GO:0001158

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Name enhancer sequence-specific DNA binding
Categary Function
Go Slim No
Go Link GO:0001158
Unique Molecular Interactions 46
Total Molecular Interactions 54
Total Single Events 695
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enhancer sequence-specific DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for enhancer sequence-specific DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
2 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
3 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
4 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
5 INT152925 Aanat Positive_regulation of Nanog 1 0.02 0.42 0.67
6 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
7 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
8 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
9 INT26669 Nanog Regulation of Binding of Tlyr1 1 0.02 0 0.28
10 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
11 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
12 INT76865 Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
13 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
14 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
15 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
16 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
17 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
18 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
19 INT118416 Gata2 Positive_regulation of Transcription of Tac2 1 0.27 0.2 0.07
20 INT118417 Gata1 Regulation of Gene_expression of Serpinb9g 1 0.17 0.12 0.06
21 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
22 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
23 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
24 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
25 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
26 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
27 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
28 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
29 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
30 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
31 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
32 INT259095 Binding of RBBP8 and LMO4 1 0.15 0.73 0
33 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
34 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
35 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
36 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
37 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
38 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
39 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
40 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
41 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
42 INT283711 Sox11 Regulation of 4930579C15Rik 1 0.28 0.74 0
43 INT269956 Gata6 Regulation of Gene_expression of Scgb1a1 1 0.17 0 0
44 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enhancer sequence-specific DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in enhancer sequence-specific DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50767 Positive_regulation of Nanog 14 0.67 3.63 8.56
2 INT28358 Gene_expression of Nanog 25 0.70 3.52 7.85
3 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
4 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
5 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
6 INT64825 Negative_regulation of Nanog 8 0.57 2.59 3.47
7 INT148190 Positive_regulation of Transcription of Nanog 1 0.49 0.2 3.17
8 INT122787 Transcription of Nanog 4 0.67 0.78 2.81
9 INT122782 Negative_regulation of Positive_regulation of Nanog 3 0.57 1.15 2.81
10 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68
11 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
12 INT27412 Regulation of Nanog 7 0.58 0.81 2.59
13 INT62692 Localization of Nanog 3 0.73 0.82 1.85
14 INT101252 Negative_regulation of Gene_expression of Gata6 1 0.51 1.3 1.74
15 INT101244 Regulation of Gata6 3 0.40 1.52 1.7
16 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
17 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
18 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
19 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
20 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
21 INT116008 Binding of Gata3 2 0.34 1.37 1.41
22 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
23 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
24 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
25 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
26 INT179583 Gene_expression of Lmo4 5 0.41 1.97 1.03
27 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
28 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
29 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
30 INT101248 Negative_regulation of Gata6 1 0.37 0.83 0.85
31 INT101251 Negative_regulation of Positive_regulation of Gata6 1 0.38 0.83 0.85
32 INT304863 Negative_regulation of Gene_expression of Nanog 4 0.41 0.91 0.84
33 INT101250 Positive_regulation of Gata6 1 0.41 0.83 0.84
34 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
35 INT101245 Transcription of Gata6 2 0.47 0.85 0.82
36 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
37 INT259113 Gene_expression of LMO4 1 0.78 71.49 0.76
38 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
39 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
40 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
41 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
42 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
43 INT54497 Binding of Nanog 1 0.35 0 0.67
44 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
45 INT62732 Positive_regulation of Gene_expression of Nanog 2 0.45 0.27 0.63
46 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
47 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
48 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
49 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
50 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
51 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
52 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
53 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
54 INT304861 Regulation of Gene_expression of Nanog 3 0.43 0.13 0.46
55 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
56 INT84326 Protein_catabolism of Nanog 1 0.02 0 0.41
57 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
58 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
59 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33
60 INT172806 Localization of ISL1 4 0.26 2.64 0.29
61 INT126059 Positive_regulation of Gata2 1 0.02 0.87 0.28
62 INT78132 Binding of Isl1 1 0.16 0 0.27
63 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
64 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
65 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
66 INT179581 Negative_regulation of Gene_expression of Lmo4 1 0.18 0.06 0.26
67 INT244742 Gene_expression of Gata2 2 0.54 0.18 0.23
68 INT259120 Regulation of Gene_expression of LMO4 1 0.45 5.61 0.23
69 INT353967 Positive_regulation of Gene_expression of Gata2 1 0.42 0.18 0.23
70 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
71 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
72 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
73 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
74 INT243778 Binding of Isl1 1 0.26 0 0.19
75 INT98772 Localization of Isl1 2 0.65 0 0.16
76 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
77 INT259111 Transcription of LMO4 1 0.72 12.56 0.16
78 INT323420 Positive_regulation of Gene_expression of Lmo4 1 0.01 0.71 0.16
79 INT259110 Negative_regulation of Gene_expression of LMO4 1 0.43 3.47 0.16
80 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
81 INT259117 Positive_regulation of Gene_expression of LMO4 1 0.70 16.1 0.13
82 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
83 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
84 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
85 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
86 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
87 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
88 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
89 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
90 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
91 INT283695 Binding of Sox11 1 0.32 0.18 0.08
92 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
93 INT259118 Positive_regulation of LMO4 1 0.70 9.69 0.06
94 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
95 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
96 INT283696 Localization of Sox11 1 0.65 0.37 0.05
97 INT248540 Positive_regulation of Gata4 2 0.23 0.95 0.03
98 INT225365 Binding of Sox9 2 0.28 0.48 0.03
99 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
100 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
101 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
102 INT245757 Localization of SOX9 4 0.62 0.8 0
103 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
104 INT274404 Binding of Gata4 2 0.16 0.89 0
105 INT180121 Phosphorylation of Isl1 1 0.27 0 0
106 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
107 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
108 INT283699 Positive_regulation of Sox11 1 0.35 0.62 0
109 INT259107 Regulation of LMO4 1 0.45 2.68 0
110 INT227625 Regulation of ISL1 1 0.05 0.35 0
111 INT211943 Transcription of Sox9 1 0.50 0.3 0
112 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
113 INT259108 Negative_regulation of LMO4 1 0.59 0.74 0
114 INT322886 Transcription of Sox9 1 0.50 0.25 0
115 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
116 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
117 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
118 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
119 INT181811 Localization of Gata4 1 0.54 0.3 0
120 INT259114 Binding of LMO4 1 0.37 4.39 0
121 INT262679 Phosphorylation of Gata1 1 0.18 0.55 0
122 INT328768 Positive_regulation of Gene_expression of Gata6 1 0.19 0.61 0
123 INT245765 Binding of SOX9 1 0.31 0.87 0
124 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
125 INT262696 Binding of Gata1 1 0.08 0.56 0
126 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
127 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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