GO:0001784

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Name phosphotyrosine binding
Categary Function
Go Slim No
Go Link GO:0001784
Unique Molecular Interactions 604
Total Molecular Interactions 757
Total Single Events 6397
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphotyrosine binding. They are ordered first by their pain relevance and then by number of times they were reported for phosphotyrosine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
4 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
5 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
6 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
7 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
8 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
9 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
10 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
11 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
12 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
13 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
14 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
15 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
16 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
17 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
18 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
19 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
20 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
21 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
22 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
23 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
24 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
25 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
26 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
27 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
28 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
29 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
30 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
31 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
32 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
33 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
34 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
35 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
36 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
37 INT116558 Ptpn5 Positive_regulation of Nfkb1 1 0.46 2.01 0.83
38 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
39 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
40 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
41 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
42 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
43 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
44 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
45 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
46 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
47 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
48 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
49 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
50 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
51 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
52 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
53 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
54 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
55 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
56 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
57 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
58 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
59 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
60 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
61 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
62 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
63 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
64 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
65 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
66 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
67 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
68 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
69 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
70 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
71 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
72 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
73 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
74 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
75 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
76 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
77 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
78 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
79 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
80 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
81 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
82 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
83 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
84 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
85 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
86 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
87 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
88 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
89 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
90 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
91 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
92 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
93 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
94 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
95 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
96 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
97 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
98 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
99 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
100 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
101 INT341211 Gopc Regulation of Shc1 1 0.02 0.68 0.45
102 INT190870 BDNF Positive_regulation of Phosphorylation of Mapk1 1 0.12 0.54 0.44
103 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
