GO:0001077

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Name RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
Categary Function
Go Slim No
Go Link GO:0001077
Unique Molecular Interactions 1030
Total Molecular Interactions 1318
Total Single Events 9728
Pain Genes Associated 82

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. They are ordered first by their pain relevance and then by number of times they were reported for RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
3 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
4 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
5 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
6 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
7 INT335405 Binding of Arntl and Npas2 1 0.28 1.82 1.61
8 INT79021 Regulation of Binding of Jun and Fos 2 0.50 0.66 1.5
9 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
10 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46
11 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
12 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
13 INT162105 Nr4a3 Regulation of ACPT-I 1 0.10 0.26 1.38
14 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
15 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
16 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
17 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
18 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
19 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
20 INT25837 Binding of Dbp and Oprl1 1 0.10 0 1.05
21 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
22 INT69011 Binding of Cebpb and Nfkb1 1 0.19 0.75 1.04
23 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
24 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
25 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
26 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 0.33 1.07 1.01
27 INT139639 Jun Negative_regulation of Positive_regulation of Vip 1 0.53 1.07 1
28 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 0.33 1.07 1
29 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
30 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
31 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 1 0.37 0.95 0.99
32 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 0.21 1.07 0.97
33 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
34 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
35 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
36 INT139638 Positive_regulation of Jun Positive_regulation of Positive_regulation of Npy 1 0.36 1.18 0.96
37 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
38 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
39 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
40 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
41 INT151263 Jun Positive_regulation of S100a8 1 0.00 0.95 0.92
42 INT82120 IK Positive_regulation of CEBPB 1 0.00 0 0.92
43 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
44 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
45 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
46 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
47 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
48 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
49 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
50 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
51 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82
52 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
53 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
54 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
55 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
56 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
57 INT90118 Jun Regulation of Gene_expression of Nfkb1 1 0.18 0.39 0.76
58 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
59 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
60 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
61 INT90123 Jun Positive_regulation of Gene_expression of Fos 1 0.47 0.39 0.76
62 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
63 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
64 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
65 INT186436 Phosphorylation of Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
66 INT186438 Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
67 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
68 INT186440 Phosphorylation of Creb1 Regulation of Jun 1 0.21 0.43 0.72
69 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
70 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
71 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7
72 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
73 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
74 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
75 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
76 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
77 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
78 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
79 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
80 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
81 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
82 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
83 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
84 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
85 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
86 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
87 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
88 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
89 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
90 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
91 INT226306 CHPT1 Positive_regulation of Localization of DBP 1 0.26 0.65 0.64
92 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
93 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
94 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 0.06 0.1 0.63
95 INT158399 Binding of Preb and Frg1 1 0.01 0.3 0.62
96 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
97 INT128869 Gabrg1 Positive_regulation of Transcription of Jun 1 0.09 0.55 0.62
98 INT54487 Rabep2 Regulation of Gene_expression of Jun 1 0.06 0 0.61
99 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
100 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
101 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
102 INT73654 Binding of Jun and Pim3 1 0.02 0.99 0.58
103 INT149480 CEBPD Positive_regulation of CEBPB 1 0.50 0.15 0.58
104 INT93063 Binding of gr and Jun 3 0.14 0.79 0.57
105 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
106 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
107 INT249001 Gabrg1 Positive_regulation of Arntl 1 0.29 0 0.55
108 INT249006 Gabrg1 Positive_regulation of Transcription of Arntl 1 0.31 0 0.55
109 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
110 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
111 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
112 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
113 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
114 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
115 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
116 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
117 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
118 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
119 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53
120 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
121 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
122 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5
123 INT200329 Dbp Negative_regulation of Gene_expression of Oprm1 1 0.03 0.07 0.5
124 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
125 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
126 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
127 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
128 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
