GO:0001756

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Name somitogenesis
Categary Process
Go Slim No
Go Link GO:0001756
Unique Molecular Interactions 453
Total Molecular Interactions 585
Total Single Events 4220
Pain Genes Associated 41

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for somitogenesis. They are ordered first by their pain relevance and then by number of times they were reported for somitogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
4 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
5 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
6 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
7 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89
8 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
9 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
10 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
11 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
12 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
13 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
14 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 0.05 0 0.74
15 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74
16 INT98771 Binding of Dll1 and Oprm1 1 0.29 0 0.74
17 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74
18 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
19 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
20 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
21 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
22 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
23 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
24 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
25 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
26 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
27 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
28 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
29 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
30 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
31 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
32 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
33 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
34 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
35 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
36 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
37 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
38 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
39 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
40 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
41 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
42 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
43 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
44 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
45 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
46 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
47 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
48 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
49 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
50 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
51 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
52 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
53 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
54 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
55 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
56 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
57 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
58 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
59 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
60 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
61 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
62 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
63 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
64 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
65 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
66 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
67 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
68 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
69 INT287098 Binding of FL and T 1 0.10 0.66 0.23
70 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
71 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
72 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
73 INT163863 Binding of MIB1 and Vim 1 0.02 1.06 0.21
74 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
75 INT163864 Binding of MIB1 and Ema 1 0.04 1.07 0.21
76 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
77 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
78 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
79 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
80 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
81 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
82 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
83 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
84 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
85 INT339336 Binding of NKX3-1 and TAC4 1 0.03 0.08 0.18
86 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
87 INT231836 Pcdh8 Regulation of Positive_regulation of Racgap1 1 0.00 0.58 0.18
88 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
89 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
90 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
91 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
92 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
93 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
94 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
95 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
96 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
97 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
98 INT231838 Pcdh8 Regulation of Cel 1 0.00 0.39 0.15
99 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
100 INT231846 Pcdh8 Negative_regulation of Positive_regulation of Cel 1 0.00 0.91 0.14
101 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
102 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
103 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
104 INT214593 Binding of FOXC1 and OAP 1 0.01 0.25 0.13
105 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
106 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
107 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
108 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
109 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
110 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
111 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12
112 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
113 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
114 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
115 INT350736 PRKDC Negative_regulation of CA2 1 0.02 0.16 0.11
116 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
117 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
118 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11
119 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
120 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
121 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
122 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
123 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
124 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
125 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
126 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
127 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
128 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
129 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
130 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
131 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
132 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
133 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
134 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
135 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08
136 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
137 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
138 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
139 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
140 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
141 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
142 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
143 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
144 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
145 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
146 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
147 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
148 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
149 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
150 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
151 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
152 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
153 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
154 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
155 INT249201 PRKDC Regulation of Regulation of CYBB 1 0.01 0.09 0.05
156 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
157 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
158 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
159 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
160 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
161 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
162 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
163 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04
164 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
165 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
166 INT231848 Pcdh8 Positive_regulation of Prkaca 1 0.00 0 0.04
167 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
168 INT231839 Pcdh8 Positive_regulation of Src 1 0.00 0 0.04
169 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
170 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
171 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
172 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
173 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
174 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
175 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
176 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
177 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
178 INT231845 Pcdh8 Positive_regulation of Prkca 1 0.00 0 0.04
179 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
180 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
181 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
182 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
183 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
184 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
185 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
186 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
187 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
188 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
189 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
190 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
191 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
192 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
193 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
194 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
195 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
196 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
