GO:0002018

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Name renin-angiotensin regulation of aldosterone production
Categary Process
Go Slim No
Go Link GO:0002018
Unique Molecular Interactions 544
Total Molecular Interactions 754
Total Single Events 7672
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for renin-angiotensin regulation of aldosterone production. They are ordered first by their pain relevance and then by number of times they were reported for renin-angiotensin regulation of aldosterone production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
2 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
3 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
4 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
5 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
6 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
7 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
8 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
9 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
10 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
11 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
12 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
13 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
14 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
15 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
16 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
17 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
18 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
19 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
20 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
21 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
22 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
23 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
24 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
25 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
26 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
27 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
28 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
29 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
30 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
31 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
32 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
33 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
34 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
35 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
36 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
37 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
38 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
39 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
40 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
41 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
42 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
43 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
44 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
45 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
46 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
47 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
48 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
49 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
50 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
51 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
52 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
53 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
54 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
55 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
56 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
57 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
58 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
59 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
60 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
61 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
62 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
63 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
64 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
65 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
66 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
67 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
68 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
69 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
70 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
71 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
72 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
73 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
74 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
75 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
76 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
77 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
78 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
79 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
80 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
81 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
82 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
83 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32
84 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
85 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
86 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
87 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
88 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
89 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
90 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
91 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
92 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
93 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
94 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
95 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
96 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
97 INT116853 Chdh Regulation of Positive_regulation of Agt 1 0.11 0.19 0.28
98 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
99 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
100 INT45545 Agt Positive_regulation of Oxt 1 0.23 0 0.27
101 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
102 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
103 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
104 INT126550 Agt Positive_regulation of Gene_expression of Nsfl1c 1 0.39 1.07 0.26
105 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
106 INT9528 Agt Positive_regulation of Localization of Pomc 2 0.50 0.14 0.25
107 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
108 INT126547 Agt Positive_regulation of Nfkb1 1 0.46 0.99 0.25
109 INT126548 Negative_regulation of Agt Positive_regulation of Nfkb1 1 0.29 0.99 0.25
110 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
111 INT126553 Agt Positive_regulation of Nfkb1 1 0.06 0.99 0.25
112 INT256028 Binding of Agt and Lnpep 1 0.19 1.16 0.24
113 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
114 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
115 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
116 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
117 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
118 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
119 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
