GO:0001824

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Name blastocyst development
Categary Process
Go Slim No
Go Link GO:0001824
Unique Molecular Interactions 110
Total Molecular Interactions 142
Total Single Events 899
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for blastocyst development. They are ordered first by their pain relevance and then by number of times they were reported for blastocyst development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93
2 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
3 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
4 INT153039 Binding of G2e3 and LOC100360318 1 0.00 0 1.01
5 INT61698 G2e3 Regulation of Localization of Abat 1 0.05 0 0.88
6 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
7 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76
8 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76
9 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
10 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
11 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
12 INT31948 Spic Regulation of Localization of Prl 1 0.02 0 0.55
13 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
14 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
15 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
16 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
17 INT122502 TNF Positive_regulation of Localization of CAPN2 1 0.24 0.18 0.38
18 INT285935 IL6 Positive_regulation of Gene_expression of POU5F1 1 0.14 2.68 0.37
19 INT97043 Binding of G2e3 and Hist1h3g 1 0.01 0.5 0.36
20 INT936 Spic Positive_regulation of Localization of Prl 1 0.09 0 0.31
21 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
22 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
23 INT25015 Binding of Spic and Vip 1 0.02 0.19 0.26
24 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24
25 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
26 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
27 INT132680 HNF1A Positive_regulation of Gene_expression of UGT1A6 1 0.30 0.08 0.21
28 INT132679 HNF1A Regulation of Gene_expression of UGT1A6 1 0.16 0.08 0.21
29 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2
30 INT310498 Gene_expression of Neurog2 Positive_regulation of Positive_regulation of Eomes 1 0.20 0.42 0.19
31 INT86892 Glp2r Regulation of Gene_expression of Cdx2 1 0.38 0 0.17
32 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15
33 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
34 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
35 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
36 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
37 INT223539 Binding of HAND1 and Szf1 1 0.33 0.92 0.13
38 INT25016 Spic Regulation of Prl 1 0.01 0.09 0.12
39 INT325057 Binding of Hand1 and Ang 1 0.01 1.29 0.12
40 INT231134 Itbq1 Regulation of HAND1 1 0.00 0.18 0.1
41 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09
42 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
43 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
44 INT201621 Binding of Cdk11b and Uvbi1 1 0.02 0.36 0.08
45 INT201613 Uvbi1 Positive_regulation of Cdk11b 1 0.03 0.36 0.08
46 INT223536 Binding of HAND1 and Hmga1 1 0.26 0.57 0.07
47 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
48 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
49 INT282552 POU5F1 Positive_regulation of FGF4 1 0.29 0.29 0.05
50 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05
51 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
52 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05
53 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04
54 INT282555 POU5F1 Positive_regulation of Positive_regulation of MAPK1 1 0.11 0.28 0.04
55 INT282556 POU5F1 Positive_regulation of GOPC 1 0.06 0.06 0.04
