GO:0001609

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Name G-protein coupled adenosine receptor activity
Categary Function
Go Slim No
Go Link GO:0001609
Unique Molecular Interactions 165
Total Molecular Interactions 195
Total Single Events 2376
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled adenosine receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled adenosine receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
2 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
3 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
4 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
5 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
6 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
7 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
8 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82
9 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82
10 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
11 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
12 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77
13 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
14 INT76498 Binding of Tacr1 and Adora2a 1 0.09 0 0.77
15 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
16 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
17 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
18 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
19 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64
20 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
21 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
22 INT308895 Adp Positive_regulation of P2ry12 1 0.14 0.11 0.55
23 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
24 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
25 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
26 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
27 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
28 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
29 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
30 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
31 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
32 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
33 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39
34 INT254123 Binding of Adora2b and Rai1 1 0.24 0.75 0.35
35 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
36 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35
37 INT115162 Adora2a Regulation of Gene_expression of Jun 1 0.49 0.36 0.34
38 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
39 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
40 INT254122 Adora2a Regulation of Aliq1 1 0.01 0.85 0.3
41 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
42 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
43 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25
44 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
45 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24
46 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
47 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
48 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
49 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
50 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
51 INT242250 Binding of P2ry1 and P2ry12 1 0.01 0.3 0.21
52 INT242244 Binding of P2ry12 and Adp 1 0.00 0.31 0.21
53 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
54 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
55 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2
56 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2
57 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
58 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16
59 INT216711 P2RY1 Negative_regulation of P2RY12 1 0.28 0.09 0.16
60 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
61 INT341815 Binding of ADORA2A and Aia1 1 0.00 1.29 0.15
62 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
63 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
64 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
65 INT224127 Grk5 Positive_regulation of Phosphorylation of Adora3 1 0.06 0 0.13
66 INT224125 Adrbk2 Positive_regulation of Phosphorylation of Adora3 1 0.04 0 0.13
67 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
68 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
69 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
70 INT172234 Binding of GPR87 and P2RY12 1 0.24 0 0.03
71 INT216788 Svs4 Positive_regulation of Gene_expression of P2ry12 1 0.04 0 0.03
72 INT224023 Binding of GOPC and P2RY12 1 0.02 0.69 0
73 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0
74 INT233523 Tlr4 Regulation of P2ry12 1 0.04 0.07 0
75 INT216785 Svs4 Regulation of Positive_regulation of P2ry12 1 0.03 0.05 0
76 INT224028 Binding of P2RY6 and P2RY12 1 0.10 0.7 0
77 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled adenosine receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled adenosine receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
3 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
4 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