120 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
121 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
122 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
123 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
124 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
125 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
126 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21
127 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
128 INT275159 Agt Positive_regulation of Phosphorylation of Stat3 1 0.04 1.44 0.2
129 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
130 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
131 INT249993 Binding of Agt and Igkv4-55 1 0.02 0.49 0.2
132 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
133 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
134 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
135 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
136 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18
137 INT41978 Binding of Agt and Htr1a 1 0.41 0.54 0.18
138 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
139 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
140 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
141 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
142 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 0.08 2.8 0.17
143 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
144 INT34717 Positive_regulation of Vip Positive_regulation of Localization of Ren 1 0.46 0 0.17
145 INT36567 Negative_regulation of AGT Positive_regulation of FBF1 1 0.36 0.5 0.17
146 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
147 INT111863 Negative_regulation of Binding of AGT and LNPEP 1 0.09 0 0.16
148 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
149 INT111861 Binding of AGT and LNPEP 1 0.07 0 0.16
150 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
151 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
152 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
153 INT72817 Agt Negative_regulation of Avp 1 0.07 0.34 0.14
154 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
155 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
156 INT34430 AGT Positive_regulation of Localization of POMC 1 0.30 0.31 0.14
157 INT170817 CMA1 Positive_regulation of Gene_expression of AGT 1 0.19 1.41 0.14
158 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
159 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14
160 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
161 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
162 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
163 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
164 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13
165 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
166 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
167 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
168 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13
169 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12
170 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12
171 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
172 INT345289 CRS Regulation of REN 1 0.03 1.02 0.12
173 INT110176 Nts Regulation of Negative_regulation of Agtr1a 1 0.24 0.09 0.12
174 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
175 INT107226 Agt Positive_regulation of AFF1 1 0.01 0 0.12
176 INT44974 Agt Positive_regulation of Gene_expression of Ptger2 1 0.02 0.42 0.12
177 INT33750 Apoa2 Regulation of Agt 1 0.07 0 0.12
178 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12
179 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
180 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
181 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
182 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
183 INT316372 Positive_regulation of Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
184 INT316374 Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
185 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11
186 INT222503 Agt Positive_regulation of Localization of Gh1 1 0.02 0.23 0.11
187 INT316377 Gopc Positive_regulation of Positive_regulation of Ren1 1 0.06 0.13 0.11
188 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11
189 INT256023 Lnpep Regulation of Gene_expression of Agt 1 0.18 0.14 0.1
190 INT46502 Agt Positive_regulation of Odc1 1 0.18 0 0.1
191 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1
192 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
193 INT148102 AGT Positive_regulation of Gene_expression of STK24 1 0.37 0.96 0.1
194 INT10906 Agt Regulation of Localization of Nppb 1 0.10 0.19 0.1
195 INT171164 Agt Regulation of Positive_regulation of Rorb 1 0.02 0.64 0.1
196 INT256029 Lnpep Regulation of Agt 1 0.18 0.14 0.1
197 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1
198 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09
199 INT2194 HIST2H2BD Regulation of REN 1 0.00 0.07 0.09
200 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for renin-angiotensin regulation of aldosterone production. They are ordered first by their pain relevance and then by number of times they were reported in renin-angiotensin regulation of aldosterone production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT46 Localization of Ren 233 0.81 46.15 62.44
2 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
3 INT654 Localization of REN 250 0.81 75.12 47.86
4 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
5 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
6 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
7 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
8 INT1116 Regulation of Ren 103 0.62 27.66 33.26
9 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
10 INT1158 Regulation of Agt 106 0.61 29.4 30.29
11 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
12 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
13 INT2140 Regulation of REN 104 0.62 28.24 24.49
14 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
15 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
16 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
17 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
18 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
19 INT2066 Localization of Agt 56 0.80 9.95 16.25
20 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
21 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
22 INT3962 Regulation of AGT 50 0.62 20.96 13.01
23 INT4199 Binding of Agt 76 0.48 21.06 12.66
24 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
25 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
26 INT398 Localization of AGT 45 0.78 16.97 11.54
27 INT661 Gene_expression of REN 100 0.78 48.21 11.36
28 INT8065 Binding of AGT 54 0.48 20.54 10.85
29 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
30 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
31 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
32 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
33 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
34 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
35 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
36 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
37 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
38 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