56 INT285936 IL17A Positive_regulation of Gene_expression of POU5F1 1 0.10 0.34 0.04
57 INT282561 POU5F1 Positive_regulation of Gene_expression of NANOG 1 0.11 0.26 0.04
58 INT282543 KDM4C Regulation of POU5F1 1 0.06 0.08 0.03
59 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
60 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
61 INT282542 KDM3A Regulation of POU5F1 1 0.06 0.08 0.03
62 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
63 INT285406 ELF3 Positive_regulation of Binding of ROS1 1 0.08 0.9 0.03
64 INT282553 POU5F1 Positive_regulation of REXO1 1 0.21 0.1 0.03
65 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
66 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
67 INT285407 ELF3 Regulation of ICAM1 1 0.03 0.91 0.03
68 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
69 INT284095 HNF1A Positive_regulation of TIMP3 1 0.38 2.3 0
70 INT279241 Binding of ELF3 and GLA 1 0.20 0.53 0
71 INT164217 Binding of Cdx1 and Cdx2 1 0.36 0 0
72 INT219256 Binding of Ddx41 and G2e3 1 0.01 1.63 0
73 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
74 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
75 INT122501 TNF Positive_regulation of CAPN2 1 0.23 0.25 0
76 INT282559 NANOG Regulation of POU5F1 1 0.14 0.45 0
77 INT333842 Hnf1a Positive_regulation of Mir194-1 1 0.02 0.18 0
78 INT282554 Binding of POU5F1 and SOX2 1 0.19 0.1 0
79 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
80 INT244329 ELF3 Positive_regulation of Gene_expression of SH3GL3 1 0.27 0.66 0
81 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
82 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
83 INT234621 CDX2 Negative_regulation of IGFBP3 1 0.38 0.8 0
84 INT284098 HNF1A Positive_regulation of SLC2A1 1 0.36 1.16 0
85 INT282551 SOX2 Regulation of POU5F1 1 0.24 0.45 0
86 INT282541 SOX2 Regulation of Transcription of POU5F1 1 0.24 0.05 0
87 INT219257 Binding of Cd79a and G2e3 1 0.01 0.08 0
88 INT282558 POU5F1 Positive_regulation of MAPK1 1 0.16 0.26 0
89 INT282607 POU5F1 Positive_regulation of Mdk 1 0.08 0.26 0
90 INT285946 IL6 Regulation of POU5F1 1 0.05 0.12 0
91 INT271760 Binding of Psmb10 and Psmc3 1 0.00 0.29 0
92 INT234623 Binding of CDX2 and IGFBP3 1 0.32 1.71 0
93 INT319677 Binding of Elf3 and Gadd45gip1 1 0.13 0.17 0
94 INT279239 ELF3 Regulation of SH3GL3 1 0.11 0.44 0
95 INT282549 POU5F1 Regulation of Transcription of SOX2 1 0.32 0.05 0
96 INT164218 Regulation of Binding of Cdx1 and Cdx2 1 0.27 0 0
97 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
98 INT282539 POU5F1 Regulation of Gene_expression of NANOG 1 0.17 0 0
99 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0
100 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0
101 INT333978 Binding of ELF3 and TRAP 1 0.15 0.06 0
102 INT219254 Binding of Gopc and G2e3 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for blastocyst development. They are ordered first by their pain relevance and then by number of times they were reported in blastocyst development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60865 Gene_expression of G2e3 20 0.73 2.1 12.76
2 INT58775 Binding of G2e3 10 0.33 0.19 11.52
3 INT58774 Negative_regulation of G2e3 8 0.38 0.22 7.75
4 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34
5 INT50022 Positive_regulation of G2e3 10 0.42 0.47 3.72
6 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
7 INT931 Localization of Spic 6 0.18 0.08 2.54
8 INT60864 Regulation of G2e3 4 0.21 0.64 2.54
9 INT210058 Regulation of ELF3 11 0.29 7.93 2.51
10 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39
11 INT52785 Localization of G2e3 5 0.66 0.33 2.26
12 INT68829 Binding of ELF3 14 0.47 7.96 2
13 INT100563 Regulation of Binding of G2e3 1 0.24 0 1.79
14 INT104745 Positive_regulation of Binding of G2e3 1 0.05 0.07 1.77
