GO:0001955

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Name blood vessel maturation
Categary Process
Go Slim No
Go Link GO:0001955
Unique Molecular Interactions 126
Total Molecular Interactions 153
Total Single Events 1591
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for blood vessel maturation. They are ordered first by their pain relevance and then by number of times they were reported for blood vessel maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
2 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
3 INT187174 RPS3AP9 Negative_regulation of MMP2 1 0.00 0.9 1.22
4 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
5 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
6 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
7 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
8 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01
9 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01
10 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
11 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85
12 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85
13 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
14 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
15 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
16 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
17 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
18 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
19 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
20 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 0.16 0.16 0.66
21 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
22 INT99602 ZNF398 Negative_regulation of MMP2 1 0.14 0.85 0.63
23 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62
24 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
25 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
26 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
27 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58
28 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
29 INT345302 MMP15 Positive_regulation of MMP2 1 0.06 1.17 0.57
30 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56
31 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55
32 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53
33 INT150790 ZNF398 Positive_regulation of Localization of MMP2 1 0.04 0.51 0.53
34 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
35 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
36 INT150792 THBS3 Negative_regulation of MMP2 1 0.11 0.49 0.51
37 INT196527 Positive_regulation of Binding of MMP1 and MMP2 1 0.44 0.74 0.51
38 INT196520 Binding of MMP1 and MMP2 1 0.33 0.74 0.51
39 INT150921 ZNF398 Negative_regulation of Gene_expression of Mmp2 1 0.00 0.46 0.5
40 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
41 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
42 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
43 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47
44 INT138152 IL6 Positive_regulation of Transcription of Mmp2 1 0.00 0.23 0.46
45 INT138154 IL1B Positive_regulation of Transcription of Mmp2 1 0.04 0.23 0.46
46 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
47 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45
48 INT314050 THL Negative_regulation of Transcription of Mmp2 1 0.16 0.81 0.44
49 INT196348 PTGER2 Negative_regulation of Negative_regulation of MMP2 1 0.01 0.29 0.43
50 INT148548 Cd44 Positive_regulation of Regulation of NPEPPS 1 0.00 0.29 0.42
51 INT314042 THL Negative_regulation of Gene_expression of Mmp2 1 0.19 2.97 0.42
52 INT148547 Cd44 Positive_regulation of NPEPPS 1 0.00 0.29 0.41
53 INT179851 Il11 Positive_regulation of Mmp2 1 0.04 0 0.38
54 INT342622 Binding of MMP14 and Mmp2 1 0.39 1.15 0.37
55 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
56 INT342617 Binding of Col18a1 and Mmp2 1 0.11 1.15 0.37
57 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
58 INT99603 ZNF398 Regulation of Transcription of MMP2 1 0.15 0.44 0.33
