GO:0001944

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Name vasculature development
Categary Process
Go Slim No
Go Link GO:0001944
Unique Molecular Interactions 593
Total Molecular Interactions 930
Total Single Events 11490
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vasculature development. They are ordered first by their pain relevance and then by number of times they were reported for vasculature development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
3 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
4 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
5 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
6 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
7 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
8 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
9 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
10 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
11 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
12 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
13 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
14 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
15 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
16 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
17 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
18 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
19 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
20 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
21 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
22 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
23 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
24 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
25 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
26 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
27 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
28 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
29 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
30 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
31 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
32 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
33 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
34 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
35 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
36 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
37 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
38 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
39 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
40 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
41 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
42 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
43 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
44 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
45 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
46 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
47 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
48 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
49 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
50 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
51 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
52 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
53 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
54 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
55 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
56 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
57 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
58 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
59 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
60 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
61 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
62 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
63 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
64 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
65 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
66 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
67 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
68 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
69 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
70 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
71 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
72 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
73 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
74 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
75 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
76 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
77 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
78 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
79 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
80 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
81 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
82 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
83 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
84 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
85 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
86 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
87 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
88 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
89 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
90 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
91 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
92 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
93 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
94 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
95 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
96 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
97 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
98 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
99 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
100 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
101 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
102 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
103 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
104 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
105 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
106 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
107 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
108 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
109 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
110 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
111 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
112 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
113 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
114 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
115 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
116 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
117 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
118 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
119 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
120 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
121 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
122 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
123 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
124 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
125 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
126 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
127 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
128 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
129 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
130 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
131 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
132 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
133 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
134 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
