GO:0001012

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Name RNA polymerase II regulatory region DNA binding
Categary Function
Go Slim No
Go Link GO:0001012
Unique Molecular Interactions 113
Total Molecular Interactions 135
Total Single Events 1388
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II regulatory region DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for RNA polymerase II regulatory region DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
2 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
3 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
4 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
5 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63
6 INT169290 CNR1 Positive_regulation of Negative_regulation of TXK 1 0.10 0.18 0.58
7 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41
8 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
9 INT116292 Gm9662 Negative_regulation of Pparg 1 0.00 0 0.33
10 INT116291 Gm9662 Negative_regulation of Positive_regulation of Pparg 1 0.00 0 0.32
11 INT235884 Htr3a Regulation of Nr3c1 1 0.00 0.63 0.32
12 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31
13 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
14 INT110373 CYP4A11 Positive_regulation of PPARG 1 0.00 0.94 0.26
15 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25
16 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
17 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
18 INT210803 Igh-Dex Regulation of Nr3c1 1 0.05 0 0.24
19 INT115148 PPARG Negative_regulation of Gene_expression of INSIG2 1 0.01 0.34 0.21
20 INT52306 Nr3c1 Negative_regulation of Transcription of Penk 1 0.26 0 0.18
21 INT81296 Positive_regulation of Pparg Regulation of Gene_expression of Hmox1 1 0.25 0.17 0.17
22 INT81297 Positive_regulation of Pparg Regulation of Gene_expression of Nos2 1 0.23 0.17 0.17
23 INT106506 Binding of Pparg and Ptgds 1 0.42 0.31 0.14
24 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14
25 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
26 INT109410 RASGRP1 Regulation of Gene_expression of PPARG 1 0.03 0.76 0.13
27 INT115145 PPARG Positive_regulation of TFAM 1 0.04 0.45 0.13
28 INT101173 Pparg Regulation of Positive_regulation of Nfkb1 1 0.03 0.07 0.12
29 INT101174 Pparg Regulation of Gene_expression of IK 1 0.00 0.07 0.12
30 INT128551 Binding of Cebpb and Nr3c1 1 0.06 0.15 0.11
31 INT157265 PPARG Positive_regulation of PPARA 1 0.22 1.15 0.09
32 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
33 INT245642 Nr3c1 Regulation of Gene_expression of Hpse 1 0.05 1.33 0.08
34 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
35 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
36 INT110856 TXK Negative_regulation of Egf 1 0.02 1.2 0.08
37 INT110377 Binding of Ncoa1 and Pparg 1 0.02 0.26 0.08
38 INT251777 Negative_regulation of TXK Positive_regulation of PDGFA 1 0.04 1 0.08
39 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
40 INT251773 TXK Positive_regulation of PDGFA 1 0.04 1 0.08
41 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08
42 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
43 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07
44 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
45 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
46 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06
47 INT279275 PDGFA Positive_regulation of TXK 1 0.05 1.02 0.06
48 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
49 INT279281 TXK Regulation of CDCP1 1 0.00 1.61 0.05
50 INT332641 Binding of PPARG and Ins1 1 0.12 1.05 0.05
51 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
52 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
53 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
54 INT292089 Binding of KIT and TXK 1 0.02 1.54 0.04
55 INT292084 Binding of FLT3 and TXK 1 0.02 1.53 0.04
56 INT292090 Negative_regulation of Binding of KIT and TXK 1 0.02 1.54 0.04
57 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
58 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04
59 INT292092 Binding of PDGFRB and TXK 1 0.05 1.53 0.04
60 INT292085 Negative_regulation of Binding of FLT3 and TXK 1 0.02 1.54 0.04
61 INT292094 Binding of FLT4 and TXK 1 0.02 1.53 0.04
62 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04
63 INT292080 Binding of FLT1 and TXK 1 0.04 1.47 0.04
64 INT120449 Pparg Positive_regulation of Negative_regulation of Il2 1 0.75 0 0.04
65 INT292079 Negative_regulation of Binding of PDGFRB and TXK 1 0.06 1.54 0.04
66 INT292086 Negative_regulation of Binding of FLT1 and TXK 1 0.04 1.48 0.04
