GO:0001786

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Name phosphatidylserine binding
Categary Function
Go Slim No
Go Link GO:0001786
Unique Molecular Interactions 115
Total Molecular Interactions 202
Total Single Events 1047
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylserine binding. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylserine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
2 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
3 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
4 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
5 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
6 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
7 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
8 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
9 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
10 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
11 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
12 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
13 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
14 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
15 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
16 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
17 INT136749 COX5A Positive_regulation of Gene_expression of SCARB1 1 0.52 0.36 0.45
18 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
19 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
20 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
21 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
22 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
23 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
24 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
25 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
26 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
27 INT289178 Regulation of PYCARD Regulation of MFGE8 1 0.05 0 0.32
28 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27
29 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
30 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
31 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
32 INT186191 Binding of SCARB1 and TBP 1 0.03 2.57 0.24
33 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
34 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
35 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
36 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
37 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
38 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
39 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
40 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
41 INT289174 PYCARD Positive_regulation of MFGE8 1 0.05 0 0.21
42 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
43 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
44 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
45 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
46 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
47 INT289176 PYCARD Regulation of Localization of MFGE8 1 0.05 0 0.18
48 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
49 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
50 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
51 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
52 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
53 INT344707 Scarb1 Positive_regulation of Positive_regulation of Hdl1 1 0.14 0.88 0.14
54 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
55 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
56 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
57 INT344705 Nr1h2 Regulation of Scarb1 1 0.04 1.53 0.12
58 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
59 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
60 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
61 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
62 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
63 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
64 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
65 INT355828 Binding of MFGE8 and SEA 1 0.01 0.07 0.07
66 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
67 INT186188 Binding of SCARB1 and PDZK1 1 0.53 0.54 0.05
68 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
69 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
70 INT186185 Binding of SCARB1 and SCARB2 1 0.22 0.58 0.05
71 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
72 INT186187 LDLR Regulation of Gene_expression of SCARB1 1 0.17 1.71 0.04
73 INT290375 Binding of Scarb1 and Gopc 1 0.15 0.29 0.04
74 INT213002 Binding of Scarb1 and Trib3 1 0.00 1.02 0.03
75 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
76 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
77 INT213011 Binding of Scarb1 and Hdl1 1 0.13 0.96 0.03
78 INT186186 LDLR Regulation of SCARB1 1 0.08 0.65 0.03
79 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
80 INT247155 Binding of Phb2 and Scarb1 1 0.01 0.33 0
81 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
82 INT186190 OLR1 Positive_regulation of SCARB1 1 0.01 0.67 0
83 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
84 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
85 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
86 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
87 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
88 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
89 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
90 INT290374 Binding of Scarb1 and Ncapg2 1 0.23 0.43 0
91 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
92 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
93 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
94 INT260520 Binding of Myc and Scarb1 1 0.33 0.16 0
95 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
96 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
97 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
98 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
99 INT186189 LDLR Positive_regulation of Gene_expression of SCARB1 1 0.14 1.27 0
100 INT290373 Binding of Cd36 and Scarb1 1 0.11 0 0
101 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
102 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
103 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
104 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
105 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
106 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
107 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
108 INT213043 Regulation of Binding of Apoa1 and Scarb1 1 0.05 1.12 0
109 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
110 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0
111 INT290372 Binding of Ngfr and Scarb1 1 0.01 0.48 0
112 INT304270 Binding of Apoa1 and Scarb1 1 0.00 0.39 0
113 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylserine binding. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylserine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
2 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
3 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
4 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
5 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
6 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
7 INT113254 Positive_regulation of MFGE8 13 0.09 2.52 5.56
8 INT136754 Gene_expression of SCARB1 64 0.77 43.28 4.82
9 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
10 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
11 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
12 INT289208 Gene_expression of MFGE8 13 0.08 0.25 3.7
13 INT289211 Localization of MFGE8 11 0.09 0.19 2.69
14 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
15 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
16 INT289207 Binding of MFGE8 1 0.06 0 1.92
17 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
18 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
19 INT136752 Positive_regulation of Gene_expression of SCARB1 5 0.69 10.63 1.76
20 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
21 INT150805 Localization of THBS1 4 0.46 2.88 1.23
22 INT289209 Regulation of MFGE8 3 0.05 0.2 1.13
23 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
24 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
25 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
26 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
27 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
28 INT113256 Negative_regulation of Positive_regulation of MFGE8 2 0.08 0.25 0.95
29 INT211557 Gene_expression of Scarb1 30 0.75 5.03 0.94
30 INT289205 Negative_regulation of MFGE8 4 0.05 0 0.94
31 INT294479 Gene_expression of Scarb1 1 0.02 3.08 0.9
32 INT136753 Regulation of Gene_expression of SCARB1 2 0.60 7.79 0.77
33 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
34 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
35 INT136751 Negative_regulation of SCARB1 6 0.43 2.65 0.7
36 INT136755 Negative_regulation of Gene_expression of SCARB1 2 0.57 6.61 0.63
37 INT212959 Binding of Scarb1 12 0.35 7.7 0.61
38 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
39 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
40 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
41 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
42 INT136757 Regulation of SCARB1 4 0.27 1.96 0.48
43 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
44 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
45 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
46 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
47 INT289192 Negative_regulation of Gene_expression of MFGE8 1 0.05 0 0.39
48 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
49 INT289212 Regulation of Localization of MFGE8 1 0.05 0 0.34
50 INT289206 Positive_regulation of Localization of MFGE8 1 0.06 0 0.34
51 INT16855 Binding of Scarb1 1 0.21 0 0.33
52 INT289210 Negative_regulation of Localization of MFGE8 1 0.05 0 0.33
53 INT16856 Positive_regulation of Binding of Scarb1 1 0.27 0 0.33
54 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
55 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
56 INT344673 Positive_regulation of Binding of Scarb1 1 0.16 0.82 0.28
57 INT289199 Regulation of Binding of MFGE8 1 0.05 0 0.24
58 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
59 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
60 INT307183 Positive_regulation of Gene_expression of Scarb1 1 0.07 0.93 0.22
61 INT186199 Binding of SCARB1 3 0.37 5.25 0.21
62 INT289203 Regulation of Gene_expression of MFGE8 1 0.05 0 0.21
63 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
64 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
65 INT290336 Negative_regulation of Scarb1 4 0.31 1.77 0.17
66 INT211552 Localization of Scarb1 3 0.60 1.27 0.17
67 INT231474 Binding of THBS1 4 0.34 2.04 0.16
68 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
69 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
70 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
71 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
72 INT59956 Positive_regulation of SCARB1 3 0.49 0.99 0.12
73 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
74 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
75 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
76 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
77 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
78 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
79 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
80 INT290345 Negative_regulation of Gene_expression of Scarb1 1 0.42 0.5 0.04
81 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
82 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
83 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
84 INT290334 Negative_regulation of Binding of Scarb1 1 0.31 0.12 0.03
85 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
86 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
87 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
88 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
89 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
90 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
91 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
92 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
93 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
94 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
95 INT186198 Positive_regulation of Transcription of SCARB1 1 0.49 0.67 0
96 INT290350 Transcription of Scarb1 1 0.50 0.24 0
97 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
98 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
99 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
100 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
101 INT290341 Positive_regulation of Negative_regulation of Scarb1 1 0.32 0.69 0
102 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
103 INT212958 Positive_regulation of Scarb1 1 0.20 1.29 0
104 INT213135 Negative_regulation of Scarb1 1 0.02 2.06 0
105 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
106 INT186195 Transcription of SCARB1 1 0.70 1.42 0
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