GO:0001626

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Name nociceptin receptor activity
Categary Function
Go Slim No
Go Link GO:0001626
Unique Molecular Interactions 149
Total Molecular Interactions 268
Total Single Events 1989
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nociceptin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for nociceptin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
3 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
4 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
5 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
6 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
7 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
8 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
9 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
10 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
11 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
12 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
13 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
14 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
15 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
16 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
17 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
18 INT31534 Binding of Sst and Oprl1 2 0.16 0.53 1.74
19 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
20 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
21 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
22 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
23 INT6768 Oprl1 Regulation of Localization of Prl 2 0.12 0 1.55
24 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
25 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
26 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
27 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
28 INT76508 Pnoc Regulation of Oprl1 1 0.47 0.25 1.32
29 INT63407 Binding of Oprl1 and Pck1 1 0.40 0 1.29
30 INT24378 Penk Regulation of Oprl1 1 0.10 0 1.29
31 INT73710 Mastl Positive_regulation of Localization of Oprl1 1 0.02 0 1.26
32 INT46021 tp Positive_regulation of Oprl1 1 0.22 0 1.26
33 INT71070 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Cck 1 0.26 0 1.24
34 INT7887 Oprl1 Regulation of Localization of Oxt 2 0.16 0 1.23
35 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
36 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
37 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
38 INT66488 Binding of Oprl1 and Cbm4 1 0.01 0 1.17
39 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16
40 INT1619 Binding of Gad1 and Oprl1 1 0.14 0 1.13
41 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 0.16 0 1.13
42 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
43 INT131314 crz Regulation of Oprl1 1 0.06 0.08 1.08
44 INT25837 Binding of Dbp and Oprl1 1 0.10 0 1.05
45 INT60047 Oprl1 Negative_regulation of Phosphorylation of Syn1 1 0.05 0.17 1.05
46 INT63181 Oprl1 Regulation of Localization of Tacr1 1 0.06 0.09 1.04
47 INT34535 Regulation of Binding of Penk and Oprl1 1 0.05 0 1.02
48 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
49 INT143492 OPRL1 Regulation of PNOC 1 0.05 0 0.99
50 INT122380 Pnoc Positive_regulation of Oprl1 1 0.36 0.55 0.98
51 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97
52 INT138072 Chn1 Positive_regulation of Oprl1 1 0.42 1.02 0.95
53 INT42861 Negative_regulation of Binding of Penk and Oprl1 1 0.45 0 0.94
54 INT72464 Positive_regulation of Binding of OPRL1 and PNOC 1 0.34 0 0.91
55 INT56431 Vta1 Regulation of Regulation of Oprl1 1 0.07 0 0.89
