GO:0000981

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Name sequence-specific DNA binding RNA polymerase II transcription factor activity
Categary Function
Go Slim No
Go Link GO:0000981
Unique Molecular Interactions 251
Total Molecular Interactions 326
Total Single Events 2064
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sequence-specific DNA binding RNA polymerase II transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for sequence-specific DNA binding RNA polymerase II transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
2 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
3 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
4 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
5 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
6 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
7 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
8 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
9 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
10 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
11 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
12 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
13 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
14 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
15 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
16 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
17 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7
18 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
19 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
20 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
21 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
22 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
23 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
24 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
25 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
26 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
27 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
28 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
29 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
30 INT143853 Ngf Positive_regulation of Nfatc4 1 0.02 0.62 0.53
31 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
32 INT143855 Ngf Regulation of Positive_regulation of Nfatc4 1 0.02 0.62 0.53
33 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
34 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
35 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
36 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
37 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
38 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
39 INT112843 Binding of OPRK1 and Nfatc4 1 0.00 0 0.48
40 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
41 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
42 INT298284 Runx3 Negative_regulation of Gene_expression of Ntrk1 1 0.26 0.39 0.43
43 INT298291 Runx3 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
44 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
45 INT298286 Runx3 Regulation of Gene_expression of Runx1 1 0.47 0.36 0.41
46 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
47 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
48 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
49 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
50 INT285935 IL6 Positive_regulation of Gene_expression of POU5F1 1 0.14 2.68 0.37
51 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
52 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
53 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
54 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
55 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
56 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
57 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
58 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
59 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
60 INT100946 TNF Positive_regulation of Localization of NFIB 1 0.01 1.3 0.29
61 INT245562 Ntrk3 Regulation of Runx3 1 0.40 0.77 0.29
62 INT100945 TNF Positive_regulation of NFIB 1 0.00 1.29 0.29
63 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
64 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
65 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
66 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
67 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
68 INT287098 Binding of FL and T 1 0.10 0.66 0.23
69 INT221781 Camk4 Positive_regulation of Mef2d 1 0.28 0.14 0.22
70 INT298275 Binding of Runx3 and Ntrk2 1 0.37 0.16 0.21
71 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
72 INT298294 Gene_expression of Runx3 Negative_regulation of Ntrk2 1 0.39 0.16 0.19
73 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
74 INT298288 Negative_regulation of Runx3 Positive_regulation of Negative_regulation of Ntrk3 1 0.35 0.27 0.17
75 INT298265 Runx3 Negative_regulation of Gene_expression of Ntrk2 1 0.61 0.25 0.17
76 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
77 INT190635 Binding of Lmo2 and Nr1h2 1 0.09 0.59 0.16
78 INT190629 Binding of Lmo2 and Usf1 1 0.11 0.6 0.16
79 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
80 INT245569 Runx3 Regulation of Gtf3a 1 0.01 0.65 0.16
81 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
82 INT190634 Binding of Lmo2 and Maz 1 0.14 0.59 0.16
83 INT245559 Runx3 Regulation of Runx1 1 0.31 0.63 0.16
84 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16
85 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
86 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
87 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
88 INT339392 Binding of Nfib and Gtf3a 1 0.00 0.53 0.14
89 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
90 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
91 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
92 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
93 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
94 INT334871 Binding of Mpz and Sox10 1 0.13 0 0.11
