GO:0001945

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Name lymph vessel development
Categary Process
Go Slim No
Go Link GO:0001945
Unique Molecular Interactions 117
Total Molecular Interactions 230
Total Single Events 1005
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lymph vessel development. They are ordered first by their pain relevance and then by number of times they were reported for lymph vessel development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
2 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
3 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
4 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
5 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
6 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
7 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
8 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
9 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66
10 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
11 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
12 INT249536 Binding of EPHA1 and Efnb2 1 0.02 0.28 0.52
13 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5
14 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
15 INT337156 Kdr Positive_regulation of Gtf3a 1 0.01 0.77 0.35
16 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
17 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
18 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
19 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
20 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27
21 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
22 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
23 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
24 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
25 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
26 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
27 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
28 INT96791 NR2F2 Positive_regulation of GDF15 1 0.23 0.14 0.14
29 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12
30 INT337155 Binding of Kdr and Ros1 1 0.06 0.46 0.12
31 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12
32 INT337159 Binding of ecs and Kdr 1 0.04 0.46 0.12
33 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12
34 INT249495 Binding of Grin2b and Efnb2 1 0.02 0.05 0.11
35 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
36 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
37 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09
38 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08
39 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
40 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07
41 INT292811 Zfp787 Negative_regulation of Phosphorylation of Kdr 1 0.01 0.45 0.06
42 INT298699 Kdr Regulation of Tek 1 0.11 0.28 0.06
43 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05
44 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05
45 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
46 INT345371 Binding of Flt4 and Kdr 1 0.10 1.12 0.05
47 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
48 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
49 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04
50 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
51 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
52 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04
53 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
54 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03
55 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03
56 INT343476 Epo Positive_regulation of Kdr 1 0.11 0.31 0.03
57 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03
58 INT343474 Epo Positive_regulation of Gene_expression of Kdr 1 0.11 0.32 0.03
59 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0
60 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
61 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0
62 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0
63 INT290592 Binding of KDR and Cdh5 1 0.07 0.08 0
64 INT312330 Binding of Kdr and Flt1 1 0.12 0.37 0
65 INT265562 Gla Positive_regulation of Gene_expression of Kdr 1 0.05 0.51 0
66 INT300447 Kdr Regulation of VEGFA 1 0.07 0.25 0
67 INT292082 MIR1200 Negative_regulation of KDR 1 0.00 1.24 0
68 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
69 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
70 INT345375 VEGFA Positive_regulation of Gene_expression of Kdr 1 0.02 1.2 0
71 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
72 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
73 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
74 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
75 INT324662 Negative_regulation of Kdr Positive_regulation of Vash1 1 0.51 0.55 0
76 INT265563 Gla Positive_regulation of Transcription of Kdr 1 0.04 0.51 0
77 INT322850 Binding of KDR and PDCD10 1 0.14 0 0
78 INT300437 Kdr Regulation of Gene_expression of Flt1 1 0.42 0.26 0
79 INT345374 VEGFA Positive_regulation of Flt4 1 0.01 2.95 0
80 INT300443 VEGFA Positive_regulation of Phosphorylation of Kdr 1 0.08 0.64 0
