GO:0001708

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Name cell fate specification
Categary Process
Go Slim No
Go Link GO:0001708
Unique Molecular Interactions 276
Total Molecular Interactions 371
Total Single Events 2548
Pain Genes Associated 28

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell fate specification. They are ordered first by their pain relevance and then by number of times they were reported for cell fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
4 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
5 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
6 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
7 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
8 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
9 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
10 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
11 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
12 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
13 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
14 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
15 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
16 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
17 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
18 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
19 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
20 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
21 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3
22 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
23 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
24 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
25 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
26 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
27 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
28 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
29 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
30 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
31 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
32 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
33 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
34 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
35 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
36 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
37 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
38 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
39 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
40 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
41 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
42 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
43 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
44 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
45 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
46 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
47 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
48 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
49 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
50 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
51 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
52 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
53 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
54 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
55 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
56 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
57 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
58 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
59 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
60 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
61 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
62 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
63 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
64 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
65 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
66 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
67 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
68 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
69 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
70 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
71 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
72 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
73 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
74 INT133992 Pou2f1 Regulation of Pou1f1 1 0.02 0 0.04
75 INT133981 Pdx1 Regulation of Pou1f1 1 0.05 0 0.04
76 INT133994 Pou1f1 Regulation of Gene_expression of Npff 1 0.15 0 0.04
77 INT133982 Pou1f1 Regulation of Pdx1 1 0.05 0 0.04
78 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
79 INT133985 Kcnip3 Regulation of Pou1f1 1 0.02 0 0.04
80 INT133993 Meis1 Regulation of Pou1f1 1 0.02 0 0.04
81 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
82 INT133979 Pou1f1 Regulation of Kcnip3 1 0.02 0 0.04
83 INT133999 Pou1f1 Regulation of Pou2f1 1 0.02 0 0.04
84 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
85 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
86 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
87 INT133986 Pou1f1 Regulation of Meis1 1 0.02 0 0.04
88 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
89 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
90 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
91 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
92 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
93 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
94 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
95 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
96 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
97 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
98 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
99 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
100 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
101 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
102 INT295126 Proc Regulation of Transcription of Pou1f1 1 0.00 0.3 0.03
103 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
104 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
105 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
106 INT222536 Ghrl Positive_regulation of Transcription of Pou1f1 1 0.03 0.13 0
107 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0
108 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
109 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
110 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
111 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
112 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
113 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
114 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
115 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
116 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
117 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
118 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
119 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
120 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
121 INT327873 Postn Regulation of Notch1 1 0.41 0 0
122 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
123 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
124 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
125 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
126 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
127 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
128 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
129 INT356083 Binding of App and Notch1 1 0.02 0.2 0
130 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
131 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
132 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
133 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
134 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
135 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
136 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
137 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
138 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
139 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
140 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
141 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
142 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
143 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
144 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
145 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
146 INT222574 Crem Positive_regulation of Pou1f1 1 0.00 0.57 0
147 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
148 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
149 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
150 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0
151 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
152 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
153 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
154 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
155 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
156 INT295124 Binding of Pou1f1 and Grxcr1 1 0.04 0.28 0
157 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
158 INT295123 Binding of Pou1f1 and Slc20a2 1 0.37 0 0
159 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
160 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
161 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
162 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
163 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
164 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
165 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
166 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
167 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
168 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
169 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
170 INT295119 Negative_regulation of Binding of Pou1f1 and Slc20a2 1 0.42 0 0
171 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
172 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
173 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
174 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
175 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
176 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
177 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
178 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
179 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
180 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
181 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
182 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
183 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
184 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
185 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
186 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
187 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
188 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
189 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
190 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
191 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
192 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
193 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
194 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
195 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
