GO:0001706

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Name endoderm formation
Categary Process
Go Slim No
Go Link GO:0001706
Unique Molecular Interactions 84
Total Molecular Interactions 125
Total Single Events 645
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endoderm formation. They are ordered first by their pain relevance and then by number of times they were reported for endoderm formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
2 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
3 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
4 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
5 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
6 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
7 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
8 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
9 INT352463 Gse1 Regulation of Gene_expression of Dusp1 1 0.07 0 0.59
10 INT109065 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.00 0 0.58
11 INT144932 DUSP5 Negative_regulation of TRPV1 1 0.00 0 0.48
12 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46
13 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
14 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
15 INT352445 Gse1 Positive_regulation of Gene_expression of Dusp1 1 0.06 0.41 0.34
16 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
17 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
18 INT352458 Dusp1 Regulation of Gene_expression of Tnc 1 0.07 0 0.28
19 INT352443 Gse1 Regulation of Dusp1 1 0.03 0 0.27
20 INT352449 Dusp1 Regulation of Gene_expression of Slc1a3 1 0.05 0 0.27
21 INT352466 Calca Regulation of Gene_expression of Dusp1 1 0.04 0 0.27
22 INT106761 Tlr4 Positive_regulation of Dusp1 1 0.01 0.16 0.21
23 INT310498 Gene_expression of Neurog2 Positive_regulation of Positive_regulation of Eomes 1 0.20 0.42 0.19
24 INT334314 Tlr4 Positive_regulation of Gene_expression of Dusp1 1 0.01 0.37 0.19
25 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
26 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
27 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
28 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1 0.48 1.49 0.11
29 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
30 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1
31 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
32 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
33 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
34 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05
35 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05
36 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04
37 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04
38 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
39 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
40 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
41 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
42 INT145336 Binding of PYGO1 and Positive_regulation of Transcription of DKK1 1 0.07 0 0
43 INT145333 Binding of BCL9 and Positive_regulation of Transcription of DKK1 1 0.41 0 0
44 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
45 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
46 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
47 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
48 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
49 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
50 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
51 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
52 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
53 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
54 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
55 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
56 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0
57 INT244857 Lbx1 Positive_regulation of Lhx1 1 0.37 0 0
58 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
59 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
60 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
61 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
62 INT293981 MYC Negative_regulation of DKK1 1 0.07 0.62 0
63 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
64 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
65 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
66 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
67 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
68 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
69 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0
70 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
71 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
72 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
73 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
74 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
75 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
76 INT221467 Binding of Creb1 and Dusp1 1 0.10 0 0
77 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endoderm formation. They are ordered first by their pain relevance and then by number of times they were reported in endoderm formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
2 INT106757 Gene_expression of Dusp1 9 0.66 10.45 7.26
3 INT106756 Positive_regulation of Gene_expression of Dusp1 7 0.59 7.65 5.24
4 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21
5 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
6 INT106760 Positive_regulation of Dusp1 16 0.59 8.5 3.35
7 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18
8 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
9 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
10 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45
11 INT188255 Gene_expression of DKK1 19 0.60 12.69 2.39
