GO:0000792

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Name heterochromatin
Categary Component
Go Slim No
Go Link GO:0000792
Unique Molecular Interactions 105
Total Molecular Interactions 121
Total Single Events 881
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported for heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
2 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
3 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
4 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
5 INT135364 Prr14 Positive_regulation of Mbd1 1 0.22 0.15 0.64
6 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
7 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
8 INT804 Aap Negative_regulation of MBD2 1 0.01 0 0.57
9 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57
10 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
11 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
12 INT155086 CASP1 Negative_regulation of DAXX 1 0.21 1.26 0.45
13 INT1066 Gm5720 Positive_regulation of MBD2 1 0.00 0.73 0.42
14 INT167551 Binding of MECP2 and SP3 1 0.01 0.06 0.35
15 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
16 INT47600 Ccno Regulation of MBD2 1 0.00 0.22 0.24
17 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
18 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
19 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
20 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
21 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
22 INT87092 Binding of PPP4C and MBD2 1 0.05 0 0.16
23 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
24 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
25 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
26 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
27 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
28 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
29 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
30 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
31 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
32 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11
33 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
34 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
35 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
36 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
37 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
38 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03
39 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
40 INT348583 MECP2 Regulation of PPARG 1 0.46 0.73 0
41 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
42 INT348594 MECP2 Regulation of Gene_expression of PPARG 1 0.34 0.43 0
43 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
44 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
45 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
46 INT346836 MECP2 Regulation of PTGS2 1 0.00 0.34 0
47 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
48 INT346837 ZNF434 Regulation of MECP2 1 0.00 0.34 0
49 INT348588 MECP2 Positive_regulation of Gene_expression of EZH2 1 0.28 0.42 0
50 INT273949 Binding of Crem and Smarca4 1 0.01 0 0
51 INT301099 Binding of MECP2 and CHDH 1 0.00 0.1 0
52 INT348596 EZH2 Positive_regulation of Gene_expression of MECP2 1 0.28 0.42 0
53 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
54 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
55 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
56 INT263540 Binding of MECP2 and RS1 1 0.00 0.18 0
57 INT268320 Cdc20 Positive_regulation of Orc2 1 0.08 0.25 0
58 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
59 INT348591 EZH2 Regulation of Negative_regulation of MECP2 1 0.15 0.73 0
60 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
61 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
62 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
63 INT348587 Binding of MECP2 and PPARG 1 0.32 0.25 0
64 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
65 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
66 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
67 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
68 INT301097 Binding of MECP2 and SNRNP70 1 0.01 1.15 0
69 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0
70 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
71 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
72 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
73 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
74 INT301094 MECP2 Regulation of Gene_expression of HSPA8 1 0.01 0.38 0
75 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
76 INT263539 Positive_regulation of Binding of MECP2 and RS1 1 0.00 0.18 0
77 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported in heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31
2 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
3 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49
4 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
5 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
6 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
7 INT167556 Binding of MECP2 7 0.27 4.57 2.6
8 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
9 INT38374 Regulation of MBD2 8 0.10 0.72 2.09
10 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
11 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
12 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
13 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
14 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
15 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
16 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
17 INT135351 Positive_regulation of Mbd1 1 0.63 0.34 1.46
18 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
19 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
20 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
21 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98
22 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96
23 INT133608 Regulation of Daxx 1 0.16 0.28 0.93
24 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
