GO:0000785

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Name chromatin
Categary Component
Go Slim No
Go Link GO:0000785
Unique Molecular Interactions 943
Total Molecular Interactions 1312
Total Single Events 8905
Pain Genes Associated 61

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chromatin. They are ordered first by their pain relevance and then by number of times they were reported for chromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
3 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
4 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
5 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
6 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
7 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
8 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
9 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
10 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
11 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
12 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
13 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
14 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
15 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
16 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
17 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
18 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
19 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
20 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
21 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
22 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
23 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
24 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
25 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
26 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
27 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
28 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
29 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
30 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
31 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
32 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
33 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
34 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
35 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
36 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
37 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
38 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
39 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
40 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
41 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
42 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
43 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
44 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
45 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
46 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
47 INT252879 Creb1 Positive_regulation of Gene_expression of Tacr1 1 0.03 0.24 0.91
48 INT219037 Creb1 Positive_regulation of Transcription of Bdnf 2 0.43 1.07 0.9
49 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
50 INT77253 Binding of gr and Creb1 1 0.03 0.4 0.9
51 INT309140 Dlat Positive_regulation of Creb1 1 0.06 1.1 0.9
52 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89
53 INT73653 Binding of Creb1 and Fos 1 0.40 1.49 0.87
54 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
55 INT116107 CDK4 Positive_regulation of Phosphorylation of EID1 1 0.01 0.32 0.86
56 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
57 INT304575 Creb1 Regulation of Gene_expression of Bdnf 1 0.04 1 0.84
58 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
59 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
60 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
61 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
62 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81
63 INT109142 Calca Positive_regulation of Transcription of Creb1 1 0.47 0.13 0.8
64 INT182839 Camk4 Positive_regulation of Creb1 3 0.49 1.81 0.79
65 INT114924 Creb1 Regulation of Positive_regulation of Oprm1 1 0.09 0.13 0.79
66 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
67 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
68 INT131194 Creb1 Positive_regulation of Gene_expression of Pdyn 1 0.26 0.08 0.79
69 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79
70 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77
71 INT261413 Positive_regulation of GRIN1 Positive_regulation of Positive_regulation of Creb1 1 0.00 0.81 0.77
72 INT106335 Olr1254 Positive_regulation of Phosphorylation of Creb1 1 0.03 0 0.76
73 INT109141 Calca Positive_regulation of Creb1 1 0.47 0.13 0.76
74 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
75 INT109143 Calca Positive_regulation of Phosphorylation of Creb1 1 0.47 0.13 0.76
76 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
77 INT186436 Phosphorylation of Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
78 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
79 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
80 INT186438 Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
81 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
82 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72
83 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
84 INT186440 Phosphorylation of Creb1 Regulation of Jun 1 0.21 0.43 0.72
85 INT142994 Binding of UPF1 and FCMTE1 1 0.00 0.91 0.7
86 INT123300 Mks1 Positive_regulation of Creb1 1 0.01 0.35 0.7
87 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
88 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
89 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
90 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
91 INT101716 JUND Regulation of Regulation of OPRM1 1 0.09 0.06 0.65
92 INT266064 Binding of PAG1 and Creb1 1 0.04 1.52 0.65
93 INT266049 Binding of Ceacam3 and Creb1 1 0.14 1.53 0.65
94 INT235881 Prkaca Positive_regulation of Creb1 2 0.10 0.16 0.64
95 INT135364 Prr14 Positive_regulation of Mbd1 1 0.22 0.15 0.64
96 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
97 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