104 INT223863 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Ltp 1 0.31 0 0.43
105 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
106 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
107 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
108 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
109 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
110 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
111 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
112 INT161521 Negative_regulation of H2-M3 Positive_regulation of Mapk1 1 0.14 0.41 0.42
113 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
114 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41
115 INT161522 H2-M3 Positive_regulation of Mapk1 1 0.15 0.41 0.41
116 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41
117 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
118 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
119 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
120 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
121 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
122 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
123 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
124 INT152239 Mapk1 Positive_regulation of Localization of Nfkb1 1 0.29 0.13 0.39
125 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
126 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
127 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
128 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
129 INT274941 Ephb2 Regulation of Phosphorylation of Mapk1 1 0.19 0 0.36
130 INT304505 Binding of Mapk1 and Uts2d 1 0.01 0.64 0.36
131 INT304532 Binding of Mdk and Mapk1 1 0.02 0.63 0.35
132 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35
133 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35
134 INT304529 Negative_regulation of Binding of Mdk and Mapk1 1 0.02 0.63 0.35
135 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
136 INT167156 FPR1 Positive_regulation of MAPK1 1 0.18 0.09 0.35
137 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
138 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
139 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
140 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33
141 INT274866 Mapk1 Positive_regulation of Gene_expression of TNF 1 0.06 0.35 0.33
142 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
143 INT167155 FPR1 Positive_regulation of Phosphorylation of MAPK1 1 0.18 0.17 0.33
144 INT337112 Negative_regulation of Nr1d2-rs2 Positive_regulation of Mapk1 1 0.00 0.14 0.33
145 INT280814 Positive_regulation of Mapk1 Positive_regulation of Transcription of Fos 1 0.02 0.06 0.33
146 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
147 INT100028 TNF Positive_regulation of Mapk3 1 0.22 0.79 0.32
148 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
149 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
150 INT291240 Map3k8 Positive_regulation of Positive_regulation of Mapk1 1 0.16 0.72 0.32
151 INT291241 Map3k8 Positive_regulation of Gene_expression of Mapk1 1 0.17 0.72 0.32
152 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
153 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
154 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
155 INT194710 MAPK1 Regulation of Gene_expression of IK 1 0.00 0.24 0.31
156 INT100029 TNF Positive_regulation of Mapk1 1 0.01 0.78 0.31
157 INT337111 Positive_regulation of Nr1d2-rs2 Negative_regulation of Positive_regulation of Mapk1 1 0.00 0.15 0.31
158 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
159 INT112797 Positive_regulation of CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.3
160 INT356287 Ngf Positive_regulation of Mapk1 1 0.05 0.17 0.3
161 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
162 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
163 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
164 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29
165 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
166 INT291254 MAP3K3 Regulation of Mapk1 1 0.00 1.25 0.29
167 INT291242 Positive_regulation of Mdk Regulation of Mapk1 1 0.03 1.28 0.29
168 INT286703 Mapk1 Positive_regulation of Phosphorylation of Hist1h3f 1 0.22 0.18 0.29
169 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
170 INT112805 CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.29
171 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28
172 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
173 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
174 INT132365 Lgals1 Positive_regulation of Mapk1 1 0.03 0.13 0.28
175 INT264472 Mapk1 Regulation of Positive_regulation of Jun 1 0.02 0 0.28
176 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
177 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28
178 INT280825 Mapk1 Positive_regulation of Avp 1 0.01 0.08 0.28
179 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
180 INT280807 Mapk1 Positive_regulation of Positive_regulation of Prkcg 1 0.01 0.08 0.28
181 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
182 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28
183 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
184 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
185 INT166156 Ccr9 Positive_regulation of Mapk3 1 0.49 1.47 0.28
186 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28
187 INT141109 Sftpa1 Positive_regulation of Mapk1 1 0.77 0.65 0.27
188 INT194682 Negative_regulation of MAPK1 Positive_regulation of Gene_expression of IL10 1 0.05 0.17 0.27
189 INT270256 MAPK1 Positive_regulation of Mknk1 1 0.03 0.52 0.27
190 INT188209 OSM Positive_regulation of MAPK1 1 0.35 0.47 0.27
191 INT116561 Ptpn5 Positive_regulation of Nfkb1 1 0.04 0.66 0.27
192 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
193 INT314040 THL Regulation of Mapk1 1 0.28 0.67 0.26
194 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
195 INT191876 Pbsn Positive_regulation of Mapk3 1 0.01 0.33 0.25
196 INT236005 Positive_regulation of MAPK1 Positive_regulation of Binding of Map2 1 0.04 0 0.25
197 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
