GO:0001843

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Name neural tube closure
Categary Process
Go Slim No
Go Link GO:0001843
Unique Molecular Interactions 472
Total Molecular Interactions 647
Total Single Events 3418
Pain Genes Associated 52

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neural tube closure. They are ordered first by their pain relevance and then by number of times they were reported for neural tube closure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
2 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
3 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
4 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
5 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
6 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 0.02 0 1.59
7 INT276687 Pax3 Positive_regulation of Nkx1-1 1 0.00 0.59 1.47
8 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
9 INT121802 DEAF1 Negative_regulation of HTR1A 1 0.46 0.88 1.29
10 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
11 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
12 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19
13 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
14 INT48809 Pax3 Negative_regulation of Binding of Tac1 1 0.22 0 1.16
15 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
16 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
17 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
18 INT117908 Em Regulation of Localization of Pax3 1 0.00 0.07 1.03
19 INT49164 Binding of Pax3 and Nka1 1 0.01 0.37 1.01
20 INT49162 Nka1 Negative_regulation of Binding of Pax3 1 0.02 0.37 1.01
21 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
22 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
23 INT4916 Binding of Pax3 and Wdyhv1 1 0.00 0 0.98
24 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
25 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
26 INT107951 Pax3 Positive_regulation of Tac1 1 0.11 1.21 0.95
27 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92
28 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91
29 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
30 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89
31 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
32 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
33 INT185329 Pax3 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.00 0.22 0.87
34 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86
35 INT189018 Nka1 Regulation of Pax3 1 0.01 0.1 0.81
36 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
37 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76
38 INT294908 Pax3 Positive_regulation of Gene_expression of Il1 1 0.03 0.45 0.76
39 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76
40 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
41 INT294906 Binding of Pax3 and Tac4 1 0.01 1.15 0.71
42 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
43 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
44 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
45 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
46 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
47 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
48 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
49 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
50 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
51 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
52 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67
53 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
54 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
55 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65
56 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
57 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
58 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
59 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58
60 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
61 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
62 INT145431 Pax3 Positive_regulation of Positive_regulation of Ros1 1 0.02 0.07 0.57
63 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
64 INT108441 Adm Positive_regulation of Sst 1 0.40 0 0.54
65 INT346146 ADM Positive_regulation of Gene_expression of PERP 1 0.02 1.54 0.51
66 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
67 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
68 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
69 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
70 INT126336 Negative_regulation of Binding of Pax3 and Tac1 1 0.01 0.66 0.49
71 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
72 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
73 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
74 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
75 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
76 INT108440 Adm Regulation of Localization of Sst 1 0.41 0 0.45
77 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
78 INT126337 Pax3 Positive_regulation of Gene_expression of Ifng 1 0.05 0.56 0.44
79 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44
80 INT126340 Pax3 Regulation of Gene_expression of Ifng 1 0.03 0.56 0.44
81 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43
82 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
83 INT294910 Pax3 Regulation of Positive_regulation of Il1 1 0.02 2.03 0.42
84 INT48038 Adm Regulation of Calca 1 0.31 0.14 0.42
85 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41
86 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
87 INT346148 Binding of ADM and VTN 1 0.15 0.93 0.39
88 INT346150 Binding of ADM and FN1 1 0.10 0.93 0.39
89 INT346140 Positive_regulation of Binding of ADM and MMRN1 1 0.04 0.93 0.39
90 INT346139 Binding of ADM and MMRN1 1 0.03 0.93 0.39
91 INT346135 Positive_regulation of Binding of ADM and FN1 1 0.13 0.93 0.39
92 INT346142 Positive_regulation of Binding of ADM and VTN 1 0.20 0.93 0.39
93 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
94 INT113992 Binding of HRH1 and LIAS 1 0.00 0.09 0.38