95 INT334862 Positive_regulation of Binding of Mpz and Sox10 1 0.17 0 0.11
96 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
97 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
98 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
99 INT302380 Tnf Positive_regulation of Nfib 1 0.00 1.41 0.09
100 INT302383 Il1b Positive_regulation of Nfib 1 0.00 1.42 0.09
101 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
102 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
103 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08
104 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
105 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
106 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08
107 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08
108 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08
109 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
110 INT226504 Binding of Nfatc1 and Nfatc4 1 0.08 0.15 0.07
111 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
112 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
113 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
114 INT118417 Gata1 Regulation of Gene_expression of Serpinb9g 1 0.17 0.12 0.06
115 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
116 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
117 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
118 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
119 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
120 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
121 INT282552 POU5F1 Positive_regulation of FGF4 1 0.29 0.29 0.05
122 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
123 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
124 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
125 INT226534 Binding of IL4 and Maf 1 0.02 0.21 0.04
126 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
127 INT282555 POU5F1 Positive_regulation of Positive_regulation of MAPK1 1 0.11 0.28 0.04
128 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
129 INT282556 POU5F1 Positive_regulation of GOPC 1 0.06 0.06 0.04
130 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
131 INT235365 Binding of Mid1 and Nfib 1 0.02 0.09 0.04
132 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
133 INT285936 IL17A Positive_regulation of Gene_expression of POU5F1 1 0.10 0.34 0.04
134 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
135 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
136 INT226506 Maf Positive_regulation of Positive_regulation of Il2ra 1 0.02 0.22 0.04
137 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
138 INT282561 POU5F1 Positive_regulation of Gene_expression of NANOG 1 0.11 0.26 0.04
139 INT282543 KDM4C Regulation of POU5F1 1 0.06 0.08 0.03
140 INT334867 Binding of C4b and Sox10 1 0.04 0 0.03
141 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
142 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
143 INT282542 KDM3A Regulation of POU5F1 1 0.06 0.08 0.03
144 INT334872 Positive_regulation of Binding of C4b and Sox10 1 0.04 0 0.03
145 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
146 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
147 INT334864 Positive_regulation of Binding of Nfatc1 and Sox10 1 0.04 0 0.03
148 INT334873 Binding of Nfatc1 and Sox10 1 0.02 0 0.03
149 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
150 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
151 INT282553 POU5F1 Positive_regulation of REXO1 1 0.21 0.1 0.03
152 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
153 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
154 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
155 INT306638 Prep Positive_regulation of Positive_regulation of Nfatc4 1 0.09 0.16 0
156 INT306648 Mstn Negative_regulation of Positive_regulation of Nfatc4 1 0.35 0.09 0
157 INT306636 Prep Positive_regulation of Nfatc4 1 0.11 0.28 0
158 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
159 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
160 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
161 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0
162 INT282559 NANOG Regulation of POU5F1 1 0.14 0.45 0
163 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
164 INT282554 Binding of POU5F1 and SOX2 1 0.19 0.1 0
165 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
166 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
167 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
168 INT272513 Binding of Mef2a and Eif2s2 1 0.03 0 0
169 INT326727 Sox10 Regulation of Regulation of Itk 1 0.02 0.06 0
170 INT180028 Gopc Regulation of Bhlhe41 1 0.12 1.17 0
171 INT306645 Gene_expression of Mstn Positive_regulation of Positive_regulation of Nfatc4 1 0.38 0.16 0
172 INT297209 Myoz1 Regulation of Mef2a 1 0.04 0.09 0
173 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
174 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
175 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
176 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
177 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
178 INT282551 SOX2 Regulation of POU5F1 1 0.24 0.45 0
179 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
180 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
181 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
182 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
183 INT282541 SOX2 Regulation of Transcription of POU5F1 1 0.24 0.05 0
184 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
185 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
186 INT217780 MIR181A1 Regulation of GATA6 1 0.17 0.7 0
187 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
188 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
189 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
190 INT282558 POU5F1 Positive_regulation of MAPK1 1 0.16 0.26 0
191 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
192 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0
193 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
194 INT282607 POU5F1 Positive_regulation of Mdk 1 0.08 0.26 0
