GO:0001822

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Name kidney development
Categary Process
Go Slim No
Go Link GO:0001822
Unique Molecular Interactions 2133
Total Molecular Interactions 2990
Total Single Events 26458
Pain Genes Associated 113

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for kidney development. They are ordered first by their pain relevance and then by number of times they were reported for kidney development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
2 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
3 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
4 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
5 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
6 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
7 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
8 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
9 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
10 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
11 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
12 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
13 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
14 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
15 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
16 INT322812 Binding of SLC12A1 and MOCOS 1 0.00 1.69 1.49
17 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
18 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
19 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
20 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
21 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
22 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
23 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
24 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
25 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
26 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
27 INT274948 Binding of Dh and Ltp 1 0.11 0.55 1.23
28 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
29 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
30 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
31 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
32 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
33 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
34 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
35 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
36 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
37 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
38 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
39 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
40 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
41 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
42 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
43 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
44 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
45 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
46 INT71000 Positive_regulation of Adarb1 Positive_regulation of Odc1 1 0.01 0 1
47 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
48 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
49 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
50 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
51 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
52 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
53 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
54 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
55 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
56 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
57 INT153685 Binding of Bcl2l11 and Gtpbp4 1 0.08 0.76 0.93
58 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
59 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
60 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
61 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
62 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
63 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
64 INT56779 Pomc Negative_regulation of Gene_expression of Odc1 2 0.31 0 0.89
65 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
66 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
67 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
68 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
69 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
70 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
71 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
72 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
73 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
74 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
75 INT61052 Binding of Adarb1 and Negative_regulation of Gene_expression of Odc1 1 0.02 0 0.81
76 INT270217 Binding of C2 and Ca2 1 0.03 1.63 0.81
77 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
78 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
79 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
80 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
81 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
82 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
83 INT77526 Oprd1 Regulation of Positive_regulation of Odc1 1 0.01 0.12 0.78
84 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
85 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
86 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
87 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
88 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
89 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
90 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
91 INT61050 Oprd1 Positive_regulation of Odc1 1 0.25 0 0.74
92 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
93 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
94 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73
95 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
96 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
97 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
98 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
99 INT157063 SLC12A1 Negative_regulation of CALCRL 1 0.00 0.34 0.73
100 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
101 INT101675 Bcl2l11 Regulation of Localization of Ggh 1 0.03 0 0.72
102 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
103 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71
104 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
105 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
106 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
107 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
108 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
109 INT120036 VEGFA Positive_regulation of Prap1 1 0.00 1 0.7
110 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
111 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
112 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
113 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
114 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
115 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
116 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
117 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
118 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
119 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
120 INT167355 VEGFA Regulation of RYBP 1 0.01 0.53 0.68
121 INT168295 PROC Regulation of Gene_expression of VEGFA 2 0.00 1.6 0.67
122 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67
123 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
124 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
125 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
126 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
127 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
128 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
129 INT251165 Trpv1 Positive_regulation of Gene_expression of Ca2 1 0.15 0.54 0.65
130 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
131 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
132 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
133 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
134 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
135 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
136 INT77529 PDYN Positive_regulation of Odc1 1 0.02 0 0.63
137 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
138 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
139 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
140 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
141 INT50816 Penk Positive_regulation of Localization of Ca2 1 0.32 0 0.62
142 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
143 INT224731 Binding of VEGFA and Cia1 1 0.01 0.91 0.61
144 INT224733 Negative_regulation of Binding of VEGFA and Cia1 1 0.01 0.91 0.61
145 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
146 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
147 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
148 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
149 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6
150 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
151 INT70254 Binding of Htr1a and Ca2 1 0.31 0.5 0.6
152 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
153 INT240070 KCNIP3 Regulation of CA2 1 0.02 0.72 0.59
154 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
155 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
156 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
157 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
158 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58
159 INT304326 Ptger1 Positive_regulation of Gene_expression of VEGFA 1 0.19 1.37 0.57
160 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
161 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
162 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
163 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
164 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
165 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
166 INT61051 Pomc Negative_regulation of Odc1 1 0.22 0 0.54
167 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
168 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
169 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
170 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
171 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
172 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53
173 INT118138 Binding of Ca2 and Mgat4a 1 0.01 0 0.53
174 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
175 INT155898 Binding of KCNJ8 and MMD 1 0.09 0.39 0.53
176 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
177 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
178 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
179 INT330544 Bcl2l11 Negative_regulation of Prkcg 1 0.03 0.38 0.52
180 INT330553 Bcl2l11 Negative_regulation of Camk2a 1 0.01 0.38 0.52
181 INT330541 Bcl2l11 Negative_regulation of Negative_regulation of Prkcg 1 0.03 0.38 0.52
182 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52
183 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52
184 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
185 INT330545 Bcl2l11 Negative_regulation of Trib3 1 0.00 0.38 0.52
186 INT297479 Ryr2 Positive_regulation of Ca2 1 0.22 0 0.52
187 INT30028 Ins1 Regulation of Odc1 2 0.11 0 0.51
188 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
189 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
190 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51
191 INT37583 Naga Regulation of Odc1 1 0.20 0 0.51
192 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
193 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
194 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
195 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
196 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
197 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
198 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
199 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49
200 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49