135 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
136 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
137 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
138 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
139 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
140 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
141 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94
142 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93
143 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
144 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
145 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
146 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88
147 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
148 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
149 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
150 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
151 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85
152 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
153 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
154 INT342991 HCL1 Positive_regulation of CALCA 1 0.03 0.71 0.84
155 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 0.11 0 0.83
156 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
157 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83
158 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
159 INT103178 Mastl Positive_regulation of Localization of Calca 1 0.13 0.36 0.81
160 INT87494 CALCA Positive_regulation of IL8 1 0.48 0.15 0.81
161 INT86150 Inhba Positive_regulation of Gene_expression of Calca 1 0.09 0.61 0.81
162 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
163 INT87492 CALCA Regulation of IL8 1 0.28 0.15 0.81
164 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
165 INT109142 Calca Positive_regulation of Transcription of Creb1 1 0.47 0.13 0.8
166 INT118010 Binding of CALCA and CD177 1 0.06 0.6 0.8
167 INT131646 Ngf Positive_regulation of Localization of Calca 1 0.21 0.35 0.8
168 INT180782 Bdnf Positive_regulation of Calca 1 0.16 0.77 0.8
169 INT86151 Olr1745 Positive_regulation of Gene_expression of Calca 1 0.51 0.6 0.8
170 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
171 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
172 INT111361 Cnr1 Negative_regulation of Localization of Calca 1 0.01 0 0.78
173 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
174 INT96783 Positive_regulation of Binding of CALCA and Calca 1 0.29 0.17 0.77
175 INT224283 Bdnf Regulation of Gene_expression of Calca 1 0.19 0.35 0.76
176 INT87493 Binding of CALCA and Positive_regulation of Gene_expression of IL8 1 0.52 0.18 0.76
177 INT109141 Calca Positive_regulation of Creb1 1 0.47 0.13 0.76
178 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76
179 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
180 INT109143 Calca Positive_regulation of Phosphorylation of Creb1 1 0.47 0.13 0.76
181 INT125626 Binding of Calca and Atp8a2 1 0.00 0.4 0.76
182 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76
183 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
184 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
185 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75
186 INT147620 Gpi Positive_regulation of Localization of Calca 1 0.10 0 0.75
187 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
188 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
189 INT63874 Calca Positive_regulation of SRPX 1 0.01 0.17 0.74
190 INT142507 Binding of Calca and Ramp1 1 0.31 0.48 0.73
191 INT145592 Vamp1 Positive_regulation of Calca 1 0.01 0.28 0.73
192 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
193 INT180769 Calca Regulation of Binding of Ngf 1 0.40 0.15 0.72
194 INT180765 Calca Regulation of Binding of Bdnf 1 0.15 0.15 0.72
195 INT68211 Binding of Calca and Chat 1 0.37 0 0.71
196 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
197 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7
198 INT159386 Positive_regulation of TRPV1 Positive_regulation of Localization of Calca 1 0.05 0.44 0.69
199 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
200 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68

Single Events

The table below shows the top 100 pain related interactions that have been reported for vasculature development. They are ordered first by their pain relevance and then by number of times they were reported in vasculature development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT626 Localization of CALCA 289 0.81 125.39 221.15
9 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
10 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
11 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
12 INT2541 Binding of Calca 200 0.48 67.14 134.62
13 INT5008 Localization of Calca 204 0.81 80.35 125.16
14 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
15 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
16 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
17 INT6761 Binding of CALCA 100 0.48 26.71 62.05
18 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
19 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
20 INT4891 Transcription of Calca 81 0.72 35.27 53.75
21 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
22 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
23 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
24 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
25 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
26 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
27 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
28 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
29 INT22499 Regulation of Calca 42 0.62 17.32 28.02
30 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
31 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
32 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
33 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
34 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
35 INT26217 Binding of Calca 22 0.48 5.22 12.57
36 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
37 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
38 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
39 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
40 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
41 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
42 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
43 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
44 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
45 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
46 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
47 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
48 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
49 INT86982 Transcription of Calca 9 0.69 2.98 5.74
50 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
51 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
52 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
53 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29
54 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
55 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
56 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
57 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
58 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
59 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
60 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
61 INT118835 Positive_regulation of Vegfa 18 0.59 11.2 3.91
62 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
63 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
64 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
65 INT137609 Localization of Vegfa 22 0.78 14.67 3.01
66 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
67 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
68 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
69 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85
