GO:0001965

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Name G-protein alpha-subunit binding
Categary Function
Go Slim No
Go Link GO:0001965
Unique Molecular Interactions 834
Total Molecular Interactions 1192
Total Single Events 9954
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein alpha-subunit binding. They are ordered first by their pain relevance and then by number of times they were reported for G-protein alpha-subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
4 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
6 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
7 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
8 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
9 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
10 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
11 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
12 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
13 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
14 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
15 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
16 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
17 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
18 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
19 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
20 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
21 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
22 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
23 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
24 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
25 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
26 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
27 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
28 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
29 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
30 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
31 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
32 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
33 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
34 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
35 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
36 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
37 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
38 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
39 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
40 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
41 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
42 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
43 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
44 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
45 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
46 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
47 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
48 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
49 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
50 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
51 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
52 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
53 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
54 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
55 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
56 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
57 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
58 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
59 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
60 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
61 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
62 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
63 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
64 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
65 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
66 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
67 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
68 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
69 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
70 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
71 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
72 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
73 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
74 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
75 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
76 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
77 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
78 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
79 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
80 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
81 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
82 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
83 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
84 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
85 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
86 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
87 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
88 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
89 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
90 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
91 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
92 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
93 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
94 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
95 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
96 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
97 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
98 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
99 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
100 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
101 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
102 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
103 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
104 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
105 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
106 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
107 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
108 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
109 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
110 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
111 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
112 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
113 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
114 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
115 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
116 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
117 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
118 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
119 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
120 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
121 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
122 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
123 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
124 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
125 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
126 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
127 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
128 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
129 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
130 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
131 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
132 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
133 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
134 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
135 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
136 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
137 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
138 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
139 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
140 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
141 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
142 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
143 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
144 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
145 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
146 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
147 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
148 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
149 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
150 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
151 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
152 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
153 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
154 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
155 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
156 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
157 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
158 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
159 INT287749 Dmbx1 Positive_regulation of Gene_expression of Lpar1 1 0.41 0.82 1.16
160 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
161 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
162 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
163 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
164 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
165 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
166 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
167 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
168 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
169 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
170 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
171 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
172 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
173 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
174 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
175 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
176 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
177 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
178 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
179 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
180 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
181 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
182 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
183 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
184 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
185 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
186 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
187 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
188 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
189 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
190 INT231391 Binding of Lpar1 and Rbm39 1 0.00 1.04 1.04
191 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
192 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
193 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
194 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
195 INT137103 Sec22b Regulation of Htr1a 1 0.09 0 1.02
196 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
197 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
198 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
199 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
