GO:0001821

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Name histamine secretion
Categary Process
Go Slim No
Go Link GO:0001821
Unique Molecular Interactions 335
Total Molecular Interactions 490
Total Single Events 3231
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histamine secretion. They are ordered first by their pain relevance and then by number of times they were reported for histamine secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
3 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
6 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
7 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
8 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
9 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
10 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
11 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
12 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
13 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
14 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
15 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
16 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
17 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
18 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
19 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
20 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
21 INT11392 Cck Positive_regulation of Cckbr 1 0.52 0 0.96
22 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
23 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
24 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
25 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
26 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
27 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
28 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
29 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
30 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
31 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
32 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
33 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
34 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
35 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
36 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
37 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
38 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
39 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
40 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
41 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
42 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
43 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
44 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
45 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
46 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
47 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
48 INT84213 Cck Regulation of Cckbr 1 0.41 0 0.67
49 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
50 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
51 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
52 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
53 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
54 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
55 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
56 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
57 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
58 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
59 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
60 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
61 INT59155 Binding of Adcyap1 and Vip 2 0.34 0.08 0.55
62 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
63 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
64 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
65 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
66 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
67 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
68 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
69 INT106662 Adcyap1 Regulation of Penk 1 0.00 0 0.49
70 INT106664 Adcyap1 Regulation of Gene_expression of Vip 1 0.00 0 0.49
71 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
72 INT106663 Adcyap1 Regulation of Vip 1 0.00 0 0.49
73 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
74 INT26009 Cck Negative_regulation of Positive_regulation of Cckbr 1 0.26 0 0.47
75 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
76 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
77 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
78 INT55261 Cck Regulation of Positive_regulation of Cckbr 1 0.18 0 0.45
79 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
80 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
81 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
82 INT55264 Pigt Regulation of Positive_regulation of Cckbr 1 0.03 0 0.44
83 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
84 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
85 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
86 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
87 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
88 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
89 INT273045 Vip Regulation of Adcyap1 1 0.17 0.5 0.38
90 INT187230 Binding of Adcyap1 and Vipr1 1 0.11 0.92 0.38
91 INT187228 Binding of Adcyap1 and Vipr2 1 0.11 0.91 0.38
92 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
93 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
94 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
95 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
96 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
97 INT190751 Adcyap1 Positive_regulation of Vipr2 2 0.16 1.02 0.36
98 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
99 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
100 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
101 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
102 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
103 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
104 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
105 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
106 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
107 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
108 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
109 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
110 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
111 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
112 INT315387 Adcyap1 Positive_regulation of Phosphorylation of Gopc 1 0.03 0.44 0.32
113 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
114 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
115 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
116 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
117 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
118 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
119 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
120 INT139125 Adcyap1 Regulation of Ier3 1 0.54 0.8 0.29
121 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
122 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
123 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
124 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
125 INT63654 VIP Positive_regulation of Adcyap1 1 0.27 0.15 0.27
126 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
127 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
128 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
129 INT74118 Adcyap1 Positive_regulation of Localization of Avp 1 0.33 0 0.26
130 INT106658 Adcyap1 Positive_regulation of Gene_expression of Npy 1 0.54 0.16 0.25
131 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
132 INT106660 Adcyap1 Positive_regulation of Gene_expression of Chga 1 0.54 0.16 0.25
133 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
