GO:0001533

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Name cornified envelope
Categary Component
Go Slim No
Go Link GO:0001533
Unique Molecular Interactions 75
Total Molecular Interactions 109
Total Single Events 535
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cornified envelope. They are ordered first by their pain relevance and then by number of times they were reported for cornified envelope. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
2 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
3 INT1654 Pomc Regulation of DSP 1 0.03 0 0.94
4 INT255321 Binding of 2E and Sprr1a 1 0.02 0 0.81
5 INT255328 Binding of Nav1 and Sprr1a 1 0.01 0 0.81
6 INT33059 Dsp Negative_regulation of Localization of LH 1 0.18 0 0.8
7 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72
8 INT346225 Binding of PRTN3 and Flg 1 0.01 1.74 0.69
9 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56
10 INT62898 Binding of Oprl1 and Dsp 1 0.35 0 0.52
11 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
12 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
13 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
14 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
15 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37
16 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36
17 INT297427 Flg Positive_regulation of Gene_expression of Il13 1 0.11 1.2 0.3
18 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
19 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
20 INT36670 Dsp Regulation of Localization of LH 1 0.12 0 0.26
21 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
22 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22
23 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
24 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2
25 INT121632 PTGER1 Positive_regulation of TGM1 1 0.00 0.67 0.19
26 INT121631 PDGFD Positive_regulation of TGM1 1 0.01 0.68 0.18
27 INT289630 Binding of CDSN and RS1 1 0.02 1.1 0.17
28 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
29 INT296233 Binding of Anxa1 and Trpa1 1 0.03 0.78 0.14
30 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13
31 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13
32 INT291622 HSD11B1 Regulation of CSTA 1 0.00 0.6 0.11
33 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
34 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
35 INT311738 Binding of Anxa1 and Plat 1 0.19 0.63 0.1
36 INT291624 SERPINH1 Regulation of CSTA 1 0.00 0.39 0.09
37 INT196337 Binding of CDSN and HBM 1 0.00 0.79 0.08
38 INT301324 Binding of CYSLTR1 and Lor 1 0.28 0 0.06
39 INT296236 Anxa1 Positive_regulation of Trpm8 1 0.04 0.09 0.05
40 INT332484 ANXA1 Positive_regulation of HSH2D 1 0.18 0.19 0.05
41 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
42 INT234990 Binding of Cish and Dsp 1 0.01 0.24 0.04
43 INT234986 Binding of Rdh2 and Dsp 1 0.00 0.24 0.04
44 INT296232 Anxa1 Regulation of Trpm8 1 0.03 0.54 0.04
45 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04
46 INT235012 Binding of NKS1 and Dsp 1 0.00 0.24 0.04
47 INT222532 Anxa1 Negative_regulation of Localization of Gh1 1 0.01 0.14 0.03
48 INT222538 Anxa1 Negative_regulation of Localization of Prl 1 0.04 0.14 0.03
49 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03
50 INT222475 Anxa1 Negative_regulation of Localization of LH 1 0.01 0.14 0.03
51 INT192044 Binding of DSP and Jup 2 0.24 2.39 0
52 INT235004 Binding of PKP1 and Dsp 1 0.00 0.14 0
