GO:0001779

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Name natural killer cell differentiation
Categary Process
Go Slim No
Go Link GO:0001779
Unique Molecular Interactions 116
Total Molecular Interactions 172
Total Single Events 578
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for natural killer cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for natural killer cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
3 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
4 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
5 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
6 INT257745 SAGE1 Positive_regulation of AXL 1 0.07 1.96 0.69
7 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
8 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62
9 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
10 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61
11 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
12 INT101087 NTF3 Positive_regulation of Gene_expression of IKZF1 1 0.04 0.3 0.55
13 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
14 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
15 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
16 INT108692 NTF3 Regulation of Gene_expression of IKZF1 1 0.69 0.7 0.49
17 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
18 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
19 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
20 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
21 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
22 INT209231 Tg(Ngf)47Kma Regulation of Tyro3 1 0.03 0 0.41
23 INT316493 Il6 Positive_regulation of Il11ra1 1 0.64 1.69 0.4
24 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4
25 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
26 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39
27 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
28 INT200313 Sp3 Regulation of Oprm1 1 0.10 0.07 0.38
29 INT200301 Sp3 Regulation of Rorb 1 0.00 0.07 0.38
30 INT167551 Binding of MECP2 and SP3 1 0.01 0.06 0.35
31 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33
32 INT253576 Binding of Lpl and Sp3 1 0.22 0.85 0.32
33 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
34 INT257740 SAGE1 Positive_regulation of Gene_expression of AXL 1 0.07 0.72 0.27
35 INT96790 SP3 Positive_regulation of GDF15 1 0.20 0.26 0.27
36 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
37 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22
38 INT253568 Negative_regulation of Binding of Lpl and Sp3 1 0.19 0.37 0.22
39 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
40 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17
41 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
42 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
43 INT200328 Sp3 Positive_regulation of Gene_expression of Oprm1 1 0.38 0 0.13
44 INT335460 FPR1 Positive_regulation of PIK3CD 1 0.17 0 0.13
45 INT223530 Binding of Tcf3 and Szf1 1 0.33 0.92 0.13
46 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
47 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
48 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12
49 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
50 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11
51 INT200320 Binding of Sp3 and Negative_regulation of Gene_expression of Oprm1 1 0.35 0.4 0.1
52 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1
53 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1
54 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1
55 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
56 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1
57 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1
58 INT328435 PIK3CD Positive_regulation of Gene_expression of VEGFA 1 0.23 0.64 0.09
59 INT247781 Binding of MERTK and Cmklr1 1 0.07 0 0.09
60 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
61 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
62 INT283721 Binding of Lpin1 and Id2 1 0.38 0.18 0.08
63 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
64 INT289244 Binding of Il11ra1 and Il6ra 1 0.01 0.33 0.07
65 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
66 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07
67 INT253570 Binding of Csnk2a2 and Sp3 1 0.16 0.2 0.07
68 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06
69 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06
70 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
71 INT328438 PRB4 Negative_regulation of PIK3CD 1 0.06 0.29 0.05
72 INT287221 Tcf3 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
73 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03
