GO:0000983

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Name RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
Categary Function
Go Slim No
Go Link GO:0000983
Unique Molecular Interactions 89
Total Molecular Interactions 121
Total Single Events 962
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
2 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94
3 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
4 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83
5 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
6 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
7 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5
8 INT138927 Ifng Positive_regulation of Gene_expression of Stat1 1 0.29 0.7 0.49
9 INT315400 IFNA1 Positive_regulation of Phosphorylation of Stat1 1 0.02 0.4 0.33
10 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
11 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33
12 INT315392 IFNA1 Positive_regulation of Stat1 1 0.02 0.4 0.3
13 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
14 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
15 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28
16 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28
17 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27
18 INT253563 Csnk2a2 Regulation of Phosphorylation of Stat1 1 0.16 0.58 0.24
19 INT163760 Ifng Positive_regulation of Phosphorylation of Stat1 1 0.12 0.08 0.23
20 INT138929 Ifng Positive_regulation of Stat1 1 0.29 0.28 0.23
21 INT138926 Regulation of Ifng Positive_regulation of Stat1 1 0.17 0.28 0.23
22 INT138931 Ifng Positive_regulation of Positive_regulation of Stat1 1 0.31 0.28 0.23
23 INT186351 Binding of Gast and Stat1 3 0.16 2.77 0.22
24 INT94338 IFNG Positive_regulation of Phosphorylation of Stat1 1 0.01 0.26 0.21
25 INT94339 IFNG Positive_regulation of Localization of Stat1 1 0.01 0.26 0.21
26 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
27 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
28 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18
29 INT140095 Stat1 Positive_regulation of Positive_regulation of Ifng 1 0.52 0.42 0.18
30 INT314078 Peo1 Negative_regulation of Stat1 1 0.31 1.23 0.17
31 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
32 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
33 INT295273 STAT1 Regulation of Transcription of Hp 1 0.00 0.63 0.15
34 INT314069 Gopc Negative_regulation of Stat1 1 0.14 0.95 0.15
35 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
36 INT295272 STAT1 Regulation of Hp 1 0.00 0.63 0.14
37 INT249598 Stat1 Positive_regulation of Gene_expression of Cd40 1 0.41 0.46 0.14
38 INT332243 Pdgfa Positive_regulation of Stat1 1 0.06 0.52 0.14
39 INT343861 Binding of IFN1@ and STAT1 1 0.00 0.13 0.14
40 INT186372 Binding of Irf1 and Stat1 1 0.04 2.06 0.14
41 INT295271 STAT1 Regulation of Gbp2 1 0.00 0.63 0.14
42 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
43 INT208300 IGIP Positive_regulation of Stat1 1 0.07 0.42 0.09
44 INT315383 Adcyap1 Regulation of Stat1 1 0.10 0.07 0.09
45 INT204902 Negative_regulation of Tlr4 Positive_regulation of Stat1 1 0.23 0.09 0.09
46 INT204879 Tlr4 Positive_regulation of Stat1 1 0.25 0.09 0.09
47 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
48 INT314075 Peo1 Regulation of Positive_regulation of Stat1 1 0.37 0.43 0.08
49 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
50 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
51 INT271284 Binding of IFNA1 and Stat1 1 0.07 0.7 0.08
52 INT141997 HEY1 Negative_regulation of CDC42BPA 1 0.00 0 0.08
53 INT314064 Gopc Negative_regulation of Positive_regulation of Stat1 1 0.12 0.57 0.08
54 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
55 INT186369 Negative_regulation of Binding of Gast and Stat1 1 0.04 1.04 0.07
56 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
57 INT204891 Tlr4 Negative_regulation of Stat1 1 0.10 0.09 0.07
58 INT186366 Binding of Stat1 and Stat6 1 0.12 1.04 0.07
59 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04
60 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04
61 INT314067 Stat1 Regulation of Nos2 1 0.13 0.2 0.03
62 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
63 INT314077 Peo1 Negative_regulation of Positive_regulation of Stat1 1 0.31 0.33 0.03
64 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
65 INT314071 Stat1 Regulation of Cxcl10 1 0.26 0.2 0.03
66 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
67 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
68 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
69 INT280543 Binding of GAST and STAT1 1 0.05 0.58 0
70 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
71 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
72 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
73 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
74 INT271280 Stat1 Regulation of Mcl1 1 0.28 0.67 0
75 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
76 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
77 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
78 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0
79 INT164891 STAT1 Positive_regulation of Gene_expression of IL1RL1 1 0.41 0.06 0
80 INT233401 COPD Regulation of HEY1 1 0.07 1.67 0
81 INT278752 Binding of NUP98 and HEY1 1 0.48 0 0
82 INT271282 Stat1 Regulation of Usp18 1 0.30 1.37 0
83 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0
84 INT278773 NUP98 Regulation of HEY1 1 0.45 0 0
85 INT278775 Binding of HOXA9 and HEY1 1 0.44 0 0
86 INT271286 IFNA1 Positive_regulation of Stat1 1 0.09 0.14 0
87 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
88 INT278211 Stat1 Positive_regulation of Gene_expression of Ciita 1 0.29 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2
2 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11
3 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89
4 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85
5 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
6 INT187286 Binding of HEY1 17 0.32 31.21 4.52
7 INT176618 Gene_expression of HEY1 29 0.59 36 4.37
8 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19
9 INT137532 Negative_regulation of HEY2 1 0.31 1.69 3.18
10 INT94327 Phosphorylation of Stat1 9 0.80 2.06 2.8
11 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