196 INT269927 Foxa2 Regulation of Gene_expression of Scgb1a1 1 0.26 0 0
197 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell fate specification. They are ordered first by their pain relevance and then by number of times they were reported in cell fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
3 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
4 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
5 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
6 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
7 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
8 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
9 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
10 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
11 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
12 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
13 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
14 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
15 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
16 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
17 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
18 INT163544 Binding of Psen1 40 0.36 15.28 2.42
19 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
20 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
21 INT60723 Localization of Psen2 5 0.68 2.11 2.02
22 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
23 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
24 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
25 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
26 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
27 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
28 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
29 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
30 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
31 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
32 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
33 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
34 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
35 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
36 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
37 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
38 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
39 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
40 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
41 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
42 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
43 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
44 INT110780 Localization of Notch1 2 0.06 0.47 1.19
45 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
46 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
47 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
48 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
49 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
50 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
51 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
52 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
53 INT6833 Binding of Notch1 4 0.36 0.05 0.94
54 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
55 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
56 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
57 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
58 INT250509 Gene_expression of Pou1f1 65 0.76 11.8 0.84
59 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
60 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
61 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
62 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
63 INT188286 Gene_expression of Pou1f1 3 0.19 0.64 0.79
64 INT270447 Binding of Smo 2 0.07 2.61 0.78
65 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
66 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
67 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
68 INT78649 Binding of Psen2 7 0.36 5.9 0.73
69 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
70 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
71 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
72 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
73 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
74 INT113042 Localization of IHH 1 0.70 0.77 0.61
75 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
76 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
77 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
78 INT133974 Binding of Pou1f1 3 0.37 0.52 0.59
79 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
80 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
81 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
82 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
83 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
84 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
85 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
86 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
87 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
88 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
89 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
90 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
91 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
92 INT206484 Localization of Shh 2 0.75 1.14 0.46
93 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
94 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
95 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
96 INT216457 Negative_regulation of Pou1f1 16 0.57 2.69 0.44
97 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
98 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
99 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
100 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
101 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
102 INT193856 Localization of Psen1 19 0.73 9.79 0.41
103 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
104 INT65606 Binding of TBX1 2 0.30 3.13 0.41
105 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
106 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
107 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
108 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
109 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
110 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
111 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
112 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
113 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
114 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
115 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
116 INT356400 Transcription of Smo 1 0.02 0.05 0.3
117 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
118 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
119 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
120 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
121 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
122 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
123 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
124 INT250514 Regulation of Gene_expression of Pou1f1 2 0.60 0.85 0.26
125 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
126 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
127 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
128 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
129 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
130 INT306427 Localization of TBX1 1 0.20 1.08 0.23
131 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
132 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
133 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
134 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
135 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
136 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
137 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
138 INT225973 Binding of Itgb1 2 0.08 1.1 0.2
139 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
140 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
141 INT149888 Localization of Ihh 1 0.75 0.77 0.2
142 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
143 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19
144 INT193945 Binding of Notch1 7 0.15 1.28 0.19
145 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
146 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
147 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
148 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
149 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
150 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
151 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
152 INT278241 Regulation of IHH 2 0.31 1.16 0.14
153 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
154 INT253190 Localization of Shh 2 0.77 1.06 0.13
155 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
156 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
157 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
158 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
159 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
160 INT222042 Localization of ITGB1 3 0.29 0.72 0.12
161 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
162 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
163 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
164 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
165 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
166 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
167 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
168 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
169 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
170 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
171 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
172 INT270442 Transcription of Shh 1 0.53 0.25 0.09
173 INT213515 Binding of Shh 8 0.37 1.92 0.08
174 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
175 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
176 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
177 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08
178 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
179 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
180 INT270453 Regulation of Shh 1 0.27 0.83 0.08
181 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
182 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
183 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
184 INT205973 Binding of SHH 3 0.35 1.03 0.07
185 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
186 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
187 INT256862 Regulation of Shh 1 0.25 0 0.07
188 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
189 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
190 INT345344 Regulation of SMO 1 0.23 1.07 0.06
191 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
192 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
193 INT193845 Localization of Notch1 2 0.78 0.32 0.05
194 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
195 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
196 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
197 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05
198 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
199 INT262772 Binding of SMO 1 0.27 0.59 0.05
200 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
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