81 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
82 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0
83 INT278372 Binding of Syk and Pycard 1 0.06 0 0
84 INT298702 Tek Regulation of Kdr 1 0.03 0.33 0
85 INT300438 Efna1 Negative_regulation of Phosphorylation of Kdr 1 0.42 0.66 0
86 INT300436 Flt1 Negative_regulation of Kdr 1 0.35 0.4 0
87 INT353125 Negative_regulation of Binding of VEGFA and Kdr 1 0.04 5.92 0
88 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
89 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
90 INT205614 Gm6668 Negative_regulation of Kdr 1 0.01 1.5 0
91 INT198012 KDR Negative_regulation of VEGFA 1 0.08 0.93 0
92 INT345372 Col18a1 Positive_regulation of Kdr 1 0.20 1.42 0
93 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0
94 INT198000 Gene_expression of KDR Negative_regulation of VEGFA 1 0.08 0.94 0
95 INT278405 Tlr4 Positive_regulation of Syk 1 0.06 0 0
96 INT265770 Binding of KDR and GOPC 1 0.10 0 0
97 INT326729 Foxc1 Positive_regulation of Gene_expression of Ehf 1 0.23 0.26 0
98 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0
99 INT278392 Syk Regulation of Positive_regulation of Ctsb 1 0.06 0 0
100 INT198010 KDR Negative_regulation of MTOR 1 0.11 0.95 0
101 INT278396 Msu Positive_regulation of Phosphorylation of Syk 1 0.25 0.27 0
102 INT198002 KDR Negative_regulation of PDGFA 1 0.09 0.94 0
103 INT213745 Binding of Kdr and Epc1 1 0.17 0 0
104 INT154173 Binding of SIPA1 and SYK 1 0.16 0.46 0
105 INT298700 Kdr Regulation of Manea 1 0.01 0.33 0
106 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0
107 INT331701 Fgf4 Positive_regulation of Gene_expression of Kdr 1 0.11 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lymph vessel development. They are ordered first by their pain relevance and then by number of times they were reported in lymph vessel development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT256282 Gene_expression of Efnb2 3 0.76 17.61 16.41
2 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
3 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
4 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
5 INT346828 Regulation of Efnb2 1 0.61 8.57 3.81
6 INT346826 Positive_regulation of Gene_expression of Efnb2 1 0.46 3.88 3.71
7 INT346829 Negative_regulation of Efnb2 1 0.42 5.08 2.94
8 INT145187 Gene_expression of Efnb2 4 0.22 3.43 2.92
9 INT193319 Positive_regulation of Efnb2 2 0.49 2.1 2.47
10 INT346831 Regulation of Gene_expression of Efnb2 1 0.44 2.83 2.47
11 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29
12 INT346834 Phosphorylation of Efnb2 1 0.62 1.54 2.19
13 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
14 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94
15 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
16 INT162725 Binding of Kdr 13 0.42 8.86 1.79
17 INT145184 Positive_regulation of Gene_expression of Efnb2 3 0.20 1.94 1.69
18 INT199567 Binding of Kdr 18 0.47 13.81 1.34
19 INT145183 Negative_regulation of Gene_expression of Efnb2 2 0.17 1.51 1.31
20 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
21 INT346832 Negative_regulation of Gene_expression of Efnb2 1 0.42 0.75 1.09
22 INT200556 Regulation of Kdr 8 0.28 6.04 1.01
23 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99
24 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
25 INT346827 Binding of Efnb2 1 0.37 1.56 0.91
26 INT249508 Phosphorylation of Efnb2 1 0.04 0.5 0.84
27 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
28 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
29 INT173100 Binding of KDR 39 0.39 22.48 0.81
30 INT297469 Regulation of Binding of Kdr 1 0.54 2.01 0.8
31 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77
32 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
33 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72
34 INT127684 Negative_regulation of Kdr 6 0.37 3.19 0.7
35 INT198330 Gene_expression of Sox18 1 0.18 0.18 0.67
36 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66
37 INT249518 Binding of Efnb2 1 0.02 0.59 0.63
38 INT289655 Regulation of Flt4 1 0.29 0.63 0.6
39 INT132324 Localization of SYK 2 0.78 1.9 0.59
40 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
41 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
42 INT346830 Localization of Efnb2 1 0.69 0.47 0.53
43 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52
44 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
45 INT249517 Positive_regulation of Phosphorylation of Efnb2 1 0.03 0.31 0.5
46 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
47 INT346833 Negative_regulation of Binding of Efnb2 1 0.42 0.6 0.45
48 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
49 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
50 INT292795 Regulation of Kdr 5 0.40 3.86 0.42
51 INT65606 Binding of TBX1 2 0.30 3.13 0.41
52 INT131773 Regulation of KDR 12 0.49 12.01 0.39
53 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
54 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37
55 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36
56 INT154175 Regulation of SYK 2 0.62 1.48 0.34
57 INT288109 Localization of Kdr 4 0.46 2.84 0.33
