GO:0001664

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Name G-protein coupled receptor binding
Categary Function
Go Slim No
Go Link GO:0001664
Unique Molecular Interactions 1680
Total Molecular Interactions 2598
Total Single Events 23557
Pain Genes Associated 58

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
4 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
5 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
6 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
7 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
8 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
9 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
10 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
11 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
12 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
13 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
14 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
15 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
16 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
17 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
18 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
19 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
20 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
21 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
22 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
23 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
24 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
25 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
26 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
27 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
28 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
29 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
30 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
31 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
32 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
33 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
34 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
35 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
36 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
37 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
38 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
39 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
40 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
41 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
42 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
43 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1 0.72 1.54 2.16
44 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
45 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
46 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
47 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
48 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
49 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
50 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
51 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
52 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
53 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
54 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
55 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
56 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
57 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
58 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
59 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
60 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
61 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
62 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
63 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
64 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
65 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
66 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
67 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
68 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
69 INT160304 Npy Regulation of Gene_expression of Fos 3 0.67 1.43 1.68
70 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
71 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
72 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
73 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
74 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
75 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
76 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
77 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
78 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
79 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
80 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
81 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
82 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
83 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
84 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
85 INT127253 Binding of Npb and Npbwr1 2 0.29 0.61 1.55
86 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
87 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
88 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
89 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
90 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
91 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
92 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
93 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
94 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
95 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
96 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
97 INT64628 Binding of Oxt and Gal 2 0.29 0.29 1.49
98 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
99 INT14375 Gal Positive_regulation of Localization of Prl 1 0.77 0 1.48
100 INT165450 Gal Regulation of Ceacam3 1 0.41 0.06 1.47
101 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
102 INT131564 Binding of Npw and Npbwr1 3 0.41 0.35 1.46
103 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
104 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
105 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
106 INT29127 Npy Positive_regulation of LH 1 0.47 0 1.45
107 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
108 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
109 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
110 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
111 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
112 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
113 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
114 INT161188 NMS Regulation of Gene_expression of Rvm 1 0.03 2 1.39
115 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
116 INT73377 Npy Regulation of Adarb1 2 0.03 0.15 1.38
117 INT27123 Binding of Pomc and Cck 2 0.31 0 1.38
118 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
119 INT212662 KCNA1 Regulation of Localization of Cort 1 0.00 1.36 1.37
120 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36
121 INT15277 Binding of Tac1 and Gal 1 0.39 0.19 1.35
122 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
123 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
124 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
125 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32
126 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
127 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
128 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
129 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
130 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
131 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27
132 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
133 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
134 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