95 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
96 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
97 INT15104 Binding of Pax3 and Penk 1 0.01 0 0.37
98 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
99 INT346145 Binding of ADM and TPX2 1 0.01 1.05 0.35
100 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
101 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
102 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
103 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
104 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
105 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
106 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
107 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
108 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
109 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3
110 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
111 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
112 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
113 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
114 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
115 INT208940 Pax3 Positive_regulation of Tacr1 1 0.07 0.55 0.29
116 INT208944 Pax3 Positive_regulation of Localization of Nfkb1 1 0.03 0.55 0.29
117 INT208941 Positive_regulation of Pax3 Positive_regulation of Tacr1 1 0.05 0.55 0.29
118 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
119 INT78780 Binding of Calca and Adm 1 0.32 0.07 0.26
120 INT78781 Binding of Adm and Calca 1 0.01 0.07 0.26
121 INT294905 Binding of Hgf and Pax3 1 0.01 1.54 0.25
122 INT294912 Binding of Pax3 and Tacr3 1 0.01 1.54 0.25
123 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
124 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
125 INT85011 ADM Regulation of CALCRL 1 0.06 0 0.24
126 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
127 INT287098 Binding of FL and T 1 0.10 0.66 0.23
128 INT346134 ADM Regulation of Gene_expression of MMRN1 1 0.04 1.29 0.23
129 INT78782 Binding of Adm and Adm 1 0.01 0.07 0.23
130 INT346143 ADM Regulation of Gene_expression of TPX2 1 0.02 1.29 0.23
131 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
132 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22
133 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
134 INT333298 Zic2 Regulation of Transcription of Slc6a4 1 0.44 0.09 0.2
135 INT76865 Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
136 INT294904 Binding of Pax3 and Slc12a3 1 0.02 1.9 0.2
137 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
138 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
139 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
140 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
141 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
142 INT231622 Pax3 Positive_regulation of Il17a 1 0.03 1.01 0.19
143 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
144 INT172254 Binding of ADM and TAS2R14 1 0.02 0 0.17
145 INT333299 Zic2 Regulation of Transcription of Ephb1 1 0.50 0.09 0.17
146 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
147 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
148 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
149 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
150 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
151 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16
152 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
153 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
154 INT172245 Binding of ADM and NCOR2 1 0.01 0 0.15
155 INT120552 Y-27632 Negative_regulation of Rock2 1 0.02 0.15 0.15
156 INT172236 Binding of ADM and APLNR 1 0.06 0 0.14
157 INT105913 Adm Negative_regulation of Adm 1 0.01 0 0.14
158 INT72029 Binding of ADM and IAPP 1 0.12 0.26 0.13
159 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
160 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
161 INT337676 Binding of TIMP1 and Scrib 1 0.01 1.24 0.13
162 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
163 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
164 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
165 INT253328 Binding of IL8 and Scrib 1 0.04 0.79 0.12
166 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
167 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
168 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
169 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
170 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
171 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
172 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
173 INT206856 Binding of Adm and Calcrl 1 0.04 1.76 0.1
174 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
175 INT179343 Adm Positive_regulation of Pscs 1 0.33 0.51 0.1
176 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
177 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
178 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
179 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
180 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
181 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
182 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
183 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
184 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
185 INT333308 Zic2 Positive_regulation of Transcription of Gtf3a 1 0.01 0.1 0.08
186 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
187 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
188 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
189 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
190 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08
191 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
192 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
193 INT346136 ADM Positive_regulation of ICAM1 1 0.20 0.92 0.08
194 INT100127 ADM Positive_regulation of PRL 1 0.28 0.51 0.08
195 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
196 INT346147 ADM Positive_regulation of Gene_expression of VCAM1 1 0.19 0.91 0.08
197 INT231835 Binding of Akt1 and Grlf1 1 0.01 0.35 0.07
