GO:0001841

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Name neural tube formation
Categary Process
Go Slim No
Go Link GO:0001841
Unique Molecular Interactions 129
Total Molecular Interactions 170
Total Single Events 711
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neural tube formation. They are ordered first by their pain relevance and then by number of times they were reported for neural tube formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
2 INT250085 Coq7 Positive_regulation of Ltp 1 0.00 0.52 1
3 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
4 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
5 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
6 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58
7 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
8 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
9 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
10 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
11 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
12 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
13 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
14 INT163863 Binding of MIB1 and Vim 1 0.02 1.06 0.21
15 INT163864 Binding of MIB1 and Ema 1 0.04 1.07 0.21
16 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
17 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
18 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
19 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
20 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
21 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18
22 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15
23 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
24 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
25 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
26 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
27 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
28 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
29 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
30 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
31 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
32 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
33 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08
34 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
35 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
36 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
37 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
38 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
39 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
40 INT251565 Binding of Casp8 and Fadd 1 0.04 1.18 0.04
41 INT251570 Binding of Casp8 and Faf1 1 0.01 1.18 0.04
42 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
43 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
44 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
45 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
46 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
47 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
48 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
49 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0
50 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0
51 INT261123 Tnfsf10 Positive_regulation of Casp8 1 0.04 1 0
52 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
53 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
54 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
55 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
56 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
57 INT352995 IPMK Regulation of PDGFA 1 0.00 0.66 0
58 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
59 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
60 INT268520 MIR19B1 Regulation of CASP8 1 0.14 1 0
61 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
62 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
63 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
64 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
65 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0
66 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
67 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0
68 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
69 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
70 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
71 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
72 INT270657 Casp8 Regulation of Localization of Ins1 1 0.03 0.68 0
73 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
74 INT352994 IPMK Regulation of VEGFA 1 0.00 0.66 0
75 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
76 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
77 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
78 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
79 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
80 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
81 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
82 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
83 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
84 INT342854 Binding of Casp8 and Mapk1 1 0.05 2.18 0
85 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
86 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0
87 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
88 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
89 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
90 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
91 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
92 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
93 INT104536 Binding of Bcl2 and MIB1 1 0.00 1.61 0
94 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
95 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
96 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
97 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
98 INT237923 CFLAR Positive_regulation of Localization of CASP8 1 0.02 1.54 0
99 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
100 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
101 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
102 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
103 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
104 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
105 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
106 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
107 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
108 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
109 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0
110 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
111 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
112 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
113 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
114 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
115 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
116 INT342852 Binding of Casp8 and Dedd2 1 0.01 1.12 0
117 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
118 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
119 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0
120 INT283711 Sox11 Regulation of 4930579C15Rik 1 0.28 0.74 0
121 INT122482 Negative_regulation of CASP3 Negative_regulation of Positive_regulation of CASP8 1 0.14 1.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neural tube formation. They are ordered first by their pain relevance and then by number of times they were reported in neural tube formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
2 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
3 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
4 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
5 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
6 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
7 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
8 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
9 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
10 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
11 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
12 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
13 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
14 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
15 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
16 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03
17 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
18 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
19 INT156875 Positive_regulation of Gene_expression of Casp8 2 0.49 2.49 0.7
20 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
21 INT80025 Positive_regulation of MIB1 5 0.40 5.41 0.64
22 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
23 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
24 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
25 INT206484 Localization of Shh 2 0.75 1.14 0.46
26 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
27 INT67098 Regulation of MIB1 3 0.24 4.23 0.42
28 INT142872 Regulation of Casp8 6 0.29 3.11 0.39
29 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
30 INT283698 Gene_expression of Sox11 1 0.68 4.6 0.33
31 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
32 INT176260 Binding of CASP8 5 0.36 2.73 0.27
33 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
34 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
35 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26
36 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
37 INT222841 Phosphorylation of Map3k7 1 0.16 0.55 0.25
38 INT65739 Gene_expression of Map3k7 1 0.54 1.41 0.25
39 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
40 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
41 INT115160 Gene_expression of CITED2 1 0.04 0.45 0.2
42 INT115153 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
43 INT116193 Protein_catabolism of Casp8 5 0.17 4.37 0.17
44 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
45 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
46 INT253190 Localization of Shh 2 0.77 1.06 0.13
47 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
48 INT89118 Protein_catabolism of MIB1 1 0.26 1.18 0.12
49 INT164637 Binding of MIB1 3 0.32 4.29 0.11
50 INT164638 Positive_regulation of Binding of MIB1 1 0.43 1.18 0.11
51 INT347994 Positive_regulation of Gene_expression of Map3k7 1 0.26 1.27 0.11
52 INT347985 Gene_expression of Map3k7 1 0.35 1.26 0.11
53 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
54 INT185901 Localization of CASP8 7 0.55 5.38 0.09
55 INT199848 Binding of Casp8 3 0.15 3.29 0.09
56 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
57 INT270442 Transcription of Shh 1 0.53 0.25 0.09
58 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
59 INT213515 Binding of Shh 8 0.37 1.92 0.08
60 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
61 INT283695 Binding of Sox11 1 0.32 0.18 0.08
62 INT270453 Regulation of Shh 1 0.27 0.83 0.08
63 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
64 INT205973 Binding of SHH 3 0.35 1.03 0.07
65 INT190543 Localization of Map3k7 1 0.33 0.74 0.07
66 INT256862 Regulation of Shh 1 0.25 0 0.07
67 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
68 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
69 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
70 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
71 INT283696 Localization of Sox11 1 0.65 0.37 0.05
72 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
73 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
74 INT336053 Regulation of Positive_regulation of CASP8 2 0.04 1.44 0.04
75 INT256923 Regulation of Gene_expression of Casp8 2 0.11 2.31 0.04
76 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
77 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
78 INT199851 Positive_regulation of Protein_catabolism of Casp8 1 0.07 1.04 0.04
79 INT181792 Positive_regulation of Gene_expression of MIB1 3 0.27 3.3 0.03
80 INT292858 Localization of Casp8 2 0.27 1.68 0.03
81 INT289614 Positive_regulation of CITED2 1 0.37 0.41 0.03
82 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
83 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
84 INT253181 Transcription of Shh 1 0.68 0.54 0.03
85 INT237978 Negative_regulation of Negative_regulation of CASP8 1 0.07 1.65 0.03
86 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0
87 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
88 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
89 INT265477 Positive_regulation of Gene_expression of CASP8 2 0.17 1.57 0
90 INT158132 Negative_regulation of IPMK 2 0.02 1.54 0
91 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0
92 INT203927 Positive_regulation of Localization of CASP8 2 0.08 1.98 0
93 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
94 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0
95 INT266482 Phosphorylation of Map3k7 1 0.18 0.26 0
96 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
97 INT283699 Positive_regulation of Sox11 1 0.35 0.62 0
98 INT322579 Positive_regulation of Binding of CASP8 1 0.09 0.25 0
99 INT260089 Localization of PTCH1 1 0.70 0.37 0
100 INT313601 Regulation of CITED2 1 0.00 0.8 0
101 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
102 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
103 INT347996 Binding of Map3k7 1 0.19 0.06 0
104 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
105 INT290929 Binding of Shh 1 0.31 0.1 0
106 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
107 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
108 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
109 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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