74 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03
75 INT328436 PRB4 Negative_regulation of Gene_expression of PIK3CD 1 0.07 0.24 0.03
76 INT328430 PRB4 Regulation of Positive_regulation of PIK3CD 1 0.06 0.4 0.03
77 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
78 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
79 INT253574 Sp3 Positive_regulation of Lpl 1 0.22 0 0.03
80 INT321402 Binding of NPHS1 and PIK3CD 1 0.02 0.73 0.03
81 INT283712 Id2 Regulation of Gene_expression of Fos 1 0.43 0 0.03
82 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
83 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
84 INT322849 Binding of PIK3CD and PDCD10 1 0.16 0 0
85 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0
86 INT328431 PIK3CD Negative_regulation of Gene_expression of VEGFA 1 0.22 0.29 0
87 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
88 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0
89 INT201542 Positive_regulation of RASSF1 Negative_regulation of ID2 1 0.36 1.41 0
90 INT283717 Id2 Regulation of 4930579C15Rik 1 0.15 0.75 0
91 INT328427 PIK3CD Negative_regulation of Phosphorylation of AKT1 1 0.09 0.29 0
92 INT322848 VEGFA Positive_regulation of PIK3CD 1 0.09 0 0
93 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
94 INT283718 Binding of Id2 and Aatf 1 0.03 0.19 0
95 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0
96 INT201536 RASSF1 Regulation of ID2 1 0.41 1.42 0
97 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
98 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0
99 INT201533 RASSF1 Positive_regulation of Gene_expression of ID2 1 0.38 1.41 0
100 INT253567 Binding of Pik3r1 and Sp3 1 0.11 0.06 0
101 INT292139 SP3 Positive_regulation of Transcription of HIVEP1 1 0.02 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for natural killer cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in natural killer cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
2 INT163913 Gene_expression of Il11ra1 18 0.69 12.62 5.34
3 INT198736 Binding of Sp3 23 0.40 4.77 4.42
4 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
5 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
6 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74
7 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
8 INT163911 Negative_regulation of Il11ra1 4 0.39 6.43 2.73
9 INT89336 Binding of SP3 6 0.47 1.75 2.63
10 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
11 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37
12 INT89250 Positive_regulation of Il11ra1 8 0.63 3.99 2.27
13 INT163912 Binding of Il11ra1 5 0.33 5.06 2.22
14 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
15 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11
16 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
17 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
18 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69
19 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59
20 INT101090 Gene_expression of IKZF1 6 0.77 2.98 1.58
21 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
22 INT136459 Gene_expression of Sp3 6 0.64 1.97 1.47
23 INT163915 Positive_regulation of Gene_expression of Il11ra1 2 0.41 1.84 1.37
24 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
25 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
26 INT264969 Localization of PIK3CD 5 0.50 0.64 1.13
27 INT163910 Negative_regulation of Gene_expression of Il11ra1 3 0.39 2.11 1.08
28 INT24266 Negative_regulation of IKZF1 6 0.37 1.55 0.96
29 INT136458 Negative_regulation of Sp3 3 0.39 1.53 0.93
30 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
31 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
32 INT167942 Binding of Stat5b 1 0.26 0 0.82
33 INT101091 Regulation of IKZF1 3 0.09 0.3 0.79
34 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
35 INT184053 Regulation of Il11ra1 3 0.16 2.03 0.68
36 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
37 INT264964 Positive_regulation of Localization of PIK3CD 1 0.13 0.05 0.62
38 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
39 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
40 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
41 INT129615 Positive_regulation of Id2 2 0.66 2.22 0.57
42 INT142972 Gene_expression of ID2 6 0.54 5.92 0.49
43 INT200264 Localization of Sp3 1 0.62 0 0.47
44 INT253558 Negative_regulation of Binding of Sp3 1 0.39 1.09 0.46
45 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45
46 INT337345 Regulation of Gene_expression of PIK3CD 1 0.20 0 0.43
47 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
48 INT98969 Regulation of Binding of SP3 1 0.26 0 0.41