56 INT83417 Binding of OPRL1 and Oprm1 1 0.01 0 0.89
57 INT64106 Oprl1 Positive_regulation of Localization of Gnrh1 1 0.03 0 0.88
58 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
59 INT44589 Negative_regulation of Oprl1 Positive_regulation of Gh1 1 0.22 0.53 0.87
60 INT42765 Binding of PDYN and Oprl1 1 0.00 0 0.87
61 INT44590 Oprl1 Positive_regulation of Gh1 1 0.23 0.53 0.87
62 INT72467 Regulation of Binding of OPRL1 and PNOC 1 0.18 0 0.86
63 INT91005 Binding of Oprl1 and CCRN4L 1 0.14 0.37 0.85
64 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
65 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8
66 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8
67 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
68 INT81977 Binding of OPRL1 and Galphaqo5 1 0.01 0 0.77
69 INT45521 Oprl1 Positive_regulation of Localization of LH 1 0.24 0 0.77
70 INT81975 Binding of OPRL1 and RASGRP1 1 0.03 0 0.76
71 INT81520 Binding of PNOC and Oprl1 1 0.24 0.1 0.75
72 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73
73 INT133938 Binding of OPRL1 and ARFGEF1 1 0.00 0 0.73
74 INT133939 Binding of OPRL1 and PDYN 1 0.00 0 0.73
75 INT133943 Binding of DNM2 and OPRL1 1 0.00 0 0.73
76 INT76069 Binding of Oprl1 and Oprm1 1 0.07 0 0.73
77 INT57094 Oprl1 Positive_regulation of Negative_regulation of Rtcd1 1 0.01 0.1 0.71
78 INT43409 Regulation of Binding of Oprl1 and P9Ehs1 1 0.01 0 0.71
79 INT43408 Binding of Oprl1 and P9Ehs1 1 0.01 0 0.71
80 INT111506 Negative_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71
81 INT111505 Positive_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71
82 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
83 INT104102 Negative_regulation of Adrbk2 Negative_regulation of Oprl1 1 0.06 0 0.7
84 INT783 Prss12 Positive_regulation of Positive_regulation of Oprl1 1 0.05 0 0.7
85 INT117677 Binding of MATN3 and OPRL1 1 0.26 0.07 0.68
86 INT40180 Regulation of Binding of Oprl1 and Scn7a 1 0.02 0 0.67
87 INT40179 Binding of Oprl1 and Scn7a 1 0.03 0 0.67
88 INT90987 Positive_regulation of Oprl1 Positive_regulation of Binding of Oprl1 1 0.00 0 0.66
89 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66
90 INT111014 Binding of OPRL1 and Oprd1 1 0.02 0 0.64
91 INT86171 Oprl1 Positive_regulation of Gene_expression of Il2 1 0.30 0 0.64
92 INT69226 Regulation of Pnoc Positive_regulation of Oprl1 1 0.19 0 0.63
93 INT73402 Binding of Oprl1 and Wdyhv1 1 0.00 0 0.61
94 INT73403 Binding of Pdyn and Oprl1 1 0.01 0 0.61
95 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
96 INT109803 Binding of Avp and Oprl1 1 0.07 0.1 0.59
97 INT5990 Positive_regulation of Oprl1 Positive_regulation of Localization of Prl 1 0.17 0 0.59
98 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59
99 INT40321 Oprl1 Regulation of Localization of LH 1 0.18 0 0.59
100 INT30483 Binding of Oprl1 and Acyp2-ps1 1 0.02 0 0.58
101 INT123465 Oprl1 Positive_regulation of ATP5G3 1 0.22 0 0.57
102 INT119281 Pnoc Regulation of Oprl1 1 0.31 0.29 0.56
103 INT3433 Vip Positive_regulation of Positive_regulation of Oprl1 1 0.26 0 0.53
104 INT85559 Binding of Pnoc and Oprl1 1 0.39 0 0.53
105 INT33349 Binding of IFNA1 and Oprl1 1 0.09 0.08 0.52
106 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
107 INT40186 Binding of Oprl1 and Srms 1 0.01 0 0.52
108 INT62898 Binding of Oprl1 and Dsp 1 0.35 0 0.52
109 INT22273 Nts Regulation of Oprl1 1 0.09 0 0.51
110 INT12754 Binding of Oprl1 and U 1 0.00 0.08 0.51
111 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
112 INT12755 Binding of Oprl1 and ERVK-5 1 0.00 0.08 0.51
113 INT57391 Binding of Tspo and Oprl1 1 0.18 0.16 0.49