Single Events

The table below shows the top 100 pain related interactions that have been reported for kidney development. They are ordered first by their pain relevance and then by number of times they were reported in kidney development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
2 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
3 INT4822 Localization of Ca2 417 0.80 99.57 96.45
4 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
5 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
6 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
7 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
8 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
9 INT46 Localization of Ren 233 0.81 46.15 62.44
10 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
11 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
12 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
13 INT654 Localization of REN 250 0.81 75.12 47.86
14 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
15 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
16 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
17 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
18 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
19 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
20 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
21 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
22 INT5489 Localization of CA2 172 0.80 39.46 33.56
23 INT1116 Regulation of Ren 103 0.62 27.66 33.26
24 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
25 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
26 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
27 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
28 INT1158 Regulation of Agt 106 0.61 29.4 30.29
29 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
30 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
31 INT2671 Positive_regulation of Odc1 82 0.70 11.03 29
32 INT2140 Regulation of REN 104 0.62 28.24 24.49
33 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
34 INT11829 Negative_regulation of Odc1 54 0.59 7.03 23.03
35 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
36 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
37 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
38 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
39 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
40 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
41 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
42 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
43 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
44 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
45 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
46 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
47 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
48 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
49 INT2066 Localization of Agt 56 0.80 9.95 16.25
50 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
51 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
52 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
53 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
54 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
55 INT3112 Regulation of Odc1 39 0.62 4.73 13.69
56 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
57 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
58 INT3962 Regulation of AGT 50 0.62 20.96 13.01
59 INT19799 Binding of Ca2 71 0.48 13.69 12.92
60 INT4199 Binding of Agt 76 0.48 21.06 12.66
61 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
62 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
63 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
64 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
65 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
66 INT398 Localization of AGT 45 0.78 16.97 11.54
67 INT661 Gene_expression of REN 100 0.78 48.21 11.36
68 INT8065 Binding of AGT 54 0.48 20.54 10.85
69 INT3535 Regulation of CA2 61 0.32 16.48 10.8
70 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
71 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
72 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
73 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
74 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
75 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
76 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
77 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
78 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
79 INT20664 Binding of ACE 60 0.48 35.27 9.16
80 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
81 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
82 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
83 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
84 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
85 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
86 INT65803 Gene_expression of Dh 10 0.32 1.24 8.07
87 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
88 INT25958 Regulation of Ace 26 0.59 11.88 7.87
89 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
90 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
91 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67
92 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
93 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
94 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
95 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
96 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
97 INT42038 Localization of ACE 26 0.80 8.88 7.06
98 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
99 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
100 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
101 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59
102 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
103 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
104 INT30025 Negative_regulation of Positive_regulation of Odc1 14 0.59 0.89 6.34
105 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
106 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
107 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
108 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
109 INT19110 Gene_expression of Odc1 19 0.78 4.51 6.11
110 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
111 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98
112 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
113 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
114 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
115 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
116 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
117 INT5490 Binding of CA2 52 0.36 9.73 5.53
118 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53
119 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
120 INT145929 Regulation of Bax 20 0.60 18.12 5.35
121 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
122 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
123 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
124 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
125 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
126 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06
127 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
128 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03
129 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
130 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
131 INT185877 Negative_regulation of Gene_expression of DCN 3 0.33 2.37 4.85
132 INT221226 Gene_expression of Kcnj8 23 0.58 1.69 4.84
133 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
134 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
135 INT58079 Localization of Tenc1 13 0.68 5.9 4.75
136 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
137 INT3097 Binding of Ren 12 0.48 3.15 4.4
138 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
139 INT26477 Regulation of ACE 26 0.45 16.31 4.33
140 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
141 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
142 INT387 Regulation of Ace 18 0.45 5.24 4.24
143 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
144 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
145 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17
146 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
147 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
148 INT71868 Regulation of Tenc1 9 0.52 10.73 4.09
149 INT123752 Regulation of Bax 19 0.60 16.45 4
150 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
151 INT112692 Localization of Bax 31 0.80 20.97 3.98
152 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
153 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
154 INT63121 Binding of APC 29 0.41 23.02 3.8
155 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
156 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
157 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
158 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
159 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
160 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
161 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25
162 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25
163 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22
164 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
165 INT30024 Regulation of Positive_regulation of Odc1 3 0.50 0.19 3.17
166 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
167 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
168 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
169 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
170 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
171 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
172 INT105884 Binding of Bcl2 19 0.35 15.67 3
173 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
174 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92
175 INT91520 Negative_regulation of Positive_regulation of CA2 7 0.30 0.99 2.92
176 INT322473 Localization of DCN 1 0.03 0.76 2.9
177 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
178 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
179 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
180 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
181 INT2042 Phosphorylation of Ca2 21 0.55 1.54 2.81
182 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
183 INT53755 Positive_regulation of Dcn 8 0.43 2.91 2.74
184 INT38632 Positive_regulation of Positive_regulation of Odc1 2 0.50 0.46 2.7
185 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69
186 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
187 INT93207 Negative_regulation of Cyp4a3 11 0.36 4.32 2.63
188 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
189 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
190 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
191 INT93562 Negative_regulation of Localization of CA2 15 0.59 1.87 2.51
192 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
193 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
194 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
195 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
196 INT210527 Positive_regulation of Gene_expression of Tenc1 14 0.38 6.37 2.45
197 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
198 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
199 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
200 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
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