198 INT132839 TPT1 Regulation of Mapk1 1 0.01 0.07 0.25
199 INT314045 THL Negative_regulation of Phosphorylation of Mapk3 1 0.13 0.7 0.25
200 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphotyrosine binding. They are ordered first by their pain relevance and then by number of times they were reported in phosphotyrosine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
3 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
4 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
5 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
6 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
7 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
8 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
9 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
10 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
11 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
12 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
13 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
14 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
15 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
16 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
17 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
18 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
19 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
20 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
21 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
22 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
23 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
24 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
25 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
26 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
27 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
28 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
29 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
30 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
31 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
32 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
33 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
34 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
35 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
36 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
37 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
38 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
39 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
40 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
41 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
42 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
43 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
44 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
45 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
46 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
47 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
48 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
49 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
50 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
51 INT245593 Gene_expression of PTPN3 32 0.38 10.68 5.09
52 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
53 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
54 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1
55 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
56 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
57 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
58 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
59 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
60 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
61 INT167647 Binding of PTPN5 2 0.32 3.21 3.38
62 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
63 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
64 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
65 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
66 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
67 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
68 INT202606 Regulation of PTPN5 1 0.26 3.92 3.04
69 INT72384 Positive_regulation of Phosphorylation of Shc1 1 0.32 0.48 2.9
70 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
71 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
72 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
73 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
74 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
75 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
76 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52
77 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
78 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
79 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
80 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
81 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1
82 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
83 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
84 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
85 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
86 INT122534 Binding of Shc1 6 0.48 3.59 1.94
87 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
88 INT202602 Positive_regulation of PTPN5 4 0.29 3.34 1.83
89 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
90 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
91 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
92 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
93 INT199222 Gene_expression of SAMSN1 14 0.57 18.97 1.61
94 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
95 INT136680 Negative_regulation of Gene_expression of Shc1 4 0.43 3.36 1.57
96 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
97 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
98 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
99 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
100 INT265567 Localization of PTPN5 1 0.49 1.39 1.47
101 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
102 INT136678 Positive_regulation of Gene_expression of Shc1 4 0.50 2.93 1.42
103 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
