GO:0001702

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Name gastrulation with mouth forming second
Categary Process
Go Slim No
Go Link GO:0001702
Unique Molecular Interactions 71
Total Molecular Interactions 88
Total Single Events 530
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for gastrulation with mouth forming second. They are ordered first by their pain relevance and then by number of times they were reported for gastrulation with mouth forming second. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
2 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
3 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72
4 INT317586 Binding of SCLY and Ppap2b 1 0.00 0.78 0.72
5 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
6 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
7 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
8 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
9 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
10 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
11 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
12 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
13 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
14 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
15 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
16 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
17 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07
18 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
19 INT281224 Binding of Calm3 and Zbtb17 1 0.00 0.11 0.06
20 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
21 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
22 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
23 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
24 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
25 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03
26 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
27 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
28 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
29 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
30 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
31 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
32 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
33 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
34 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
35 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0
36 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
37 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
38 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
39 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
40 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
41 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
42 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
43 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
44 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
45 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
46 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
47 INT244857 Lbx1 Positive_regulation of Lhx1 1 0.37 0 0
48 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0
49 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
50 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0
51 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
52 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
53 INT327448 Binding of REN and PPAP2B 1 0.01 0.26 0
54 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
55 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
56 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
57 INT189684 RNF2 Regulation of TERT 1 0.02 0.46 0
58 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
59 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
60 INT172981 PAN3 Negative_regulation of SMAD4 1 0.01 0.98 0
61 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for gastrulation with mouth forming second. They are ordered first by their pain relevance and then by number of times they were reported in gastrulation with mouth forming second. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
2 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
3 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
4 INT317583 Positive_regulation of Ppap2b 1 0.09 2.14 2.09
5 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
6 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
7 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
8 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
9 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
10 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
11 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
12 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
13 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
14 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
15 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
16 INT280495 Regulation of PPAP2B 1 0.06 1.64 1
17 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
18 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
19 INT317581 Binding of Ppap2b 1 0.05 0.85 0.76
20 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
21 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
22 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
23 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
24 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
25 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
26 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
27 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
28 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
29 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
30 INT154470 Gene_expression of Ppap2b 2 0.60 1.05 0.53
31 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
32 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
33 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
34 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
35 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
36 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
37 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
38 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
39 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
40 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
41 INT92100 Binding of Smad4 5 0.31 2.23 0.3
42 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
43 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
44 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
45 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
46 INT2486 Negative_regulation of Ppap2b 1 0.19 0 0.26
47 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
48 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
49 INT173655 Binding of LRP5 10 0.39 3.06 0.22
50 INT154471 Positive_regulation of Gene_expression of Ppap2b 1 0.04 0.1 0.19
51 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
52 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
53 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
54 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
55 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
56 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
57 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
58 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
59 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
60 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
61 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
62 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
63 INT254790 Localization of Smad4 2 0.37 0.54 0.06
64 INT281218 Binding of Zbtb17 1 0.01 0.11 0.06
65 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
66 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
67 INT185429 Regulation of Lhx1 1 0.12 1.33 0.04
68 INT242172 Protein_catabolism of LRP5 1 0.64 0.06 0.04
69 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
70 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
71 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
72 INT248540 Positive_regulation of Gata4 2 0.23 0.95 0.03
73 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03
74 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0
75 INT297757 Transcription of Lrp5 2 0.68 0.82 0
76 INT274404 Binding of Gata4 2 0.16 0.89 0
77 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
78 INT334327 Regulation of SMAD4 2 0.35 1.73 0
79 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0
80 INT307613 Phosphorylation of LRP5 1 0.08 0.1 0
81 INT222633 Negative_regulation of Acvr2a 1 0.10 0 0
82 INT268368 Transcription of SMAD4 1 0.54 1.7 0
83 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
84 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
85 INT185426 Binding of Lhx1 1 0.36 1.96 0
86 INT173644 Negative_regulation of Gene_expression of LRP5 1 0.15 0.59 0
87 INT286084 Regulation of Acvr2a 1 0.02 0.32 0
88 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
89 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
90 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
91 INT286081 Regulation of Gene_expression of Acvr2a 1 0.05 0.32 0
92 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
93 INT173000 Negative_regulation of Localization of SMAD4 1 0.22 0.98 0
94 INT173008 Localization of SMAD4 1 0.38 0.97 0
95 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
96 INT342375 Positive_regulation of Binding of Lrp5 1 0.46 0.85 0
97 INT334289 Regulation of Binding of SMAD4 1 0.16 0 0
98 INT302465 Localization of LRP5 1 0.61 0 0
99 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
100 INT334288 Regulation of Negative_regulation of SMAD4 1 0.16 0 0
101 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
102 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
103 INT228250 Positive_regulation of Smad4 1 0.45 1.93 0
104 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
105 INT181811 Localization of Gata4 1 0.54 0.3 0
106 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
107 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
108 INT222620 Binding of Acvr2a 1 0.08 0 0
109 INT286082 Positive_regulation of Gene_expression of Acvr2a 1 0.06 1.25 0
110 INT218281 Binding of Acvr2b 1 0.36 0.07 0
111 INT307611 Positive_regulation of Phosphorylation of LRP5 1 0.05 0.1 0
112 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
113 INT228247 Regulation of Positive_regulation of Smad4 1 0.26 0.97 0
114 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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