15 INT122503 Localization of CAPN2 1 0.35 1.43 1.76
16 INT85955 Negative_regulation of Localization of G2e3 2 0.48 0.05 1.63
17 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56
18 INT10369 Positive_regulation of Spic 4 0.03 1.99 1.54
19 INT930 Regulation of Spic 2 0.38 0.53 1.52
20 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32
21 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
22 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13
23 INT325047 Gene_expression of Hand1 1 0.07 6.42 1.06
24 INT86889 Gene_expression of Cdx2 8 0.60 4.23 1.02
25 INT70248 Positive_regulation of Positive_regulation of G2e3 1 0.13 0.17 0.94
26 INT113121 Negative_regulation of Binding of G2e3 1 0.07 0 0.88
27 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
28 INT155150 Gene_expression of Spic 5 0.26 1.21 0.86
29 INT243018 Negative_regulation of Dcpp1 1 0.15 0.11 0.86
30 INT243016 Binding of Dcpp1 1 0.12 0.11 0.86
31 INT243014 Negative_regulation of Binding of Dcpp1 1 0.15 0.11 0.86
32 INT31946 Positive_regulation of Localization of Spic 2 0.11 0 0.84
33 INT128143 Negative_regulation of Gene_expression of G2e3 4 0.09 0 0.82
34 INT25014 Negative_regulation of Positive_regulation of Spic 2 0.02 0.08 0.81
35 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
36 INT282599 Regulation of Gene_expression of POU5F1 10 0.62 4.89 0.71
37 INT243020 Positive_regulation of Dcpp1 1 0.24 0.08 0.69
38 INT231131 Regulation of HAND1 5 0.27 1.81 0.63
39 INT325055 Binding of Hand1 1 0.04 2.15 0.58
40 INT143958 Negative_regulation of Gene_expression of Cdx2 1 0.13 0.1 0.58
41 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
42 INT234260 Regulation of Regulation of ELF3 1 0.17 1.01 0.52
43 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49
44 INT243019 Gene_expression of Dcpp1 1 0.23 0 0.48
45 INT230634 Negative_regulation of POU5F1 10 0.43 1.03 0.46
46 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45
47 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
48 INT122508 Positive_regulation of Localization of CAPN2 1 0.23 0.18 0.38
49 INT122509 Regulation of Localization of CAPN2 1 0.12 0.28 0.37
50 INT122505 Regulation of CAPN2 1 0.20 0.28 0.37
51 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
52 INT122507 Negative_regulation of Localization of CAPN2 1 0.21 0.4 0.34
53 INT271762 Binding of HAND1 3 0.10 3.66 0.31
54 INT190032 Negative_regulation of Cdx2 2 0.38 0.74 0.3
55 INT122506 Gene_expression of CAPN2 1 0.26 0.19 0.29
56 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
57 INT325048 Positive_regulation of Gene_expression of Hand1 1 0.05 1.16 0.28
58 INT282571 Negative_regulation of Positive_regulation of POU5F1 1 0.38 0 0.28
59 INT190010 Transcription of Cdx2 1 0.53 0.69 0.26
60 INT156595 Gene_expression of CDX2 10 0.69 7.8 0.25
61 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25
62 INT164210 Gene_expression of Cdx2 3 0.56 2.22 0.25
63 INT20301 Positive_regulation of Binding of Hnf1a 1 0.02 0 0.21
64 INT20302 Binding of Hnf1a 1 0.02 0 0.2
65 INT310483 Positive_regulation of Eomes 2 0.38 0.85 0.19
66 INT310478 Positive_regulation of Transcription of Eomes 1 0.23 0.42 0.19
67 INT310466 Positive_regulation of Positive_regulation of Eomes 1 0.23 0.42 0.19
68 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
69 INT244330 Localization of ELF3 8 0.56 2.71 0.18
70 INT128141 Positive_regulation of Gene_expression of G2e3 4 0.07 0 0.18
71 INT170390 Transcription of Eomes 2 0.31 0.51 0.18
72 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16
73 INT310481 Regulation of Eomes 1 0.28 0.1 0.15
74 INT153448 Regulation of Gene_expression of G2e3 1 0.07 0 0.15
75 INT299806 Transcription of Spic 1 0.12 0.29 0.15
76 INT245116 Regulation of Gene_expression of ELF3 3 0.41 1.36 0.14
