GO:0000400

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Name four-way junction DNA binding
Categary Function
Go Slim No
Go Link GO:0000400
Unique Molecular Interactions 142
Total Molecular Interactions 222
Total Single Events 1382
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for four-way junction DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for four-way junction DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
2 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
3 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
4 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
5 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
6 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
7 INT30042 Binding of YY1 and Gnrhr 1 0.18 0 1.47
8 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
9 INT154114 PENK Positive_regulation of YY1 1 0.50 0.06 1.41
10 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
11 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
12 INT56882 Binding of YY1 and Ppbp 1 0.01 0 1.11
13 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
14 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
15 INT59518 YY1 Positive_regulation of SGCG 1 0.50 0.32 0.99
16 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
17 INT118204 ST14 Regulation of YY1 1 0.04 0 0.93
18 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
19 INT30955 YY1 Negative_regulation of Negative_regulation of LH 1 0.23 0.47 0.87
20 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
21 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
22 INT166672 YY1 Regulation of Binding of UGT1A6 1 0.48 0 0.76
23 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
24 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
25 INT7049 Binding of YY1 and Oprd1 1 0.01 0 0.73
26 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
27 INT166671 YY1 Regulation of Positive_regulation of UGT1A6 1 0.48 0 0.7
28 INT133942 Binding of YY1 and ARFGEF1 1 0.05 0 0.69
29 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
30 INT133936 Binding of DNM2 and YY1 1 0.29 0 0.69
31 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
32 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
33 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
34 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
35 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
36 INT114950 YY1 Positive_regulation of Positive_regulation of PPARA 1 0.52 0.25 0.64
37 INT34005 YY1 Regulation of KNG1 1 0.04 0.38 0.63
38 INT135498 Binding of YY1 and MRGPRX4 1 0.00 0.2 0.62
39 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
40 INT74656 YY1 Positive_regulation of Localization of IL2 1 0.07 0.09 0.58
41 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55
42 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
43 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
44 INT57546 Binding of YY1 and GNPTAB 1 0.00 0 0.53
45 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
46 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
47 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
48 INT135500 Positive_regulation of YY1 Positive_regulation of MRGPRX4 1 0.01 0.06 0.52
49 INT135501 MRGPRX4 Positive_regulation of YY1 1 0.00 0.06 0.52
50 INT135497 YY1 Positive_regulation of MRGPRX4 1 0.01 0.06 0.52
51 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
52 INT135503 MRGPRX4 Regulation of YY1 1 0.01 0.05 0.5
53 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
54 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
55 INT168130 Mir190 Positive_regulation of Phosphorylation of Yy1 1 0.54 0 0.45
56 INT128521 Binding of YY1 and IGKV2-26 1 0.12 0 0.45
57 INT168131 Phosphorylation of Yy1 Positive_regulation of Gene_expression of Mir190 1 0.32 0 0.45
58 INT168129 Binding of Yy1 and Positive_regulation of Transcription of Tln2 1 0.02 0 0.44
59 INT8356 Binding of YY1 and Smpd1 1 0.32 0 0.43
60 INT168132 Binding of Yy1 and Tln2 1 0.01 0 0.43
61 INT62066 Binding of YY1 and Pdyn 1 0.00 0 0.42
62 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
63 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
64 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
65 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
66 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
67 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
68 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
69 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
70 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
71 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
72 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
73 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
74 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
75 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
76 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
77 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
78 INT151884 Binding of PRLR and YY1 1 0.01 0 0.23
79 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
80 INT61346 Positive_regulation of YY1 Positive_regulation of Localization of SST 1 0.54 0 0.22
81 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
82 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
83 INT64382 Positive_regulation of Binding of YY1 and Tyr 1 0.11 0 0.21
84 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
85 INT64383 Binding of YY1 and Tyr 1 0.09 0 0.21
86 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
87 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
88 INT79206 Binding of MGP and YY1 1 0.34 0 0.19
89 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
90 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
91 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
92 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
93 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
94 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
95 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
96 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
97 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
98 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
99 INT144589 Binding of YY1 and Oprl1 1 0.04 0.73 0.13
100 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
101 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
102 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
103 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
104 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
105 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
106 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
107 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
108 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
109 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
110 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
111 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
112 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
113 INT319111 Binding of Yy1 and Sap30 1 0.01 0 0.04
114 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
115 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
116 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
117 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0
118 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
119 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
120 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0
121 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
122 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0
123 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
124 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0
125 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0
126 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
127 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0
128 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0