12 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
13 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94
14 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76
15 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
16 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
17 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
18 INT89871 Gene_expression of Gata4 11 0.69 1.05 1.53
19 INT207092 Localization of Dusp1 6 0.70 4.7 1.51
20 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
21 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
22 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
23 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
24 INT109069 Transcription of Gata4 4 0.64 0.52 1.01
25 INT109070 Positive_regulation of Transcription of Gata4 1 0.03 0 1.01
26 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
27 INT42766 Localization of Dusp1 1 0.10 0 0.84
28 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
29 INT188251 Localization of DKK1 6 0.50 3.26 0.77
30 INT242131 Localization of Dkk1 5 0.79 6 0.76
31 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
32 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
33 INT226221 Binding of Dusp1 1 0.04 0.92 0.68
34 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
35 INT89867 Negative_regulation of Gene_expression of Gata4 3 0.38 0.17 0.61
36 INT89868 Negative_regulation of Gata4 1 0.38 0 0.57
37 INT191677 Positive_regulation of Gene_expression of Dusp1 2 0.20 4.93 0.55
38 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
39 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
40 INT144943 Positive_regulation of DUSP5 1 0.00 0 0.47
41 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
42 INT218920 Phosphorylation of Dusp1 5 0.44 1.13 0.41
43 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
44 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
45 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
46 INT106758 Negative_regulation of Positive_regulation of Dusp1 1 0.18 0.3 0.37
47 INT109058 Positive_regulation of Gene_expression of Gata4 2 0.29 0 0.33
48 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
49 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
50 INT111097 Negative_regulation of Dusp1 3 0.58 1.41 0.32
51 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31
52 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
53 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3
54 INT106759 Negative_regulation of Gene_expression of Dusp1 2 0.36 0.59 0.3
55 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28
56 INT19917 Regulation of DKK1 3 0.24 1.61 0.28
57 INT352436 Positive_regulation of Positive_regulation of Dusp1 1 0.17 0.32 0.28
58 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
59 INT218923 Regulation of Dusp1 1 0.07 1.85 0.21
60 INT310483 Positive_regulation of Eomes 2 0.38 0.85 0.19
61 INT310478 Positive_regulation of Transcription of Eomes 1 0.23 0.42 0.19
62 INT310466 Positive_regulation of Positive_regulation of Eomes 1 0.23 0.42 0.19
63 INT170390 Transcription of Eomes 2 0.31 0.51 0.18
64 INT185427 Negative_regulation of Lhx1 4 0.42 3.48 0.17
65 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
66 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
67 INT310567 Negative_regulation of Dusp1 1 0.10 0.07 0.17
68 INT344979 Negative_regulation of Gene_expression of DKK1 1 0.17 0.98 0.17
69 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
70 INT242127 Positive_regulation of Localization of Dkk1 1 0.05 0.35 0.17
71 INT344980 Negative_regulation of Localization of DKK1 1 0.17 0.97 0.16
72 INT334313 Positive_regulation of Phosphorylation of Dusp1 1 0.38 0.33 0.16
73 INT310481 Regulation of Eomes 1 0.28 0.1 0.15
74 INT221451 Negative_regulation of Positive_regulation of Dusp1 2 0.35 1.17 0.14
75 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
76 INT188252 Positive_regulation of DKK1 4 0.41 2.94 0.08
77 INT145370 Transcription of DKK1 3 0.53 1.07 0.05
78 INT341569 Regulation of DUSP5 1 0.09 0.28 0.05
79 INT185429 Regulation of Lhx1 1 0.12 1.33 0.04
80 INT321885 Localization of Dkk1 1 0.56 0.87 0.04
81 INT248540 Positive_regulation of Gata4 2 0.23 0.95 0.03
82 INT170377 Gene_expression of Eomes 2 0.42 0.37 0.03
83 INT336415 Positive_regulation of Gene_expression of Eomes 1 0.38 0.17 0.03
84 INT274404 Binding of Gata4 2 0.16 0.89 0
85 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
86 INT200864 Positive_regulation of Sox17 2 0.50 0.07 0
87 INT336412 Negative_regulation of Gene_expression of Eomes 1 0.23 0.11 0
88 INT269903 Localization of Sox17 1 0.75 0.07 0
89 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
90 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
91 INT185426 Binding of Lhx1 1 0.36 1.96 0
92 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
93 INT269907 Positive_regulation of Localization of Sox17 1 0.50 0.2 0
94 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
95 INT269904 Regulation of Sox17 1 0.45 0 0
96 INT269876 Binding of Sox17 1 0.48 0.72 0
97 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
98 INT165336 Negative_regulation of Negative_regulation of Dkk1 1 0.33 0 0
99 INT269885 Negative_regulation of Sox17 1 0.42 0.32 0
100 INT269891 Positive_regulation of Gene_expression of Sox17 1 0.69 0.4 0
101 INT269878 Negative_regulation of Gene_expression of Sox17 1 0.42 0 0
102 INT269892 Transcription of Sox17 1 0.71 0 0
103 INT181811 Localization of Gata4 1 0.54 0.3 0
104 INT269898 Positive_regulation of Binding of Sox17 1 0.44 0 0
105 INT336413 Negative_regulation of Eomes 1 0.32 0.11 0
106 INT211940 Regulation of Negative_regulation of Dkk1 1 0.36 0.21 0
107 INT284880 Binding of Eomes 1 0.03 0 0
108 INT269869 Gene_expression of Sox17 1 0.77 2.48 0
109 INT269882 Regulation of Gene_expression of Sox17 1 0.61 0.14 0
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