197 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
198 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
199 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
200 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for somitogenesis. They are ordered first by their pain relevance and then by number of times they were reported in somitogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
6 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7
7 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25
8 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
9 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
10 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
11 INT56884 Gene_expression of Dll1 9 0.48 1.15 8.98
12 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71
13 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
14 INT55859 Binding of Dll1 6 0.35 0 7.64
15 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
16 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
17 INT58607 Negative_regulation of Dll1 9 0.43 1.89 7.06
18 INT70287 Positive_regulation of Gene_expression of Dll1 6 0.70 3.58 6.55
19 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
20 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
21 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91
22 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
23 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
24 INT60585 Regulation of TP53 59 0.59 54.55 5.21
25 INT204449 Gene_expression of T 17 0.32 9.77 4.77
26 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
27 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
28 INT2213 Regulation of EP300 10 0.54 4.72 4.5
29 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
30 INT71406 Regulation of Dll1 3 0.35 0.79 4.44
31 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
32 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
33 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
34 INT72179 Negative_regulation of Dll1 5 0.33 4.09 3.84
35 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
36 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
37 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
38 INT49190 Regulation of Dll1 3 0.44 0.26 3.24
39 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
40 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
41 INT55148 Binding of Dll1 5 0.48 0.66 2.97
42 INT8103 Binding of TP53 46 0.44 40.2 2.96
43 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
44 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73
45 INT66891 Negative_regulation of Positive_regulation of Dll1 1 0.41 0 2.72
46 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
47 INT67329 Positive_regulation of Positive_regulation of Dll1 2 0.32 0 2.56
48 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
49 INT163544 Binding of Psen1 40 0.36 15.28 2.42
50 INT55952 Transcription of TP53 16 0.61 12.14 2.36
51 INT108148 Positive_regulation of Prkdc 2 0.16 0.49 2.31
52 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
53 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
54 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
55 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
56 INT60723 Localization of Psen2 5 0.68 2.11 2.02
57 INT171514 Binding of EP300 13 0.32 4.32 2.01
58 INT130112 Gene_expression of DLL3 1 0.25 0 2
59 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
60 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
61 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
62 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
63 INT65855 Localization of TP53 18 0.76 17.08 1.89
64 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
65 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
66 INT159099 Negative_regulation of Positive_regulation of Dll1 1 0.25 0.74 1.76
67 INT159100 Regulation of Positive_regulation of Dll1 1 0.26 0.7 1.73
68 INT172622 Localization of EP300 8 0.65 2.56 1.72
69 INT159098 Negative_regulation of Gene_expression of Dll1 1 0.18 0.62 1.65
70 INT52757 Localization of Dll1 1 0.20 0 1.6
71 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
72 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
73 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
74 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
75 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
76 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
77 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
78 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
79 INT118155 Regulation of Positive_regulation of Prkdc 1 0.10 0.49 1.42
80 INT172953 Binding of Trp53 33 0.37 20.76 1.41
81 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
82 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
83 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
84 INT145221 Binding of Tp53 10 0.37 8.59 1.37
85 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
86 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
87 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
88 INT133371 Negative_regulation of Binding of Dll1 1 0.41 0.5 1.22
89 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21
90 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
91 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
92 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
93 INT174156 Localization of Trp53 16 0.72 13.52 1.18
94 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
95 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
96 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
97 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
98 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
99 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
100 INT208427 Regulation of T 3 0.25 3.28 1.08
101 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
102 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03
103 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
104 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
105 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
106 INT167650 Binding of Ep300 1 0.09 0.14 1
107 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
108 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
109 INT203445 Gene_expression of Hes7 3 0.03 2.93 0.96
110 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
111 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
112 INT166935 Gene_expression of Prkdc 10 0.65 3.14 0.9
113 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
114 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
115 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
116 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
117 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
118 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
119 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
120 INT287094 Transcription of T 1 0.29 1.41 0.8
121 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
122 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
123 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
124 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
125 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
126 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
127 INT168189 Positive_regulation of PLXNA2 1 0.20 0.49 0.75
128 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74
129 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
130 INT78649 Binding of Psen2 7 0.36 5.9 0.73
131 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
132 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
133 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7
134 INT139089 Negative_regulation of Gene_expression of Dll1 2 0.43 0 0.69
135 INT28118 Binding of Atm 13 0.38 12.24 0.68
136 INT226411 Binding of T 2 0.15 1.56 0.68
137 INT342318 Localization of PLXNA2 1 0.25 0.75 0.67
138 INT80025 Positive_regulation of MIB1 5 0.40 5.41 0.64
139 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
140 INT39728 Regulation of TCAP 1 0.00 0 0.61
141 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
142 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
143 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
144 INT48212 Binding of ATM 5 0.47 3.89 0.57
145 INT160778 Transcription of ATM 1 0.40 1.03 0.57
146 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
147 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
148 INT181281 Localization of NKX3-1 1 0.12 0.3 0.5
149 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
150 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46
151 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
152 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
153 INT84724 Negative_regulation of Gene_expression of NKX3-1 1 0.41 0.43 0.44
154 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
155 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
156 INT67098 Regulation of MIB1 3 0.24 4.23 0.42
157 INT193856 Localization of Psen1 19 0.73 9.79 0.41
158 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
159 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
160 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
161 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
162 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
163 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
164 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
165 INT130109 Negative_regulation of Gene_expression of DLL3 1 0.14 0 0.38
166 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
167 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
168 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
169 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
170 INT187587 Binding of Ep300 11 0.35 2.37 0.34
171 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
172 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
173 INT130110 Regulation of Gene_expression of DLL3 1 0.20 0 0.33
174 INT207073 Localization of Pax1 2 0.63 0.87 0.32
175 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
176 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
177 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
178 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
179 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
180 INT125524 Positive_regulation of Gene_expression of PRKDC 2 0.09 1 0.29
181 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
182 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
183 INT167438 Localization of ATM 3 0.55 1.61 0.27
184 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
185 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
186 INT180393 Positive_regulation of Gene_expression of Prkdc 3 0.49 1.17 0.26
187 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
188 INT203505 Positive_regulation of Gene_expression of Pcdh8 1 0.12 0.31 0.26
189 INT214611 Positive_regulation of Localization of FOXC1 1 0.07 0.34 0.26
190 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
191 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25
192 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
193 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
194 INT130115 Positive_regulation of DLL3 1 0.07 0 0.25
195 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
196 INT203488 Gene_expression of Pcdh8 1 0.16 0.31 0.25
197 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
198 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
199 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
200 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
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