25 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
26 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
27 INT144880 Negative_regulation of DAXX 4 0.23 2.15 0.73
28 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
29 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
30 INT133603 Gene_expression of Daxx 1 0.28 0.27 0.7
31 INT133606 Regulation of Gene_expression of Daxx 1 0.16 0.27 0.7
32 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
33 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
34 INT280463 Binding of Mecp2 3 0.37 4 0.63
35 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
36 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
37 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
38 INT8053 Regulation of Negative_regulation of MBD2 1 0.16 0 0.5
39 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
40 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
41 INT155088 Positive_regulation of DAXX 1 0.22 1.27 0.45
42 INT329686 Gene_expression of CBX7 1 0.77 54.06 0.45
43 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
44 INT85854 Binding of SALL1 5 0.36 1.4 0.41
45 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
46 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
47 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
48 INT167557 Positive_regulation of Binding of MECP2 1 0.10 0.06 0.36
49 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
50 INT162983 Binding of Daxx 1 0.10 0.1 0.36
51 INT135354 Positive_regulation of Binding of Mbd1 1 0.39 0.1 0.36
52 INT130043 Positive_regulation of Daxx 1 0.51 0.54 0.35
53 INT135357 Binding of Mbd1 1 0.29 0.1 0.35
54 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
55 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
56 INT159509 Positive_regulation of MECP2 3 0.42 1.8 0.31
57 INT159508 Positive_regulation of Gene_expression of MECP2 1 0.42 0.72 0.29
58 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
59 INT159507 Regulation of Positive_regulation of MECP2 1 0.24 0.72 0.29
60 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
61 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
62 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
63 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
64 INT41148 Binding of MBD2 1 0.18 0 0.17
65 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
66 INT329689 Regulation of Gene_expression of CBX7 1 0.45 0.44 0.15
67 INT329694 Negative_regulation of Gene_expression of CBX7 1 0.58 8.06 0.14
68 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
69 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
70 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
71 INT46899 Negative_regulation of Positive_regulation of MBD2 1 0.00 0 0.1
72 INT329940 Gene_expression of Sall1 1 0.02 0 0.1
73 INT27567 Positive_regulation of Gene_expression of MBD2 1 0.01 0 0.09
74 INT47659 Localization of MBD2 2 0.70 0.72 0.08
75 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
76 INT120535 Positive_regulation of Negative_regulation of MBD2 1 0.01 0.22 0.07
77 INT224825 Regulation of Gene_expression of SALL1 1 0.37 0.07 0.07
78 INT282807 Localization of MECP2 1 0.73 1.18 0.06
79 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
80 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
81 INT346844 Regulation of MECP2 2 0.17 0.35 0.04
82 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
83 INT260908 Positive_regulation of Smarca4 2 0.21 0.53 0.03
84 INT332918 Localization of Suv39h1 1 0.73 0.11 0.03
85 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
86 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
87 INT277595 Localization of Hdac1 4 0.73 0.81 0
88 INT261751 Regulation of Hdac1 2 0.41 0 0
89 INT279810 Negative_regulation of Positive_regulation of SALL1 1 0.03 0.07 0
90 INT348615 Regulation of Gene_expression of MECP2 1 0.33 0.66 0
91 INT329692 Positive_regulation of CBX7 1 0.50 2.52 0
92 INT346846 Transcription of MECP2 1 0.01 0.28 0
93 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
94 INT192615 Localization of Atrx 1 0.74 0.1 0
95 INT319154 Transcription of Hdac1 1 0.66 0 0
96 INT192609 Negative_regulation of Gene_expression of Atrx 1 0.37 0.28 0
97 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
98 INT192616 Negative_regulation of Atrx 1 0.43 1.04 0
99 INT192608 Regulation of Atrx 1 0.39 0.67 0
100 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
101 INT348620 Negative_regulation of MECP2 1 0.43 1.45 0
102 INT192610 Positive_regulation of Atrx 1 0.50 0.78 0
103 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
104 INT192613 Positive_regulation of Binding of Atrx 1 0.69 0.09 0
105 INT329691 Regulation of CBX7 1 0.27 2.5 0
106 INT320939 Transcription of Mecp2 1 0.69 0.2 0
107 INT328132 Regulation of Mecp2 1 0.40 1 0
108 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
109 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
110 INT328548 Negative_regulation of Gene_expression of Cbx5 1 0.05 0.08 0
111 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
112 INT329690 Positive_regulation of Gene_expression of CBX7 1 0.69 15.58 0
113 INT328546 Gene_expression of Cbx5 1 0.07 0.08 0
114 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
115 INT192617 Binding of Atrx 1 0.48 0.58 0
116 INT260913 Negative_regulation of Smarca4 1 0.18 0.29 0
117 INT329695 Negative_regulation of CBX7 1 0.43 1.14 0
118 INT273916 Binding of Smarca4 1 0.01 0 0
119 INT329688 Binding of CBX7 1 0.37 0.95 0
120 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
121 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
122 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
123 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
124 INT301453 Positive_regulation of Sall1 1 0.04 0.08 0
125 INT268301 Gene_expression of Orc2 1 0.33 0.26 0
126 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
127 INT297392 Positive_regulation of Binding of SALL1 1 0.49 0 0
128 INT192614 Gene_expression of Atrx 1 0.77 1.75 0
129 INT192607 Transcription of Atrx 1 0.68 0.4 0
130 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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