53 INT309955 Binding of Pkp2 and Dsp 1 0.12 0.1 0
54 INT234969 Jup Regulation of Gene_expression of Dsp 1 0.01 0.54 0
55 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0
56 INT309956 Binding of Dsc1 and Dsp 1 0.01 0.1 0
57 INT309976 Binding of Pygm and Dsp 1 0.00 0.1 0
58 INT235019 Binding of DSC1 and DSP 1 0.39 0.07 0
59 INT332487 ANXA1 Regulation of Gene_expression of SGPP2 1 0.45 0.08 0
60 INT235018 Binding of DSP and GOPC 1 0.02 0.19 0
61 INT234987 Binding of Jup and Dsp 1 0.01 0.18 0
62 INT309957 Binding of Dsg1b and Dsp 1 0.01 0.1 0
63 INT235015 Binding of DSP and Dsp 1 0.02 0.25 0
64 INT192048 Binding of DSP and Ryr2 1 0.24 1.1 0
65 INT234974 Binding of Lat and Dsp 1 0.00 0 0
66 INT234993 Binding of Car2 and Dsp 1 0.00 0 0
67 INT291623 Binding of CRP and CSTA 1 0.03 0.38 0
68 INT349355 CSF2 Negative_regulation of CSTA 1 0.01 1.43 0
69 INT196338 Binding of CDSN and HRASLS 1 0.00 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cornified envelope. They are ordered first by their pain relevance and then by number of times they were reported in cornified envelope. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
2 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
3 INT62547 Positive_regulation of Gene_expression of Anxa1 5 0.42 4.52 3.27
4 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
5 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
6 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93
7 INT38872 Negative_regulation of Dsp 10 0.42 3.51 2.73
8 INT33057 Binding of Dsp 9 0.36 4.05 2.66
9 INT165726 Positive_regulation of Anxa1 7 0.29 3.16 2.57
10 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
11 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
12 INT31395 Negative_regulation of Lor 7 0.51 1.04 1.57
13 INT25771 Regulation of DSP 8 0.10 3.67 1.55
14 INT42152 Gene_expression of Dsp 7 0.66 4.13 1.52
15 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
16 INT2620 Regulation of TGM1 1 0.01 3.27 1.5
17 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41
18 INT29955 Regulation of Dsp 3 0.54 0.61 1.26
19 INT70088 Binding of TGM1 9 0.41 5.3 1.22
20 INT112498 Gene_expression of TGM1 18 0.55 10.76 1.21
21 INT9205 Binding of DSP 12 0.44 9.9 1.21
22 INT214235 Binding of CDSN 3 0.34 3.5 1.15
23 INT116406 Negative_regulation of CDSN 2 0.02 0.23 1.08
24 INT101889 Negative_regulation of DSP 3 0.42 1.61 1.05
25 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
26 INT115481 Gene_expression of CDSN 6 0.10 2.53 1.03
27 INT228871 Negative_regulation of Gene_expression of Anxa1 2 0.03 1.92 1.01
28 INT122151 Localization of Anxa1 1 0.75 0.53 1
29 INT29956 Positive_regulation of Dsp 5 0.41 1.81 0.98
30 INT63037 Regulation of CSTA 10 0.37 13.37 0.92
31 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81
32 INT80498 Gene_expression of DSP 15 0.75 7.06 0.79
33 INT157776 Localization of TGM1 2 0.39 2.52 0.74
34 INT25961 Positive_regulation of Positive_regulation of DSP 1 0.04 0.28 0.63
35 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57
36 INT166836 Negative_regulation of Positive_regulation of ANXA1 2 0.39 1.15 0.57
37 INT122149 Binding of Anxa1 1 0.36 0.22 0.57
38 INT37750 Localization of ANXA1 2 0.74 1.72 0.56
39 INT297421 Positive_regulation of Flg 1 0.40 1.6 0.53
40 INT37749 Positive_regulation of Localization of ANXA1 1 0.01 0.67 0.53
41 INT31396 Positive_regulation of Lor 3 0.41 0.26 0.52
42 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51
43 INT166837 Binding of ANXA1 2 0.34 0.85 0.51
