GO:0001798

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Name positive regulation of type IIa hypersensitivity
Categary Process
Go Slim No
Go Link GO:0001798
Unique Molecular Interactions 89
Total Molecular Interactions 111
Total Single Events 1125
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of type IIa hypersensitivity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of type IIa hypersensitivity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
2 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7
3 INT46964 C3 Positive_regulation of Tcm 1 0.00 1.26 0.66
4 INT30129 Binding of C3 and Gast 1 0.06 0.09 0.62
5 INT149479 CEBPD Positive_regulation of C3 1 0.30 0.14 0.57
6 INT119030 Binding of POMC and Ighg1 1 0.06 0 0.52
7 INT274945 Binding of Fcgr1 and Gopc 1 0.02 0 0.49
8 INT203150 Binding of Ighg2b and IgG2a 1 0.11 1.35 0.47
9 INT331731 Binding of C3 and CD79A 1 0.02 0.85 0.46
10 INT68252 Penk Positive_regulation of Transcription of Ighg1 1 0.44 0 0.44
11 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39
12 INT112020 Binding of Ighg1 and IgG2a 2 0.25 0.36 0.36
13 INT155166 Binding of C2 and C3 1 0.40 0 0.34
14 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
15 INT112019 Binding of Ifng and Ighg1 1 0.10 0.3 0.33
16 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
17 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
18 INT284047 Vtcn1 Negative_regulation of Gene_expression of Ighg2b 1 0.05 0.68 0.3
19 INT235958 Binding of Ighg1 and Aqp4 1 0.14 1.32 0.3
20 INT235977 Binding of AQP4 and Ighg1 1 0.03 1.31 0.3
21 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
22 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
23 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27
24 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
25 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
26 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23
27 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2
28 INT181082 Binding of C3 and C3ar1 1 0.03 1.31 0.19
29 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19
30 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19
31 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17
32 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17
33 INT344590 Binding of IFN1@ and C3 1 0.32 0.3 0.16
34 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16
35 INT107647 Ighg1 Negative_regulation of Arigg4 1 0.01 0.5 0.14
36 INT107645 Arigg4 Negative_regulation of Ighg1 1 0.01 0.5 0.14
37 INT351144 Binding of Ighg2b and Ighg2a 1 0.00 0.78 0.12
38 INT61916 Binding of Fcgr1 and IgG2a 1 0.47 0.93 0.12
39 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
40 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11
41 INT185073 Bpifa2 Positive_regulation of Ighg1 1 0.27 0.93 0.09
42 INT45452 Binding of C2 and C3 1 0.34 0.08 0.08
43 INT41831 Binding of ALB and C3 1 0.22 0.07 0.08
44 INT351142 Binding of Cd3e and Ighg2b 1 0.03 0.6 0.07
45 INT74033 Binding of IGHG3 and Ighg1 2 0.08 0.87 0.06
46 INT218503 Cfb Positive_regulation of C3 1 0.01 0.29 0.06
47 INT61915 Binding of Fcgr1 and Slc3a2 1 0.02 0.43 0.06
48 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06
49 INT171543 IL4 Positive_regulation of Transcription of C3 1 0.28 0 0.05
50 INT171542 IL4 Positive_regulation of Gene_expression of C3 1 0.19 0 0.05
51 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05
52 INT320353 IFNA1 Positive_regulation of Gene_expression of Ighg2b 1 0.02 0 0.05
53 INT223520 Erv4 Regulation of Regulation of Fcgr1 1 0.06 0.93 0.05
54 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04
55 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04
56 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04
57 INT281652 GOPC Positive_regulation of C3 1 0.22 0.22 0.04
58 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
59 INT289410 Binding of C3 and Cfb 1 0.01 0.36 0.03
60 INT279533 CFH Positive_regulation of C3 1 0.07 1.8 0
61 INT320351 Pnp Regulation of Ighg2b 1 0.02 0.31 0
62 INT229934 Binding of C3 and GPI 1 0.01 0 0
63 INT215128 Ighm Regulation of Ighg1 1 0.12 0.27 0