114 INT81036 Binding of Oprl1 and Rbm39 1 0.02 0.13 0.47
115 INT81035 Binding of Oprl1 and Pomc 1 0.03 0.13 0.47
116 INT63279 Binding of Oprl1 and Gpm6a 1 0.01 0 0.47
117 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45
118 INT60022 Oprl1 Positive_regulation of Localization of Rhd 1 0.18 0.1 0.44
119 INT83567 Matk Negative_regulation of Oprl1 1 0.00 0 0.42
120 INT93558 Binding of Oprl1 and Btd 1 0.00 0 0.37
121 INT114468 Pdyn Regulation of Oprl1 1 0.21 0.14 0.37
122 INT72465 PNOC Positive_regulation of OPRL1 1 0.30 0 0.36
123 INT30524 Crh Regulation of Oprl1 1 0.15 0.15 0.33
124 INT30525 Acyp2-ps1 Regulation of Oprl1 1 0.04 0.15 0.33
125 INT30523 Pomc Regulation of Oprl1 1 0.06 0.15 0.33
126 INT50069 Binding of Oprl1 and Oprd1 1 0.02 0 0.32
127 INT106397 Positive_regulation of OPRL1 Positive_regulation of ADRBK1 1 0.46 0.09 0.31
128 INT101562 Binding of TNPO1 and Oprl1 1 0.00 0.12 0.3
129 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
130 INT65362 Negative_regulation of Binding of Oprl1 and Ceacam1 1 0.00 0 0.28
131 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
132 INT65363 Binding of Oprl1 and Ceacam1 1 0.00 0 0.28
133 INT65523 Binding of Adarb1 and Oprl1 1 0.02 0 0.28
134 INT29140 POMC Regulation of Oprl1 1 0.00 0 0.27
135 INT65507 Oprl1 Positive_regulation of Gene_expression of Pomc 1 0.28 0 0.26
136 INT84607 Oprl1 Regulation of Adrb3 1 0.19 0.25 0.24
137 INT67992 Binding of Prl and Oprl1 1 0.33 0.16 0.24
138 INT16811 Binding of Scd1 and Oprl1 1 0.00 0 0.24
139 INT100514 Binding of Oprl1 and Tbpl1 1 0.02 0 0.22
140 INT144589 Binding of YY1 and Oprl1 1 0.04 0.73 0.13
141 INT108598 Positive_regulation of Oprl1 Positive_regulation of Phosphorylation of P2ry2 1 0.10 0 0.13
142 INT34497 Binding of Oprl1 and Ache 1 0.40 0 0.1
143 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07
144 INT92272 Binding of OPRL1 and GNPTAB 1 0.02 0 0.07
145 INT146722 Cnp Positive_regulation of Positive_regulation of Oprl1 1 0.17 0.34 0.07
146 INT90319 Binding of Slc6a3 and Positive_regulation of Regulation of Oprl1 1 0.14 0 0
147 INT74217 Oprl1 Negative_regulation of Positive_regulation of Icam1 1 0.18 0.11 0
148 INT146022 Oprl1 Positive_regulation of Negative_regulation of Il2 1 0.16 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nociceptin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in nociceptin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
2 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
3 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
4 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
5 INT114 Binding of Oprl1 139 0.48 23 103.35
6 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
7 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
8 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
9 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
10 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
11 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52
12 INT6765 Localization of Oprl1 49 0.81 5.11 28.87
13 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
14 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62
15 INT32910 Positive_regulation of Gene_expression of Oprl1 22 0.70 7.07 19.03
16 INT40811 Binding of OPRL1 26 0.48 2.76 18.68
17 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57
18 INT1612 Regulation of Binding of Oprl1 19 0.62 2.34 12.45
19 INT72804 Negative_regulation of OPRL1 16 0.43 1.79 12.14
20 INT18573 Regulation of Positive_regulation of Oprl1 11 0.45 0.78 9.91
21 INT1617 Positive_regulation of Binding of Oprl1 10 0.59 0.63 9.79