44 INT206858 Regulation of ANXA1 3 0.56 2.4 0.45
45 INT122150 Positive_regulation of Localization of Anxa1 1 0.47 0.28 0.44
46 INT166839 Negative_regulation of ANXA1 1 0.37 0.88 0.43
47 INT70086 Negative_regulation of Binding of TGM1 1 0.50 1.58 0.4
48 INT234864 Gene_expression of Dsp 30 0.47 17.72 0.37
49 INT106421 Positive_regulation of CDSN 1 0.02 0.31 0.37
50 INT66189 Regulation of CDSN 5 0.03 0.77 0.35
51 INT116727 Gene_expression of Flg 3 0.53 3.13 0.34
52 INT163253 Binding of Flg 3 0.31 3.6 0.32
53 INT117968 Regulation of Anxa1 1 0.39 1.36 0.31
54 INT234865 Binding of Dsp 1 0.02 2.48 0.25
55 INT63036 Negative_regulation of CSTA 4 0.36 9.42 0.22
56 INT120903 Gene_expression of Lor 3 0.52 0.27 0.22
57 INT164835 Positive_regulation of Gene_expression of Lor 1 0.17 0.27 0.22
58 INT234855 Localization of Dsp 1 0.03 1.65 0.22
59 INT70087 Negative_regulation of TGM1 2 0.50 2.62 0.21
60 INT234895 Positive_regulation of Binding of Dsp 1 0.02 0.13 0.15
61 INT287734 Binding of Anxa1 1 0.03 0.18 0.14
62 INT243382 Positive_regulation of CSTA 4 0.05 14.65 0.12
63 INT316526 Localization of Flg 1 0.35 0.85 0.12
64 INT316527 Positive_regulation of Localization of Flg 1 0.22 0.86 0.12
65 INT228409 Localization of DSP 5 0.73 2.39 0.11
66 INT84750 Negative_regulation of Gene_expression of DSP 2 0.42 0.41 0.11
67 INT291629 Localization of CSTA 1 0.08 1.05 0.11
68 INT296223 Regulation of Localization of Anxa1 1 0.03 0.35 0.11
69 INT296227 Localization of Anxa1 1 0.05 0.34 0.11
70 INT291628 Positive_regulation of Gene_expression of CSTA 1 0.05 0.52 0.09
71 INT291630 Regulation of Gene_expression of CSTA 2 0.06 1.01 0.08
72 INT291627 Binding of CSTA 2 0.04 1.58 0.08
73 INT290117 Negative_regulation of Gene_expression of ANXA1 1 0.57 1.15 0.08
74 INT234922 Negative_regulation of Dsp 1 0.02 6.01 0.08
75 INT206862 Regulation of Gene_expression of ANXA1 2 0.18 1.76 0.04
76 INT332510 Protein_catabolism of ANXA1 1 0.60 0.08 0.04
77 INT234884 Negative_regulation of Binding of Dsp 1 0.03 1.49 0.04
78 INT234880 Regulation of Gene_expression of Dsp 1 0.02 4.75 0.03
79 INT296228 Positive_regulation of Positive_regulation of Anxa1 1 0.03 0.34 0.03
80 INT234898 Negative_regulation of Gene_expression of Dsp 1 0.02 3.92 0.03
81 INT226298 Positive_regulation of Gene_expression of TGM1 4 0.24 2.66 0
82 INT214236 Localization of CDSN 3 0.69 0.93 0
83 INT349357 Negative_regulation of Transcription of CSTA 1 0.02 1.26 0
84 INT234859 Negative_regulation of Positive_regulation of Dsp 1 0.02 0.85 0
85 INT234912 Protein_catabolism of Dsp 1 0.05 2.04 0
86 INT349361 Negative_regulation of Gene_expression of CSTA 1 0.02 1.57 0
87 INT289448 Transcription of TGM1 1 0.19 0.1 0
88 INT164754 Localization of Lor 1 0.69 0 0
89 INT116726 Negative_regulation of Gene_expression of Flg 1 0.01 0.45 0
90 INT349362 Transcription of CSTA 1 0.02 1.38 0
91 INT349359 Regulation of Transcription of CSTA 1 0.01 0.15 0
92 INT301391 Protein_catabolism of Anxa1 1 0.01 1.03 0
93 INT214232 Regulation of Gene_expression of CDSN 1 0.02 0.14 0
94 INT234868 Regulation of Dsp 1 0.02 0.83 0
95 INT243393 Negative_regulation of Positive_regulation of CSTA 1 0.02 0.38 0
96 INT126662 Binding of Lor 1 0.29 0 0
97 INT227018 Regulation of Gene_expression of DSP 1 0.14 0.92 0
98 INT234874 Positive_regulation of Dsp 1 0.02 0.79 0
99 INT349360 Positive_regulation of Transcription of CSTA 1 0.02 1.25 0
100 INT234921 Positive_regulation of Localization of Dsp 1 0.02 0 0
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