GO:0001958

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Name endochondral ossification
Categary Process
Go Slim No
Go Link GO:0001958
Unique Molecular Interactions 258
Total Molecular Interactions 316
Total Single Events 3386
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endochondral ossification. They are ordered first by their pain relevance and then by number of times they were reported for endochondral ossification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
2 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
3 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
4 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
5 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
6 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
7 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
8 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
9 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
10 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88
11 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
12 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
13 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
14 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72
15 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
16 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63
17 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
18 INT223934 HSPG2 Negative_regulation of Gene_expression of Cux1 1 0.03 0 0.53
19 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
20 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
21 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
22 INT261498 CBS Positive_regulation of DSE 1 0.00 0 0.5
23 INT88889 Binding of HSPG2 and CALCRL 1 0.00 0 0.48
24 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47
25 INT280188 Binding of Cbs and Trpv1 1 0.26 1.03 0.47
26 INT223936 HSPG2 Positive_regulation of Gene_expression of Cux1 1 0.03 0 0.46
27 INT223935 HSPG2 Positive_regulation of Cux1 1 0.03 0 0.45
28 INT343642 Adp Positive_regulation of Localization of Hspg2 1 0.01 0 0.44
29 INT343643 Adp Positive_regulation of Positive_regulation of Hspg2 1 0.01 0 0.43
30 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
31 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42
32 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
33 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39
34 INT261499 CBS Positive_regulation of CNR1 1 0.01 0.48 0.35
35 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
36 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
37 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
38 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32
39 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32
40 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
41 INT7417 Calca Positive_regulation of Localization of FGFR3 1 0.03 0.09 0.3
42 INT7405 CALCA Negative_regulation of FGFR3 1 0.00 0.1 0.3
43 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
44 INT7419 Calca Regulation of Localization of FGFR3 1 0.02 0.09 0.3
45 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
46 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
47 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
48 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
49 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
50 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
51 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
52 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
53 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
54 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
55 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
56 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
57 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
58 INT308084 Binding of HSPG2 and OXT 1 0.04 0.25 0.23
59 INT62090 CXCR1 Positive_regulation of HSPG2 1 0.54 0.18 0.23
60 INT221781 Camk4 Positive_regulation of Mef2d 1 0.28 0.14 0.22
61 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
62 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
63 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
64 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
65 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
66 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
67 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
68 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
69 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
70 INT111152 Pthlh Positive_regulation of Localization of Avp 1 0.53 0.26 0.18
71 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
72 INT193562 Nr1i3 Positive_regulation of Hspg2 1 0.00 0 0.17
73 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
74 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
75 INT315491 Hspg2 Negative_regulation of Gene_expression of Il4 1 0.04 0.22 0.17
76 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
77 INT107889 Binding of Pthlh and Pth1r 1 0.06 0 0.14
78 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
79 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
80 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
81 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
82 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
83 INT315492 Hspg2 Negative_regulation of Gene_expression of Il2 1 0.06 0.14 0.14
84 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
85 INT107892 Binding of Pthlh and PTH2 1 0.27 0 0.14
86 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
87 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
88 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
89 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
90 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
91 INT248259 Binding of HSPG2 and Gtf3a 1 0.00 0.33 0.12
92 INT354620 AR Positive_regulation of Hspg2 1 0.00 0 0.12
93 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
94 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
95 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
96 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
97 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1
98 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
99 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1
100 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
101 INT325654 Binding of Nab1 and Gopc 1 0.04 0.63 0.09
102 INT324583 Hspg2 Positive_regulation of Trpm5 1 0.19 0 0.09
103 INT315490 Hspg2 Negative_regulation of Il2 1 0.08 0 0.09
104 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
105 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09
106 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
107 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
108 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
109 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09
110 INT325653 Positive_regulation of Binding of Nab1 and Gopc 1 0.05 0.63 0.09
111 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09
112 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
113 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
114 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
115 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
116 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08
117 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
118 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
119 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
120 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
121 INT220537 HSPG2 Positive_regulation of NOSTRIN 1 0.04 0 0.05
122 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
123 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05
124 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
125 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
126 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
127 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
128 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
129 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
130 INT275125 Binding of HLA-DOA and HSPG2 1 0.01 1.42 0.04
131 INT346303 Binding of MR1 and Col2a1 1 0.00 0.09 0.04
