GO:0002016

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Name regulation of blood volume by renin-angiotensin
Categary Process
Go Slim No
Go Link GO:0002016
Unique Molecular Interactions 124
Total Molecular Interactions 152
Total Single Events 2398
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of blood volume by renin-angiotensin. They are ordered first by their pain relevance and then by number of times they were reported for regulation of blood volume by renin-angiotensin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
2 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
3 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
4 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
5 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
6 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
7 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
8 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
9 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
10 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
11 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
12 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
13 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
14 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
15 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
16 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
17 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
18 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
19 INT81506 Drd3 Regulation of Positive_regulation of Fos 1 0.28 0 0.37
20 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
21 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
22 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
23 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
24 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
25 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
26 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
27 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
28 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
29 INT51631 Binding of DRD3 and PENK 1 0.08 0 0.33
30 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
31 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
32 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
33 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
34 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
35 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
36 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
37 INT105004 Binding of DRD3 and PDYN 1 0.23 0.49 0.26
38 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26
39 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
40 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
41 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
42 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
43 INT46400 Negative_regulation of Drd3 Positive_regulation of Localization of Prl 1 0.15 0.09 0.22
44 INT46399 Negative_regulation of Drd3 Positive_regulation of Prl 1 0.15 0.09 0.22
45 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
46 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
47 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
48 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
49 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
50 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
51 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
52 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
53 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
54 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
55 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
56 INT34717 Positive_regulation of Vip Positive_regulation of Localization of Ren 1 0.46 0 0.17
57 INT36567 Negative_regulation of AGT Positive_regulation of FBF1 1 0.36 0.5 0.17
58 INT111863 Negative_regulation of Binding of AGT and LNPEP 1 0.09 0 0.16
59 INT111861 Binding of AGT and LNPEP 1 0.07 0 0.16
60 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
61 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
62 INT34430 AGT Positive_regulation of Localization of POMC 1 0.30 0.31 0.14
63 INT170817 CMA1 Positive_regulation of Gene_expression of AGT 1 0.19 1.41 0.14
64 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
65 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
66 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
67 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13
68 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12
69 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
70 INT316372 Positive_regulation of Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
71 INT316374 Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
72 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11
73 INT316377 Gopc Positive_regulation of Positive_regulation of Ren1 1 0.06 0.13 0.11
74 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
75 INT148102 AGT Positive_regulation of Gene_expression of STK24 1 0.37 0.96 0.1
76 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1
77 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
78 INT88137 Ren Regulation of Gene_expression of Spp1 1 0.04 0.24 0.09
79 INT254641 CGA Positive_regulation of AGT 1 0.17 1.51 0.08
80 INT354753 Ren Regulation of Agt 1 0.14 0.98 0.08
81 INT267969 Binding of AGT and TRPV1 1 0.00 0.44 0.08
82 INT267970 Negative_regulation of Binding of AGT and TRPV1 1 0.00 0.44 0.08
83 INT254639 CGA Positive_regulation of Gene_expression of AGT 1 0.18 1.51 0.08
84 INT354754 Regulation of Ren Regulation of Agt 1 0.14 0.98 0.08
85 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
86 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07
87 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06
88 INT88773 Positive_regulation of Binding of AGT and Agtrap 1 0.01 0.88 0.05
89 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
90 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
91 INT230816 Binding of ras and Ren1 1 0.11 0.77 0.04
92 INT88774 Binding of AGT and Agtrap 2 0.01 2.13 0.03
93 INT274285 AGT Positive_regulation of Gene_expression of VEGFA 1 0.01 0.98 0.03
94 INT351663 Binding of AGT and Agt 1 0.32 0.57 0.03
95 INT274288 AGT Positive_regulation of Gene_expression of Vegfa 1 0.07 0.98 0.03
96 INT321405 AGT Positive_regulation of MAPK8 1 0.00 0.94 0.03
97 INT274284 AGT Positive_regulation of Binding of VEGFA 1 0.01 0.99 0.03
98 INT88772 Negative_regulation of Binding of AGT and Agtrap 1 0.02 0.89 0.03
99 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03
100 INT229713 Binding of Agt and Ren 1 0.14 0 0
101 INT229714 Positive_regulation of Binding of Agt and Ren 1 0.18 0 0
102 INT316373 Binding of Ren1 and Gopc 1 0.05 0.44 0
103 INT281902 Binding of AGT and AKR1A1 1 0.01 0.08 0
104 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0
105 INT209802 MRXS5 Positive_regulation of Localization of Ren1 1 0.01 0 0
106 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 0.52 0.23 0
107 INT34763 Binding of AGT and PTGER2 1 0.04 0.24 0
108 INT265950 Clas4 Negative_regulation of Gene_expression of AGT 1 0.02 0.62 0
109 INT34764 Binding of AGT and PTGIR 1 0.08 0.24 0
110 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0
111 INT288910 REN Regulation of Gene_expression of AGT 1 0.40 1.34 0
112 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
113 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0