129 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0
130 INT212525 MSH6 Positive_regulation of Binding of C1qa 1 0.00 0.38 0
131 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0
132 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0
133 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0
134 INT300617 Binding of MSH6 and MLH1 1 0.28 0.53 0
135 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0
136 INT212528 Binding of MSH6 and Apcs 1 0.00 0.68 0
137 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for four-way junction DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in four-way junction DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6437 Binding of YY1 154 0.47 26.3 90.46
2 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16
3 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06
4 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8
5 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
6 INT3359 Regulation of YY1 32 0.60 8.19 19.2
7 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
8 INT18647 Localization of YY1 16 0.78 4.04 9.77
9 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
10 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
11 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
12 INT33419 Positive_regulation of Gene_expression of YY1 10 0.67 4.15 7.08
13 INT25647 Negative_regulation of Binding of YY1 10 0.57 1.47 6.77
14 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
15 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
16 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
17 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
18 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
19 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
20 INT73750 Regulation of Gene_expression of YY1 7 0.44 0.28 3.91
21 INT53891 Positive_regulation of Positive_regulation of YY1 5 0.49 0.24 3.65
22 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
23 INT29356 Positive_regulation of Binding of YY1 8 0.67 0.22 3.49
24 INT53889 Negative_regulation of Positive_regulation of YY1 6 0.41 0.57 3.05
25 INT53890 Transcription of YY1 8 0.67 1.53 2.88
26 INT168116 Phosphorylation of Yy1 1 0.71 0 2.57
27 INT59709 Negative_regulation of Negative_regulation of YY1 3 0.57 0.07 2.55
28 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12
29 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
30 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
31 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
32 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
33 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
34 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
35 INT79802 Phosphorylation of YY1 2 0.80 0.07 1.7
36 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
37 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
38 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
39 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
40 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
41 INT59708 Regulation of Negative_regulation of YY1 1 0.44 0.07 1.21
42 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
43 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
44 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
45 INT108012 Regulation of Localization of YY1 1 0.26 0 0.91
46 INT168123 Positive_regulation of Phosphorylation of Yy1 1 0.60 0 0.89
47 INT168114 Binding of Yy1 1 0.32 0 0.85
48 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
49 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
50 INT92142 Binding of MSH2 5 0.46 5.64 0.75
51 INT92222 Positive_regulation of Phosphorylation of YY1 1 0.49 0 0.74
52 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
53 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
54 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
55 INT280463 Binding of Mecp2 3 0.37 4 0.63
56 INT197832 Localization of MEN1 1 0.80 11.01 0.63
57 INT69546 Protein_catabolism of YY1 2 0.64 0.35 0.58
58 INT178222 Gene_expression of Yy1 5 0.57 2.06 0.56
59 INT71130 Regulation of Positive_regulation of YY1 1 0.44 0 0.55
60 INT16657 Positive_regulation of Negative_regulation of YY1 1 0.49 0.42 0.55
61 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
62 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
63 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
64 INT96263 Positive_regulation of Transcription of YY1 2 0.49 0.75 0.51
65 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
66 INT13381 Regulation of Binding of YY1 2 0.44 0 0.46
67 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
68 INT150433 Negative_regulation of Yy1 3 0.20 0.56 0.45
69 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
70 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43
71 INT168126 Regulation of Phosphorylation of Yy1 1 0.39 0 0.43
72 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
73 INT168119 Negative_regulation of Binding of Yy1 1 0.37 0 0.42
74 INT168122 Negative_regulation of Phosphorylation of Yy1 1 0.37 0 0.42
75 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
76 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
77 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
78 INT150432 Positive_regulation of Regulation of Yy1 1 0.19 0.39 0.35
79 INT150435 Regulation of Yy1 1 0.11 0.39 0.35
80 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
81 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
82 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
83 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
84 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
85 INT150434 Regulation of Negative_regulation of Yy1 1 0.13 0.15 0.23
86 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
87 INT13867 Negative_regulation of Regulation of YY1 1 0.41 0 0.21
88 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
89 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
90 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
91 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
92 INT182623 Localization of MSH2 3 0.77 5.49 0.12
93 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
94 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
95 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
96 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07
97 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06
98 INT319061 Localization of Yy1 1 0.12 0 0.04
99 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
100 INT190020 Gene_expression of Msh2 2 0.69 0.69 0
101 INT212518 Localization of MSH6 2 0.10 2.66 0
102 INT190035 Binding of Msh6 2 0.28 2.72 0
103 INT206928 Transcription of MSH2 1 0.52 0.4 0
104 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
105 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
106 INT197841 Positive_regulation of MEN1 1 0.41 2.38 0
107 INT337372 Regulation of Transcription of YY1 1 0.16 0.76 0
108 INT197843 Regulation of Localization of MEN1 1 0.45 0.24 0
109 INT197838 Transcription of MEN1 1 0.69 0.13 0
110 INT190015 Binding of Msh2 1 0.27 1.41 0
111 INT305347 Negative_regulation of Gene_expression of Msh6 1 0.25 2.22 0
112 INT211715 Negative_regulation of Gene_expression of MSH6 1 0.06 1.09 0
113 INT320939 Transcription of Mecp2 1 0.69 0.2 0
114 INT328132 Regulation of Mecp2 1 0.40 1 0
115 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
116 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
117 INT107984 Positive_regulation of Gene_expression of MSH2 1 0.11 0 0
118 INT182624 Positive_regulation of Positive_regulation of MSH2 1 0.45 1.24 0
119 INT197824 Positive_regulation of Transcription of MEN1 1 0.50 0.13 0
120 INT304071 Binding of MSH6 1 0.28 1.11 0
121 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
122 INT305349 Gene_expression of Msh6 1 0.46 2.21 0
123 INT197834 Binding of MEN1 1 0.48 3.32 0
124 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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