GO:0001503

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Name ossification
Categary Process
Go Slim No
Go Link GO:0001503
Unique Molecular Interactions 1312
Total Molecular Interactions 1861
Total Single Events 14355
Pain Genes Associated 97

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ossification. They are ordered first by their pain relevance and then by number of times they were reported for ossification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
3 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
4 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
5 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
6 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
7 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
8 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
9 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
10 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
11 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
12 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
13 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
14 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
15 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
16 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
17 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
18 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
19 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
20 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
21 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
22 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
23 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
24 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
25 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
26 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
27 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
28 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
29 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
30 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
31 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
32 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
33 INT193288 CAP1 Positive_regulation of Pth 1 0.04 0.08 1.14
34 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
35 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
36 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
37 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
38 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
39 INT150787 ZNF398 Positive_regulation of Gene_expression of SPARC 1 0.13 1.02 1.05
40 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
41 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
42 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03
43 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
44 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
45 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
46 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
47 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
48 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
49 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
50 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
51 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
52 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
53 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
54 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
55 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
56 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
57 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
58 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
59 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
60 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
61 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
62 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
63 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
64 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
65 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
66 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
67 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
68 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
69 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
70 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
71 INT193275 Phax Regulation of Pth 1 0.01 0.16 0.81
72 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
73 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
74 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
75 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
76 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
77 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
78 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
79 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
80 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
81 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
82 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
83 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
84 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
85 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
86 INT150268 MMP8 Regulation of Transcription of SFTPA1 1 0.05 0.43 0.75
87 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
88 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
89 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
90 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
91 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
92 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
93 INT162239 Binding of COL7A1 and MMP8 1 0.04 0.86 0.73
94 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
95 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
96 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
97 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
98 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
99 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
100 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
101 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
102 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
103 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7
104 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
105 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
106 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
107 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
108 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
109 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
110 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
111 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
112 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
113 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
114 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
115 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
116 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
117 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
118 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
119 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
120 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
121 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
122 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64
123 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
124 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
125 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
126 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
127 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62
128 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
129 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
130 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
131 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
132 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
133 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
134 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61
135 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
136 INT179850 Binding of Ecm1 and Il11 1 0.02 0 0.6
137 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
138 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
139 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
140 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
141 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6
142 INT193289 CAP1 Regulation of Pth 1 0.02 0 0.59
143 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
144 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
145 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
146 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58
147 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
148 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
149 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
150 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
151 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
152 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
153 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
154 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
155 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
156 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
157 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
158 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
159 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
160 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
161 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
162 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53
163 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
164 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
165 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
166 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
167 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
168 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
169 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51
170 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51
171 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
172 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
173 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
174 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
175 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
176 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
177 INT127664 Negative_regulation of PDE4A Negative_regulation of MMP9 1 0.37 0.76 0.48
178 INT127665 Negative_regulation of PDE4A Negative_regulation of Transcription of MMP9 1 0.37 0.76 0.48
179 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
180 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
181 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
182 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
183 INT250858 Mmp3 Regulation of Protein_catabolism of Ecm1 1 0.01 1.11 0.47
184 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
185 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
186 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
187 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
188 INT125568 Binding of Casr and Ncoa6 3 0.50 1.13 0.46
189 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
190 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
191 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
192 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
193 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
194 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
195 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45
196 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
197 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
198 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
199 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
200 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43

