GO:0001300

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Name chronological cell aging
Categary Process
Go Slim No
Go Link GO:0001300
Unique Molecular Interactions 166
Total Molecular Interactions 247
Total Single Events 2055
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chronological cell aging. They are ordered first by their pain relevance and then by number of times they were reported for chronological cell aging. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
8 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
9 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
10 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
11 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
12 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
13 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
14 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
15 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
16 INT32719 ENG Regulation of LH 2 0.00 0 0.64
17 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
18 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
19 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
20 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
21 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
22 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
23 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
24 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
25 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
26 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
27 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
28 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
29 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
30 INT102213 Binding of ENG and HP 1 0.01 0 0.47
31 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
32 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
33 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
34 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
35 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
36 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
37 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
38 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
39 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
40 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
41 INT55404 Binding of ENG and Th 1 0.02 0 0.3
42 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
43 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
44 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
45 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
46 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
47 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
48 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
49 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
50 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
51 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22
52 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
53 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 0.02 0.28 0.22
54 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
55 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2
56 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
57 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
58 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
59 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
60 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
61 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
62 INT180671 Binding of Plat and Regulation of Serpine1 1 0.16 0.06 0.14
63 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
64 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
65 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
66 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
67 INT99737 Serpinf2 Negative_regulation of Localization of SERPINE1 1 0.00 0.24 0.12
68 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
69 INT22670 PLAT Positive_regulation of SERPINE1 1 0.03 0.1 0.1
70 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1
71 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1
72 INT22672 Positive_regulation of Binding of SERPINE1 and PLAT 1 0.03 0.1 0.1
73 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
74 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
75 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
76 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
77 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07
78 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07
79 INT57268 SERPINE1 Positive_regulation of SERPINC1 1 0.07 0.94 0.07
80 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06
81 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
82 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
83 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
84 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
85 INT319120 CRP Positive_regulation of Gene_expression of SERPINE1 1 0.70 0.54 0.04
86 INT348694 Atp9a Negative_regulation of Serpine1 1 0.00 0.24 0.03
87 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
88 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
89 INT355637 OLR1 Positive_regulation of Gene_expression of SERPINE1 1 0.03 1.15 0
90 INT32148 POMC Regulation of ENG 1 0.24 0 0
91 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
92 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
93 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
94 INT22668 PNMA1 Regulation of SERPINE1 1 0.03 0 0
95 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
96 INT78416 Binding of Serpine1 and Vwf 1 0.00 0.11 0
97 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
98 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
99 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
100 INT130414 TNFSF14 Positive_regulation of SERPINE1 1 0.29 0 0
101 INT130223 Binding of Serpinc1 and Serpine1 1 0.00 0.13 0
102 INT197040 SERPINE1 Regulation of PLAU 1 0.31 0.68 0
103 INT265934 SREBF1 Positive_regulation of Transcription of SERPINE1 1 0.01 0.62 0
104 INT22677 Binding of SERPINE1 and SGCG 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chronological cell aging. They are ordered first by their pain relevance and then by number of times they were reported in chronological cell aging. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
4 INT10799 Localization of ENG 63 0.78 18.67 27.28
5 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
6 INT7674 Regulation of ENG 42 0.30 11.41 14.44
7 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
8 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
9 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
10 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
11 INT23375 Binding of ENG 17 0.47 6.02 6.46
12 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
13 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
14 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
15 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
16 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
17 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
18 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
19 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
20 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
21 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
22 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
23 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
24 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
25 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
26 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
27 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
28 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
29 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
30 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
31 INT20100 Binding of Serpine1 16 0.29 6.78 1.18
32 INT15919 Positive_regulation of Gene_expression of Serpine1 6 0.41 4.5 1.15
33 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
34 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97
35 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83
36 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69
37 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
38 INT70971 Negative_regulation of Positive_regulation of SERPINE1 3 0.40 2.65 0.58
39 INT20099 Regulation of Positive_regulation of Serpine1 2 0.40 1.75 0.52
40 INT58015 Regulation of Gene_expression of Serpine1 3 0.41 2.61 0.47
41 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47
42 INT35435 Negative_regulation of Positive_regulation of Serpine1 5 0.42 2.26 0.46
43 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38
44 INT187606 Negative_regulation of Gene_expression of Serpine1 3 0.05 1.78 0.36
45 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33
46 INT48719 Negative_regulation of Transcription of SERPINE1 1 0.42 0.17 0.26
47 INT180280 Positive_regulation of Phosphorylation of SERPINE1 2 0.48 0 0.24
48 INT180281 Phosphorylation of SERPINE1 2 0.78 0 0.24
49 INT202186 Negative_regulation of Phosphorylation of SERPINE1 1 0.41 0 0.24
50 INT100870 Positive_regulation of Binding of SERPINE1 2 0.49 1.24 0.21
51 INT48723 Regulation of Transcription of SERPINE1 1 0.27 0.26 0.2
52 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
53 INT25009 Regulation of Localization of Serpine1 2 0.36 0.15 0.17
54 INT270426 Regulation of Binding of SERPINE1 1 0.06 0.42 0.17
55 INT82636 Negative_regulation of Localization of Serpine1 1 0.29 1.01 0.16
56 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14
57 INT305016 Positive_regulation of Negative_regulation of SERPINE1 1 0.10 1.13 0.11
58 INT277070 Negative_regulation of Negative_regulation of SERPINE1 1 0.12 0.55 0.1
59 INT51990 Transcription of Serpine1 3 0.45 2.01 0.09
60 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
61 INT245881 Negative_regulation of Negative_regulation of Serpine1 1 0.04 1.66 0.09
62 INT81879 Regulation of Regulation of SERPINE1 1 0.27 0.73 0.06
63 INT190471 Transcription of ENG 3 0.21 1.76 0
64 INT66115 Regulation of Binding of Serpine1 1 0.09 0.12 0
65 INT353031 Negative_regulation of Transcription of Serpine1 1 0.02 0.69 0
66 INT143064 Positive_regulation of Localization of Serpine1 1 0.13 0 0
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