134 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
135 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
136 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
137 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
138 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
139 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
140 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
141 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
142 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
143 INT190741 Adcyap1 Positive_regulation of Gria2 1 0.00 0 0.24
144 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
145 INT69073 Adcyap1 Regulation of Localization of Gnrh1 2 0.66 0 0.22
146 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
147 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
148 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
149 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
150 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
151 INT273046 Vip Negative_regulation of Gene_expression of Adcyap1 1 0.20 1.14 0.21
152 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
153 INT190745 Adcyap1 Regulation of Car2 1 0.08 0 0.21
154 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
155 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
156 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
157 INT80049 Adcyap1 Positive_regulation of Positive_regulation of Slc4a4 1 0.19 0 0.2
158 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
159 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
160 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
161 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
162 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19
163 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
164 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
165 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
166 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
167 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
168 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
169 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
170 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
171 INT315396 Adcyap1 Regulation of IFNA1 1 0.02 0.14 0.17
172 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
173 INT190749 Adcyap1 Positive_regulation of Vipr1 1 0.11 0 0.17
174 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
175 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
176 INT190744 Adcyap1 Positive_regulation of Car2 1 0.10 0.08 0.16
177 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
178 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
179 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
180 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
181 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
182 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
183 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
184 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
185 INT74030 Adcyap1 Positive_regulation of Transcription of Penk 1 0.56 0.24 0.15
186 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
187 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
188 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
189 INT190747 Adcyap1 Regulation of Positive_regulation of Prkaca 1 0.05 0 0.14
190 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 0.36 0 0.14
191 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
192 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
193 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
194 INT219920 EDNRA Positive_regulation of Trpv1 1 0.14 0 0.13
195 INT334759 Ednra Regulation of Gabrg1 1 0.01 0 0.13
196 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
197 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
198 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
199 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
200 INT315388 Binding of Adcyap1r1 and Adcyap1 1 0.02 0.5 0.12

Single Events

The table below shows the top 100 pain related interactions that have been reported for histamine secretion. They are ordered first by their pain relevance and then by number of times they were reported in histamine secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
5 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
6 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
7 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
8 INT5048 Binding of Edn1 55 0.47 18.86 19.16
9 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
10 INT54077 Gene_expression of Adcyap1 62 0.78 23.17 16.75
11 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
12 INT9191 Localization of EDN1 94 0.81 57.01 14.78
13 INT58896 Localization of Adcyap1 35 0.81 4.57 14.77
14 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
15 INT48259 Positive_regulation of Adcyap1 33 0.67 10.94 14.39
16 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
17 INT6365 Localization of Edn1 56 0.81 18.84 13.83
18 INT65965 Gene_expression of Adcyap1 52 0.78 22.53 13.14
19 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
20 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
21 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
22 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
23 INT6361 Localization of Edn1 30 0.81 19.09 9.7
24 INT106199 Positive_regulation of Adcyap1 32 0.68 13.68 9.14
25 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
26 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
27 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
28 INT10237 Binding of EDN1 40 0.48 16 8.48
29 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
30 INT52116 Regulation of Adcyap1 20 0.53 6.1 8.14
31 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
32 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
33 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
34 INT6856 Gene_expression of Cckbr 10 0.77 1.8 7.69
35 INT51062 Negative_regulation of Cckbr 7 0.59 1.98 7.68
36 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
37 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
38 INT65964 Regulation of Adcyap1 13 0.45 10.1 7.54
39 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
40 INT167049 Binding of Ednra 3 0.07 3.47 6.84
41 INT43224 Negative_regulation of Adcyap1 17 0.54 3.69 6.19
42 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
43 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
44 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
45 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
46 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
47 INT36256 Regulation of Ada 9 0.62 4.99 5.07
48 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
49 INT26008 Positive_regulation of Cckbr 5 0.65 1.47 5.01
50 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
51 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
52 INT246315 Localization of Ednra 22 0.15 2.73 4.64
53 INT21953 Binding of Ednra 12 0.33 4.72 4.56
54 INT66048 Positive_regulation of Gene_expression of Adcyap1 5 0.49 8.21 4.52
55 INT54776 Binding of Cckbr 5 0.42 0 4.45
56 INT106548 Localization of Adcyap1 14 0.80 5.05 4.33
57 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
58 INT138209 Positive_regulation of Localization of Adcyap1 2 0.41 2.07 4.08
59 INT134590 Localization of ADA 7 0.65 8.43 3.96
60 INT115877 Negative_regulation of Adcyap1 14 0.59 5.31 3.74
61 INT59154 Binding of Adcyap1 12 0.48 4.16 3.71
62 INT52170 Regulation of Cckbr 5 0.58 1.34 3.69
63 INT58897 Regulation of Localization of Adcyap1 4 0.45 1.82 3.48
64 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
65 INT72798 Binding of ADA 12 0.47 7.84 3.39
66 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
67 INT120823 Positive_regulation of Gene_expression of Adcyap1 10 0.68 6.71 3.22
68 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17
69 INT34604 Binding of Ada 11 0.31 4.15 3.1
70 INT9766 Positive_regulation of Ada 2 0.47 0.4 3.09
71 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