129 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
130 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
131 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
132 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
133 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
134 INT247639 Binding of Jun and Atf3 2 0.09 3.06 0.44
135 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
136 INT127075 Bdnf Regulation of Gene_expression of Jun 1 0.11 0.28 0.43
137 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
138 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
139 INT249011 Gabrg1 Regulation of Clock 1 0.19 0 0.43
140 INT200339 Preb Negative_regulation of Gene_expression of Oprm1 1 0.02 0.08 0.4
141 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
142 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
143 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
144 INT345007 CSF2 Regulation of DBP 1 0.14 0.82 0.39
145 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
146 INT65060 Slc3a1 Positive_regulation of Jun 1 0.00 0 0.37
147 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
148 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
149 INT249004 Helt Regulation of Clock 1 0.01 0.09 0.37
150 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
151 INT249015 Regulation of Helt Regulation of Clock 1 0.01 0.09 0.37
152 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
153 INT151551 Regulation of Camk4 Positive_regulation of Atf2 1 0.34 0.36 0.37
154 INT151547 Camk4 Positive_regulation of Atf2 1 0.38 0.36 0.37
155 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36
156 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
157 INT345009 DBP Regulation of CCBE1 1 0.00 0.81 0.36
158 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
159 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
160 INT99292 Pth Positive_regulation of Jun 1 0.10 0.13 0.36
161 INT90722 Nr4a1 Positive_regulation of Egr1 1 0.20 0.48 0.35
162 INT288164 Jun Regulation of Gene_expression of Mmp13 1 0.02 0.41 0.35
163 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
164 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
165 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
166 INT90724 Egr3 Positive_regulation of Egr1 1 0.33 0.48 0.35
167 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
168 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
169 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
170 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
171 INT324224 Binding of OTX2 and H9 1 0.11 0.17 0.33
172 INT95552 Binding of Dbp and Shbg 3 0.01 2.09 0.32
173 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
174 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
175 INT288165 Binding of Jun and Ugcg 1 0.02 0.45 0.32
176 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
177 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
178 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
179 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
180 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
181 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
182 INT124261 Jun Regulation of Gene_expression of Cpox 1 0.13 0.44 0.32
183 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
184 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32
185 INT110463 Binding of Jun and Gtf3a 1 0.04 0 0.32
186 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
187 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
188 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32
189 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
190 INT50698 Binding of Jun and Penk 6 0.52 0 0.31
191 INT124259 Negative_regulation of Plat Positive_regulation of Jun 4 0.11 1.74 0.31
192 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
193 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
194 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
195 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
196 INT110459 Binding of Atf2 and Jun 1 0.32 0 0.31
197 INT99154 Binding of DBP and SIL1 1 0.02 0.16 0.31
198 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
199 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
200 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3

Single Events

The table below shows the top 100 pain related interactions that have been reported for RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. They are ordered first by their pain relevance and then by number of times they were reported in RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
2 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
3 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
4 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
5 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
6 INT666 Gene_expression of Jun 124 0.78 54.61 33.67
7 INT47764 Binding of Jun 106 0.48 22.62 31.39
8 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73
9 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
10 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
11 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
12 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
13 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61
14 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
15 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
16 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
17 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
18 INT41558 Localization of Sp1 9 0.48 0.56 14.9
19 INT2758 Binding of Dbp 36 0.44 8.3 14.47
20 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
21 INT17593 Regulation of Jun 37 0.60 5.5 14.35
22 INT173505 Localization of Hand2 63 0.57 45.32 13.66
23 INT47708 Gene_expression of Nr4a1 30 0.78 5.12 13.59
24 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37
25 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
26 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06
27 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36
28 INT52233 Transcription of Jun 37 0.66 6.39 11.15
29 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08
30 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
31 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
32 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
33 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
34 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32
35 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
36 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
37 INT61264 Regulation of Jun 36 0.61 18.42 8.71
38 INT47701 Positive_regulation of Nr4a1 26 0.70 4.45 8.64
39 INT64815 Binding of Jun 49 0.48 21.47 8.59
40 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4
41 INT53975 Positive_regulation of Binding of Jun 28 0.70 4.67 8.16
42 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
43 INT64816 Transcription of Jun 31 0.69 16.01 7.64
44 INT9476 Regulation of Gene_expression of Jun 14 0.43 4.25 7.61
45 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
46 INT10344 Localization of Jun 23 0.73 6.36 7.46
47 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
48 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
49 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
50 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
51 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91
52 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9
53 INT47817 Positive_regulation of Positive_regulation of Jun 21 0.66 3.7 6.83
54 INT48555 Binding of SP1 30 0.46 11.38 6.53
55 INT170385 Regulation of Clock 29 0.49 4.95 6.39
56 INT47765 Negative_regulation of Binding of Jun 21 0.43 5.05 6.38
57 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
58 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
59 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97
60 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
61 INT73649 Phosphorylation of Jun 28 0.80 11.01 5.87
62 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