22 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72
23 INT3431 Negative_regulation of Positive_regulation of Oprl1 14 0.46 2.55 9.65
24 INT1321 Localization of Oprl1 18 0.76 1.74 9.56
25 INT21223 Positive_regulation of Gene_expression of Oprl1 10 0.70 2.21 9.24
26 INT12734 Regulation of Binding of Oprl1 10 0.62 2.23 7.71
27 INT78432 Negative_regulation of Gene_expression of Oprl1 6 0.58 3.27 7.24
28 INT94855 Regulation of Gene_expression of Oprl1 9 0.62 1.82 6.66
29 INT1597 Negative_regulation of Binding of Oprl1 11 0.59 1.38 6.62
30 INT29051 Regulation of OPRL1 6 0.60 1.29 5.81
31 INT92280 Transcription of OPRL1 10 0.70 1.36 5.68
32 INT67214 Transcription of Oprl1 9 0.69 1.8 5.66
33 INT6764 Regulation of Regulation of Oprl1 5 0.45 0.58 5.28
34 INT40800 Regulation of Gene_expression of Oprl1 8 0.61 1.82 4.73
35 INT42852 Positive_regulation of Transcription of Oprl1 5 0.50 1.06 3.96
36 INT28326 Positive_regulation of Negative_regulation of Oprl1 6 0.44 2.01 3.78
37 INT1508 Positive_regulation of Binding of Oprl1 6 0.62 1.38 3.54
38 INT14558 Regulation of Positive_regulation of Oprl1 6 0.43 2.49 3.5
39 INT72472 Positive_regulation of Gene_expression of OPRL1 4 0.68 0.07 3.39
40 INT46986 Negative_regulation of Negative_regulation of Oprl1 5 0.43 0.13 3.37
41 INT106401 Negative_regulation of Gene_expression of OPRL1 3 0.40 0.07 2.92
42 INT12117 Regulation of Negative_regulation of Oprl1 6 0.44 1.49 2.82
43 INT45375 Protein_catabolism of Oprl1 2 0.85 0.56 2.71
44 INT33996 Positive_regulation of Negative_regulation of Oprl1 4 0.53 1.34 2.68
45 INT90905 Phosphorylation of Oprl1 3 0.50 0.19 2.47
46 INT114848 Regulation of Transcription of Oprl1 3 0.62 1.79 2.44
47 INT121601 Positive_regulation of Localization of Oprl1 1 0.70 1.58 2.22
48 INT85739 Negative_regulation of Regulation of Oprl1 2 0.36 0.46 1.98
49 INT105704 Positive_regulation of Regulation of Oprl1 2 0.46 1.23 1.95
50 INT6763 Regulation of Localization of Oprl1 4 0.44 0.25 1.86
51 INT37145 Regulation of Negative_regulation of Oprl1 3 0.23 0.19 1.83
52 INT76994 Negative_regulation of Gene_expression of Oprl1 3 0.59 0.75 1.73
53 INT114847 Negative_regulation of Transcription of Oprl1 4 0.43 0.75 1.69
54 INT99450 Regulation of Gene_expression of OPRL1 1 0.40 0.43 1.55
55 INT1318 Positive_regulation of Positive_regulation of Oprl1 3 0.64 0.33 1.52
56 INT54752 Negative_regulation of Negative_regulation of Oprl1 2 0.41 0.25 1.39
57 INT95830 Phosphorylation of Oprl1 1 0.02 0 1.27
58 INT106409 Localization of OPRL1 2 0.73 0.27 1.26
59 INT32562 Negative_regulation of Localization of Oprl1 2 0.49 0.43 1.23
60 INT106405 Positive_regulation of Positive_regulation of OPRL1 2 0.49 0.31 1.07
61 INT52886 Regulation of Regulation of Oprl1 1 0.41 0.61 0.85
62 INT110504 Negative_regulation of Negative_regulation of OPRL1 1 0.37 0.22 0.76
63 INT90146 Negative_regulation of Binding of OPRL1 1 0.58 0.07 0.74
64 INT160754 Negative_regulation of Transcription of OPRL1 1 0.43 0.13 0.73
65 INT40229 Regulation of Localization of Oprl1 1 0.13 0 0.64
66 INT40810 Positive_regulation of Binding of OPRL1 1 0.47 0 0.52
67 INT1320 Positive_regulation of Localization of Oprl1 1 0.20 0 0.51
68 INT33368 Positive_regulation of Regulation of Oprl1 1 0.50 0 0.27
69 INT74608 Negative_regulation of Positive_regulation of OPRL1 1 0.35 0.26 0.19
70 INT67771 Regulation of Positive_regulation of OPRL1 1 0.03 0.09 0.18
71 INT92279 Regulation of Transcription of OPRL1 1 0.44 0 0.17
72 INT92277 Positive_regulation of Transcription of OPRL1 1 0.49 0 0.07
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