72 INT53374 Binding of Edn1 17 0.43 11.66 2.98
73 INT131494 Regulation of ADA 8 0.52 7.37 2.97
74 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
75 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
76 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
77 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
78 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
79 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
80 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
81 INT54076 Transcription of Adcyap1 4 0.67 1.65 1.98
82 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
83 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
84 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
85 INT77300 Negative_regulation of Positive_regulation of Adcyap1 3 0.35 0 1.88
86 INT66047 Regulation of Gene_expression of Adcyap1 2 0.58 3.36 1.84
87 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
88 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
89 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
90 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
91 INT34605 Localization of Ada 7 0.80 0.13 1.61
92 INT72021 Localization of Ednra 7 0.58 3.13 1.53
93 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
94 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
95 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
96 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
97 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
98 INT137927 Positive_regulation of Positive_regulation of Ada 1 0.03 1.31 1.47
99 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
100 INT30277 Protein_catabolism of Ada 3 0.52 0.9 1.42
101 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
102 INT59153 Positive_regulation of Binding of Adcyap1 3 0.43 0.56 1.37
103 INT141010 Positive_regulation of Gene_expression of Cckbr 1 0.44 0.67 1.34
104 INT141009 Transcription of Cckbr 1 0.47 0.67 1.33
105 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
106 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
107 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
108 INT106549 Binding of Adcyap1 3 0.35 1.83 1.08
109 INT238636 Regulation of Ada 2 0.15 1.12 1.06
110 INT85610 Positive_regulation of Positive_regulation of Cckbr 1 0.14 0.25 1.06
111 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
112 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
113 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
114 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
115 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
116 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
117 INT238637 Binding of Ada 2 0.26 1.01 0.94
118 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
119 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
120 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
121 INT43221 Negative_regulation of Negative_regulation of Adcyap1 1 0.18 0 0.85
122 INT68200 Protein_catabolism of Ada 2 0.44 0.68 0.83
123 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
124 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
125 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
126 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
127 INT210014 Regulation of Binding of Adcyap1 1 0.38 0.25 0.73
128 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
129 INT210012 Regulation of Transcription of Adcyap1 1 0.44 0.48 0.7
130 INT40605 Negative_regulation of Negative_regulation of Ada 1 0.32 0 0.7
131 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
132 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
133 INT210011 Negative_regulation of Gene_expression of Adcyap1 1 0.36 1.22 0.69
134 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
135 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
136 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
137 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
138 INT137580 Negative_regulation of Gene_expression of Adcyap1 3 0.43 0.15 0.57
139 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
140 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
141 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
142 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
143 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
144 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
145 INT126442 Negative_regulation of Gene_expression of Ednra 3 0.33 1.94 0.51
146 INT68358 Regulation of Positive_regulation of Adcyap1 1 0.44 0 0.5
147 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49
148 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
149 INT26007 Negative_regulation of Positive_regulation of Cckbr 1 0.33 0 0.47
150 INT203480 Negative_regulation of Transcription of Adcyap1 1 0.41 0.81 0.47
151 INT51063 Regulation of Negative_regulation of Cckbr 1 0.25 0 0.47
152 INT203479 Transcription of Adcyap1 1 0.67 0.81 0.47
153 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
154 INT143682 Negative_regulation of Gene_expression of Ada 2 0.54 0.28 0.44
155 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
156 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
157 INT115876 Regulation of Gene_expression of Adcyap1 1 0.38 0.47 0.44
158 INT324888 Transcription of Ednra 2 0.13 0.66 0.43
159 INT56363 Regulation of Gene_expression of Ada 1 0.06 0.59 0.42
160 INT158057 Positive_regulation of Positive_regulation of EDNRA 2 0.15 0 0.41
161 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
162 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
163 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
164 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
165 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
166 INT72022 Positive_regulation of Localization of Ednra 2 0.32 0.07 0.3
167 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29
168 INT334747 Regulation of Binding of Ednra 1 0.06 0.05 0.28
169 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
170 INT190727 Negative_regulation of Positive_regulation of Adcyap1 1 0.27 0 0.25
171 INT69072 Positive_regulation of Negative_regulation of Adcyap1 1 0.50 0 0.25
172 INT54751 Localization of Cckbr 1 0.71 0 0.21
173 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
174 INT334746 Positive_regulation of Localization of Ednra 1 0.07 0 0.2
175 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
176 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
177 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
178 INT324881 Regulation of Transcription of Ednra 1 0.08 0.66 0.19
179 INT72023 Positive_regulation of Localization of EDNRA 1 0.02 0.07 0.18
180 INT72025 Negative_regulation of Localization of EDNRA 1 0.01 0.07 0.18
181 INT72020 Negative_regulation of Localization of Ednra 1 0.24 0.07 0.18
182 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17
183 INT284590 Regulation of Localization of Adcyap1 1 0.07 0 0.17
184 INT190732 Regulation of Positive_regulation of Adcyap1 1 0.33 0 0.13
185 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
186 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
187 INT70908 Transcription of EDNRA 1 0.08 0.33 0.12
188 INT70906 Negative_regulation of Transcription of EDNRA 1 0.05 0.33 0.12
189 INT116635 Positive_regulation of Localization of Adcyap1 1 0.70 0 0.11
190 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
191 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
192 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
193 INT273033 Regulation of Binding of Adcyap1 1 0.31 0.63 0.1
194 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
195 INT315377 Negative_regulation of Binding of Adcyap1 1 0.18 0.07 0.09
196 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
197 INT87511 Regulation of Regulation of Adcyap1 1 0.23 0.57 0.08
198 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
199 INT334742 Negative_regulation of Transcription of Ednra 1 0.06 0 0.08
200 INT334749 Positive_regulation of Transcription of Ednra 1 0.07 0 0.08
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