12 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
13 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
14 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94
15 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89
16 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
17 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71
18 INT186309 Binding of Stat1 18 0.48 5.31 1.58
19 INT140089 Positive_regulation of Stat1 5 0.68 3.42 1.58
20 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
21 INT139326 Gene_expression of Stat1 6 0.76 2.49 1.41
22 INT121820 Binding of STAT1 9 0.46 2.54 1.4
23 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19
24 INT180580 Binding of HEYL 7 0.17 4.49 1.15
25 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
26 INT178262 Transcription of Stat1 4 0.59 4.73 1.12
27 INT139325 Positive_regulation of Gene_expression of Stat1 3 0.68 1.18 1.1
28 INT163755 Positive_regulation of Phosphorylation of Stat1 4 0.60 1.87 1.09
29 INT139324 Positive_regulation of Phosphorylation of Stat1 3 0.44 1 1.09
30 INT187289 Regulation of HEY1 5 0.39 7.8 1.03
31 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
32 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
33 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
34 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
35 INT26531 Regulation of Srf 3 0.18 0.62 0.9
36 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89
37 INT199483 Transcription of Stat1 2 0.43 1.14 0.89
38 INT163758 Regulation of Stat1 17 0.54 5.23 0.87
39 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
40 INT45293 Transcription of Srf 2 0.47 0.79 0.76
41 INT174553 Localization of Stat1 17 0.80 6.62 0.73
42 INT121333 Localization of HEY1 11 0.65 18.17 0.72
43 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
44 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68
45 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
46 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
47 INT178250 Positive_regulation of Transcription of Stat1 2 0.43 2.72 0.64
48 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
49 INT148385 Positive_regulation of HEY2 1 0.38 1.09 0.62
50 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
51 INT138919 Regulation of Gene_expression of Stat1 4 0.60 4.58 0.49
52 INT180578 Regulation of HEYL 3 0.06 3.15 0.49
53 INT94328 Localization of Stat1 4 0.31 0.86 0.48
54 INT138914 Regulation of Positive_regulation of Stat1 3 0.45 1.02 0.48
55 INT186279 Negative_regulation of Binding of Stat1 3 0.42 0.96 0.45
56 INT187287 Negative_regulation of Gene_expression of HEY1 2 0.16 2.96 0.45
57 INT328807 Positive_regulation of Positive_regulation of Stat1 1 0.24 0.08 0.45
58 INT129429 Negative_regulation of Stat1 2 0.41 1.09 0.44
59 INT245262 Negative_regulation of Gene_expression of Stat1 9 0.42 2.87 0.42
60 INT138910 Negative_regulation of Positive_regulation of Stat1 3 0.57 0.81 0.39
61 INT328813 Negative_regulation of Phosphorylation of Stat1 1 0.21 0 0.37
62 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
63 INT206142 Localization of STAT1 7 0.78 3.09 0.31
64 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
65 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3
66 INT189834 Regulation of Phosphorylation of Stat1 3 0.36 0.72 0.3
67 INT121817 Positive_regulation of Binding of STAT1 2 0.67 0.49 0.3
68 INT122401 Binding of Stat1 1 0.07 0.81 0.28
69 INT120958 Protein_catabolism of HEY1 1 0.44 0.14 0.28
70 INT7610 Localization of Srf 3 0.67 0.98 0.27
71 INT94329 Positive_regulation of Localization of Stat1 1 0.02 0.26 0.22
72 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
73 INT314061 Regulation of Negative_regulation of Stat1 1 0.23 0.79 0.21
74 INT121819 Regulation of Binding of STAT1 1 0.59 0.05 0.19
75 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
76 INT271262 Negative_regulation of Negative_regulation of Stat1 2 0.42 1.4 0.18
77 INT188215 Negative_regulation of Phosphorylation of STAT1 2 0.31 0.48 0.17
78 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
79 INT89766 Binding of SRF 1 0.17 0.89 0.15
80 INT180592 Negative_regulation of Gene_expression of HEYL 1 0.03 0.3 0.15
81 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
82 INT231559 Negative_regulation of Gene_expression of STAT1 2 0.06 0.36 0.14
83 INT180593 Positive_regulation of Gene_expression of HEYL 1 0.03 0.18 0.12
84 INT186065 Positive_regulation of Phosphorylation of STAT1 3 0.25 1.95 0.1
85 INT266451 Regulation of Gene_expression of HEY1 1 0.02 2.03 0.09
86 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
87 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
88 INT22789 Binding of Srf 1 0.37 0.07 0.07
89 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
90 INT206148 Positive_regulation of Transcription of STAT1 2 0.21 0.72 0.06
91 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
92 INT139018 Negative_regulation of Positive_regulation of STAT1 1 0.27 0.82 0.06
93 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
94 INT253553 Positive_regulation of Regulation of Stat1 1 0.27 0.43 0.04
95 INT268102 Transcription of SRF 1 0.53 0.85 0.03
96 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
97 INT277248 Localization of HEY2 1 0.73 0.5 0.03
98 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
99 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
100 INT277762 Negative_regulation of Negative_regulation of STAT1 1 0.42 0.29 0
101 INT139020 Regulation of Negative_regulation of STAT1 1 0.29 0.35 0
102 INT180583 Negative_regulation of HEYL 1 0.03 0 0
103 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
104 INT271254 Negative_regulation of Localization of Stat1 1 0.42 0.15 0
105 INT210818 Phosphorylation of HEYL 1 0.04 0.08 0
106 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
107 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
108 INT266450 Negative_regulation of Regulation of HEY1 1 0.02 0.72 0
109 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
110 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
111 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
112 INT314060 Positive_regulation of Negative_regulation of Stat1 1 0.38 0.29 0
113 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
114 INT277587 Localization of Mef2c 1 0.65 0.43 0
115 INT341052 Gene_expression of HEY2 1 0.04 0.12 0
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