98 INT266047 Creb1 Regulation of Ceacam3 1 0.20 1.15 0.62
99 INT186429 Camk2a Regulation of Regulation of Creb1 1 0.09 0.09 0.62
100 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62
101 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62
102 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
103 INT123301 Car2 Positive_regulation of Creb1 1 0.21 0.28 0.61
104 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 0.00 0.09 0.6
105 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59
106 INT186434 Trib3 Positive_regulation of Phosphorylation of Creb1 1 0.05 0.26 0.58
107 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
108 INT317637 Ngf Regulation of Creb1 1 0.10 0.11 0.57
109 INT92974 Creb1 Regulation of Positive_regulation of Galr1 1 0.32 0 0.57
110 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57
111 INT305732 Tst Positive_regulation of Creb1 1 0.12 0.33 0.57
112 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
113 INT73656 Creb1 Positive_regulation of Transcription of Pdyn 1 0.42 0.97 0.56
114 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
115 INT296169 Binding of Htr4 and Creb1 1 0.49 0.1 0.56
116 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55
117 INT105424 Creb1 Positive_regulation of Gene_expression of Penk 1 0.49 0 0.55
118 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
119 INT114928 Positive_regulation of Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.16 0.05 0.54
120 INT305738 Binding of Creb1 and Atf6b 1 0.08 0.34 0.53
121 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
122 INT119546 Nfe2l2 Regulation of Gene_expression of Fos 1 0.48 0.94 0.52
123 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
124 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
125 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
126 INT219038 Creb1 Regulation of Gene_expression of Bdnf 1 0.25 0.25 0.49
127 INT200321 Binding of Rest and Negative_regulation of Gene_expression of Oprm1 1 0.36 0.05 0.49
128 INT352031 Binding of NR3C1 and JUND 1 0.10 2.87 0.48
129 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48
130 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
131 INT305735 Binding of Bdnf and Creb1 1 0.08 0.49 0.47
132 INT118396 Nfe2l2 Positive_regulation of Gene_expression of Cars 1 0.05 0.26 0.47
133 INT305746 Positive_regulation of Creb1 Positive_regulation of BDNF 1 0.32 0.41 0.47
134 INT305743 Binding of Bdnf and Positive_regulation of Positive_regulation of Creb1 1 0.11 0.49 0.47
135 INT235882 Creb1 Positive_regulation of Positive_regulation of Bdnf 1 0.11 0.17 0.47
136 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
137 INT305736 Positive_regulation of Creb1 Positive_regulation of Bdnf 1 0.10 0.41 0.46
138 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
139 INT317640 Slc3a1 Positive_regulation of Creb1 1 0.12 0.58 0.46
140 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
141 INT161162 Creb1 Regulation of Nts 1 0.19 0.15 0.45
142 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
143 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
144 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45
145 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45
146 INT283731 Trib3 Positive_regulation of Creb1 2 0.01 0.16 0.44
147 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
148 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
149 INT309113 Edc4 Positive_regulation of Gene_expression of Creb1 1 0.03 0.45 0.43
150 INT106333 Olr1254 Positive_regulation of Creb1 1 0.02 0 0.43
151 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
152 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
153 INT309145 Positive_regulation of Edc4 Positive_regulation of Creb1 1 0.02 0.35 0.42
154 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
155 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
156 INT200327 Oprm1 Negative_regulation of Gene_expression of Rest 1 0.31 0 0.41
157 INT186148 Camk4 Positive_regulation of Phosphorylation of Creb1 2 0.50 1.11 0.4
158 INT235868 Creb1 Negative_regulation of Atf6b 1 0.02 0.21 0.4
159 INT200314 Oprm1 Regulation of Rest 1 0.20 0.1 0.39
160 INT200353 Rest Negative_regulation of Oprm1 1 0.31 0.1 0.39
161 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39
162 INT147473 Nfe2l2 Positive_regulation of Gene_expression of Hmox1 1 0.74 0.49 0.39
163 INT122502 TNF Positive_regulation of Localization of CAPN2 1 0.24 0.18 0.38
164 INT57219 Binding of ATF3 and JUND 1 0.31 0.39 0.38
165 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38
166 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
167 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
168 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
169 INT28991 Tmpo Positive_regulation of Gene_expression of Pomc 1 0.34 0.82 0.37
170 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36
171 INT147475 co Positive_regulation of Gene_expression of Nfe2l2 1 0.01 0.57 0.36
172 INT340607 Bdnf Regulation of Gene_expression of Creb1 1 0.36 0.31 0.36
173 INT274937 Ephb2 Regulation of Phosphorylation of Creb1 1 0.21 0 0.36
174 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
175 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
176 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
177 INT200352 Binding of Rest and Rcor2 1 0.16 0.44 0.34
178 INT83348 GSR Negative_regulation of JUND 1 0.20 0.72 0.33
179 INT20468 Ran Negative_regulation of Localization of Prl 1 0.30 0 0.33
180 INT175552 Binding of CASR and UPF1 1 0.01 0.89 0.33
181 INT273955 Creb1 Positive_regulation of Transcription of Crh 1 0.14 0.96 0.33
182 INT214987 Binding of FANCC and Sigmar1 1 0.06 0.34 0.32
183 INT207212 Creb1 Regulation of Bdnf 1 0.17 0.92 0.32
184 INT126851 Prkcg Positive_regulation of Creb1 1 0.46 0.09 0.32
185 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
186 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32
187 INT209855 NFE2L2 Positive_regulation of Gene_expression of CD36 1 0.27 0.72 0.32
188 INT126852 Prkaca Positive_regulation of Creb1 1 0.27 0.09 0.32
189 INT124258 Creb1 Regulation of Gene_expression of Cpox 1 0.17 0.44 0.32
190 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
191 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
192 INT169612 OGFR Regulation of RAN 1 0.23 0.14 0.3