49 INT337344 Negative_regulation of Negative_regulation of PIK3CD 1 0.19 0 0.4
50 INT89333 Negative_regulation of SP3 1 0.38 0.77 0.39
51 INT89335 Negative_regulation of Binding of SP3 1 0.38 0.77 0.39
52 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
53 INT98960 Positive_regulation of Binding of SP3 1 0.67 0 0.37
54 INT179795 Transcription of Il11ra1 1 0.50 0 0.36
55 INT283683 Binding of Id2 5 0.35 0.8 0.35
56 INT200265 Regulation of Sp3 2 0.37 0.25 0.34
57 INT176612 Localization of Il11ra1 2 0.71 0.86 0.33
58 INT176611 Negative_regulation of Localization of Il11ra1 1 0.03 0.89 0.33
59 INT176610 Positive_regulation of Localization of Il11ra1 1 0.03 0.86 0.33
60 INT200276 Positive_regulation of Sp3 1 0.42 0.17 0.28
61 INT209222 Gene_expression of Tyro3 3 0.22 0.47 0.27
62 INT200251 Phosphorylation of Sp3 2 0.67 0.42 0.24
63 INT118478 Transcription of IKZF1 1 0.48 0.52 0.23
64 INT129612 Positive_regulation of Gene_expression of Id2 4 0.67 3.61 0.22
65 INT291969 Negative_regulation of Gene_expression of IKZF1 1 0.13 1.15 0.22
66 INT269045 Positive_regulation of Binding of Il11ra1 1 0.19 0.72 0.22
67 INT136452 Negative_regulation of Negative_regulation of Sp3 1 0.28 0.65 0.2
68 INT167940 Regulation of Stat5b 1 0.43 0 0.19
69 INT161606 Positive_regulation of MERTK 1 0.67 0.9 0.18
70 INT42242 Binding of MERTK 1 0.36 0.77 0.18
71 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
72 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
73 INT136454 Positive_regulation of Gene_expression of Sp3 1 0.33 0.44 0.16
74 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
75 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
76 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15
77 INT316435 Positive_regulation of Positive_regulation of Il11ra1 1 0.46 0.29 0.15
78 INT291973 Binding of IKZF1 1 0.13 0.52 0.14
79 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13
80 INT90229 Transcription of Tcf3 2 0.12 0.39 0.13
81 INT70018 Localization of AXL 2 0.55 0.49 0.13
82 INT200261 Positive_regulation of Transcription of Sp3 1 0.42 0 0.13
83 INT200280 Transcription of Sp3 1 0.57 0 0.13
84 INT283702 Transcription of Id2 1 0.66 0.64 0.13
85 INT347724 Gene_expression of MERTK 1 0.58 0.65 0.12
86 INT283708 Localization of Id2 2 0.71 0.72 0.11
87 INT142970 Positive_regulation of Gene_expression of ID2 2 0.40 2.39 0.11
88 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
89 INT142968 Negative_regulation of Gene_expression of ID2 1 0.19 0.98 0.11
90 INT200268 Positive_regulation of Binding of Sp3 2 0.39 0.8 0.1
91 INT142971 Negative_regulation of Positive_regulation of ID2 1 0.20 0.69 0.09
92 INT142969 Positive_regulation of ID2 1 0.21 0.68 0.09
93 INT253546 Positive_regulation of Phosphorylation of Sp3 1 0.29 0.42 0.09
94 INT316446 Phosphorylation of Il11ra1 1 0.57 0.44 0.09
95 INT211005 Gene_expression of SP3 1 0.03 0.58 0.09
96 INT129614 Positive_regulation of Positive_regulation of Id2 1 0.48 0.31 0.08
97 INT328448 Negative_regulation of Gene_expression of PIK3CD 1 0.21 0.84 0.08
98 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
99 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
100 INT129613 Regulation of Gene_expression of Id2 1 0.43 0.24 0.06
101 INT253554 Regulation of Negative_regulation of Sp3 1 0.30 0 0.05
102 INT295091 Positive_regulation of Gene_expression of Tcf3 2 0.19 0.4 0.04
103 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
104 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
105 INT320732 Binding of PIK3CD 3 0.20 1.66 0
106 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
107 INT217179 Negative_regulation of AXL 2 0.01 1.9 0
108 INT217193 Negative_regulation of Negative_regulation of AXL 1 0.01 1.12 0
109 INT295084 Regulation of Gene_expression of Tcf3 1 0.20 0.36 0
110 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
111 INT292209 Regulation of SP3 1 0.17 0.34 0
112 INT286577 Binding of ID2 1 0.19 0.12 0
113 INT136451 Protein_catabolism of Sp3 1 0.66 0.15 0
114 INT136461 Positive_regulation of Protein_catabolism of Sp3 1 0.46 0.15 0
115 INT311855 Regulation of Negative_regulation of PIK3CD 1 0.04 0.28 0
116 INT283686 Regulation of Id2 1 0.26 0.31 0
117 INT253555 Regulation of Binding of Sp3 1 0.30 0.06 0
118 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
119 INT175420 Positive_regulation of Positive_regulation of AXL 1 0.01 0.54 0
120 INT291337 Negative_regulation of Positive_regulation of AXL 1 0.00 0.79 0
121 INT183656 Transcription of MERTK 1 0.67 0.08 0
122 INT353174 Gene_expression of Stat5b 1 0.48 0 0
123 INT70020 Binding of AXL 1 0.03 0.08 0
124 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
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