5 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
6 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
7 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
8 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63
9 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
10 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
11 INT19155 Binding of Adora1 25 0.47 6.41 10.72
12 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
13 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
14 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
15 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
16 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
17 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
18 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
19 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
20 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
21 INT9167 Binding of Adora1 6 0.40 0.53 6.9
22 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
23 INT148308 Regulation of P2ry12 8 0.44 6.2 6.23
24 INT111384 Gene_expression of Adora3 18 0.75 10.53 5.73
25 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
26 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
27 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
28 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
29 INT150464 Positive_regulation of P2ry12 5 0.67 4.39 4.3
30 INT165182 Gene_expression of P2ry12 4 0.65 4.29 4.08
31 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
32 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
33 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
34 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
35 INT215604 Localization of Adora1 10 0.78 1.47 3.49
36 INT183249 Binding of P2ry12 12 0.47 7.4 3.3
37 INT148306 Transcription of P2ry12 4 0.69 2.45 3.14
38 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
39 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
40 INT111385 Negative_regulation of Adora3 7 0.43 3.91 2.8
41 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
42 INT258590 Gene_expression of ADORA3 8 0.36 0.17 2.67
43 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
44 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
45 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
46 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
47 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43
48 INT183167 Positive_regulation of Gene_expression of Adora2a 4 0.70 2.37 2.31
49 INT354232 Regulation of Gene_expression of P2ry12 1 0.26 2.47 2.19
50 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
51 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
52 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02
53 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
54 INT72785 Positive_regulation of Positive_regulation of Adora2a 2 0.10 1.34 1.96
55 INT194847 Negative_regulation of Positive_regulation of Adora2a 3 0.32 4.52 1.88
56 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
57 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
58 INT52523 Positive_regulation of Adora3 2 0.49 1.39 1.79
59 INT216715 Gene_expression of P2RY12 24 0.72 3.42 1.77
60 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
61 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
62 INT76198 Positive_regulation of ADORA3 3 0.45 1.53 1.7
63 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
64 INT164544 Positive_regulation of Gene_expression of P2ry12 4 0.67 2.41 1.64
65 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
66 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
67 INT76496 Localization of Adora2a 3 0.48 0.3 1.54
68 INT107376 Negative_regulation of P2ry12 12 0.43 4.39 1.5
69 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
70 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
71 INT194849 Negative_regulation of Gene_expression of Adora3 2 0.18 2.08 1.29
72 INT91595 Regulation of Gene_expression of Adora2a 1 0.52 0 1.19
73 INT119124 Positive_regulation of ADORA2A 4 0.35 0.96 1.14
74 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
75 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
76 INT185696 Negative_regulation of P2RY12 8 0.57 4.87 1.12
77 INT258593 Regulation of ADORA3 1 0.21 0 1.12
78 INT216849 Binding of ADORA2A 2 0.05 0 1.11
79 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
80 INT308875 Positive_regulation of P2ry12 1 0.43 0.9 1.02
81 INT119125 Regulation of ADORA2A 2 0.31 0 1.01
82 INT52524 Regulation of Adora3 3 0.44 1.17 0.96
83 INT52090 Transcription of Adora2a 3 0.41 0.33 0.96
84 INT72006 Positive_regulation of Negative_regulation of Adora2a 2 0.40 0.26 0.94
85 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
86 INT77215 Localization of ADORA2A 2 0.77 0 0.91
87 INT252417 Negative_regulation of P2ry12 2 0.37 1.59 0.89
88 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
89 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
90 INT302869 Phosphorylation of Adora2a 1 0.49 0.25 0.78
91 INT302868 Positive_regulation of Phosphorylation of Adora2a 1 0.41 0.25 0.78
92 INT80147 Negative_regulation of Binding of Adora2a 2 0.43 0.15 0.77