193 INT186430 Creb1 Positive_regulation of Trib3 1 0.04 0.17 0.3
194 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
195 INT118655 Bdnf Positive_regulation of Phosphorylation of Creb1 1 0.44 0.16 0.3
196 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
197 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
198 INT118653 Binding of Bdnf and Creb1 1 0.39 0.19 0.3
199 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
200 INT101810 Binding of NFE2L2 and KEAP1 7 0.53 4.12 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for chromatin. They are ordered first by their pain relevance and then by number of times they were reported in chromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
2 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
3 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
4 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
5 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
6 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
7 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
8 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
9 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
10 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
11 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
12 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
13 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
14 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
15 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
16 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
17 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
18 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
19 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
20 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
21 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
22 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
23 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
24 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
25 INT16713 Binding of Creb1 53 0.48 20.24 13.06
26 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83
27 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
28 INT118390 Positive_regulation of Nfe2l2 82 0.70 20.41 10.61
29 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
30 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
31 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94
32 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
33 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
34 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96
35 INT93673 Transcription of Creb1 19 0.66 9.27 8.26
36 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
37 INT116619 Positive_regulation of Positive_regulation of Creb1 25 0.69 8.32 7.3
38 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
39 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
40 INT106330 Regulation of Positive_regulation of Creb1 11 0.56 5.57 7.06
41 INT39242 Negative_regulation of TMPO 29 0.58 5.15 7.04
42 INT114642 Negative_regulation of Positive_regulation of Creb1 12 0.57 2.32 6.75
43 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
44 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
45 INT92971 Binding of Creb1 31 0.47 11.3 6.22
46 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
47 INT118388 Localization of Nfe2l2 40 0.81 9.59 5.89
48 INT61986 Localization of Creb1 16 0.69 2.12 5.66
49 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
50 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
51 INT60585 Regulation of TP53 59 0.59 54.55 5.21
52 INT102019 Regulation of Gene_expression of Creb1 14 0.61 5.27 5.08
53 INT83728 Localization of TMPO 42 0.46 0.46 5.06
54 INT102202 Negative_regulation of Positive_regulation of Creb1 11 0.58 4.55 4.99
55 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
56 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
57 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
58 INT2213 Regulation of EP300 10 0.54 4.72 4.5
59 INT121866 Localization of Creb1 13 0.73 1.95 4.48
60 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
61 INT178751 Positive_regulation of TMPO 51 0.44 1.47 4.41
62 INT119544 Gene_expression of Nfe2l2 50 0.77 19.32 4.19
63 INT59836 Positive_regulation of Upf1 24 0.02 4.42 3.99
64 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
65 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87
66 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
67 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
68 INT12844 Binding of TP63 15 0.47 10.57 3.38
69 INT118393 Positive_regulation of Localization of Nfe2l2 9 0.70 2.82 3.3
70 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26
71 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
72 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
73 INT8103 Binding of TP53 46 0.44 40.2 2.96
74 INT199255 Binding of Rest 14 0.41 1.43 2.94
75 INT15757 Gene_expression of JUND 11 0.75 2.47 2.86
76 INT111554 Positive_regulation of Regulation of Creb1 4 0.50 2.12 2.85
77 INT156021 Positive_regulation of Transcription of Creb1 8 0.57 3.36 2.83
78 INT118394 Positive_regulation of Positive_regulation of Nfe2l2 13 0.70 1.4 2.81
79 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
80 INT39243 Regulation of TMPO 20 0.61 5.66 2.67
81 INT200963 Regulation of UPF1 10 0.01 2.18 2.67
82 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
83 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
84 INT158666 Regulation of Transcription of Creb1 6 0.45 2.41 2.44
85 INT269402 Phosphorylation of TMPO 17 0.32 0.17 2.36
86 INT55952 Transcription of TP53 16 0.61 12.14 2.36
87 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
88 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
89 INT269372 Positive_regulation of Localization of TMPO 19 0.23 0.25 2.23
90 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
91 INT87168 Positive_regulation of Binding of Creb1 4 0.48 4.6 2.21
92 INT159118 Protein_catabolism of Creb1 3 0.61 0.37 2.17
93 INT106718 Regulation of Positive_regulation of Creb1 9 0.45 3.7 2.16
94 INT120650 Negative_regulation of UPF1 14 0.02 6.86 2.14
95 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
96 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