198 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
199 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
200 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for neural tube closure. They are ordered first by their pain relevance and then by number of times they were reported in neural tube closure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8534 Localization of Pax3 85 0.59 28.71 82.82
2 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47
3 INT4913 Binding of Pax3 52 0.28 9.57 42.67
4 INT6584 Negative_regulation of Pax3 31 0.39 14.64 27.97
5 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
6 INT28336 Positive_regulation of Pax3 37 0.33 20.94 25.66
7 INT70557 Negative_regulation of Localization of Pax3 1 0.36 1.15 17.32
8 INT70556 Positive_regulation of Localization of Pax3 9 0.34 3.13 12.11
9 INT121223 Positive_regulation of Gene_expression of Pax3 17 0.16 4.52 12.06
10 INT70555 Regulation of Pax3 13 0.35 3.62 12.05
11 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
12 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21
13 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
14 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
15 INT118782 Protein_catabolism of Pax3 7 0.94 0.46 6.95
16 INT4911 Negative_regulation of Binding of Pax3 7 0.22 1.89 6.17
17 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13
18 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
19 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
20 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92
21 INT204449 Gene_expression of T 17 0.32 9.77 4.77
22 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22
23 INT76815 Regulation of Gene_expression of Pax3 4 0.12 3.81 3.65
24 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58
25 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
26 INT170438 Negative_regulation of Gene_expression of Pax3 4 0.04 1.03 3.42
27 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
28 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
29 INT116540 Binding of Twist1 35 0.48 16.32 2.85
30 INT212394 Gene_expression of Zic2 44 0.78 2.88 2.82
31 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81
32 INT76875 Positive_regulation of Adm 12 0.58 3.36 2.72
33 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66
34 INT48807 Regulation of Binding of Pax3 2 0.13 0 2.59
35 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
36 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53
37 INT121224 Positive_regulation of Positive_regulation of Pax3 5 0.14 2.32 2.4
38 INT70558 Regulation of Localization of Pax3 1 0.20 0.07 2.29
39 INT250727 Negative_regulation of ADM 3 0.38 8.32 2.26
40 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
41 INT141968 Positive_regulation of ADM 12 0.65 11.19 2
42 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
43 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
44 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
45 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
46 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
47 INT102449 Binding of ADM 12 0.33 5.85 1.73
48 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
49 INT213959 Transcription of Pax3 2 0.03 0.68 1.54
50 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
51 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
52 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
53 INT118988 Negative_regulation of Adm 3 0.10 1.05 1.41
54 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39
55 INT10873 Localization of Twist1 21 0.74 10.43 1.37
56 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
57 INT214073 Binding of TSC1 9 0.37 22 1.34
58 INT102228 Localization of Adm 9 0.69 1.58 1.34
59 INT169743 Regulation of Positive_regulation of Adm 1 0.37 0.38 1.32
60 INT189015 Negative_regulation of Positive_regulation of Pax3 1 0.12 0.31 1.31
61 INT252389 Negative_regulation of Gene_expression of ADM 2 0.38 4.78 1.3
62 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
63 INT48037 Regulation of Adm 8 0.44 3.96 1.24
64 INT170442 Positive_regulation of Binding of Pax3 2 0.17 2.05 1.24
65 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
66 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
67 INT141969 Positive_regulation of Gene_expression of ADM 4 0.57 4.07 1.2
68 INT118779 Positive_regulation of Protein_catabolism of Pax3 1 0.47 0.05 1.2
69 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
70 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
71 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
72 INT81757 Regulation of Gene_expression of Adm 6 0.44 2.86 1.16
73 INT141179 Negative_regulation of Apaf1 2 0.41 1.53 1.14
74 INT141181 Negative_regulation of Transcription of Apaf1 1 0.40 1.42 1.14
75 INT141182 Transcription of Apaf1 1 0.68 1.41 1.14
76 INT150838 Positive_regulation of Gene_expression of Adm 4 0.06 1.98 1.11
77 INT146553 Positive_regulation of Rock2 4 0.44 2.56 1.09
78 INT208427 Regulation of T 3 0.25 3.28 1.08
79 INT136044 Gene_expression of Rock2 7 0.78 0.19 1.06
80 INT108347 Regulation of Adm 5 0.26 2.55 1.04
81 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
82 INT179583 Gene_expression of Lmo4 5 0.41 1.97 1.03
83 INT190031 Binding of Scrib 19 0.36 21.9 1.01
84 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
85 INT73465 Transcription of TSC1 4 0.07 3.47 0.96
86 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
87 INT83109 Binding of LIAS 4 0.28 0 0.93
88 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
89 INT225094 Localization of ADM 5 0.63 3.89 0.91
90 INT118783 Negative_regulation of Protein_catabolism of Pax3 1 0.35 0.09 0.89
91 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
92 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
93 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
94 INT15247 Negative_regulation of Negative_regulation of Pax3 1 0.16 0 0.86
95 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
96 INT118987 Localization of Adm 4 0.50 0.34 0.84
97 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
98 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