104 INT178898 Gene_expression of PTPN5 4 0.38 3.06 1.4
105 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
106 INT245598 Positive_regulation of PTPN3 3 0.34 1.13 1.23
107 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
108 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
109 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
110 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
111 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
112 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03
113 INT151946 Positive_regulation of Regulation of Mapk3 1 0.16 1.31 0.96
114 INT199226 Positive_regulation of SAMSN1 6 0.57 10.2 0.9
115 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86
116 INT278709 Gene_expression of CBL 4 0.14 3.91 0.85
117 INT95786 Positive_regulation of Positive_regulation of Mapk3 2 0.40 1.27 0.8
118 INT245596 Positive_regulation of Gene_expression of PTPN3 5 0.25 0.92 0.79
119 INT72380 Positive_regulation of Shc1 10 0.69 6.87 0.77
120 INT117031 Binding of Samsn1 6 0.21 6.82 0.76
121 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76
122 INT167081 Binding of Mapk3 2 0.29 0.27 0.76
123 INT145697 Regulation of Phosphorylation of Mapk3 1 0.60 0.24 0.68
124 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
125 INT219030 Positive_regulation of Localization of Mapk3 1 0.34 0.49 0.63
126 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
127 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
128 INT191347 Regulation of Shc1 6 0.27 3.6 0.6
129 INT75524 Positive_regulation of Regulation of MAPK1 1 0.43 1.12 0.59
130 INT199225 Localization of SAMSN1 1 0.62 6.07 0.57
131 INT166018 Protein_catabolism of MAPK3 1 0.23 0.59 0.56
132 INT190645 Positive_regulation of Negative_regulation of Mapk1 1 0.44 0.39 0.54
133 INT170475 Negative_regulation of Gene_expression of Mapk1 7 0.41 2.44 0.53
134 INT136679 Negative_regulation of Shc1 3 0.59 2.5 0.51
135 INT319248 Positive_regulation of Positive_regulation of Cbl 1 0.08 0.94 0.51
136 INT72379 Localization of Shc1 4 0.74 0.89 0.49
137 INT319278 Positive_regulation of Cbl 1 0.08 0.92 0.49
138 INT109911 Positive_regulation of Localization of MAPK1 4 0.33 0.56 0.48
139 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
140 INT191861 Negative_regulation of Gene_expression of Mapk3 3 0.08 1.07 0.45
141 INT112709 Negative_regulation of Gene_expression of Mapk3 3 0.38 4.15 0.45
142 INT167980 Regulation of Regulation of Mapk3 1 0.07 0.92 0.45
143 INT159151 Negative_regulation of Negative_regulation of Mapk1 1 0.32 0.38 0.45
144 INT238793 Gene_expression of Cbl 6 0.03 3.01 0.43
145 INT163361 Negative_regulation of SAMSN1 2 0.42 6.6 0.43
146 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
147 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41
148 INT245599 Regulation of Gene_expression of PTPN3 1 0.22 0.57 0.41
149 INT189030 Phosphorylation of PTPN3 3 0.31 1.17 0.39
150 INT167084 Binding of Cbl 3 0.10 1.34 0.39
151 INT274923 Protein_catabolism of Mapk1 1 0.47 0 0.39
152 INT274911 Positive_regulation of Protein_catabolism of Mapk1 1 0.27 0 0.39
153 INT114740 Binding of GRB2 8 0.36 2.24 0.37
154 INT121782 Transcription of Mapk1 3 0.50 1.58 0.35
155 INT243089 Gene_expression of Ldlrap1 2 0.65 0.14 0.35
156 INT245591 Negative_regulation of Gene_expression of PTPN3 2 0.21 0.44 0.35
157 INT109907 Protein_catabolism of MAPK1 2 0.58 1.82 0.34
158 INT157416 Positive_regulation of Samsn1 6 0.53 4.28 0.33
159 INT119081 Negative_regulation of Gene_expression of MAPK3 2 0.41 2 0.33
160 INT130113 Regulation of Regulation of MAPK1 1 0.22 0.16 0.33
161 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
162 INT149995 Negative_regulation of Mapk3 5 0.52 2.64 0.32
163 INT245595 Localization of PTPN3 1 0.39 0.67 0.29
164 INT245592 Regulation of PTPN3 3 0.22 0.88 0.28
165 INT170860 Localization of Samsn1 2 0.23 1.16 0.27
166 INT121780 Regulation of Transcription of Mapk3 1 0.18 0.31 0.27
167 INT314021 Negative_regulation of Localization of Mapk3 1 0.12 1.52 0.27
168 INT121779 Transcription of Mapk3 1 0.48 0.31 0.27
169 INT314020 Localization of Mapk3 1 0.19 1.51 0.27
170 INT199224 Negative_regulation of Positive_regulation of SAMSN1 3 0.48 4.77 0.25
171 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
172 INT199221 Binding of SAMSN1 2 0.29 2.36 0.24
173 INT109931 Positive_regulation of Protein_catabolism of MAPK1 1 0.33 0.14 0.24
174 INT252717 Positive_regulation of Gene_expression of SAMSN1 1 0.03 1.53 0.24
175 INT194801 Binding of MAPK1 7 0.29 1.9 0.23
176 INT164149 Negative_regulation of Localization of Mapk1 3 0.33 1.32 0.22
177 INT200898 Positive_regulation of Localization of Mapk1 1 0.30 0 0.22
178 INT261680 Positive_regulation of Negative_regulation of MAPK1 2 0.33 1.2 0.21
179 INT245597 Positive_regulation of Localization of PTPN3 1 0.34 0.07 0.21
180 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2
181 INT178411 Regulation of Negative_regulation of Mapk1 1 0.44 0.94 0.19
182 INT218284 Gene_expression of Grb10 15 0.72 1.85 0.18
183 INT356268 Regulation of Localization of Mapk1 1 0.04 0.35 0.17
184 INT189039 Negative_regulation of PTPN3 3 0.21 1.01 0.16
185 INT190389 Transcription of MAPK1 2 0.44 2.58 0.15
186 INT240987 Binding of Mapk3 1 0.19 0.15 0.15
187 INT351894 Negative_regulation of SHC1 1 0.12 0.69 0.14
188 INT323231 Positive_regulation of Binding of Samsn1 1 0.18 0.55 0.14
189 INT167723 Positive_regulation of Localization of Mapk1 2 0.10 0.76 0.13
190 INT243075 Regulation of Gene_expression of Ldlrap1 2 0.44 0.15 0.13
191 INT245594 Positive_regulation of Positive_regulation of PTPN3 1 0.23 0.42 0.13
192 INT177448 Regulation of Cbl 2 0.12 0.37 0.12
193 INT236920 Positive_regulation of Binding of Mapk1 2 0.39 0.71 0.12
194 INT319291 Protein_catabolism of Cbl 1 0.14 0.79 0.12
195 INT337866 Binding of Ldlrap1 1 0.18 0.56 0.12
196 INT191353 Localization of SHC1 2 0.73 0.75 0.1
197 INT199228 Regulation of Gene_expression of SAMSN1 1 0.37 1.48 0.1
198 INT291370 Phosphorylation of SHC1 1 0.14 0.57 0.1
199 INT119719 Positive_regulation of CBL 3 0.49 1.67 0.09
200 INT274825 Negative_regulation of Negative_regulation of Mapk1 1 0.08 0.06 0.08
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