CCNE1 Positive_regulation of IL6 1 0.00 1.93 0.31
23 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
24 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
25 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
26 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
27 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
28 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
29 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
30 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
31 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
32 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
33 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16
34 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
35 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
36 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
37 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
38 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
39 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
40 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
41 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
42 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
43 INT184522 Positive_regulation of Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.95 0.11
44 INT184521 Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.94 0.11
45 INT184520 Ptger2 Regulation of Ccnd1 1 0.00 0.94 0.11
46 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
47 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
48 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
49 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
50 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
51 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
52 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07
53 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
54 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
55 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
56 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
57 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
58 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
59 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
60 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
61 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
62 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
63 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
64 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
65 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
66 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
67 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
68 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04
69 INT207702 CCND1 Regulation of MSMB 1 0.22 0.69 0.04
70 INT189665 CHKB Regulation of Gene_expression of CCND3 1 0.03 0.42 0.04
71 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
72 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
73 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
74 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
75 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
76 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
77 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
78 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
79 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
80 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03
81 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03
82 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
83 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
84 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
85 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0
86 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
87 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
88 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
89 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
90 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
91 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
92 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
93 INT311405 CCND3 Regulation of Celf1 1 0.41 0.14 0
94 INT269932 Pcna Negative_regulation of Cdkn2b 1 0.09 0.07 0
95 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
96 INT272514 Cdk4 Positive_regulation of Phosphorylation of Ccnd3 1 0.01 0 0
97 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
98 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
99 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
100 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
101 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
102 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
103 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
104 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
105 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
106 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0
107 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
108 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
109 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
110 INT293815 MAPK1 Positive_regulation of Gene_expression of CCND3 1 0.01 0 0
111 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
112 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
113 INT269920 Positive_regulation of Binding of Ccnd1 and Qsox1 1 0.10 0 0
114 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
115 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
116 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
117 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
118 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
119 INT333843 Ccne1 Regulation of Regulation of Mir103-2 1 0.06 0 0
120 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
121 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
122 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 0.07 0 0
123 INT269926 Cdkn2b Negative_regulation of Pcna 1 0.08 0.07 0
124 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
125 INT269925 Binding of Ccnd1 and Qsox1 1 0.07 0 0
126 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
127 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
128 INT237980 CCND3 Regulation of Gene_expression of Birc5 1 0.06 0.96 0
129 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
130 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
131 INT233274 Tpt1 Regulation of Cdkn1a 1 0.05 0.26 0
132 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
133 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
134 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
135 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0
136 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
137 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
138 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0
139 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
140 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
141 INT315486 Slfn1 Negative_regulation of Ccnd1 1 0.07 0.28 0
142 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
143 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
144 INT182935 KCNIP3 Regulation of CDKN1A 1 0.45 0.96 0
145 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
146 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
147 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
148 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
149 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
150 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