114 INT92824 AGT Regulation of Gene_expression of REN 1 0.05 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of blood volume by renin-angiotensin. They are ordered first by their pain relevance and then by number of times they were reported in regulation of blood volume by renin-angiotensin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT46 Localization of Ren 233 0.81 46.15 62.44
2 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
3 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
4 INT1116 Regulation of Ren 103 0.62 27.66 33.26
5 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
6 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
7 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
8 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
9 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
10 INT3962 Regulation of AGT 50 0.62 20.96 13.01
11 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
12 INT398 Localization of AGT 45 0.78 16.97 11.54
13 INT8065 Binding of AGT 54 0.48 20.54 10.85
14 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
15 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
16 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
17 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
18 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
19 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
20 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
21 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
22 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
23 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
24 INT24011 Binding of Drd3 13 0.47 3.03 4.64
25 INT3097 Binding of Ren 12 0.48 3.15 4.4
26 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
27 INT76714 Binding of Drd3 9 0.37 2.33 4.09
28 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
29 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
30 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
31 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
32 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
33 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
34 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
35 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
36 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
37 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
38 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
39 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
40 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
41 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
42 INT51047 Regulation of Drd3 4 0.53 2 2.2
43 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
44 INT105008 Binding of DRD3 5 0.36 3.15 2.05
45 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99
46 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
47 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
48 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
49 INT44164 Localization of Ren1 18 0.49 10.53 1.49
50 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
51 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
52 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
53 INT11241 Transcription of AGT 4 0.52 1.83 1.27
54 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
55 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
56 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
57 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
58 INT89328 Regulation of Transcription of Drd3 2 0.22 0.51 1.21
59 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
60 INT4570 Negative_regulation of Drd3 4 0.39 0.09 1.2
61 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
62 INT78266 Localization of NKX2-1 2 0.73 0.16 1.12
63 INT60441 Positive_regulation of Positive_regulation of Drd3 1 0.21 0 1.07
64 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
65 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02
66 INT88083 Negative_regulation of Drd3 3 0.58 0.88 1.01
67 INT127052 Transcription of Drd3 2 0.37 0.06 1
68 INT82989 Regulation of DRD3 1 0.23 0.45 0.99
69 INT13074 Positive_regulation of NKX2-1 4 0.19 0.86 0.87
70 INT89331 Positive_regulation of Transcription of Drd3 1 0.21 0.09 0.85
71 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
72 INT119491 Positive_regulation of Positive_regulation of Drd3 1 0.46 0.17 0.83
73 INT99723 Binding of Ren1 7 0.27 3.98 0.82
74 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
75 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
76 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
77 INT15039 Negative_regulation of NKX2-1 3 0.21 0 0.72
78 INT34769 Regulation of Gene_expression of AGT 3 0.19 1.39 0.67
79 INT127050 Positive_regulation of Transcription of Drd3 1 0.26 0.06 0.62
80 INT3552 Regulation of Gene_expression of Ren 3 0.41 1.39 0.6
81 INT89285 Positive_regulation of Gene_expression of Drd3 2 0.60 0.09 0.52
82 INT47645 Negative_regulation of Localization of AGT 2 0.11 1.09 0.49
83 INT27723 Regulation of Negative_regulation of Ren 4 0.45 1.14 0.44
84 INT119492 Positive_regulation of Negative_regulation of Drd3 1 0.69 0.07 0.43
85 INT33017 Negative_regulation of Protein_catabolism of AGT 3 0.37 0 0.42
86 INT124636 Negative_regulation of Positive_regulation of Drd3 1 0.43 0.09 0.41
87 INT124635 Localization of Drd3 1 0.75 0.08 0.39
88 INT317624 Regulation of Phosphorylation of Drd3 1 0.05 0.46 0.36
89 INT317616 Phosphorylation of Drd3 1 0.12 0.46 0.36
90 INT162823 Regulation of Gene_expression of Ren1 4 0.62 2.69 0.35
91 INT86135 Regulation of Localization of Ren1 4 0.25 1.67 0.35
92 INT261442 Negative_regulation of Gene_expression of Drd3 1 0.04 0.7 0.35
93 INT95605 Regulation of Binding of AGT 3 0.44 0.2 0.34
94 INT27928 Phosphorylation of AGT 1 0.52 0.15 0.34
95 INT27929 Negative_regulation of Phosphorylation of AGT 1 0.27 0.15 0.34
96 INT25424 Transcription of Ren 2 0.57 1.21 0.33
97 INT105005 Positive_regulation of Positive_regulation of DRD3 1 0.48 0.5 0.28
98 INT93527 Positive_regulation of Localization of Ren1 2 0.28 1.27 0.27
99 INT105006 Positive_regulation of DRD3 1 0.48 0.5 0.27
100 INT24010 Negative_regulation of Binding of Drd3 1 0.39 0 0.27
101 INT3331 Positive_regulation of Protein_catabolism of AGT 1 0.33 0 0.27
102 INT89286 Positive_regulation of Binding of Drd3 1 0.69 0 0.23
103 INT104734 Negative_regulation of Gene_expression of Ren1 2 0.34 1.9 0.21
104 INT89284 Regulation of Binding of Drd3 1 0.45 0 0.2
105 INT344112 Regulation of Transcription of Drd3 1 0.04 0 0.2
106 INT99724 Transcription of Ren1 2 0.36 0.14 0.18
107 INT41621 Negative_regulation of Positive_regulation of Ren1 2 0.43 0.6 0.18
108 INT142511 Regulation of Binding of Ren 1 0.45 0.81 0.17
109 INT316364 Regulation of Negative_regulation of Ren1 1 0.25 0.53 0.16
110 INT24324 Regulation of NKX2-1 1 0.03 0.1 0.13
111 INT214619 Positive_regulation of Negative_regulation of AGT 1 0.04 0.98 0.13
112 INT25423 Regulation of Transcription of Ren 1 0.11 0.1 0.1
113 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08
114 INT230801 Positive_regulation of Negative_regulation of Ren1 2 0.28 1.12 0.08
115 INT288915 Regulation of Positive_regulation of AGT 1 0.41 0.82 0.08
116 INT209798 Protein_catabolism of Ren1 1 0.08 0.78 0.06
117 INT104732 Positive_regulation of Transcription of Ren1 1 0.31 0 0.04
118 INT242099 Binding of Nkx2-1 1 0.02 1.15 0
119 INT316368 Negative_regulation of Localization of Ren1 1 0.24 2.15 0
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