58 INT145190 Positive_regulation of Efnb2 2 0.20 0.18 0.32
59 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
60 INT173097 Localization of KDR 20 0.73 12.73 0.31
61 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31
62 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
63 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
64 INT249515 Regulation of Phosphorylation of Efnb2 1 0.01 0.2 0.29
65 INT247096 Binding of NR2F2 1 0.01 0.74 0.29
66 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
67 INT173091 Transcription of KDR 3 0.55 1.39 0.27
68 INT148798 Regulation of Phosphorylation of KDR 1 0.44 0 0.27
69 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
70 INT291184 Regulation of Gene_expression of Kdr 3 0.54 4.81 0.25
71 INT125027 Positive_regulation of Kdr 15 0.50 7.73 0.24
72 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
73 INT306427 Localization of TBX1 1 0.20 1.08 0.23
74 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
75 INT278154 Regulation of Syk 1 0.05 0.98 0.22
76 INT278147 Localization of Syk 1 0.30 0.98 0.22
77 INT200555 Negative_regulation of Gene_expression of Kdr 8 0.38 3.78 0.19
78 INT318204 Positive_regulation of Positive_regulation of KDR 2 0.14 0.68 0.19
79 INT309916 Negative_regulation of NR2F2 1 0.02 0.7 0.18
80 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
81 INT105269 Negative_regulation of Positive_regulation of KDR 2 0.41 1.35 0.15
82 INT297468 Transcription of Kdr 6 0.63 1.85 0.14
83 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
84 INT323422 Regulation of Regulation of Kdr 1 0.17 0.5 0.13
85 INT292809 Phosphorylation of Kdr 3 0.72 1.99 0.12
86 INT292807 Negative_regulation of Phosphorylation of Kdr 3 0.37 1.56 0.12
87 INT198328 Negative_regulation of Sox18 1 0.11 0 0.12
88 INT289653 Negative_regulation of Transcription of Flt4 1 0.20 0.62 0.12
89 INT289652 Transcription of Flt4 1 0.34 0.62 0.12
90 INT200557 Regulation of Gene_expression of Kdr 6 0.44 2.72 0.11
91 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
92 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
93 INT275411 Binding of Syk 1 0.09 0.12 0.1
94 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09
95 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09
96 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09
97 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09
98 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09
99 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08
100 INT198325 Binding of Sox18 1 0.09 0 0.08
101 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
102 INT200853 Negative_regulation of Binding of Kdr 2 0.11 0.93 0.06
103 INT179116 Localization of Kdr 1 0.58 4.65 0.06
104 INT189580 Positive_regulation of Gene_expression of KDR 9 0.49 5.9 0.05
105 INT198034 Positive_regulation of Localization of KDR 3 0.29 2.17 0.05
106 INT320783 Binding of Flt4 2 0.26 0.98 0.05
107 INT198332 Regulation of Sox18 1 0.11 0 0.05
108 INT278363 Binding of Syk 1 0.32 0.3 0.04
109 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
110 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
111 INT255669 Regulation of Positive_regulation of Kdr 1 0.08 1.1 0.03
112 INT199552 Phosphorylation of Kdr 4 0.38 1.27 0
113 INT265544 Transcription of Kdr 4 0.50 3.14 0
114 INT291191 Negative_regulation of Gene_expression of Kdr 4 0.24 4.46 0
115 INT265799 Regulation of Binding of KDR 2 0.38 0.64 0
116 INT248544 Transcription of Foxc1 2 0.67 0.48 0
117 INT300429 Negative_regulation of Transcription of Kdr 2 0.38 0.49 0
118 INT265783 Regulation of Localization of KDR 2 0.37 0.64 0
119 INT324642 Positive_regulation of Protein_catabolism of Kdr 1 0.61 0.64 0
120 INT302619 Regulation of Transcription of Kdr 1 0.32 0.47 0
121 INT154178 Binding of SYK 1 0.37 0.46 0
122 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
123 INT347528 Negative_regulation of Flt4 1 0.29 0.13 0
124 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
125 INT353123 Negative_regulation of Negative_regulation of Kdr 1 0.05 0.78 0
126 INT265779 Positive_regulation of Protein_catabolism of KDR 1 0.41 0.08 0
127 INT324652 Protein_catabolism of Kdr 1 0.87 0.64 0
128 INT198334 Localization of Sox18 1 0.17 0.2 0
129 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
130 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
131 INT300433 Positive_regulation of Phosphorylation of Kdr 1 0.61 1.1 0
132 INT314739 Transcription of TBX1 1 0.32 0.8 0
133 INT179106 Positive_regulation of Localization of Kdr 1 0.33 0.44 0
134 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
135 INT322861 Positive_regulation of Binding of KDR 1 0.13 0 0
136 INT198329 Negative_regulation of Gene_expression of Sox18 1 0.10 0 0
137 INT199564 Negative_regulation of Phosphorylation of Kdr 1 0.27 1.12 0
138 INT265808 Protein_catabolism of KDR 1 0.81 0.08 0
139 INT179113 Negative_regulation of Localization of Kdr 1 0.31 0.41 0
140 INT324653 Positive_regulation of Transcription of Kdr 1 0.41 0.64 0
141 INT278346 Positive_regulation of Negative_regulation of Syk 1 0.33 0 0
142 INT198326 Positive_regulation of Sox18 1 0.12 0 0
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