132 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
133 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04
134 INT275124 Binding of HSPG2 and LTA 1 0.12 1.45 0.04
135 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
136 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04
137 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
138 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03
139 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
140 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
141 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
142 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03
143 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03
144 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
145 INT170329 Binding of Col4a1 and Col1a1 1 0.03 0.14 0.03
146 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
147 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
148 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
149 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
150 INT330484 Binding of Cxadr and Hspg2 1 0.18 0.52 0.03
151 INT170331 Binding of Col7a1 and Col1a1 1 0.00 0.14 0.03
152 INT249159 HSPG2 Positive_regulation of Gene_expression of ITPR3 2 0.01 0.06 0
153 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
154 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
155 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
156 INT243768 Egr2 Regulation of Gene_expression of Nab2 1 0.47 0.14 0
157 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
158 INT352756 Hspg2 Negative_regulation of Sms 1 0.21 0.08 0
159 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
160 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
161 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0
162 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
163 INT243767 Egr2 Regulation of Gene_expression of Nab1 1 0.63 0.14 0
164 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
165 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
166 INT195062 PTHLH Positive_regulation of Gene_expression of Pygm 1 0.00 0.67 0
167 INT180847 Binding of COL1A1 and NID2 1 0.05 0.91 0
168 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
169 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
170 INT240122 Nab2 Regulation of Egr1 1 0.09 0.59 0
171 INT343541 PTHLH Positive_regulation of GYPA 1 0.03 0.95 0
172 INT165506 HSPG2 Negative_regulation of Gene_expression of CYBB 1 0.03 0.06 0
173 INT256103 Serpina3k Negative_regulation of Positive_regulation of Hspg2 1 0.02 0.15 0
174 INT63391 SLTM Regulation of Gene_expression of Col2a1 1 0.00 0 0
175 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
176 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
177 INT243770 Egr1 Regulation of Nab2 1 0.28 0.09 0
178 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
179 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
180 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
181 INT195052 PTHLH Positive_regulation of Positive_regulation of CPOX 1 0.07 0.67 0
182 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0
183 INT212009 Binding of PRL and PTHLH 1 0.32 0.48 0
184 INT89477 PTHLH Negative_regulation of Gene_expression of TNFRSF11B 1 0.14 0.15 0
185 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
186 INT165511 Binding of HSPG2 and NOSTRIN 1 0.02 0.07 0
187 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
188 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
189 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
190 INT346524 Binding of PTHLH and PTH2R 1 0.10 0 0
191 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
192 INT343639 Grm1 Positive_regulation of Hspg2 1 0.00 0 0
193 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
194 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
195 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
196 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
197 INT97091 HSPG2 Regulation of PRKCA 1 0.04 0 0
198 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
199 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
200 INT165510 HSPG2 Negative_regulation of Gene_expression of NFKB1 1 0.01 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endochondral ossification. They are ordered first by their pain relevance and then by number of times they were reported in endochondral ossification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
2 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65
3 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
4 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32
5 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
6 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
7 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
8 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
9 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
10 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
11 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06
12 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
13 INT261511 Localization of CBS 1 0.02 5.06 7.27
14 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03
15 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
16 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
17 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
18 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
19 INT88784 Negative_regulation of stm 11 0.56 0.51 5.33
20 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95
21 INT17312 Binding of HSPG2 30 0.41 33.01 4.88
22 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
23 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
24 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53
25 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
26 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
27 INT98357 Binding of Gnas 11 0.41 1.87 4.35
28 INT107771 Localization of HSPG2 10 0.78 8.47 4.3
29 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
30 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
31 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
32 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
33 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
34 INT47678 Positive_regulation of Positive_regulation of HSPG2 7 0.49 3.94 3.56
35 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
36 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
37 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
38 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
39 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
40 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
41 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
42 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
43 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
44 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
45 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
46 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
47 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
48 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
49 INT151037 Gene_expression of Col10a1 13 0.68 4.47 2.64
50 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
51 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
52 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
53 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
54 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
55 INT7410 Positive_regulation of Localization of FGFR3 9 0.45 1.97 2.36
56 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
57 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23
58 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
59 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
60 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
61 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
62 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
63 INT88783 Positive_regulation of stm 4 0.39 0 1.98
64 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
65 INT120407 Positive_regulation of Localization of HSPG2 2 0.49 2.11 1.92