59 INT99598 ZNF398 Negative_regulation of Gene_expression of MMP2 1 0.10 0.44 0.33
60 INT340615 COL4A4 Regulation of MMP2 1 0.11 0.95 0.32
61 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31
62 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
63 INT99601 ZNF398 Negative_regulation of Transcription of MMP2 1 0.10 0.41 0.3
64 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28
65 INT148223 CXCL14 Regulation of Localization of Mmp2 1 0.01 0.71 0.26
66 INT244687 Mmp14 Positive_regulation of Mmp2 1 0.23 0.48 0.25
67 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
68 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
69 INT225118 Foxm1 Positive_regulation of Gene_expression of MMP2 1 0.01 0.34 0.23
70 INT163403 VEGFA Positive_regulation of MMP2 1 0.52 0.13 0.23
71 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2
72 INT304279 ETS1 Positive_regulation of MMP2 1 0.05 1.83 0.17
73 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17
74 INT304282 ETS1 Positive_regulation of Gene_expression of MMP2 1 0.05 1.83 0.17
75 INT267138 Binding of CDH5 and PECAM1 2 0.16 2.69 0.16
76 INT220531 Atf3 Negative_regulation of Gene_expression of Mmp2 1 0.02 1.09 0.16
77 INT301121 Tgm7 Regulation of Gene_expression of Mmp2 1 0.52 2.53 0.16
78 INT85274 SGCG Positive_regulation of Mmp2 1 0.09 0.46 0.16
79 INT220515 Il10 Negative_regulation of Gene_expression of Mmp2 1 0.01 1.1 0.16
80 INT245314 Binding of HYAL1 and MMP2 1 0.16 0.29 0.15
81 INT250908 Binding of Mmp2 and Tsp1 1 0.04 0.09 0.15
82 INT245312 Negative_regulation of Binding of HYAL1 and MMP2 1 0.19 0.29 0.15
83 INT250906 Binding of Mmp2 and Thbs2 1 0.06 0.09 0.15
84 INT34484 FPR1 Positive_regulation of Localization of MMP2 1 0.36 0.15 0.15
85 INT195443 MMP2 Positive_regulation of Protein_catabolism of Mmp9 1 0.15 0.95 0.14
86 INT314039 THL Negative_regulation of Binding of Mmp2 1 0.16 1.62 0.14
87 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14
88 INT250911 Thbs2 Regulation of Mmp2 1 0.05 0.3 0.13
89 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13
90 INT163404 Negative_regulation of VEGFA Positive_regulation of MMP2 1 0.48 0.07 0.12
91 INT343472 Epo Positive_regulation of Gene_expression of Mmp2 1 0.15 0.62 0.12
92 INT245313 Negative_regulation of Binding of MMP2 and TIMP1 1 0.01 0.45 0.11
93 INT264409 MMP2 Regulation of MMP3 1 0.07 0.06 0.11
94 INT264398 MMP9 Regulation of MMP2 1 0.07 0.06 0.11
95 INT264402 MMP2 Regulation of MMP14 1 0.10 0.06 0.11
96 INT264390 MMP3 Regulation of MMP2 1 0.07 0.06 0.11
97 INT183797 IL17A Positive_regulation of Positive_regulation of MMP2 1 0.03 0.24 0.1
98 INT294457 KLK4 Negative_regulation of MMP2 1 0.01 0 0.1
99 INT355584 VEGFA Positive_regulation of Positive_regulation of CDH5 1 0.06 1.35 0.09
100 INT205160 Binding of CD44 and MMP2 1 0.09 0.61 0.07
101 INT343480 Epo Positive_regulation of Mmp2 1 0.15 0.31 0.06
102 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05
103 INT275463 ZNF69 Negative_regulation of MMP2 1 0.01 0 0.05
104 INT265564 Ocln Regulation of Gene_expression of Cdh5 1 0.01 1.03 0.05
105 INT209157 MMP9 Negative_regulation of MMP2 1 0.00 0.16 0.05
106 INT66856 Rln1 Positive_regulation of Localization of Mmp2 1 0.30 0 0.05
107 INT209156 MMP2 Negative_regulation of TIMP1 1 0.00 0.17 0.05
108 INT275464 ZNF69 Negative_regulation of Gene_expression of MMP2 1 0.01 0 0.05
109 INT351423 Sparc Positive_regulation of Mmp2 1 0.02 1.31 0.04
110 INT301130 Binding of VEGFA and Mmp2 1 0.03 1.33 0.03
111 INT301126 Tgm7 Regulation of Localization of Mmp2 1 0.38 0.2 0.03
112 INT290592 Binding of KDR and Cdh5 1 0.07 0.08 0
113 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
114 INT335303 Binding of IRF6 and MMP2 1 0.01 0 0
115 INT67563 TNF Positive_regulation of Localization of MMP2 1 0.00 0 0
116 INT290590 Binding of Cdh5 and Prom1 1 0.05 0.08 0
117 INT171757 Binding of MMP2 and SLC7A5 1 0.03 0.29 0
118 INT335301 Binding of MMP2 and SLC15A4 1 0.00 0 0
119 INT327403 Bcl2 Positive_regulation of Localization of Mmp2 1 0.19 0.93 0