151 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0
152 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
153 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
154 INT189676 CCND3 Regulation of Transcription of TERT 1 0.02 0.06 0
155 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0
156 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0
157 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
158 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
159 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
160 INT295043 Akt1 Positive_regulation of Cdk2 1 0.10 0.93 0
161 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
162 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
163 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
164 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
165 INT269914 Tpt1 Negative_regulation of Pcna 1 0.08 0.07 0
166 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
167 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
168 INT186051 IFI27 Regulation of Gene_expression of CCND1 1 0.30 0.66 0
169 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
170 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
171 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0
172 INT215709 Slc3a1 Regulation of Cdk4 1 0.01 0.05 0
173 INT293811 Negative_regulation of EIF4E Negative_regulation of Gene_expression of CCND3 1 0.02 0.32 0
174 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0
175 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0
176 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
177 INT182917 Binding of VDR and Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.31 0
178 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
179 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
180 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
181 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
182 INT269952 Pcna Negative_regulation of Tpt1 1 0.09 0.07 0
183 INT333850 Binding of Ccne1 and Cdk2 1 0.26 0 0
184 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
185 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
186 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
187 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
188 INT311376 Binding of Ccnd3 and Celf1 1 0.06 0.07 0
189 INT229007 MIA3 Positive_regulation of Gene_expression of Ccnd1 1 0.01 0.55 0
190 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
191 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
192 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
193 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
194 INT224290 ESR1 Positive_regulation of CCND1 1 0.17 0.07 0
195 INT182931 VDR Positive_regulation of Gene_expression of CDKN1A 1 0.48 0.86 0
196 INT182911 KCNIP3 Positive_regulation of CDKN1A 1 0.51 0.35 0
197 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0
198 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0
199 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
200 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase holoenzyme complex. They are ordered first by their pain relevance and then by number of times they were reported in cyclin-dependent protein kinase holoenzyme complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
2 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
3 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
4 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
5 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
6 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
7 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
8 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
9 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
10 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
11 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
12 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65
13 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
14 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
15 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
16 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
17 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
18 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
19 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
20 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66
21 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
22 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26
23 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
24 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15
25 INT93398 Negative_regulation of Gene_expression of Ccnd1 5 0.44 2.61 2.12
26 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08
27 INT68952 Localization of PCNA 17 0.62 5.64 1.78
28 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77
29 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
30 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
31 INT116116 Phosphorylation of CDK4 3 0.56 2.18 1.56
32 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31
33 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15
34 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07
35 INT147602 Negative_regulation of CDK4 8 0.35 4.6 1.04
36 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
37 INT250699 Binding of CDK6 3 0.33 2.54 0.97
38 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9
39 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87
40 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86
41 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86
42 INT146013 Negative_regulation of Gene_expression of Ccne1 4 0.21 1.19 0.85
43 INT146014 Gene_expression of Ccne1 5 0.54 1.31 0.84
44 INT111485 Gene_expression of Pcna 2 0.75 0 0.83
45 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81
46 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79
47 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
48 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77
49 INT306883 Negative_regulation of Phosphorylation of CDK4 1 0.17 1.06 0.71
50 INT114876 Negative_regulation of Gene_expression of Cdk4 3 0.38 2.3 0.7
51 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
52 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
53 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63
54 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6
55 INT114872 Negative_regulation of Gene_expression of Cdk2 2 0.35 1.21 0.6
56 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
57 INT58987 Positive_regulation of Ccne1 1 0.49 0 0.59
58 INT58988 Positive_regulation of Gene_expression of Ccne1 1 0.67 0 0.59
59 INT128498 Regulation of CCND1 17 0.39 12.51 0.58
60 INT58989 Gene_expression of Ccne1 2 0.75 0.79 0.58
61 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
62 INT111484 Positive_regulation of Gene_expression of Pcna 1 0.67 0 0.54
63 INT146802 Positive_regulation of Ccnd1 4 0.38 1.37 0.53
64 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51
65 INT176264 Binding of PCNA 21 0.21 9.08 0.51
66 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5
67 INT146522 Negative_regulation of Positive_regulation of CCND1 3 0.30 2.04 0.48
68 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
69 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47
70 INT93400 Negative_regulation of Ccnd1 4 0.33 0.77 0.47
71 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
72 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45
73 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