99 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
100 INT287094 Transcription of T 1 0.29 1.41 0.8
101 INT74019 Regulation of TSC1 27 0.35 23.61 0.79
102 INT259113 Gene_expression of LMO4 1 0.78 71.49 0.76
103 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
104 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
105 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
106 INT226411 Binding of T 2 0.15 1.56 0.68
107 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
108 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
109 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
110 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
111 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
112 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
113 INT116247 Positive_regulation of Localization of Adm 1 0.04 0.17 0.62
114 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
115 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
116 INT163857 Gene_expression of Dlc1 1 0.03 0.17 0.6
117 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
118 INT167608 Regulation of Rock2 2 0.33 2.47 0.59
119 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
120 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
121 INT74101 Negative_regulation of Adm 3 0.06 1.2 0.53
122 INT136043 Negative_regulation of Gene_expression of Rock2 1 0.43 0 0.53
123 INT126628 Positive_regulation of Rock2 4 0.70 3.56 0.52
124 INT346181 Regulation of Gene_expression of ADM 1 0.35 1.67 0.52
125 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
126 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
127 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47
128 INT116387 Binding of Adm 6 0.47 1 0.46
129 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45
130 INT214067 Regulation of Scrib 11 0.20 12.48 0.45
131 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
132 INT170437 Regulation of Positive_regulation of Pax3 1 0.03 0 0.45
133 INT226985 Gene_expression of Lias 1 0.09 1.37 0.45
134 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
135 INT71561 Positive_regulation of Gene_expression of Adm 4 0.61 2.67 0.43
136 INT207726 Regulation of ADM 4 0.40 2.14 0.42
137 INT85854 Binding of SALL1 5 0.36 1.4 0.41
138 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
139 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
140 INT148091 Phosphorylation of Vasp 2 0.21 0.72 0.41
141 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
142 INT326554 Regulation of Zic2 3 0.39 2.02 0.39
143 INT346173 Negative_regulation of Positive_regulation of ADM 1 0.38 1.02 0.39
144 INT190017 Localization of Scrib 6 0.10 7 0.38
145 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
146 INT94933 Positive_regulation of Gene_expression of Bcl10 1 0.01 1.74 0.38
147 INT333281 Localization of Zic2 1 0.75 0 0.37
148 INT108326 Positive_regulation of Gene_expression of Scrib 5 0.26 9.02 0.36
149 INT217464 Binding of Traf6 5 0.29 1.28 0.35
150 INT30049 Gene_expression of Bcl10 4 0.51 2.36 0.35
151 INT150839 Regulation of Gene_expression of Adm 1 0.04 0.89 0.35
152 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
153 INT143687 Positive_regulation of Dlc1 1 0.01 0.46 0.34
154 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
155 INT126627 Gene_expression of Rock2 9 0.60 3.33 0.32
156 INT184803 Localization of TSC1 5 0.37 6.13 0.32
157 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
158 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
159 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
160 INT267831 Negative_regulation of Positive_regulation of Scrib 1 0.04 1.56 0.31
161 INT286753 Negative_regulation of Positive_regulation of Apaf1 1 0.09 2.82 0.31
162 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3
163 INT309354 Regulation of Pax2 1 0.10 0 0.29
164 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
165 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
166 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
167 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26
168 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
169 INT179581 Negative_regulation of Gene_expression of Lmo4 1 0.18 0.06 0.26
170 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26
171 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
172 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
173 INT102450 Positive_regulation of Binding of ADM 1 0.29 0 0.24
174 INT122601 Transcription of Adm 1 0.29 0.73 0.24
175 INT147486 Negative_regulation of Positive_regulation of Rock2 1 0.06 1.67 0.24
176 INT122603 Positive_regulation of Transcription of Adm 1 0.26 0.74 0.24
177 INT181665 Localization of Apaf1 2 0.49 1.67 0.23
178 INT150837 Positive_regulation of Regulation of Adm 1 0.06 0.64 0.23
179 INT259120 Regulation of Gene_expression of LMO4 1 0.45 5.61 0.23
180 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
181 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
182 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21
183 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
184 INT102227 Protein_catabolism of Adm 1 0.30 0 0.21
185 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
186 INT159956 Phosphorylation of Rock2 3 0.79 1.57 0.2
187 INT115160 Gene_expression of CITED2 1 0.04 0.45 0.2
188 INT115153 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
189 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
190 INT243929 Binding of Vasp 2 0.47 2.27 0.19
191 INT267829 Regulation of Gene_expression of Scrib 2 0.20 5.89 0.19
192 INT267830 Regulation of Negative_regulation of Scrib 1 0.04 0.95 0.19
193 INT263407 Binding of Rock2 1 0.02 0 0.18
194 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
195 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
196 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
197 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
198 INT226983 Localization of Lias 1 0.11 0.3 0.17
199 INT226982 Regulation of Lias 1 0.04 0.3 0.17
200 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
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