66 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
67 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
68 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
69 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
70 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
71 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
72 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
73 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
74 INT248253 Positive_regulation of Gene_expression of HSPG2 3 0.44 4.61 1.65
75 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
76 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
77 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
78 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
79 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
80 INT121347 Binding of GNAS 8 0.13 3.99 1.47
81 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
82 INT53735 Regulation of FGFR3 4 0.26 0.76 1.45
83 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
84 INT262545 Positive_regulation of Positive_regulation of Hspg2 4 0.49 1.39 1.41
85 INT145809 Gene_expression of stm 9 0.65 3.66 1.4
86 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
87 INT159378 Localization of Hspg2 6 0.80 0.9 1.35
88 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
89 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
90 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
91 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
92 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
93 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
94 INT34626 Binding of Cbs 2 0.37 3.27 1.27
95 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
96 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
97 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
98 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
99 INT144645 Localization of Cbs 2 0.64 1.02 1.22
100 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
101 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
102 INT81235 Regulation of Localization of FGFR3 2 0.26 0 1.12
103 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
104 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
105 INT120395 Regulation of HSPG2 4 0.26 5.96 1.03
106 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
107 INT4971 Regulation of Cbs 2 0.44 1.66 1
108 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
109 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
110 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
111 INT43484 Binding of Runx2 7 0.37 3.22 0.95
112 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
113 INT261514 Positive_regulation of Localization of CBS 1 0.01 0.67 0.91
114 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
115 INT235828 Binding of Hspg2 4 0.25 2.24 0.89
116 INT202190 Gene_expression of CBS 7 0.32 4.19 0.88
117 INT52215 Localization of Bmp6 1 0.73 0.37 0.88
118 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
119 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
120 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
121 INT151033 Positive_regulation of Gene_expression of Col10a1 2 0.26 1.06 0.86
122 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85
123 INT275075 Localization of stm 1 0.08 0.06 0.85
124 INT168089 Regulation of Localization of HSPG2 2 0.20 0.86 0.81
125 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
126 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
127 INT53734 Regulation of Positive_regulation of FGFR3 1 0.26 0 0.77
128 INT173506 Positive_regulation of Col2a1 4 0.20 3.42 0.76
129 INT215783 Localization of Gnas 1 0.12 1.64 0.76
130 INT211315 Binding of FGFR3 7 0.35 0.97 0.75
131 INT280194 Regulation of Gene_expression of Cbs 1 0.61 1.54 0.73
132 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7
133 INT272706 Negative_regulation of Localization of Hspg2 2 0.18 0 0.68
134 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
135 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66
136 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
137 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
138 INT39994 Positive_regulation of BMP6 1 0.50 0 0.63
139 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
140 INT39992 Positive_regulation of Negative_regulation of BMP6 1 0.47 0 0.62
141 INT261508 Negative_regulation of CBS 1 0.01 0.39 0.61
142 INT63389 Localization of Col2a1 7 0.68 1.95 0.6
143 INT39993 Regulation of BMP6 2 0.39 0.29 0.6
144 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
145 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
146 INT275074 Positive_regulation of Gene_expression of stm 1 0.05 0.17 0.56
147 INT82332 Regulation of stm 2 0.08 0 0.55
148 INT125583 Regulation of Positive_regulation of HSPG2 2 0.44 0.1 0.54
149 INT68092 Negative_regulation of Localization of COL1A1 1 0.48 0 0.53
150 INT354787 Regulation of Binding of HSPG2 1 0.23 1.63 0.53
151 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
152 INT235835 Negative_regulation of Gene_expression of Hspg2 3 0.15 1.26 0.52
153 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
154 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
155 INT32183 Positive_regulation of Negative_regulation of Col2a1 2 0.46 1.01 0.49
156 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49
157 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
158 INT75381 Positive_regulation of Negative_regulation of HSPG2 2 0.49 0.09 0.46
159 INT52214 Regulation of Gene_expression of Bmp6 1 0.37 0.19 0.46
160 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
161 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45
162 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
163 INT151034 Regulation of Gene_expression of Col10a1 1 0.17 0 0.43
164 INT343622 Positive_regulation of Localization of Hspg2 1 0.08 0 0.43
165 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
166 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
167 INT261515 Positive_regulation of CBS 2 0.47 2.63 0.41
168 INT300893 Protein_catabolism of HSPG2 1 0.27 1.1 0.41
169 INT320812 Positive_regulation of Localization of COL1A1 1 0.05 1.04 0.4
170 INT110258 Negative_regulation of PTHLH 6 0.56 5.42 0.39
171 INT140982 Negative_regulation of Gene_expression of Pthlh 1 0.30 0.39 0.39
172 INT88782 Positive_regulation of Negative_regulation of stm 1 0.15 0 0.39
173 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38
174 INT223932 Regulation of Negative_regulation of HSPG2 1 0.03 0.06 0.38
175 INT98870 Negative_regulation of Positive_regulation of HSPG2 2 0.41 0 0.37
176 INT218035 Positive_regulation of Positive_regulation of FGFR3 1 0.10 0 0.37
177 INT111345 Negative_regulation of Cbs 2 0.30 2.82 0.36
178 INT259859 Regulation of CBS 1 0.01 1.26 0.34
179 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34
180 INT182549 Regulation of Positive_regulation of Hspg2 1 0.07 0.2 0.34
181 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
182 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
183 INT54833 Positive_regulation of Col2a1 5 0.52 1.1 0.32
184 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
185 INT254811 Localization of Col1a1 3 0.29 1.39 0.3
186 INT82118 Positive_regulation of Pthlh 3 0.47 2.46 0.3
187 INT88899 Positive_regulation of Binding of HSPG2 1 0.01 0 0.3
188 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3
189 INT269370 Negative_regulation of Gene_expression of HSPG2 2 0.07 0.93 0.29
190 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
191 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
192 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
193 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27
194 INT259857 Regulation of Gene_expression of CBS 1 0.01 1.07 0.27
195 INT176464 Protein_catabolism of Col1a1 1 0.19 0.83 0.26
196 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
197 INT181524 Negative_regulation of Binding of Col2a1 1 0.13 1.05 0.25
198 INT271432 Positive_regulation of Regulation of Col1a1 1 0.10 0.61 0.24
199 INT76857 Transcription of HSPG2 6 0.60 5.07 0.23
200 INT108902 Localization of GNAS 5 0.13 1.31 0.23
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