74 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
75 INT101568 Negative_regulation of Pcna 1 0.41 5.24 0.42
76 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
77 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
78 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
79 INT189755 Gene_expression of CCND3 42 0.65 10.88 0.39
80 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
81 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
82 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
83 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
84 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
85 INT304298 Positive_regulation of CCNE1 2 0.46 2.95 0.31
86 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3
87 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
88 INT186057 Binding of CCND1 8 0.31 5.92 0.26
89 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
90 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24
91 INT201638 Positive_regulation of Cdk4 5 0.58 3.38 0.24
92 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
93 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19
94 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19
95 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
96 INT42569 Binding of Ccne1 1 0.21 0.38 0.19
97 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
98 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15
99 INT201656 Positive_regulation of Positive_regulation of Cdk4 2 0.06 2.34 0.15
100 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
101 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
102 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
103 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
104 INT145248 Negative_regulation of Negative_regulation of Ccnd1 1 0.23 0.47 0.13
105 INT256849 Regulation of Pcna 1 0.05 0.3 0.13
106 INT196428 Negative_regulation of Binding of Ccnd1 1 0.14 1.17 0.13
107 INT201462 Binding of CDK2 12 0.39 5.2 0.12
108 INT204063 Gene_expression of Cdk4 3 0.21 0.9 0.12
109 INT196427 Negative_regulation of Transcription of Ccnd1 1 0.14 1.17 0.12
110 INT169908 Localization of Ccnd1 7 0.57 2.68 0.11
111 INT125588 Positive_regulation of Gene_expression of Pcna 5 0.49 1.57 0.11
112 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
113 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1
114 INT170849 Binding of Cdk4 3 0.16 2.44 0.1
115 INT302244 Negative_regulation of CCNE1 1 0.01 1.03 0.1
116 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
117 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
118 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
119 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
120 INT302272 Localization of CDK2 2 0.30 1.09 0.09
121 INT215750 Transcription of Ccnd1 2 0.14 2.23 0.09
122 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
123 INT145375 Transcription of CCND1 7 0.52 3.86 0.07
124 INT185284 Binding of CDK4 7 0.25 4.79 0.07
125 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
126 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
127 INT173183 Regulation of CCNE1 1 0.05 0.4 0.06
128 INT173191 Regulation of CDK4 1 0.26 0.39 0.06
129 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
130 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
131 INT215731 Positive_regulation of Transcription of Ccnd1 1 0.13 0.1 0.06
132 INT293783 Regulation of Gene_expression of CCND3 1 0.07 1.45 0.06
133 INT176590 Positive_regulation of Transcription of CCND1 1 0.17 0.27 0.05
134 INT269893 Negative_regulation of Gene_expression of Pcna 2 0.18 0.86 0.04
135 INT316430 Positive_regulation of Negative_regulation of Cdkn1a 1 0.19 1.24 0.04
136 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03
137 INT293760 Regulation of CCND3 6 0.07 1.99 0.03
138 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03
139 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
140 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
141 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
142 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
143 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03
144 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03
145 INT302266 Negative_regulation of Phosphorylation of CCNE1 1 0.02 0.29 0.03
146 INT176239 Regulation of Gene_expression of Pcna 1 0.04 0.58 0.03
147 INT293773 Positive_regulation of Gene_expression of CCND3 9 0.10 2.72 0
148 INT189752 Negative_regulation of Gene_expression of CCND3 6 0.09 1.89 0
149 INT176250 Positive_regulation of Pcna 6 0.13 3.52 0
150 INT196430 Gene_expression of Ccnd3 5 0.14 1.92 0
151 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0
152 INT237973 Negative_regulation of CCND3 4 0.08 2.93 0
153 INT293769 Positive_regulation of CCND3 3 0.06 0.23 0
154 INT314725 Gene_expression of CCNE1 3 0.52 2.45 0
155 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
156 INT236713 Regulation of Cdk4 3 0.22 1.35 0
157 INT236692 Phosphorylation of Cdk4 2 0.35 0.82 0
158 INT169427 Transcription of CDK2 2 0.09 0.42 0
159 INT325167 Gene_expression of CDK6 2 0.43 0 0
160 INT269897 Positive_regulation of Ccne1 2 0.35 0 0
161 INT245623 Negative_regulation of Cdk4 2 0.18 1.24 0
162 INT282087 Regulation of Ccne1 2 0.19 1.44 0
163 INT242456 Binding of Cdk2 2 0.16 1.29 0
164 INT306876 Phosphorylation of CCND3 2 0.35 0.21 0
165 INT169956 Positive_regulation of Transcription of PCNA 2 0.10 0.09 0
166 INT271100 Regulation of Positive_regulation of CDKN1A 2 0.44 1.52 0
167 INT215727 Regulation of Gene_expression of Ccnd1 2 0.12 0.49 0
168 INT295036 Positive_regulation of Positive_regulation of Cdk2 2 0.34 0.93 0
169 INT201643 Binding of Pcna 2 0.36 0 0
170 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0
171 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0
172 INT236705 Phosphorylation of Cdk2 2 0.31 1.39 0
173 INT236700 Phosphorylation of Ccnd1 2 0.18 1.89 0
174 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0
175 INT233247 Transcription of Cdkn1a 1 0.39 0.26 0
176 INT311364 Binding of CCND3 1 0.36 0.47 0
177 INT247423 Phosphorylation of Cdk4 1 0.32 1.14 0
178 INT277672 Localization of Cdkn1a 1 0.07 0.95 0
179 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
180 INT247426 Negative_regulation of Phosphorylation of Cdk4 1 0.17 1.15 0
181 INT295035 Negative_regulation of Positive_regulation of Cdk2 1 0.22 0.87 0
182 INT333800 Localization of Ccne1 1 0.53 0.22 0
183 INT305634 Localization of CCND1 1 0.07 2.69 0
184 INT327105 Transcription of CCND3 1 0.04 0.28 0
185 INT276362 Protein_catabolism of CCND1 1 0.10 0.66 0
186 INT169913 Positive_regulation of Gene_expression of Cdk2 1 0.21 0.08 0
187 INT277859 Protein_catabolism of Cdk2 1 0.43 0.23 0
188 INT333815 Regulation of Gene_expression of Ccne1 1 0.43 0 0
189 INT333793 Transcription of Cdk2 1 0.46 0 0
190 INT297265 Positive_regulation of Positive_regulation of CCND1 1 0.07 0.94 0
191 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
192 INT271087 Phosphorylation of Pcna 1 0.01 0.65 0
193 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0
194 INT201654 Localization of Cdk4 1 0.08 0 0
195 INT114219 Positive_regulation of Pcna 1 0.06 0.45 0
196 INT293777 Regulation of Positive_regulation of CCND3 1 0.05 0 0
197 INT201631 Localization of Pcna 1 0.01 0.5 0
198 INT333816 Regulation of Positive_regulation of Cdk2 1 0.30 0 0
199 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
200 INT330350 Positive_regulation of Negative_regulation of CCND1 1 0.08 1.3 0
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