67 INT292093 Negative_regulation of Binding of FLT4 and TXK 1 0.03 1.53 0.04
68 INT279285 PDGFB Positive_regulation of TXK 1 0.05 0.52 0.03
69 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
70 INT208410 IGF1 Positive_regulation of TXK 1 0.08 0.9 0.03
71 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
72 INT348583 MECP2 Regulation of PPARG 1 0.46 0.73 0
73 INT348594 MECP2 Regulation of Gene_expression of PPARG 1 0.34 0.43 0
74 INT187621 Gnrh1 Regulation of Gene_expression of Pparg 1 0.00 0.09 0
75 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
76 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0
77 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0
78 INT348584 EZH2 Regulation of Gene_expression of PPARG 1 0.30 0.43 0
79 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0
80 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0
81 INT290031 Binding of INS and PPARG 1 0.11 0.47 0
82 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
83 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0
84 INT290022 Binding of PPARG and DDX12P 1 0.00 1.77 0
85 INT294095 Binding of TXK and Gtf3a 1 0.00 2.33 0
86 INT348593 ZACN Regulation of Positive_regulation of PPARG 1 0.14 0.41 0
87 INT290030 Binding of PPARD and PPARG 1 0.09 0.38 0
88 INT268599 Mir10a Regulation of TXK 1 0.01 1.09 0
89 INT290024 Binding of PPARG and RXRG 1 0.15 0.39 0
90 INT348587 Binding of MECP2 and PPARG 1 0.32 0.25 0
91 INT130602 Pparg Regulation of Pscs 1 0.11 0.29 0
92 INT187623 Lhb Regulation of Gene_expression of Pparg 1 0.02 0.09 0
93 INT223583 TXK Negative_regulation of ERBB2 1 0.07 0.18 0
94 INT279283 TXK Regulation of PDGFRB 1 0.06 0.68 0
95 INT223581 TXK Negative_regulation of DBP 1 0.00 0.47 0
96 INT348586 RSPH1 Positive_regulation of Gene_expression of PPARG 1 0.02 0.23 0
97 INT290026 Binding of PPARG and CHDH 1 0.10 6.61 0
98 INT303947 Binding of LEPR and TXK 1 0.00 0.63 0
99 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0
100 INT348595 Binding of PPARG and ZACN 1 0.07 0.38 0
101 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 0.04 0.35 0
102 INT294094 Binding of TXK and Eltd1 1 0.00 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II regulatory region DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in RNA polymerase II regulatory region DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
2 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2
3 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
4 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53
5 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
6 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03
7 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7
8 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59
9 INT67612 Binding of PPARG 38 0.48 22.67 8.94
10 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65
11 INT49749 Negative_regulation of Nr3c1 13 0.43 6.25 7.36
12 INT103399 Positive_regulation of Positive_regulation of Pparg 11 0.66 7 7.36
13 INT7564 Positive_regulation of Nr3c1 16 0.68 4.98 6.25
14 INT67609 Binding of Pparg 17 0.46 9.53 6.06
15 INT100078 Positive_regulation of Positive_regulation of PPARG 11 0.70 3.6 5.86
16 INT52814 Negative_regulation of Nr3c1 9 0.57 5.69 5.41
17 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38
18 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4
19 INT79692 Negative_regulation of PPARG 24 0.59 16 4.31
20 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06
21 INT72936 Gene_expression of Pparg 39 0.77 19.01 4.02
22 INT112070 Negative_regulation of Gene_expression of Pparg 6 0.59 3.72 3.96
23 INT78845 Binding of Pparg 16 0.44 11.67 3.53
24 INT131165 Positive_regulation of Gene_expression of Nr3c1 8 0.70 7.18 3.44
25 INT110956 Negative_regulation of Positive_regulation of Pparg 5 0.41 3.68 3.11
26 INT112071 Regulation of Gene_expression of Pparg 4 0.62 4.62 3.09
27 INT99187 Negative_regulation of Positive_regulation of PPARG 5 0.42 5.07 2.99
28 INT77250 Positive_regulation of Gene_expression of Nr3c1 4 0.44 3.32 2.64
29 INT8484 Localization of Nr3c1 8 0.53 3.12 2.32
30 INT81294 Negative_regulation of Positive_regulation of Pparg 7 0.58 4.39 2.2
31 INT78844 Regulation of Pparg 6 0.41 4 2.19
32 INT99039 Negative_regulation of Gene_expression of Nr3c1 2 0.37 1.96 2.08
33 INT118291 Binding of TXK 19 0.10 11.77 1.94
34 INT135313 Regulation of Gene_expression of Nr3c1 3 0.39 3.44 1.94
35 INT52305 Binding of Nr3c1 7 0.15 3.95 1.9
36 INT167456 Regulation of Gene_expression of Nr3c1 2 0.14 0.76 1.87