70 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
71 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
72 INT57354 Positive_regulation of Positive_regulation of Calca 3 0.60 1.42 2.78
73 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74
74 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
75 INT43719 Positive_regulation of Vegfa 21 0.69 5.15 2.64
76 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53
77 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
78 INT123528 Negative_regulation of Gene_expression of Vegfa 10 0.57 7.08 2.31
79 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28
80 INT58752 Positive_regulation of Binding of CALCA 3 0.49 0.73 2.09
81 INT152902 Positive_regulation of Transcription of CALCA 5 0.66 0.99 2.07
82 INT105247 Positive_regulation of Gene_expression of Vegfa 12 0.67 12.07 2.05
83 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
84 INT54986 Negative_regulation of Positive_regulation of Calca 2 0.43 0.93 2.02
85 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
86 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94
87 INT24291 Positive_regulation of Negative_regulation of CALCA 3 0.61 0.67 1.91
88 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
89 INT117003 Binding of Sfpi1 5 0.47 5.04 1.74
90 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
91 INT316162 Localization of TCF21 1 0.18 0.28 1.71
92 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7
93 INT12442 Localization of Vegfa 11 0.73 4.85 1.68
94 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
95 INT241566 Negative_regulation of Negative_regulation of Calca 1 0.03 0.72 1.63
96 INT105248 Negative_regulation of Vegfa 8 0.47 6.19 1.61
97 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
98 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
99 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
100 INT48300 Regulation of Binding of Calca 2 0.39 0.73 1.49
101 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
102 INT52250 Positive_regulation of Regulation of CALCA 1 0.48 0.08 1.43
103 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39
104 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
105 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37
106 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
107 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
108 INT36588 Protein_catabolism of Calca 7 0.87 1.98 1.31
109 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
110 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
111 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18
112 INT188376 Negative_regulation of Gene_expression of Vegfa 5 0.30 5.29 1.18
113 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
114 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
115 INT332771 Phosphorylation of Tcf21 1 0.09 0.21 1.07
116 INT332772 Positive_regulation of Phosphorylation of Tcf21 1 0.06 0.21 1.07
117 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
118 INT95719 Negative_regulation of Phosphorylation of Calca 1 0.41 0.09 1.02
119 INT95718 Positive_regulation of Phosphorylation of Calca 1 0.49 0.09 1.01
120 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1
121 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
122 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92
123 INT102677 Negative_regulation of TCF21 2 0.41 0.22 0.89
124 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
125 INT54985 Positive_regulation of Regulation of Calca 2 0.47 0.33 0.86
126 INT97673 Protein_catabolism of Calca 1 0.50 0.15 0.82
127 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
128 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
129 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
130 INT12443 Regulation of Localization of Vegfa 2 0.20 0 0.72
131 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72
132 INT198330 Gene_expression of Sox18 1 0.18 0.18 0.67
133 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
134 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
135 INT340625 Protein_catabolism of Vegfa 1 0.05 1.61 0.64
136 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
137 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
138 INT72911 Positive_regulation of Negative_regulation of Calca 1 0.43 0.07 0.63
139 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
140 INT113042 Localization of IHH 1 0.70 0.77 0.61
141 INT289655 Regulation of Flt4 1 0.29 0.63 0.6
142 INT281366 Regulation of Tcf21 1 0.09 0.23 0.59
143 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56
144 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
145 INT316161 Negative_regulation of Gene_expression of TCF21 1 0.10 0.11 0.56
146 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54
147 INT59481 Negative_regulation of Negative_regulation of CALCA 2 0.43 0.08 0.54
148 INT172964 Binding of Vegfa 14 0.47 10.62 0.53
149 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
150 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
151 INT253108 Phosphorylation of Stk11 4 0.65 2.13 0.52
152 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52
153 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
154 INT105677 Binding of Vegfa 7 0.37 5.22 0.51
155 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51
156 INT130801 Localization of SFRP4 4 0.28 2.41 0.49
157 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
158 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
159 INT206484 Localization of Shh 2 0.75 1.14 0.46
160 INT186593 Gene_expression of SFRP5 1 0.16 3.94 0.46
161 INT201856 Regulation of SFRP4 1 0.00 1.4 0.46
162 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
163 INT222229 Localization of Tcf21 1 0.57 0.45 0.45
164 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
165 INT268877 Regulation of Gene_expression of Vegfa 2 0.58 4.73 0.42
166 INT152023 Regulation of Vegfa 4 0.52 3.99 0.41
167 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
168 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
169 INT43720 Regulation of Positive_regulation of Vegfa 1 0.03 0.41 0.41
170 INT43722 Positive_regulation of Regulation of Vegfa 1 0.06 0.41 0.41
171 INT129849 Positive_regulation of Localization of Vegfa 1 0.46 0.35 0.39
172 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
173 INT181025 Localization of Sfpi1 3 0.80 4.96 0.38
174 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37
175 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
176 INT150081 Gene_expression of Ccm2 4 0.77 1.56 0.36
177 INT242545 Regulation of Regulation of Calca 1 0.15 0 0.36
178 INT233109 Regulation of Positive_regulation of CALCA 1 0.30 0.23 0.36
179 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
180 INT351970 Gene_expression of Stk11 1 0.75 33.89 0.35
181 INT84555 Negative_regulation of Spi1 6 0.42 0.71 0.34
182 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
183 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
184 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
185 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
186 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
187 INT181020 Positive_regulation of Gene_expression of Sfpi1 2 0.67 1.11 0.31
188 INT201843 Negative_regulation of SFRP4 1 0.01 0.63 0.31
189 INT181051 Transcription of Sfpi1 1 0.62 1.1 0.29
190 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
191 INT196006 Regulation of FLT4 2 0.25 2.24 0.27
192 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
193 INT224619 Regulation of Positive_regulation of Vegfa 1 0.05 0.57 0.27
194 INT224638 Positive_regulation of Positive_regulation of Vegfa 1 0.06 0.57 0.27
195 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
196 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
197 INT109537 Transcription of Vegfa 2 0.44 1.32 0.26
198 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
199 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
200 INT150085 Binding of Ccm2 7 0.39 0.85 0.25
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