Single Events

The table below shows the top 100 pain related interactions that have been reported for ossification. They are ordered first by their pain relevance and then by number of times they were reported in ossification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
2 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
3 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
4 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
5 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
6 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
7 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
8 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
9 INT99610 Localization of MMP9 126 0.79 48.46 32.67
10 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
11 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
12 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54
13 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26
14 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
15 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
16 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
17 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
18 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
19 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
20 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
21 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
22 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
23 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
24 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
25 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
26 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
27 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
28 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91
29 INT41558 Localization of Sp1 9 0.48 0.56 14.9
30 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
31 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
32 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
33 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
34 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
35 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
36 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
37 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
38 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
39 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
40 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
41 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
42 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
43 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
44 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
45 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
46 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
47 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
48 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
49 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96
50 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
51 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
52 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
53 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
54 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
55 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
56 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
57 INT22083 Regulation of Pth 55 0.62 22.32 8.9
58 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
59 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
60 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
61 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
62 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24
63 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
64 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
65 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
66 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
67 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
68 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
69 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
70 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49
71 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
72 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
73 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
74 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
75 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
76 INT50669 Negative_regulation of Ptn 15 0.58 5.56 6.88
77 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
78 INT48555 Binding of SP1 30 0.46 11.38 6.53
79 INT6052 Gene_expression of Ptn 12 0.78 8.4 6.5
80 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
81 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33
82 INT11154 Binding of EGFR 149 0.48 96.23 6.29
83 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
84 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
85 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
86 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
87 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75
88 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
89 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
90 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
91 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
92 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
93 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
94 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
95 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
96 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
97 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12
98 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
99 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
100 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
101 INT62570 Binding of Pth 48 0.48 26.45 4.85
102 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
103 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
104 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
105 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
106 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
107 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73
108 INT346257 Binding of RUNX2 1 0.44 9.05 4.64
109 INT87268 Positive_regulation of BMP8B 5 0.19 0.53 4.6
110 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
111 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49
112 INT198736 Binding of Sp3 23 0.40 4.77 4.42
113 INT4097 Localization of Pth 66 0.81 47.17 4.36
114 INT148901 Binding of Sort1 2 0.39 3.65 4.32
115 INT134968 Localization of Ecm1 20 0.32 27.27 4.31
116 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
117 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
118 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
119 INT113485 Localization of MMP14 11 0.77 3.44 4.19
120 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
121 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
122 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
123 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
124 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15
125 INT99608 Transcription of MMP9 18 0.65 9.67 4.11
126 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
127 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
128 INT97128 Localization of SPP1 32 0.80 21.75 4.02
129 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
130 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87
131 INT133312 Binding of MMP9 25 0.42 16.79 3.83
132 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
133 INT175555 Gene_expression of CASR 17 0.78 14.83 3.73
134 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
135 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68
136 INT20936 Binding of MGP 13 0.40 3.55 3.59
137 INT87269 Localization of BMP8B 1 0.07 0.24 3.58
138 INT57439 Regulation of MMP8 6 0.62 2.2 3.54
139 INT346244 Positive_regulation of RUNX2 1 0.63 7.42 3.54
140 INT132187 Gene_expression of Ecm1 14 0.21 8.12 3.52
141 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
142 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47
143 INT15827 Regulation of Fn1 8 0.54 4.67 3.47
144 INT148899 Regulation of Sort1 2 0.50 2.72 3.46
145 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
146 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
147 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
148 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43
149 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
150 INT171233 Binding of Ecm1 25 0.07 12.41 3.36
151 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
152 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
153 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33
154 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
155 INT307634 Binding of BMP1 1 0.36 3.12 3.26
156 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
157 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
158 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
159 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
160 INT123409 Binding of Sp1 20 0.39 3.18 3.15
161 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
162 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
163 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09
164 INT74506 Localization of Casr 16 0.76 1.95 3.06
165 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
166 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
167 INT105884 Binding of Bcl2 19 0.35 15.67 3
168 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
169 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
170 INT103607 Binding of Sp1 7 0.42 1.26 2.92
171 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
172 INT116540 Binding of Twist1 35 0.48 16.32 2.85
173 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
174 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
175 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83
176 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
177 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76
178 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73
179 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
180 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
181 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
182 INT89336 Binding of SP3 6 0.47 1.75 2.63
183 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
184 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
185 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
186 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
187 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
188 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
189 INT140525 Regulation of Gene_expression of Ptn 4 0.62 2.59 2.49
190 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
191 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46
192 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
193 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
194 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39
195 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
196 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
197 INT134964 Regulation of Ecm1 13 0.10 7.45 2.37
198 INT160080 Localization of Ecm1 6 0.15 4.86 2.36
199 INT121379 Positive_regulation of Casr 13 0.66 2.92 2.34
200 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
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