135 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
136 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
137 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
138 INT50386 Bdnf Regulation of Npy 1 0.21 0.47 1.24
139 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 0.05 0.12 1.24
140 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
141 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
142 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23
143 INT34473 Pomc Regulation of Slc3a1 1 0.03 0.07 1.23
144 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
145 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
146 INT82754 Cck Positive_regulation of Positive_regulation of Pomc 1 0.39 0.3 1.21
147 INT62368 Gal Positive_regulation of Localization of LH 3 0.36 0 1.2
148 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
149 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
150 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
151 INT34661 Abat Positive_regulation of Localization of Pomc 1 0.04 0 1.18
152 INT146879 CRX Regulation of NMS 2 0.02 1.86 1.17
153 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
154 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
155 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
156 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
157 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
158 INT30359 Pomc Regulation of Localization of Oxt 1 0.03 0 1.13
159 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
160 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
161 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
162 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
163 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
164 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
165 INT85718 pcp Regulation of Npy 1 0.03 0 1.07
166 INT62365 Gal Regulation of Localization of LH 1 0.33 0 1.07
167 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
168 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
169 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
170 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06
171 INT149741 Rf Negative_regulation of Qrfp 1 0.00 0.26 1.06
172 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
173 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
174 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
175 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
176 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
177 INT58807 Pomc Negative_regulation of Localization of LH 2 0.06 0 1.02
178 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
179 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
180 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
181 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
182 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
183 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 0.33 1.07 1.01
184 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
185 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
186 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 0.33 1.07 1
187 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
188 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
189 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
190 INT22109 Positive_regulation of Pomc Positive_regulation of Penk 1 0.35 0 0.99
191 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
192 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
193 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
194 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
195 INT5107 Gal Positive_regulation of Localization of Sstr1 1 0.09 0 0.98
196 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
197 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 0.21 1.07 0.97
198 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
199 INT36186 Npy Positive_regulation of Localization of Gnrh1 4 0.75 0.09 0.96
200 INT116185 Npy Negative_regulation of Positive_regulation of Npy1r 1 0.41 0.32 0.96

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
5 INT738 Regulation of POMC 459 0.62 111.19 243.74
6 INT1308 Localization of Pomc 457 0.81 66.83 217.5
7 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
8 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
9 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
10 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
11 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
12 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
13 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21
14 INT695 Binding of POMC 304 0.48 56.66 126.85
15 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
16 INT1438 Localization of Pomc 360 0.81 101.26 116.47
17 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2
18 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35
19 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
20 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72
21 INT6107 Localization of Npy 180 0.81 26.76 81.67
22 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21
23 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41
24 INT462 Regulation of Pomc 157 0.62 41.67 67.27
25 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
26 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
27 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
28 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
29 INT1463 Binding of Pomc 129 0.48 15.89 56.27
30 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
31 INT5338 Regulation of Npy 92 0.62 25.54 51.24
32 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
33 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75
34 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
35 INT1295 Binding of Pomc 85 0.48 12.92 42.8
36 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27
37 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
38 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
39 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36
40 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
41 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4
42 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
43 INT65698 Localization of CCL2 118 0.81 77.54 32.69
44 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43
45 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
46 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
47 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
48 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35
49 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
50 INT82882 Localization of Ccl2 61 0.80 41.96 28
51 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
52 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
53 INT17925 Transcription of Npy 53 0.72 15.75 25.56
54 INT12424 Binding of Npy 48 0.48 8.23 24.26
55 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13
56 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
57 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
58 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
59 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
60 INT16764 Transcription of Qrfp 39 0.69 6.29 21.61
61 INT8389 Localization of Qrfp 38 0.78 5.11 21.39
62 INT5040 Regulation of Gal 42 0.60 12.72 21.18
63 INT4841 Localization of Npff 26 0.80 4.36 19.91
64 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58
65 INT11243 Localization of NPY 33 0.78 11.18 19.24
66 INT8392 Regulation of Gene_expression of Qrfp 37 0.54 6.9 19.02
67 INT5099 Localization of Gal 46 0.81 10.66 18.93
68 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
69 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
70 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28
71 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
