GO:0001501

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Name skeletal system development
Categary Process
Go Slim No
Go Link GO:0001501
Unique Molecular Interactions 1262
Total Molecular Interactions 1646
Total Single Events 15508
Pain Genes Associated 123

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for skeletal system development. They are ordered first by their pain relevance and then by number of times they were reported for skeletal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64
2 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38
3 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
4 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
5 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
6 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
7 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
8 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
9 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
10 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
11 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
12 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
13 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
14 INT111892 Ptger2 Regulation of Ptger1 1 0.08 2.09 1.55
15 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 0.03 1.28 1.49
16 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
17 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
18 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
19 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
20 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
21 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
22 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
23 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
24 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
25 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
26 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
27 INT274948 Binding of Dh and Ltp 1 0.11 0.55 1.23
28 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
29 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
30 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
31 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
32 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
33 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 0.03 0.68 1.12
34 INT270054 HOXD12 Positive_regulation of Gene_expression of SFTPA1 1 0.01 0.68 1.12
35 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
36 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
37 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
38 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
39 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
40 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1
41 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
42 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
43 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
44 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
45 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
46 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
47 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
48 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
49 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91
50 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
51 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89
52 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88
53 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
54 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
55 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
56 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88
57 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
58 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
59 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
60 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
61 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
62 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
63 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
64 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
65 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
66 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
67 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
68 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83
69 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
70 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
71 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
72 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
73 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
74 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
75 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
76 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
77 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
78 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
79 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
80 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
81 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
82 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
83 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
84 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
85 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
86 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
87 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
88 INT118463 Ptger2 Positive_regulation of Ptger1 1 0.33 0.48 0.74
89 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
90 INT119313 Cpox Regulation of Gene_expression of Ptger2 1 0.02 0.6 0.74
91 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
92 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
93 INT326457 Runx1 Regulation of Mrgpra3 1 0.37 0.1 0.71
94 INT326456 Runx1 Regulation of Pip4k2b 1 0.09 0.11 0.71
95 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
96 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
97 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7
98 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
99 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
100 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
101 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
102 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
103 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
104 INT117677 Binding of MATN3 and OPRL1 1 0.26 0.07 0.68
105 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
106 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
107 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
108 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
109 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
110 INT64884 Negative_regulation of Ptger2 Positive_regulation of Ina 1 0.03 0.24 0.65
111 INT207410 Ptger2 Regulation of Gene_expression of Tacr1 1 0.02 0.69 0.65
112 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
113 INT30730 Penk Positive_regulation of Binding of Ptger2 1 0.02 0 0.65
114 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
115 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
116 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
117 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64
118 INT8695 Binding of Calca and Lgals3 1 0.02 0.09 0.62
119 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
120 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
121 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
122 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
123 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
124 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
125 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
126 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
127 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6
128 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
129 INT280895 Runx1 Positive_regulation of Gene_expression of Ret 2 0.33 0.2 0.58
130 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
131 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
132 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
133 INT215176 Ptger2 Regulation of Ptger3 2 0.09 1.16 0.56
134 INT75992 Binding of Pvalb and Lgals3 1 0.00 0 0.56
135 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
136 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
137 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
138 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
139 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
140 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54
141 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
142 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
143 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52
144 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
145 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
146 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
147 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52
148 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
149 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
150 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
151 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
152 INT206961 Lipg Regulation of Ptger2 1 0.01 0.85 0.51
153 INT207466 LGALS3 Positive_regulation of Gene_expression of ADAMTS5 1 0.15 0.88 0.51
154 INT206958 Lipg Regulation of Gene_expression of Ptger2 1 0.01 0.85 0.51
155 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51
156 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
157 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51
158 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
159 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
160 INT311963 Ifx Negative_regulation of FBN1 1 0.00 0.44 0.5
161 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
162 INT84508 Ptger2 Regulation of Son 1 0.18 0 0.49
163 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
164 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
165 INT31712 Ptger2 Positive_regulation of Localization of Ins1 1 0.13 0.06 0.49
166 INT127664 Negative_regulation of PDE4A Negative_regulation of MMP9 1 0.37 0.76 0.48
167 INT127665 Negative_regulation of PDE4A Negative_regulation of Transcription of MMP9 1 0.37 0.76 0.48
168 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
169 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
170 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
171 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
172 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
173 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
174 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
175 INT224674 S100a4 Positive_regulation of Gene_expression of Mmp9 1 0.03 0.85 0.45
176 INT248310 Crx Regulation of MATN3 1 0.07 0.65 0.45
177 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
178 INT314044 THL Negative_regulation of Transcription of Mmp9 1 0.20 0.81 0.45
179 INT215174 Ptger2 Regulation of Gene_expression of Ptger1 1 0.13 0.62 0.44
180 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
181 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
182 INT326458 Runx1 Negative_regulation of Gene_expression of Calca 1 0.18 0.05 0.43
183 INT298287 Runx1 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
184 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42
185 INT226070 Binding of CRP and MMP9 1 0.51 1.13 0.42
186 INT133002 Mmp9 Regulation of Negative_regulation of Igfbp3 1 0.26 0.39 0.42
187 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
188 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
189 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
190 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
191 INT298286 Runx3 Regulation of Gene_expression of Runx1 1 0.47 0.36 0.41
192 INT215171 Ptger2 Regulation of P2rx3 1 0.23 0.45 0.41
193 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
194 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
195 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
196 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
197 INT298270 Gene_expression of Runx1 Positive_regulation of Ntrk3 1 0.35 0.34 0.4
198 INT298584 IL1B Regulation of Gene_expression of TNFRSF11B 1 0.22 0.7 0.4
199 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
200 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4