120 INT244688 Binding of Mmp16 and Mmp2 1 0.31 0.69 0
121 INT67561 TNF Positive_regulation of MMP2 1 0.00 0 0
122 INT335297 IRF6 Positive_regulation of Gene_expression of MMP2 1 0.01 0.07 0
123 INT67562 Negative_regulation of TNF Positive_regulation of MMP2 1 0.00 0.05 0
124 INT301123 Tgm7 Regulation of Positive_regulation of Mmp2 1 0.23 1.47 0
125 INT244689 Mmp16 Regulation of Mmp2 1 0.18 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for blood vessel maturation. They are ordered first by their pain relevance and then by number of times they were reported in blood vessel maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9
2 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
3 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71
4 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
5 INT34487 Localization of MMP2 56 0.81 31.41 23.61
6 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
7 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72
8 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
9 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16
10 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
11 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
12 INT34485 Negative_regulation of Localization of MMP2 17 0.50 9.96 10.49
13 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42
14 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
15 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
16 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79
17 INT108628 Regulation of MMP2 27 0.60 14.85 6.06
18 INT123551 Regulation of Mmp2 17 0.57 11.6 6
19 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55
20 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41
21 INT106813 Positive_regulation of RECK 1 0.69 2.39 5.38
22 INT90374 Positive_regulation of Positive_regulation of MMP2 14 0.50 10.12 5.08
23 INT29502 Localization of Mmp2 18 0.79 3.49 4.64
24 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48
25 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79
26 INT106817 Gene_expression of RECK 8 0.77 2.78 3.62
27 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99
28 INT106468 Regulation of Gene_expression of MMP2 11 0.50 3.53 2.77
29 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47
30 INT55736 Transcription of MMP2 11 0.68 5.78 2.28
31 INT180923 Negative_regulation of Localization of Mmp2 6 0.46 7.84 2.17
32 INT106814 Positive_regulation of Gene_expression of RECK 2 0.69 1.04 2.1
33 INT263046 Negative_regulation of Gene_expression of Mmp2 7 0.34 5.98 2.09
34 INT185829 Negative_regulation of Positive_regulation of MMP2 7 0.40 4.93 2.02
35 INT46332 Binding of Mmp2 10 0.34 5.63 2
36 INT14914 Regulation of Cdh5 5 0.52 4.59 1.85
37 INT91396 Positive_regulation of Negative_regulation of MMP2 3 0.33 0.97 1.8
38 INT152292 Regulation of Gene_expression of Mmp2 6 0.61 3.46 1.76
39 INT47889 Binding of MMP2 9 0.41 6.37 1.68
40 INT86294 Regulation of Gene_expression of Mmp2 3 0.60 1.12 1.62
41 INT133443 Transcription of Mmp2 8 0.69 2.48 1.61
42 INT34486 Regulation of Localization of MMP2 4 0.35 2.19 1.54
43 INT173716 Positive_regulation of Cd44 7 0.44 4.65 1.45
44 INT86292 Positive_regulation of Positive_regulation of Mmp2 4 0.46 3.09 1.4
45 INT109105 Positive_regulation of Protein_catabolism of MMP2 3 0.46 1.98 1.38
46 INT317979 Positive_regulation of Transcription of Mmp2 4 0.46 2.63 1.37
47 INT238074 Negative_regulation of Positive_regulation of Mmp2 4 0.34 1.79 1.31
48 INT123924 Positive_regulation of Gene_expression of Cd44 2 0.46 1.11 1.25
49 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23
50 INT135390 Binding of Cd44 3 0.45 1.91 1.09
51 INT96581 Negative_regulation of Negative_regulation of MMP2 4 0.57 3.1 1.04
52 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
53 INT106816 Negative_regulation of RECK 1 0.37 0.34 1.01
54 INT106812 Transcription of RECK 2 0.68 0.76 1
55 INT180925 Positive_regulation of Localization of Mmp2 4 0.54 3.21 0.95