77 INT25013 Binding of Spic 2 0.09 0.09 0.13
78 INT249107 Positive_regulation of HNF1A 1 0.49 0.2 0.13
79 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
80 INT325045 Negative_regulation of Hand1 1 0.04 1.26 0.12
81 INT278790 Binding of POU5F1 8 0.43 0.67 0.11
82 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
83 INT278785 Positive_regulation of Binding of POU5F1 2 0.45 0.19 0.07
84 INT210255 Positive_regulation of Negative_regulation of Cdx2 1 0.33 0 0.07
85 INT86888 Regulation of Gene_expression of Cdx2 1 0.48 0 0.07
86 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06
87 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
88 INT216377 Transcription of POU5F1 9 0.69 0.58 0.05
89 INT282603 Positive_regulation of Positive_regulation of POU5F1 1 0.45 0 0.05
90 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04
91 INT325051 Regulation of Hand1 1 0.04 1.87 0.04
92 INT231130 Positive_regulation of Positive_regulation of HAND1 1 0.30 0 0.04
93 INT170377 Gene_expression of Eomes 2 0.42 0.37 0.03
94 INT282944 Negative_regulation of Negative_regulation of POU5F1 1 0.11 0 0.03
95 INT231132 Negative_regulation of Gene_expression of HAND1 1 0.25 0 0.03
96 INT336415 Positive_regulation of Gene_expression of Eomes 1 0.38 0.17 0.03
97 INT282605 Regulation of POU5F1 4 0.55 0.4 0
98 INT282585 Localization of POU5F1 3 0.67 0.08 0
99 INT162522 Positive_regulation of Localization of G2e3 3 0.17 0.19 0
100 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0
101 INT285409 Positive_regulation of Positive_regulation of ELF3 2 0.27 1.21 0
102 INT265316 Binding of Tgfbr1 2 0.35 0.59 0
103 INT265326 Regulation of Tgfbr1 2 0.43 0.17 0
104 INT245179 Localization of HAND1 1 0.19 1.09 0
105 INT336412 Negative_regulation of Gene_expression of Eomes 1 0.23 0.11 0
106 INT278808 Regulation of Binding of POU5F1 1 0.01 0 0
107 INT240923 Regulation of Hnf1a 1 0.19 0.48 0
108 INT315214 Negative_regulation of Regulation of Tgfbr1 1 0.41 0 0
109 INT211662 Positive_regulation of Elf3 1 0.49 0.27 0
110 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0
111 INT309646 Negative_regulation of Transcription of POU5F1 1 0.43 0 0
112 INT219250 Binding of G2e3 1 0.01 0.51 0
113 INT185018 Positive_regulation of CDX2 1 0.62 0.36 0
114 INT318092 Gene_expression of Psmc3 1 0.04 0.84 0
115 INT198405 Binding of CDX2 1 0.32 1.01 0
116 INT219246 Gene_expression of G2e3 1 0.02 1.76 0
117 INT272228 Localization of TGFBR1 1 0.34 0.74 0
118 INT150487 Positive_regulation of CAPN2 1 0.13 0.09 0
119 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
120 INT294842 Positive_regulation of Negative_regulation of POU5F1 1 0.41 0.49 0
121 INT265319 Positive_regulation of Negative_regulation of Tgfbr1 1 0.47 0.53 0
122 INT219966 Phosphorylation of CDX2 1 0.71 0.63 0
123 INT164203 Binding of Cdx2 1 0.33 0 0
124 INT144920 Positive_regulation of Gene_expression of TGFBR1 1 0.65 0 0
125 INT164202 Regulation of Cdx2 1 0.25 0 0
126 INT184983 Negative_regulation of Gene_expression of CDX2 1 0.52 0.71 0
127 INT319635 Binding of Elf3 1 0.09 0.17 0
128 INT219245 Regulation of G2e3 1 0.01 0.37 0
129 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
130 INT150482 Positive_regulation of Positive_regulation of CAPN2 1 0.13 0.09 0
131 INT219251 Positive_regulation of G2e3 1 0.01 0.14 0
132 INT310176 Localization of Tgfbr1 1 0.11 0.83 0
133 INT336413 Negative_regulation of Eomes 1 0.32 0.11 0
134 INT310179 Positive_regulation of Positive_regulation of Tgfbr1 1 0.08 0 0
135 INT284880 Binding of Eomes 1 0.03 0 0
136 INT205577 Positive_regulation of Gene_expression of Hnf1a 1 0.49 1.1 0
137 INT164215 Positive_regulation of Gene_expression of Cdx2 1 0.43 0 0
138 INT211650 Gene_expression of Elf3 1 0.54 0.22 0
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