GO:0001819

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Name positive regulation of cytokine production
Categary Process
Go Slim No
Go Link GO:0001819
Unique Molecular Interactions 1239
Total Molecular Interactions 1699
Total Single Events 17153
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cytokine production. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cytokine production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
3 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
4 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
5 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
6 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
7 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
8 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
9 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
10 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
11 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
12 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
13 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
14 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
15 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
16 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
17 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
18 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
19 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
20 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
21 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
22 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
23 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
24 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
25 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
26 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
27 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
28 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
29 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
30 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
31 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
32 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
33 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
34 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
35 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
36 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
37 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
38 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
39 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
40 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
41 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
42 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
43 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
44 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
45 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
46 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
47 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
48 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
49 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
50 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
51 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
52 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
53 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
54 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
55 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
56 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
57 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
58 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
59 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
60 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
61 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
62 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
63 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
64 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
65 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
66 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
67 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
68 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
69 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
70 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
71 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
72 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
73 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
74 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
75 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
76 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
77 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
78 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
79 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
80 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
81 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
82 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
83 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
84 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
85 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
86 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
87 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
88 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
89 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
90 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
91 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
92 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
93 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
94 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
95 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
96 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
97 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
98 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
99 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
100 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
101 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
102 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
103 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
104 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
105 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
106 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
107 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
108 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
109 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
110 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
111 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
112 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
113 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
114 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
115 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
116 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
117 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
118 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
119 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
120 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
121 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
122 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
123 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
124 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
125 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
126 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
127 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
128 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
129 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
130 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
131 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
132 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
133 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
134 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
135 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
136 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
137 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
138 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
139 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
140 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
141 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
142 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
143 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79
144 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
145 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
146 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
147 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
148 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
149 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
150 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
151 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
152 INT130138 TNF Negative_regulation of Gene_expression of S100A10 1 0.06 1.32 0.78
153 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
154 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
155 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
156 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
157 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77
158 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
159 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
160 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
161 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76
162 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
163 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
164 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
165 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
166 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
167 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
168 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
169 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
170 INT301141 Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
171 INT301142 Negative_regulation of Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
172 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
173 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
174 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
175 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
176 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
177 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
178 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
179 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
180 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
181 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
182 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
183 INT113499 TNF Positive_regulation of Gene_expression of BHLHE23 1 0.25 0.1 0.71
184 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
185 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
186 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
187 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
188 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
189 INT117533 TNF Positive_regulation of Positive_regulation of SETBP1 1 0.34 0.29 0.7
190 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
191 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7
192 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
193 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
194 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
195 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
196 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
197 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
198 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
199 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
200 INT113959 TNF Positive_regulation of Gene_expression of IK 1 0.02 0.66 0.69

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cytokine production. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cytokine production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
10 INT9660 Regulation of TNF 363 0.62 312.94 139.99
11 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
12 INT10166 Localization of Tnf 237 0.81 153.95 88.64
13 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
14 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
15 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
16 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
17 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
18 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
19 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
20 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
21 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
22 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
23 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
24 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
25 INT13354 Transcription of TNF 108 0.72 85.81 42.32
26 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
27 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
28 INT35406 Localization of Tnf 94 0.81 64.63 31.65
29 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
30 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
31 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
32 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
33 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
34 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
35 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
36 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
37 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
38 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
39 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
40 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
41 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
42 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
43 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
44 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
45 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
46 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
47 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
48 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
49 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
50 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
51 INT75908 Regulation of LEP 77 0.60 60.16 15.19
52 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
53 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
54 INT10173 Binding of Tnf 45 0.48 35.6 14.32
55 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
56 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
57 INT3962 Regulation of AGT 50 0.62 20.96 13.01
58 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
59 INT73641 Regulation of Lep 45 0.62 26.2 12.59
60 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
61 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
62 INT398 Localization of AGT 45 0.78 16.97 11.54
63 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
64 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
65 INT8065 Binding of AGT 54 0.48 20.54 10.85
66 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
67 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
68 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
69 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
70 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
71 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
72 INT82082 Localization of Lep 63 0.81 26.41 8.56
73 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
74 INT75907 Binding of LEP 53 0.46 46.65 8.44
75 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
76 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
77 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
78 INT68299 Binding of Tnf 17 0.39 12.55 7.49
79 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
80 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
81 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
82 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
83 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
84 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
85 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
86 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
87 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
88 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
89 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
90 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
91 INT65356 Localization of LEP 46 0.79 41.17 5.43
92 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
93 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
94 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
95 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
96 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
97 INT97391 Binding of Lep 18 0.48 8.97 4.47
98 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
99 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
100 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
101 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
102 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
103 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
104 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
105 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
106 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
107 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
108 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
109 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
110 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
111 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
112 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
113 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
114 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
115 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
116 INT91899 Binding of Sod1 17 0.47 11.56 2.63
117 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
118 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
119 INT31989 Binding of SOD1 43 0.47 19.38 2.55
120 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
121 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
122 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
123 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
124 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33
125 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
126 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
127 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
128 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
129 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
130 INT209027 Positive_regulation of Positive_regulation of Slc11a1 3 0.14 2.41 2.18
131 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14
132 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
133 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
134 INT83392 Transcription of Lep 6 0.54 5.07 2.04
135 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
136 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
137 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
138 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
139 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
140 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
141 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
142 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
143 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
144 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66
145 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
146 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
147 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
148 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
149 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
150 INT91900 Localization of Sod1 12 0.77 6.62 1.51
151 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
152 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
153 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
154 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
155 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
156 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
157 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
158 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
159 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
160 INT116008 Binding of Gata3 2 0.34 1.37 1.41
161 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
162 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
163 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
164 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
165 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
166 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
167 INT11241 Transcription of AGT 4 0.52 1.83 1.27
168 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
169 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
170 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
171 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
172 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
173 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
174 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
175 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
176 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
177 INT159543 Localization of SOD1 29 0.75 8.62 1.06
178 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
179 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
180 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
181 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
182 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
183 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
184 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
185 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
186 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
187 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
188 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
189 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
190 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
191 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
192 INT89340 Positive_regulation of EREG 5 0.69 4.98 0.77
193 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
194 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
195 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
196 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
197 INT156533 Transcription of LEP 9 0.69 4.35 0.74
198 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
199 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
200 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
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