Single Events

The table below shows the top 100 pain related interactions that have been reported for skeletal system development. They are ordered first by their pain relevance and then by number of times they were reported in skeletal system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
2 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
5 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
6 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
7 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
8 INT99610 Localization of MMP9 126 0.79 48.46 32.67
9 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
10 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
11 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
12 INT22764 Localization of Ptger2 81 0.64 24.38 26.77
13 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
14 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
15 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
16 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
17 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92
18 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67
19 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
20 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
21 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
22 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
23 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
24 INT11335 Regulation of Ptger2 46 0.51 22.3 15.42
25 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
26 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
27 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
28 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
29 INT35029 Positive_regulation of Gene_expression of Ptger2 66 0.43 26.37 13.99
30 INT3174 Negative_regulation of Ptger2 43 0.38 20.95 13.43
31 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53
32 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44
33 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38
34 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
35 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89
36 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
37 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7
38 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
39 INT11894 Negative_regulation of Gene_expression of Ptger2 47 0.55 16.95 11.59
40 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
41 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
42 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
43 INT158070 Localization of Aes 23 0.65 19.93 10.9
44 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
45 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
46 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
47 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16
48 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12
49 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
50 INT245538 Negative_regulation of Gene_expression of Runx1 20 0.58 11.68 9.97
51 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
52 INT82829 Gene_expression of COMP 104 0.78 57 9.81
53 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
54 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
55 INT6361 Localization of Edn1 30 0.81 19.09 9.7
56 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
57 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
58 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
59 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
60 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
61 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96
62 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
63 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
64 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
65 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
66 INT34777 Localization of IGF1 82 0.80 42.68 8.62
67 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29
68 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
69 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13
70 INT25953 Positive_regulation of Localization of Ptger2 29 0.42 5.91 8.1
71 INT65803 Gene_expression of Dh 10 0.32 1.24 8.07
72 INT8694 Binding of Lgals3 38 0.48 14.82 8.05
73 INT150422 Positive_regulation of Aes 24 0.43 15.63 8
74 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
75 INT30729 Binding of Ptger2 36 0.29 7.66 7.35
76 INT264641 Binding of AES 25 0.42 18.56 6.98
77 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
78 INT168600 Binding of Mmp9 14 0.44 12.79 6.92
79 INT52180 Binding of Aes 38 0.42 23.16 6.7
80 INT39116 Regulation of Gene_expression of Ptger2 29 0.51 10.25 6.46
81 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
82 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33
83 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
84 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
85 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32
86 INT169596 Transcription of Runx1 12 0.71 5.55 6.27
87 INT245515 Regulation of Runx1 14 0.61 5.07 6.22
88 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
89 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
90 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
91 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
92 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
93 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91
94 INT188844 Gene_expression of AES 44 0.58 33.94 5.85
95 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
96 INT22765 Negative_regulation of Localization of Ptger2 14 0.34 3 5.75
97 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
98 INT15284 Positive_regulation of Lgals3 21 0.47 8.88 5.52
99 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48
100 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
101 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
102 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
103 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
104 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
105 INT201130 Localization of AES 31 0.63 25.45 5.12
106 INT84561 Binding of COL1A2 18 0.47 11.76 5.09
107 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
108 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06
109 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03
110 INT245536 Regulation of Gene_expression of Runx1 11 0.58 6.22 4.88
111 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
112 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8
113 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8
114 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
115 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
116 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73
117 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
118 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
119 INT87268 Positive_regulation of BMP8B 5 0.19 0.53 4.6
120 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57
121 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52
122 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46
123 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46
124 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
125 INT98357 Binding of Gnas 11 0.41 1.87 4.35
126 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
127 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25
128 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
129 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
130 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17
131 INT99608 Transcription of MMP9 18 0.65 9.67 4.11
132 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07
133 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
134 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
135 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
136 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99
137 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
138 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
139 INT270065 Positive_regulation of HOXD12 1 0.05 1.11 3.86
140 INT207426 Gene_expression of COL10A1 27 0.65 12.02 3.85
141 INT133312 Binding of MMP9 25 0.42 16.79 3.83
142 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75
143 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
144 INT81231 Gene_expression of LGALS3 26 0.74 9.38 3.66
145 INT59900 Binding of MATN3 13 0.42 17.19 3.59
146 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59
147 INT87269 Localization of BMP8B 1 0.07 0.24 3.58
148 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55
149 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55
150 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5
151 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
152 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
153 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45
154 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
155 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
156 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39
157 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39
158 INT12844 Binding of TP63 15 0.47 10.57 3.38
159 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
160 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
161 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
162 INT118095 Regulation of COMP 7 0.43 9.69 3.33
163 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32
164 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
165 INT307634 Binding of BMP1 1 0.36 3.12 3.26
166 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22
167 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19
168 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
169 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
170 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
171 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
172 INT28094 Binding of PTH 29 0.37 13.57 3.09
173 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
174 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
175 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
176 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
177 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02
178 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
179 INT53374 Binding of Edn1 17 0.43 11.66 2.98
180 INT16130 Binding of IGF1 67 0.48 27.43 2.95
181 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93
182 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
183 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
184 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
185 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
186 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
187 INT14448 Localization of COL5A2 34 0.67 17.35 2.85
188 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8
189 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
190 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
191 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73
192 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73
193 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72
194 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
195 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
196 INT39005 Negative_regulation of FBN1 7 0.42 4.97 2.6
197 INT142908 Localization of FGFR1 18 0.38 11.46 2.57
198 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
199 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
200 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
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