195 INT285946 IL6 Regulation of POU5F1 1 0.05 0.12 0
196 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
197 INT296999 Binding of EPS15 and TFAP2A 1 0.06 0.2 0
198 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
199 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
200 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sequence-specific DNA binding RNA polymerase II transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in sequence-specific DNA binding RNA polymerase II transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT203490 Gene_expression of Runx3 19 0.76 27.56 12.57
3 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
4 INT95794 Gene_expression of GRHL3 9 0.68 5.57 9.9
5 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
6 INT127961 Transcription of GRHL3 1 0.45 4.34 8.17
7 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
8 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
9 INT127964 Regulation of Transcription of GRHL3 1 0.28 2.54 4.84
10 INT204449 Gene_expression of T 17 0.32 9.77 4.77
11 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34
12 INT127962 Positive_regulation of GRHL3 3 0.32 2.67 3.69
13 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
14 INT127963 Positive_regulation of Gene_expression of GRHL3 1 0.44 1.85 3.4
15 INT116540 Binding of Twist1 35 0.48 16.32 2.85
16 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68
17 INT125439 Positive_regulation of NFIB 4 0.67 6.71 2.52
18 INT203441 Positive_regulation of Gene_expression of Runx3 4 0.66 4.35 2.49
19 INT108131 Localization of GRHL3 3 0.73 1.03 2.18
20 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
21 INT93764 Binding of GRHL3 3 0.36 1.79 2.07
22 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
23 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9
24 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
25 INT280889 Gene_expression of Sox10 19 0.72 3.45 1.78
26 INT101252 Negative_regulation of Gene_expression of Gata6 1 0.51 1.3 1.74
27 INT101244 Regulation of Gata6 3 0.40 1.52 1.7
28 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
29 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
30 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
31 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
32 INT245537 Negative_regulation of Runx3 4 0.56 4 1.53
33 INT219259 Binding of Nfib 1 0.36 1.46 1.46
34 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
35 INT298250 Negative_regulation of Gene_expression of Runx3 1 0.56 1.92 1.45
36 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
37 INT10873 Localization of Twist1 21 0.74 10.43 1.37
38 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
39 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32
40 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
41 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22
42 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
43 INT93765 Negative_regulation of Binding of GRHL3 1 0.41 0.43 1.14
44 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13
45 INT151261 Negative_regulation of Nfib 2 0.47 2.12 1.11
46 INT208427 Regulation of T 3 0.25 3.28 1.08
47 INT151260 Gene_expression of Nfib 5 0.75 1.83 1.06
48 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
49 INT151262 Binding of Nfib 1 0.36 1.02 1.03
50 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
51 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
52 INT134274 Positive_regulation of Nfatc4 2 0.47 0.7 1
53 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
54 INT306295 Regulation of NFIB 1 0.13 2.43 0.97
55 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
56 INT351296 Regulation of Maf 1 0.01 0.9 0.88
57 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
58 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
59 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
60 INT137572 Gene_expression of Maz 3 0.66 10.9 0.85
61 INT298253 Regulation of Gene_expression of Runx3 1 0.59 1.21 0.85
62 INT101248 Negative_regulation of Gata6 1 0.37 0.83 0.85
63 INT101251 Negative_regulation of Positive_regulation of Gata6 1 0.38 0.83 0.85
64 INT101250 Positive_regulation of Gata6 1 0.41 0.83 0.84
65 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
66 INT101245 Transcription of Gata6 2 0.47 0.85 0.82
67 INT149817 Gene_expression of Bhlhe41 2 0.43 2.47 0.81
68 INT287094 Transcription of T 1 0.29 1.41 0.8
69 INT245539 Positive_regulation of Runx3 4 0.49 3.11 0.79
70 INT306276 Binding of NFIB 1 0.14 1.73 0.77
71 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
72 INT120239 Gene_expression of NFIB 3 0.65 1.01 0.72
73 INT282599 Regulation of Gene_expression of POU5F1 10 0.62 4.89 0.71
74 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
75 INT245535 Transcription of Runx3 3 0.71 2.03 0.7
76 INT149819 Regulation of Gene_expression of Bhlhe41 1 0.29 0 0.7
77 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
78 INT149804 Regulation of Bhlhe41 1 0.29 0 0.69
79 INT173794 Gene_expression of Maf 3 0.12 1.39 0.68
80 INT226411 Binding of T 2 0.15 1.56 0.68
81 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
82 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
83 INT100948 Localization of NFIB 2 0.12 1.8 0.62
84 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
85 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
86 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
87 INT80300 Gene_expression of TFAP2A 5 0.54 2.76 0.59
88 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
89 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
90 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
91 INT230634 Negative_regulation of POU5F1 10 0.43 1.03 0.46
92 INT137574 Positive_regulation of Gene_expression of Maz 2 0.42 4.67 0.41
93 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
94 INT287488 Negative_regulation of NFIB 2 0.13 1.39 0.4
95 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
96 INT245531 Binding of Runx3 2 0.46 1.12 0.39
97 INT80302 Binding of TFAP2A 7 0.39 1.67 0.38
98 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
99 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