64 INT215131 Ighg1 Regulation of Ighg2b 1 0.16 0.27 0
65 INT289412 Binding of C4A and C3 1 0.11 0.26 0
66 INT215127 Ighg1 Regulation of Ighm 1 0.12 0.27 0
67 INT254866 Positive_regulation of C3 Negative_regulation of Rock1 1 0.02 0 0
68 INT353106 Binding of amd and C3 1 0.09 1.69 0
69 INT84739 Binding of Ighg1 and Cea 1 0.31 0.43 0
70 INT218508 Negative_regulation of Binding of C3 and Cfb 1 0.01 0 0
71 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0
72 INT320352 Pnp Positive_regulation of Ighg2b 1 0.03 0.08 0
73 INT279501 C3ar1 Positive_regulation of C3 1 0.01 0 0
74 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0
75 INT254861 C3 Negative_regulation of Rock1 1 0.02 0 0
76 INT279530 MBL2 Positive_regulation of Positive_regulation of C3 1 0.26 1.71 0
77 INT229930 C3AR1 Positive_regulation of C3 1 0.00 0 0
78 INT284829 Binding of FCGR3A and Ighg1 1 0.00 0.13 0
79 INT289295 Binding of CD59 and Fcgr3 1 0.01 1.06 0
80 INT215129 Ighg1 Regulation of Gene_expression of Ctsd 1 0.35 0.26 0
81 INT194243 Binding of SFSWAP and Ighg1 1 0.01 0.46 0
82 INT229932 C4B Positive_regulation of C3 1 0.07 0 0
83 INT345059 Binding of C3 and C2 1 0.00 0 0
84 INT215132 Ighm Regulation of Ighg2b 1 0.11 0.27 0
85 INT215130 Ighg1 Regulation of Negative_regulation of Ctsd 1 0.21 0.27 0
86 INT279537 ICAM3 Positive_regulation of C3 1 0.06 0.85 0
87 INT299708 Binding of C3 and PSMC2 1 0.00 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of type IIa hypersensitivity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of type IIa hypersensitivity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT756 Gene_expression of C3 138 0.75 100.6 19.2
2 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92
3 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63
4 INT573 Negative_regulation of C3 60 0.59 41.37 7.78
5 INT178198 Gene_expression of C3 62 0.78 39.5 7.69
6 INT1120 Gene_expression of C3 33 0.67 22.86 7.56
7 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01
8 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83
9 INT9223 Localization of Ighg1 22 0.78 11.03 3.67
10 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89
11 INT9460 Positive_regulation of C3 6 0.69 3.96 2.81
12 INT155160 Binding of C3 20 0.47 7.77 2.61
13 INT49930 Binding of Ighg1 21 0.37 13.27 2.43
14 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36
15 INT29094 Binding of C3 39 0.37 12.65 2.27
16 INT35689 Localization of C3 17 0.75 5.3 1.98
17 INT16385 Regulation of C3 20 0.41 9.98 1.92
18 INT184006 Gene_expression of Ighg2b 21 0.71 7.97 1.86
19 INT68250 Regulation of Gene_expression of Ighg1 7 0.40 2.99 1.56
20 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54
21 INT182037 Localization of C3 10 0.68 6.69 1.54
22 INT112013 Negative_regulation of Gene_expression of Ighg1 7 0.38 3.57 1.42
23 INT10885 Negative_regulation of C3 9 0.38 11.86 1.35
24 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32
25 INT68248 Transcription of Ighg1 3 0.61 3.02 1.25
26 INT148212 Negative_regulation of Gene_expression of C3 2 0.43 5.47 1.24
27 INT93055 Regulation of C3 4 0.40 1.81 1.12
28 INT139679 Positive_regulation of Ighg2b 11 0.55 10.57 1.1
29 INT180382 Gene_expression of Fcgr3 9 0.34 7.94 1.1
30 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06
31 INT116360 Protein_catabolism of C3 19 0.64 4.4 1
32 INT238250 Regulation of Gene_expression of C3 2 0.27 2.16 0.98
33 INT171113 Binding of Ighg2b 3 0.47 2.85 0.96
34 INT138683 Regulation of Ighg1 15 0.30 7.95 0.94
35 INT111668 Binding of C3 4 0.36 3.84 0.87
36 INT79956 Positive_regulation of Positive_regulation of C3 4 0.35 4.17 0.86
37 INT28689 Negative_regulation of Positive_regulation of C3 4 0.23 1.28 0.85
38 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75
39 INT181711 Positive_regulation of Gene_expression of Fcgr3 2 0.08 1.67 0.74
40 INT179530 Transcription of C3 4 0.69 2.59 0.7
41 INT116361 Positive_regulation of Protein_catabolism of C3 6 0.45 1.86 0.69
42 INT46173 Transcription of C3 4 0.61 3.54 0.53
43 INT184049 Positive_regulation of Gene_expression of Ighg2b 2 0.40 1.54 0.53
44 INT45447 Positive_regulation of Gene_expression of C3 2 0.42 0.9 0.49