63 INT88286 Phosphorylation of Atf2 11 0.66 1.93 5.69
64 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59
65 INT90752 Positive_regulation of Gene_expression of Nr4a1 13 0.70 2.83 5.53
66 INT60585 Regulation of TP53 59 0.59 54.55 5.21
67 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18
68 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
69 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
70 INT88282 Positive_regulation of Phosphorylation of Atf2 8 0.44 1.77 4.85
71 INT203506 Positive_regulation of Pou4f1 3 0.49 6.17 4.85
72 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
73 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78
74 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
75 INT48747 Positive_regulation of Dbp 7 0.24 1.28 4.69
76 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
77 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
78 INT29231 Regulation of Dbp 44 0.53 10.08 4.47
79 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
80 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
81 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45
82 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26
83 INT9098 Positive_regulation of DBP 30 0.69 15.77 4.26
84 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
85 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
86 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03
87 INT156131 Binding of Hand2 14 0.25 10.35 3.99
88 INT47705 Regulation of Nr4a1 10 0.62 0.84 3.9
89 INT6661 Positive_regulation of Positive_regulation of Jun 31 0.50 7.12 3.89
90 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88
91 INT64817 Positive_regulation of Binding of Jun 16 0.69 6.78 3.81
92 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
93 INT123502 Binding of Egr1 11 0.35 6.7 3.77
94 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
95 INT15776 Localization of Jun 10 0.74 3.9 3.69
96 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
97 INT12598 Binding of DBP 20 0.48 13.11 3.62
98 INT77251 Positive_regulation of Atf2 8 0.70 2.45 3.62
99 INT86977 Positive_regulation of Nr4a3 7 0.10 0.73 3.5
100 INT61570 Positive_regulation of Transcription of Jun 10 0.35 1.62 3.45
101 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
102 INT70387 Negative_regulation of Positive_regulation of Jun 14 0.37 3.76 3.23
103 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18
104 INT123409 Binding of Sp1 20 0.39 3.18 3.15
105 INT114276 Gene_expression of Nr4a1 20 0.77 7.71 3.14
106 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
107 INT8103 Binding of TP53 46 0.44 40.2 2.96
108 INT103607 Binding of Sp1 7 0.42 1.26 2.92
109 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
110 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
111 INT64819 Positive_regulation of Transcription of Jun 6 0.50 4.41 2.79
112 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
113 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
114 INT128328 Gene_expression of Arntl 44 0.74 3.77 2.63
115 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
116 INT88285 Transcription of Atf2 4 0.36 1.56 2.62
117 INT69007 Binding of Cebpb 10 0.48 2.21 2.6
118 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
119 INT194495 Regulation of Transcription of Jun 4 0.26 2.85 2.6
120 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
121 INT86980 Transcription of Nr4a3 4 0.45 0.24 2.58
122 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
123 INT125439 Positive_regulation of NFIB 4 0.67 6.71 2.52
124 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
125 INT52326 Negative_regulation of Atf2 7 0.45 0.94 2.5
126 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48
127 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
128 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
129 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41
130 INT90314 Regulation of Gene_expression of Nr4a1 2 0.61 0.23 2.37
131 INT55952 Transcription of TP53 16 0.61 12.14 2.36
132 INT47700 Transcription of Nr4a1 9 0.69 1.37 2.25
133 INT15243 Regulation of Egr1 19 0.61 7.6 2.13
134 INT53981 Regulation of Binding of Jun 5 0.44 0.63 2.12
135 INT59358 Regulation of Gene_expression of Jun 10 0.61 3.7 2.11
136 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
137 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
138 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
139 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
140 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
141 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
142 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
143 INT100046 Gene_expression of BTG2 16 0.20 10.81 1.95
144 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
145 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
146 INT65855 Localization of TP53 18 0.76 17.08 1.89
147 INT53982 Regulation of Positive_regulation of Jun 4 0.54 0.9 1.89
148 INT100064 Regulation of DBP 17 0.45 6.06 1.85
149 INT170387 Transcription of Clock 11 0.63 1.78 1.83
150 INT28173 Localization of DBP 8 0.73 3.4 1.83
151 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
152 INT149812 Gene_expression of Dbp 6 0.39 1.47 1.79
153 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
154 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75
155 INT316162 Localization of TCF21 1 0.18 0.28 1.71
156 INT90751 Negative_regulation of Gene_expression of Nr4a1 3 0.59 0.75 1.69
157 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
158 INT114279 Positive_regulation of Nr4a1 9 0.59 3.37 1.59
159 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
160 INT57877 Negative_regulation of Positive_regulation of Egr1 4 0.42 1.63 1.57
161 INT231917 Gene_expression of Cebpb 10 0.25 4.45 1.56
162 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
163 INT82122 Positive_regulation of CEBPB 3 0.67 0.51 1.54
164 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
165 INT114270 Gene_expression of Plscr1 6 0.47 1.33 1.49
166 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
167 INT110444 Positive_regulation of Atf2 7 0.50 2 1.48
168 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
169 INT217825 Regulation of Gene_expression of MITF 3 0.00 5.2 1.47
170 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
171 INT219259 Binding of Nfib 1 0.36 1.46 1.46
172 INT149815 Positive_regulation of Gene_expression of Clock 7 0.46 0.87 1.45
173 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
174 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
175 INT248979 Transcription of Arntl 15 0.69 3.47 1.43
176 INT128316 Regulation of Gene_expression of Arntl 6 0.43 0.68 1.43
177 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
178 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
179 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
180 INT172953 Binding of Trp53 33 0.37 20.76 1.41
181 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
182 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
183 INT116008 Binding of Gata3 2 0.34 1.37 1.41
184 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
185 INT248976 Positive_regulation of Clock 8 0.48 0.15 1.38
186 INT96063 Positive_regulation of Phosphorylation of Jun 7 0.67 4.06 1.38
187 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
188 INT86979 Positive_regulation of Transcription of Nr4a3 1 0.02 0.13 1.38
189 INT145221 Binding of Tp53 10 0.37 8.59 1.37
190 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
191 INT86978 Regulation of Nr4a3 1 0.02 0.06 1.37
192 INT141344 Transcription of Egr1 11 0.70 5.59 1.34
193 INT290803 Binding of Arntl 10 0.37 1.82 1.34
194 INT71304 Binding of CEBPB 3 0.36 2.69 1.32
195 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
196 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
197 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
198 INT130207 Phosphorylation of ATF2 5 0.60 1.34 1.25
199 INT89765 Positive_regulation of NR4A1 12 0.69 8.13 1.23
200 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
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