37 INT26750 Positive_regulation of Nr3c1 6 0.46 5.46 1.75
38 INT117438 Positive_regulation of Gene_expression of Pparg 11 0.69 8 1.63
39 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62
40 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55
41 INT49448 Positive_regulation of Positive_regulation of Nr3c1 1 0.38 0 1.55
42 INT7578 Transcription of Nr3c1 5 0.32 0.43 1.47
43 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45
44 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1
45 INT79689 Regulation of PPARG 10 0.62 8.04 1.07
46 INT91776 Negative_regulation of Gene_expression of Nr3c1 4 0.42 2.26 1.03
47 INT98817 Regulation of Pparg 3 0.26 1.62 1.03
48 INT119519 Positive_regulation of Gene_expression of TXK 3 0.09 2.92 1.02
49 INT107714 Localization of PPARG 4 0.73 0.88 0.91
50 INT248304 Positive_regulation of Localization of Nr3c1 2 0.10 1.39 0.87
51 INT103400 Transcription of Pparg 2 0.67 3.15 0.85
52 INT110089 Positive_regulation of Binding of PPARG 1 0.70 1.04 0.7
53 INT94148 Positive_regulation of Binding of Pparg 2 0.43 1.16 0.66
54 INT116288 Negative_regulation of Pparg 4 0.42 1.69 0.62
55 INT7576 Positive_regulation of Transcription of Nr3c1 1 0.19 0.3 0.62
56 INT142184 Regulation of TXK 10 0.11 8.25 0.59
57 INT96323 Regulation of Transcription of Nr3c1 1 0.20 0 0.59
58 INT165706 Negative_regulation of Negative_regulation of PPARG 3 0.23 1.05 0.58
59 INT115156 Regulation of Positive_regulation of PPARG 2 0.25 0.86 0.54
60 INT130600 Negative_regulation of Binding of Pparg 1 0.42 1.96 0.54
61 INT144098 Localization of Pparg 2 0.59 0.73 0.52
62 INT158946 Negative_regulation of Pparg 3 0.43 1.53 0.51
63 INT73624 Transcription of PPARG 7 0.72 3.25 0.49
64 INT129748 Transcription of Nr3c1 1 0.58 0.53 0.48
65 INT129747 Regulation of Transcription of Nr3c1 1 0.22 0.53 0.48
66 INT290850 Regulation of Positive_regulation of Nr3c1 1 0.12 0.75 0.47
67 INT171683 Negative_regulation of Negative_regulation of TXK 3 0.06 1.28 0.46
68 INT52815 Regulation of Negative_regulation of Nr3c1 1 0.08 0.05 0.43
69 INT98818 Regulation of Positive_regulation of Pparg 1 0.03 0.14 0.41
70 INT78849 Transcription of Pparg 3 0.53 2.31 0.38
71 INT192343 Positive_regulation of Phosphorylation of TXK 4 0.06 1.42 0.37
72 INT192347 Phosphorylation of TXK 12 0.22 6.71 0.36
73 INT81290 Positive_regulation of Positive_regulation of Pparg 1 0.45 0.37 0.36
74 INT107713 Positive_regulation of Localization of PPARG 1 0.59 0.07 0.36
75 INT128546 Binding of Nr3c1 4 0.34 1.4 0.35
76 INT78847 Positive_regulation of Transcription of Pparg 2 0.44 0.47 0.35
77 INT166885 Negative_regulation of Gene_expression of Pparg 5 0.41 2.6 0.26
78 INT158945 Negative_regulation of Negative_regulation of Pparg 1 0.43 0.73 0.26
79 INT78848 Regulation of Binding of Pparg 1 0.45 0.5 0.25
80 INT279293 Localization of TXK 3 0.18 1.52 0.22
81 INT178257 Positive_regulation of Transcription of Pparg 1 0.49 2.25 0.21
82 INT151659 Regulation of Positive_regulation of Nr3c1 1 0.03 0.1 0.2
83 INT161753 Regulation of Gene_expression of Pparg 2 0.35 1.28 0.19
84 INT317595 Negative_regulation of Transcription of Nr3c1 1 0.05 0.14 0.18
85 INT81292 Regulation of Positive_regulation of Pparg 1 0.41 0.17 0.17
86 INT277845 Negative_regulation of Gene_expression of TXK 2 0.04 0.92 0.16
87 INT115155 Phosphorylation of PPARG 1 0.58 0.44 0.13
88 INT268931 Positive_regulation of Regulation of Nr3c1 1 0.10 0.34 0.13
89 INT101172 Localization of Pparg 6 0.58 3.62 0.12
90 INT78846 Negative_regulation of Regulation of Pparg 1 0.32 0.23 0.12
91 INT229009 Positive_regulation of Localization of Pparg 1 0.39 1.86 0.1
92 INT176589 Negative_regulation of Binding of TXK 6 0.09 2.06 0.05
93 INT134850 Positive_regulation of Negative_regulation of Nr3c1 1 0.02 0 0.04
94 INT279299 Positive_regulation of Localization of TXK 1 0.12 0.5 0.03
95 INT266933 Regulation of Gene_expression of TXK 1 0.08 0.31 0
96 INT245628 Regulation of Localization of Nr3c1 1 0.15 0 0
97 INT229010 Phosphorylation of Pparg 1 0.63 2.95 0
98 INT290036 Regulation of Binding of PPARG 1 0.45 0.66 0
99 INT348617 Regulation of Negative_regulation of PPARG 1 0.24 0.42 0
100 INT332933 Regulation of Transcription of PPARG 1 0.43 1.71 0
101 INT332925 Protein_catabolism of PPARG 1 0.63 1.04 0
102 INT266929 Positive_regulation of Negative_regulation of TXK 1 0.07 0.2 0
103 INT279300 Negative_regulation of Phosphorylation of TXK 1 0.11 0.92 0
104 INT176568 Protein_catabolism of TXK 1 0.01 0.13 0
105 INT266930 Positive_regulation of Positive_regulation of TXK 1 0.12 0 0
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