200 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein alpha-subunit binding. They are ordered first by their pain relevance and then by number of times they were reported in G-protein alpha-subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
4 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
5 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
6 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
7 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
8 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
9 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
10 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
11 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
12 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
13 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
14 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
15 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
16 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
17 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
18 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
19 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
20 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
21 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
22 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
23 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
24 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
25 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
26 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
27 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
28 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
29 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
30 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
31 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
32 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
33 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
34 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
35 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
36 INT6177 Binding of Htr1a 65 0.47 17.65 30.59
37 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
38 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
39 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
40 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
41 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
42 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89
43 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
44 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
45 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
46 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
47 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
48 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
49 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
50 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
51 INT7487 Gene_expression of Htr1a 36 0.75 11.08 20.05
52 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
53 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
54 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
55 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
56 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
57 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
58 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
59 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
60 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
61 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14
62 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
63 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
64 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
65 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
66 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
67 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
68 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
69 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
70 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
71 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
72 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
73 INT49538 Binding of Gria1 22 0.47 2.66 13.35
74 INT90184 Gene_expression of KCNJ6 7 0.67 4.14 12.57
75 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
76 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03
77 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
78 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
79 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
80 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
81 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
82 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
83 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
84 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
85 INT8072 Localization of Gria1 17 0.75 2.62 10.04
86 INT7044 Positive_regulation of Positive_regulation of Htr1a 17 0.67 3.5 10
87 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
88 INT96298 Negative_regulation of Gria1 25 0.57 10.61 9.7
89 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
90 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
91 INT62997 Gene_expression of Kcnj6 17 0.77 2.16 9.44
92 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
93 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
94 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
95 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
96 INT10208 Negative_regulation of Binding of Htr1a 18 0.57 13.98 8.91
97 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77
98 INT34106 Negative_regulation of Htr1a 14 0.57 4.72 8.73
99 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
100 INT166119 Negative_regulation of Gene_expression of Lpar1 17 0.51 13.86 8.7
101 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
102 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
103 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
104 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
105 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
106 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08
107 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
108 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
109 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
110 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
111 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
112 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
113 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
114 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
115 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
116 INT57023 Negative_regulation of Gene_expression of Gria1 20 0.58 6.92 7.17
117 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
118 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
119 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
120 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
121 INT139149 Binding of Gria1 22 0.37 5.71 6.88
122 INT120298 Negative_regulation of Phosphorylation of Gria1 6 0.57 8.99 6.68
123 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
124 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
125 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37
126 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
127 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
128 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
129 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
130 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
131 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
132 INT6228 Localization of Htr1a 14 0.78 0.46 6.2
133 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
134 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
135 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
136 INT94927 Transcription of Gria1 12 0.69 3.14 5.94
137 INT85563 Positive_regulation of KCNJ6 6 0.50 0.4 5.89
138 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73
139 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
140 INT72336 Transcription of Htr1a 7 0.69 3.09 5.61
141 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
142 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
143 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
144 INT59718 Regulation of Htr1a 10 0.44 3.9 5.44
145 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
146 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
147 INT165490 Regulation of Lpar1 8 0.45 15.31 5.05
148 INT351354 Localization of Lpar1 1 0.40 6.93 5.05
149 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
150 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
151 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
152 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
153 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
154 INT281850 Binding of KCNJ6 1 0.37 0.93 4.57
155 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
156 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
157 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
158 INT98357 Binding of Gnas 11 0.41 1.87 4.35
159 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
160 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
161 INT287726 Gene_expression of Lpar3 10 0.76 3.89 4.13
162 INT92902 Negative_regulation of Positive_regulation of Gria1 6 0.57 1.06 4.1
163 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
164 INT88156 Regulation of Gria1 12 0.54 2.5 4.06
165 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
166 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
167 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
168 INT129990 Positive_regulation of Phosphorylation of Gria1 11 0.61 3.44 3.87
169 INT66473 Negative_regulation of Kcnj6 6 0.50 1.26 3.87
170 INT77583 Positive_regulation of Gene_expression of Htr1a 6 0.49 4.23 3.72
171 INT23026 Negative_regulation of Positive_regulation of Htr1a 9 0.42 0.42 3.69
172 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
173 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
174 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
175 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
176 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
177 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
178 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
179 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
180 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
181 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
182 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
183 INT84564 Regulation of Positive_regulation of Gria1 2 0.33 1.86 3.3
184 INT51427 Positive_regulation of Positive_regulation of Gria1 11 0.45 1.33 3.28
185 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
186 INT142701 Gene_expression of Kcnj6 8 0.78 0.34 3.25
187 INT46754 Localization of F2r 7 0.78 2.36 3.24
188 INT85564 Negative_regulation of KCNJ6 6 0.25 0 3.24
189 INT160153 Gene_expression of Htr1a 7 0.65 2.95 3.23
190 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
191 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
192 INT41340 Binding of Htr1a 5 0.47 0.76 3.16
193 INT231377 Regulation of Gene_expression of Lpar1 7 0.53 5.55 3.12
194 INT170343 Positive_regulation of Gene_expression of Gria1 10 0.61 2.77 3.09
195 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
196 INT72322 Positive_regulation of Localization of Htr1a 5 0.49 0 3.08
197 INT351355 Positive_regulation of Localization of Lpar1 1 0.25 3.94 2.87
198 INT54754 Localization of Htr2a 6 0.73 0.73 2.85
199 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84
200 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
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