45 INT203131 Regulation of Binding of Ighg2b 1 0.31 1.36 0.49
46 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45
47 INT220886 Regulation of C3 2 0.36 1.04 0.43
48 INT68237 Positive_regulation of Transcription of Ighg1 1 0.44 0 0.43
49 INT241407 Phosphorylation of C3 2 0.24 0.16 0.42
50 INT61912 Gene_expression of Fcgr1 3 0.69 1.13 0.41
51 INT238253 Localization of C3 1 0.37 1.76 0.41
52 INT39350 Positive_regulation of Ighg2a 2 0.35 2.39 0.37
53 INT220962 Positive_regulation of Localization of Ighg1 2 0.46 2.58 0.37
54 INT27205 Binding of Fcgr1 1 0.02 0 0.37
55 INT274912 Regulation of Gene_expression of Fcgr1 1 0.05 0 0.35
56 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34
57 INT1121 Protein_catabolism of C3 1 0.96 1.8 0.34
58 INT224714 Localization of Ighg2b 4 0.73 0.48 0.33
59 INT323835 Negative_regulation of Binding of Ighg1 1 0.23 0.67 0.31
60 INT323834 Regulation of Binding of Ighg1 1 0.24 0.69 0.31
61 INT46174 Positive_regulation of Transcription of C3 1 0.13 0.25 0.3
62 INT215118 Negative_regulation of Ighg2b 2 0.30 0.93 0.28
63 INT238247 Transcription of C3 1 0.43 0.12 0.23
64 INT238248 Negative_regulation of Transcription of C3 1 0.26 0.12 0.23
65 INT181039 Negative_regulation of Positive_regulation of C3 1 0.32 1.42 0.22
66 INT236354 Negative_regulation of Negative_regulation of C3 2 0.25 2.19 0.21
67 INT245266 Positive_regulation of Localization of C3 1 0.23 1.11 0.21
68 INT181041 Negative_regulation of Gene_expression of C3 1 0.32 1.37 0.2
69 INT220895 Negative_regulation of Binding of C3 3 0.28 0.95 0.16
70 INT238679 Negative_regulation of Localization of Ighg1 2 0.39 0.61 0.15
71 INT317803 Negative_regulation of Ighg2a 1 0.02 0.71 0.15
72 INT317802 Regulation of Ighg2a 1 0.01 0.49 0.14
73 INT317804 Regulation of Gene_expression of Ighg2a 1 0.01 0.5 0.14
74 INT79957 Regulation of Positive_regulation of C3 2 0.32 1.55 0.13
75 INT317801 Gene_expression of Ighg2a 1 0.03 0.49 0.13
76 INT181582 Phosphorylation of C3 1 0.34 1.2 0.12
77 INT79184 Positive_regulation of Fcgr3 2 0.13 0.52 0.1
78 INT303410 Regulation of Ighg2b 2 0.25 1.22 0.09
79 INT303412 Positive_regulation of Regulation of Ighg2b 2 0.43 1.23 0.09
80 INT1122 Positive_regulation of Protein_catabolism of C3 1 0.45 0.45 0.09
81 INT107642 Positive_regulation of Positive_regulation of Ighg1 2 0.30 1.35 0.08
82 INT61911 Negative_regulation of Gene_expression of Fcgr1 1 0.38 0.39 0.07
83 INT334858 Positive_regulation of Phosphorylation of C3 1 0.13 0 0.06
84 INT223510 Regulation of Fcgr1 1 0.11 0.92 0.05
85 INT218489 Negative_regulation of Localization of C3 1 0.08 0.24 0.04
86 INT192405 Positive_regulation of Regulation of Ighg1 1 0.26 0 0.04
87 INT218479 Negative_regulation of Protein_catabolism of C3 1 0.09 0.24 0.04
88 INT247840 Regulation of Gene_expression of C3 1 0.45 0.13 0.04
89 INT218481 Positive_regulation of Binding of C3 2 0.35 1.23 0.03
90 INT211289 Binding of Fcgr3 1 0.19 0.28 0.03
91 INT320337 Regulation of Gene_expression of Ighg2b 1 0.25 0 0.03
92 INT320331 Negative_regulation of Gene_expression of Ighg2b 1 0.39 0.05 0.03
93 INT334843 Negative_regulation of Phosphorylation of C3 1 0.15 0 0.03
94 INT211301 Negative_regulation of Binding of Fcgr3 1 0.22 0.34 0.03
95 INT277787 Protein_catabolism of Ighg1 1 0.35 0.11 0.03
96 INT246352 Positive_regulation of Regulation of C3 1 0.03 1.05 0.03
97 INT218480 Negative_regulation of Binding of C3 5 0.10 1.54 0
98 INT279566 Negative_regulation of Transcription of C3 1 0.30 1.49 0
99 INT218495 Negative_regulation of Negative_regulation of C3 1 0.08 0 0
100 INT344200 Localization of Fcgr1 1 0.28 0.4 0
101 INT218491 Phosphorylation of C3 1 0.19 0 0
102 INT218476 Regulation of Protein_catabolism of C3 1 0.06 0 0
103 INT218483 Regulation of Binding of C3 1 0.10 0 0
104 INT279446 Regulation of Binding of C3 1 0.18 0 0
105 INT218475 Regulation of Phosphorylation of C3 1 0.10 0 0
106 INT344196 Positive_regulation of Localization of Fcgr1 1 0.19 0.4 0
107 INT170735 Positive_regulation of Gene_expression of Fcgr1 1 0.15 0.74 0
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