93 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
94 INT89663 Localization of Adora2a 1 0.74 0.74 0.75
95 INT194852 Protein_catabolism of Adora2a 1 0.56 0.6 0.75
96 INT148310 Regulation of Regulation of P2ry12 1 0.43 0.09 0.74
97 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
98 INT183250 Negative_regulation of Binding of P2ry12 2 0.16 0.98 0.73
99 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
100 INT148303 Localization of P2ry12 1 0.67 0.09 0.72
101 INT215602 Localization of Adora3 2 0.73 0.63 0.7
102 INT224109 Phosphorylation of Adora2a 1 0.52 0.07 0.69
103 INT354233 Positive_regulation of Regulation of P2ry12 1 0.45 0.33 0.68
104 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
105 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
106 INT216750 Positive_regulation of Gene_expression of ADORA2B 1 0.34 0 0.64
107 INT216761 Positive_regulation of Binding of ADORA2B 1 0.34 0 0.63
108 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
109 INT215637 Regulation of Regulation of Adora2a 1 0.14 0.16 0.61
110 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
111 INT141458 Regulation of Gene_expression of Adora2a 2 0.45 0.67 0.57
112 INT215639 Positive_regulation of Binding of Adora2a 1 0.24 0.24 0.55
113 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
114 INT216713 Positive_regulation of Gene_expression of P2RY12 1 0.65 0.55 0.51
115 INT224106 Regulation of Negative_regulation of Adora2a 1 0.17 0.26 0.51
116 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
117 INT216757 Protein_catabolism of ADORA2B 1 0.67 0 0.5
118 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
119 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
120 INT216753 Regulation of Binding of ADORA2B 1 0.18 0 0.48
121 INT224107 Negative_regulation of Negative_regulation of Adora2a 1 0.28 0.32 0.48
122 INT72143 Regulation of Binding of Adora2a 1 0.17 0 0.45
123 INT216855 Negative_regulation of ADORA2B 1 0.32 0.05 0.43
124 INT224043 Phosphorylation of Adora3 1 0.15 0.2 0.43
125 INT258589 Regulation of Gene_expression of ADORA3 1 0.21 0 0.42
126 INT102385 Regulation of Transcription of Adora2a 1 0.21 0.09 0.4
127 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
128 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
129 INT323020 Positive_regulation of Binding of P2ry12 1 0.06 0.49 0.37
130 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37
131 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
132 INT119123 Regulation of Positive_regulation of ADORA2A 1 0.31 0 0.35
133 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
134 INT216723 Regulation of P2RY12 5 0.42 1.82 0.33
135 INT172280 Binding of P2RY12 3 0.35 0.77 0.33
136 INT216733 Localization of P2RY12 2 0.70 0.32 0.33
137 INT216728 Negative_regulation of Gene_expression of P2RY12 1 0.40 0.11 0.33
138 INT215609 Transcription of Adora3 2 0.62 0.35 0.31
139 INT92881 Transcription of ADORA1 1 0.69 0 0.31
140 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
141 INT221765 Positive_regulation of Gene_expression of Adora2a 2 0.49 0.2 0.27
142 INT327817 Negative_regulation of ADORA2A 1 0.17 1.83 0.27
143 INT224108 Positive_regulation of Localization of Adora2a 1 0.32 0.14 0.27
144 INT224114 Regulation of Localization of Adora2a 1 0.29 0.14 0.27
145 INT216719 Regulation of Gene_expression of P2RY12 1 0.57 0.22 0.26
146 INT93646 Positive_regulation of P2RY12 3 0.65 1.08 0.23
147 INT186700 Localization of Adora1 1 0.23 0 0.23
148 INT224117 Negative_regulation of Positive_regulation of Adora2a 1 0.27 0.11 0.22
149 INT224105 Regulation of Phosphorylation of Adora2a 1 0.17 0 0.21
150 INT216720 Negative_regulation of Binding of P2RY12 1 0.40 0 0.2
151 INT308882 Transcription of P2ry12 1 0.46 0.61 0.19
152 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
153 INT224115 Positive_regulation of Phosphorylation of Adora2a 1 0.32 0 0.16
154 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
155 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
156 INT224103 Negative_regulation of Phosphorylation of Adora2a 1 0.27 0 0.16
157 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
158 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
159 INT224050 Negative_regulation of Phosphorylation of Adora3 1 0.10 0.08 0.11
160 INT224044 Regulation of Regulation of Adora3 1 0.06 0.09 0.11
161 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
162 INT241728 Regulation of Transcription of Adora2a 1 0.42 0.27 0.07
163 INT241734 Regulation of Transcription of Adora3 1 0.39 0.27 0.07
164 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
165 INT241725 Transcription of Adora2a 1 0.67 0.27 0.07
166 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
167 INT215605 Positive_regulation of Localization of Adora3 1 0.49 0 0.05
168 INT216727 Regulation of Positive_regulation of P2RY12 1 0.42 0.16 0.03
169 INT183251 Negative_regulation of Regulation of P2ry12 1 0.16 0 0
170 INT327819 Localization of ADORA2B 1 0.22 0.3 0
171 INT216721 Negative_regulation of Negative_regulation of P2RY12 1 0.40 0.35 0
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