100 INT137573 Binding of Maz 2 0.31 3.78 0.38
101 INT306297 Negative_regulation of Binding of NFIB 1 0.13 0.79 0.36
102 INT106402 Positive_regulation of TFAP2A 2 0.13 0.35 0.35
103 INT125438 Negative_regulation of Positive_regulation of NFIB 1 0.41 1.25 0.34
104 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
105 INT173635 Negative_regulation of TFAP2A 3 0.34 2.93 0.33
106 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
107 INT274626 Positive_regulation of Positive_regulation of GRHL3 1 0.22 0.67 0.32
108 INT298247 Positive_regulation of Transcription of Runx3 1 0.66 0.53 0.32
109 INT100947 Negative_regulation of Localization of NFIB 1 0.01 1.3 0.29
110 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
111 INT245521 Regulation of Runx3 1 0.23 0.76 0.28
112 INT282571 Negative_regulation of Positive_regulation of POU5F1 1 0.38 0 0.28
113 INT292207 Negative_regulation of Gene_expression of TFAP2A 1 0.05 1.2 0.27
114 INT173787 Positive_regulation of Maf 1 0.10 0.06 0.26
115 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
116 INT190599 Positive_regulation of Maz 1 0.20 1.05 0.24
117 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
118 INT168232 Positive_regulation of Transcription of Nfib 1 0.45 0.22 0.2
119 INT168235 Transcription of Nfib 1 0.52 0.22 0.2
120 INT168231 Negative_regulation of Transcription of Nfib 1 0.42 0.23 0.2
121 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
122 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
123 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
124 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
125 INT190551 Localization of Lmo2 1 0.21 0.6 0.17
126 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
127 INT190558 Negative_regulation of Localization of Maz 1 0.21 0.61 0.17
128 INT190574 Localization of Maz 1 0.37 0.6 0.17
129 INT245527 Negative_regulation of Transcription of Runx3 1 0.42 0.59 0.17
130 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
131 INT251938 Positive_regulation of Gene_expression of MEF2A 1 0.12 0.14 0.17
132 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
133 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16
134 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
135 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
136 INT251939 Gene_expression of MEF2A 1 0.18 0.14 0.16
137 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
138 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
139 INT305524 Positive_regulation of Sox10 2 0.39 0.36 0.14
140 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
141 INT249108 Regulation of MEF2A 1 0.17 0.28 0.14
142 INT280888 Localization of Sox10 1 0.69 0.06 0.13
143 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
144 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
145 INT190566 Gene_expression of Lmo2 1 0.43 0.9 0.12
146 INT278790 Binding of POU5F1 8 0.43 0.67 0.11
147 INT305529 Negative_regulation of Positive_regulation of Sox10 1 0.33 0.36 0.11
148 INT294379 Phosphorylation of Mef2a 1 0.56 0 0.1
149 INT294371 Positive_regulation of Phosphorylation of Mef2a 1 0.42 0 0.1
150 INT318400 Localization of Nfib 1 0.73 0 0.09
151 INT235781 Positive_regulation of PAX6 2 0.50 0.36 0.08
152 INT280891 Transcription of Sox10 2 0.64 0.28 0.08
153 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
154 INT278785 Positive_regulation of Binding of POU5F1 2 0.45 0.19 0.07
155 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
156 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
157 INT290401 Gene_expression of Mef2a 1 0.64 1.81 0.07
158 INT226404 Transcription of Nfatc4 1 0.41 0.15 0.07
159 INT262953 Binding of PAX6 13 0.48 5.28 0.06
160 INT262951 Transcription of PAX6 6 0.72 3.33 0.06
161 INT262955 Regulation of PAX6 2 0.27 0.87 0.06
162 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
163 INT97754 Regulation of Gene_expression of TFAP2A 1 0.36 0.13 0.06
164 INT339183 Positive_regulation of GATA6 1 0.16 0.66 0.06
165 INT257607 Regulation of Maz 1 0.27 2.07 0.06
166 INT216377 Transcription of POU5F1 9 0.69 0.58 0.05
167 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
168 INT325191 Positive_regulation of Nfib 1 0.12 1.08 0.05
169 INT282603 Positive_regulation of Positive_regulation of POU5F1 1 0.45 0 0.05
170 INT180026 Positive_regulation of Bhlhe41 1 0.35 0.79 0.05
171 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
172 INT262963 Negative_regulation of PAX6 4 0.59 4.92 0.04
173 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
174 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
175 INT69474 Protein_catabolism of T 1 0.64 0 0.04
176 INT235783 Positive_regulation of Gene_expression of PAX6 7 0.50 1.59 0.03
177 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03
178 INT264704 Regulation of Hes1 4 0.44 1.03 0.03
179 INT248540 Positive_regulation of Gata4 2 0.23 0.95 0.03
180 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
181 INT282944 Negative_regulation of Negative_regulation of POU5F1 1 0.11 0 0.03
182 INT262954 Regulation of Transcription of PAX6 1 0.62 2.33 0.03
183 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
184 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
185 INT287486 Phosphorylation of NFIB 1 0.03 0.5 0.03
186 INT257610 Regulation of Gene_expression of Maz 1 0.31 0.19 0.03
187 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
188 INT290421 Transcription of Mef2d 1 0.52 0 0.03
189 INT290426 Positive_regulation of Mef2a 1 0.38 0.46 0.03
190 INT290422 Transcription of Mef2a 1 0.65 0 0.03
191 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03
192 INT282605 Regulation of POU5F1 4 0.55 0.4 0
193 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0
194 INT282585 Localization of POU5F1 3 0.67 0.08 0
195 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
196 INT307189 Localization of Med1 3 0.53 0.32 0
197 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
198 INT280886 Regulation of Sox10 2 0.42 0.15 0
199 INT272480 Negative_regulation of Mef2a 2 0.40 0 0
200 INT274404 Binding of Gata4 2 0.16 0.89 0
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