72 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
73 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
74 INT113602 Positive_regulation of Gene_expression of Ccl2 48 0.70 48.71 17.85
75 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58
76 INT7667 Regulation of Gene_expression of Npy 28 0.60 16.65 16.11
77 INT8379 Regulation of Qrfp 26 0.60 2.56 15.82
78 INT149816 Gene_expression of Prok2 21 0.78 18.99 15.68
79 INT1416 Transcription of POMC 40 0.72 10.71 15.38
80 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34
81 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14
82 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
83 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8
84 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59
85 INT14264 Binding of Gal 39 0.47 5.7 14.48
86 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
87 INT8986 Positive_regulation of Gene_expression of Gal 24 0.67 10.96 14.09
88 INT46582 Binding of Npff 20 0.48 1.49 13.99
89 INT24962 Positive_regulation of Qrfp 16 0.50 5.81 13.92
90 INT4842 Regulation of Npff 13 0.54 4.59 13.62
91 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57
92 INT12281 Negative_regulation of Gene_expression of Npy 23 0.59 7.45 13.41
93 INT8086 Negative_regulation of Localization of Npy 24 0.59 3.31 12.76
94 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
95 INT23254 Positive_regulation of Localization of Npy 27 0.65 3.01 11.98
96 INT61706 Regulation of Gene_expression of Gal 17 0.62 10.09 11.96
97 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88
98 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
99 INT14513 Localization of Ghrl 52 0.78 29.26 11.63
100 INT5011 Negative_regulation of Gal 30 0.57 9.88 11.49
101 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26
102 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26
103 INT14034 Positive_regulation of Gene_expression of Qrfp 18 0.29 1.67 11.17
104 INT55217 Binding of Qrfp 10 0.35 3.1 10.94
105 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76
106 INT19155 Binding of Adora1 25 0.47 6.41 10.72
107 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15
108 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
109 INT106200 Binding of Ccl2 22 0.42 16.7 9.75
110 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7
111 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68
112 INT135407 Negative_regulation of Ccl2 33 0.57 32.74 9.45
113 INT140224 Localization of Ccl2 32 0.72 26.91 9.39
114 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3
115 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
116 INT138700 Negative_regulation of Gene_expression of Ccl2 27 0.57 24.1 9.08
117 INT224964 Localization of Ghrl 30 0.59 7.71 8.77
118 INT48761 Transcription of Gal 13 0.69 8.53 8.61
119 INT81597 Transcription of Npff 10 0.69 5.52 8.53
120 INT15189 Localization of Npy 26 0.79 9.09 8.28
121 INT5340 Negative_regulation of Positive_regulation of Npy 12 0.55 3.83 8.23
122 INT5339 Positive_regulation of Positive_regulation of Npy 13 0.68 4.5 8.15
123 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07
124 INT7588 Regulation of NPY 13 0.44 6.97 7.97
125 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
126 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
127 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
128 INT82881 Regulation of Ccl2 19 0.57 15.29 7.19
129 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
130 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
131 INT11839 Protein_catabolism of Pomc 15 0.98 0.77 6.99
132 INT53729 Localization of Cort 14 0.69 6.31 6.97
133 INT9167 Binding of Adora1 6 0.40 0.53 6.9
134 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
135 INT8087 Regulation of Localization of Npy 16 0.45 2.41 6.81
136 INT31226 Localization of PPY 20 0.78 9.93 6.8
137 INT81493 Transcription of CCL2 20 0.65 13.63 6.78
138 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
139 INT131563 Gene_expression of Npw 12 0.78 2.36 6.71
140 INT4840 Positive_regulation of Localization of Npff 7 0.69 0.79 6.69
141 INT27868 Positive_regulation of Positive_regulation of Cort 9 0.59 1.13 6.64
142 INT49002 Positive_regulation of Localization of Qrfp 5 0.61 1.52 6.59
143 INT120895 Binding of CCL2 22 0.37 15.86 6.55
144 INT115391 Gene_expression of Cort 18 0.59 9.43 6.53
145 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
146 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
147 INT92504 Negative_regulation of Ccl2 17 0.43 8.98 6.29
148 INT53773 Positive_regulation of Transcription of Npy 11 0.70 3.75 6.29
149 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
150 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
151 INT16765 Regulation of Transcription of Qrfp 12 0.17 0.88 6.12
152 INT81596 Positive_regulation of Gene_expression of Npff 6 0.69 3.41 6.1
153 INT12316 Negative_regulation of Cort 10 0.38 5.89 6.08
154 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06
155 INT8910 Negative_regulation of Qrfp 10 0.53 2.8 6.02
156 INT32532 Regulation of Positive_regulation of Pomc 11 0.61 3.2 5.93
157 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
158 INT51239 Negative_regulation of Transcription of Npy 9 0.57 2.85 5.87
159 INT91712 Localization of Prok2 11 0.80 8 5.85
160 INT15190 Regulation of Npy 17 0.61 5.33 5.84
161 INT34742 Gene_expression of Gnat3 44 0.67 6.83 5.65
162 INT83290 Regulation of Gene_expression of Ccl2 8 0.59 9.06 5.56
163 INT6276 Negative_regulation of Positive_regulation of Pomc 12 0.57 3.65 5.49
164 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
165 INT140223 Regulation of Ccl2 15 0.45 13.1 5.41
166 INT226106 Negative_regulation of Ghrl 12 0.40 3.98 5.39
167 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
168 INT22022 Regulation of PPY 8 0.26 5.52 5.02
169 INT117855 Negative_regulation of Ghrl 29 0.57 17.52 5
170 INT161220 Binding of Ccl2 17 0.46 17.63 4.94
171 INT53959 Negative_regulation of Npff 6 0.57 0.55 4.86
172 INT53442 Gene_expression of Npff 12 0.76 0.57 4.75
173 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
174 INT103073 Positive_regulation of Positive_regulation of Ccl2 10 0.50 6.74 4.7
175 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69
176 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
177 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65
178 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
179 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
180 INT7575 Regulation of Transcription of Pomc 8 0.60 1.57 4.59
181 INT10806 Positive_regulation of Transcription of Pomc 13 0.50 1.74 4.58
182 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57
183 INT15312 Negative_regulation of Gene_expression of Gal 8 0.57 2.77 4.55
184 INT24420 Transcription of Pomc 13 0.69 3.32 4.54
185 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
186 INT14714 Negative_regulation of NPY 10 0.58 4.41 4.52
187 INT18371 Regulation of Positive_regulation of Npy 8 0.60 2.49 4.38
188 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
189 INT114189 Positive_regulation of Cort 12 0.69 4.39 4.33
190 INT22337 Negative_regulation of Transcription of Pomc 12 0.59 2.17 4.32
191 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
192 INT212655 Positive_regulation of Gene_expression of Cort 6 0.39 5.57 4.23
193 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
194 INT131562 Gene_expression of Npb 7 0.78 1.19 4.17
195 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15
196 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14
197 INT14499 Regulation of Regulation of Pomc 7 0.61 0.15 4.06
198 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86
199 INT48599 Positive_regulation of Positive_regulation of Gal 4 0.49 2.32 3.86
200 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
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