97 INT154651 Negative_regulation of Nfe2l2 19 0.59 10.48 2.01
98 INT171514 Binding of EP300 13 0.32 4.32 2.01
99 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
100 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
101 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
102 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
103 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91
104 INT65855 Localization of TP53 18 0.76 17.08 1.89
105 INT269406 Binding of TMPO 35 0.31 1.43 1.82
106 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
107 INT122503 Localization of CAPN2 1 0.35 1.43 1.76
108 INT119540 Binding of Nfe2l2 29 0.48 6.34 1.74
109 INT172622 Localization of EP300 8 0.65 2.56 1.72
110 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
111 INT101816 Localization of NFE2L2 17 0.77 6.91 1.69
112 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69
113 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
114 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
115 INT6438 Positive_regulation of RAN 6 0.42 2.09 1.59
116 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
117 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
118 INT116116 Phosphorylation of CDK4 3 0.56 2.18 1.56
119 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
120 INT15758 Positive_regulation of Gene_expression of JUND 5 0.23 0.99 1.53
121 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
122 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
123 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
124 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
125 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
126 INT135351 Positive_regulation of Mbd1 1 0.63 0.34 1.46
127 INT59837 Regulation of Upf1 5 0.03 1.37 1.45
128 INT147471 Positive_regulation of Gene_expression of Nfe2l2 10 0.57 4.18 1.43
129 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
130 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
131 INT172953 Binding of Trp53 33 0.37 20.76 1.41
132 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
133 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
134 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4
135 INT165005 Binding of REST 26 0.43 2.81 1.39
136 INT145221 Binding of Tp53 10 0.37 8.59 1.37
137 INT190880 Binding of Ncor2 11 0.27 2.24 1.34
138 INT200979 Regulation of Gene_expression of UPF1 4 0.28 2.19 1.31
139 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
140 INT214983 Positive_regulation of FANCC 11 0.15 1.81 1.29
141 INT63905 Regulation of RB1 13 0.62 12.67 1.28
142 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
143 INT269381 Positive_regulation of Phosphorylation of TMPO 9 0.20 0 1.27
144 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
145 INT98923 Negative_regulation of Localization of Creb1 3 0.50 0.66 1.26
146 INT200972 Positive_regulation of Gene_expression of UPF1 6 0.31 1.51 1.23
147 INT269411 Positive_regulation of Gene_expression of TMPO 9 0.23 0.65 1.22
148 INT103164 Binding of UPF1 4 0.29 4.15 1.22
149 INT169721 Negative_regulation of Negative_regulation of Creb1 1 0.43 0.09 1.22
150 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
151 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
152 INT121867 Positive_regulation of Localization of Creb1 2 0.60 0.43 1.2
153 INT174156 Localization of Trp53 16 0.72 13.52 1.18
154 INT144623 Negative_regulation of Gene_expression of Nfe2l2 10 0.47 3.6 1.17
155 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
156 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
157 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
158 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
159 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
160 INT207201 Positive_regulation of Transcription of Creb1 4 0.50 0.69 1.09
161 INT71476 Negative_regulation of Regulation of Creb1 1 0.18 0.17 1.06
162 INT19501 Gene_expression of MYCN 5 0.75 3.06 1.05
163 INT70667 Regulation of JUND 3 0.33 2.36 1.05
164 INT147602 Negative_regulation of CDK4 8 0.35 4.6 1.04
165 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
166 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
167 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
168 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
169 INT167650 Binding of Ep300 1 0.09 0.14 1
170 INT269384 Negative_regulation of Gene_expression of TMPO 10 0.23 0.47 0.97
171 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
172 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
173 INT190591 Positive_regulation of Rest 3 0.37 2.52 0.92
174 INT269413 Regulation of Localization of TMPO 7 0.18 0 0.86
175 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86
176 INT200255 Localization of Rest 1 0.68 0.14 0.86
177 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
178 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
179 INT172479 Positive_regulation of NFE2L2 74 0.70 35.22 0.79
180 INT114877 Gene_expression of Cdk4 12 0.69 5.98 0.79
181 INT269401 Regulation of Gene_expression of TMPO 8 0.18 2.89 0.78
182 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
183 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
184 INT44293 Regulation of TP63 6 0.24 2.88 0.76
185 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
186 INT83350 Negative_regulation of JUND 4 0.52 1.68 0.75
187 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
188 INT70423 Binding of HDAC3 1 0.01 0.36 0.75
189 INT144540 Negative_regulation of Gene_expression of Sin3a 1 0.57 0.85 0.75
190 INT144544 Gene_expression of Sin3a 1 0.75 0.84 0.74
191 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
192 INT101722 Binding of JUND 12 0.31 2.21 0.73
193 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
194 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
195 INT114536 Regulation of Negative_regulation of Creb1 1 0.45 0 0.72
196 INT306883 Negative_regulation of Phosphorylation of CDK4 1 0.17 1.06 0.71
197 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
198 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
199 INT114876 Negative_regulation of Gene_expression of Cdk4 3 0.38 2.3 0.7
200 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
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