56 INT29501 Positive_regulation of Localization of Mmp2 3 0.60 0.42 0.94
57 INT135392 Localization of Cd44 1 0.75 1.74 0.93
58 INT29500 Regulation of Localization of Mmp2 3 0.53 0.47 0.92
59 INT55738 Positive_regulation of Transcription of MMP2 3 0.65 1.79 0.92
60 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
61 INT152290 Regulation of Transcription of Mmp2 1 0.27 0.15 0.8
62 INT123773 Positive_regulation of Positive_regulation of Mmp2 2 0.17 1.83 0.75
63 INT265557 Protein_catabolism of Mmp2 3 0.55 3.15 0.73
64 INT266797 Negative_regulation of Negative_regulation of Mmp2 1 0.05 0.96 0.7
65 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69
66 INT283569 Protein_catabolism of Mmp2 5 0.77 3.25 0.56
67 INT244679 Binding of Mmp2 4 0.30 3.75 0.54
68 INT342614 Positive_regulation of Binding of Mmp2 1 0.46 0.6 0.54
69 INT108629 Negative_regulation of Regulation of MMP2 1 0.41 0.7 0.52
70 INT96580 Negative_regulation of Protein_catabolism of MMP2 2 0.55 0.6 0.51
71 INT166100 Phosphorylation of MMP2 1 0.32 0.56 0.51
72 INT145144 Positive_regulation of Negative_regulation of Mmp2 1 0.11 0.7 0.46
73 INT188173 Gene_expression of CDH5 14 0.49 3.17 0.44
74 INT244683 Regulation of Positive_regulation of Mmp2 2 0.36 0.78 0.43
75 INT339435 Binding of Cdh5 1 0.31 3.37 0.3
76 INT103070 Negative_regulation of Gene_expression of Cd44 1 0.38 0.43 0.29
77 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
78 INT29504 Negative_regulation of Localization of Mmp2 1 0.58 0.13 0.26
79 INT148219 Regulation of Localization of Mmp2 1 0.02 0.69 0.25
80 INT203080 Negative_regulation of Cd44 1 0.14 0.3 0.24
81 INT148791 Negative_regulation of Phosphorylation of Cdh5 2 0.07 0.97 0.22
82 INT148790 Phosphorylation of Cdh5 2 0.14 0.97 0.21
83 INT291081 Positive_regulation of Protein_catabolism of Mmp2 1 0.29 0.96 0.2
84 INT291083 Negative_regulation of Protein_catabolism of Mmp2 1 0.24 0.96 0.2
85 INT151968 Regulation of Gene_expression of RECK 1 0.52 0.3 0.2
86 INT182476 Positive_regulation of Gene_expression of Cdh5 5 0.40 1.65 0.17
87 INT151969 Regulation of RECK 1 0.52 0.52 0.17
88 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
89 INT275479 Negative_regulation of Transcription of MMP2 2 0.25 0.43 0.16
90 INT277989 Positive_regulation of CDH5 3 0.11 1.66 0.15
91 INT148792 Positive_regulation of Phosphorylation of Cdh5 1 0.08 0 0.14
92 INT266328 Positive_regulation of Cdh5 4 0.40 0.77 0.12
93 INT265543 Negative_regulation of Transcription of Mmp2 1 0.09 1.27 0.1
94 INT337690 Regulation of Protein_catabolism of MMP2 1 0.02 0.26 0.09
95 INT265553 Negative_regulation of Transcription of Mmp2 2 0.30 1.18 0.08
96 INT239985 Negative_regulation of Cdh5 2 0.27 0.47 0.08
97 INT339433 Localization of Cdh5 1 0.48 0.37 0.08
98 INT339438 Negative_regulation of Localization of Cdh5 1 0.27 0.37 0.08
99 INT188176 Positive_regulation of Gene_expression of CDH5 3 0.32 0.75 0.07
100 INT327398 Negative_regulation of Regulation of Mmp2 1 0.28 1.25 0.07
101 INT301115 Negative_regulation of Positive_regulation of Mmp2 3 0.38 3.04 0.06
102 INT239993 Negative_regulation of Gene_expression of Cdh5 3 0.31 0.76 0.04
103 INT265545 Regulation of Gene_expression of Cdh5 1 0.05 1.01 0.04
104 INT314241 Transcription of CDH5 1 0.31 0.07 0.04
105 INT226885 Regulation of Regulation of Mmp2 1 0.17 0.32 0.03
106 INT275481 Negative_regulation of Binding of MMP2 1 0.28 0.07 0.03
107 INT299521 Regulation of Cd44 1 0.12 0.36 0
108 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
109 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
110 INT232507 Regulation of CDH5 1 0.15 0.22 0
111 INT283562 Positive_regulation of Protein_catabolism of Mmp2 1 0.05 0.34 0
112 INT343454 Phosphorylation of Mmp2 1 0.19 0.1 0
113 INT342613 Negative_regulation of Binding of Mmp2 1 0.40 0.08 0
114 INT188174 Negative_regulation of Gene_expression of CDH5 1 0.27 0 0
115 INT165561 Negative_regulation of Negative_regulation of Mmp2 1 0.00 0.07 0
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