39 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
40 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
41 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
42 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
43 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
44 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
45 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
46 INT3097 Binding of Ren 12 0.48 3.15 4.4
47 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
48 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
49 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
50 INT9822 Binding of Agtr2 9 0.36 3 3.93
51 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
52 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
53 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
54 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
55 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
56 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
57 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
58 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
59 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
60 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
61 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
62 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
63 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
64 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
65 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
66 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
67 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
68 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
69 INT3533 Binding of REN 24 0.37 10.84 2.16
70 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
71 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
72 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
73 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
74 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
75 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
76 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
77 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
78 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
79 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
80 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
81 INT3152 Transcription of Agt 7 0.72 5.09 1.68
82 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
83 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
84 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
85 INT44164 Localization of Ren1 18 0.49 10.53 1.49
86 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
87 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
88 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
89 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
90 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
91 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
92 INT239215 Binding of Agt 9 0.38 6.75 1.35
93 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
94 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
95 INT11241 Transcription of AGT 4 0.52 1.83 1.27
96 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
97 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
98 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
99 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
100 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
101 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
102 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
103 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
104 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
105 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
106 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
107 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
108 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
109 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
110 INT230806 Positive_regulation of Gene_expression of Agt 11 0.55 16.08 0.83
111 INT99723 Binding of Ren1 7 0.27 3.98 0.82
112 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
113 INT5312 Regulation of Gene_expression of REN 4 0.41 0.73 0.76
114 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
115 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
116 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
117 INT137080 Positive_regulation of Positive_regulation of Agtr2 3 0.26 2.34 0.74
118 INT137081 Positive_regulation of Regulation of Agtr2 1 0.24 0.54 0.72
119 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71
120 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71
121 INT148074 Regulation of Agt 9 0.49 5.42 0.7
122 INT38735 Protein_catabolism of Agt 7 0.99 2.79 0.7
123 INT141062 Negative_regulation of Gene_expression of Agtr2 2 0.18 1.61 0.7
124 INT160461 Phosphorylation of Agt 1 0.31 0.4 0.7
125 INT160463 Positive_regulation of Phosphorylation of Agt 1 0.19 0.41 0.7
126 INT34769 Regulation of Gene_expression of AGT 3 0.19 1.39 0.67
127 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65
128 INT112666 Positive_regulation of Transcription of Agtr2 1 0.32 0.74 0.65
129 INT2592 Positive_regulation of Negative_regulation of REN 3 0.24 0.34 0.64
130 INT3552 Regulation of Gene_expression of Ren 3 0.41 1.39 0.6
131 INT267971 Regulation of Localization of AGTR1 1 0.16 1.46 0.57
132 INT159150 Negative_regulation of Positive_regulation of Agtr1a 1 0.38 0.72 0.56
133 INT40021 Regulation of Binding of Agt 4 0.59 1.53 0.53
134 INT32618 Regulation of Positive_regulation of Agt 2 0.43 0.42 0.52
135 INT47645 Negative_regulation of Localization of AGT 2 0.11 1.09 0.49
136 INT99588 Positive_regulation of Binding of Agt 2 0.69 0.23 0.45
137 INT27723 Regulation of Negative_regulation of Ren 4 0.45 1.14 0.44
138 INT14039 Regulation of Regulation of Agt 1 0.30 0 0.44
139 INT33017 Negative_regulation of Protein_catabolism of AGT 3 0.37 0 0.42
140 INT107385 Regulation of Negative_regulation of AGTR1 2 0.15 1.26 0.42
141 INT182507 Negative_regulation of Gene_expression of AGTR1 1 0.40 1.13 0.4
142 INT330125 Transcription of AGTR1 1 0.52 1.29 0.39
143 INT162823 Regulation of Gene_expression of Ren1 4 0.62 2.69 0.35
144 INT86135 Regulation of Localization of Ren1 4 0.25 1.67 0.35
145 INT224111 Phosphorylation of Agtr1a 1 0.01 0 0.35
146 INT95605 Regulation of Binding of AGT 3 0.44 0.2 0.34
147 INT102889 Positive_regulation of Localization of AGTR1 3 0.38 0.43 0.34
148 INT126578 Regulation of Gene_expression of Agtr2 2 0.49 1.08 0.34
149 INT27928 Phosphorylation of AGT 1 0.52 0.15 0.34
150 INT27929 Negative_regulation of Phosphorylation of AGT 1 0.27 0.15 0.34
151 INT25424 Transcription of Ren 2 0.57 1.21 0.33
152 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32
153 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3
154 INT43398 Regulation of Localization of Agt 1 0.28 0 0.3
155 INT93527 Positive_regulation of Localization of Ren1 2 0.28 1.27 0.27
156 INT3331 Positive_regulation of Protein_catabolism of AGT 1 0.33 0 0.27
157 INT136741 Protein_catabolism of Agtr2 1 0.07 0 0.26
158 INT164617 Protein_catabolism of Agt 2 0.79 5.3 0.25
159 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25
160 INT63417 Regulation of Negative_regulation of Agtr1a 1 0.26 0.1 0.25
161 INT239213 Localization of Agt 6 0.64 3.26 0.22
162 INT104734 Negative_regulation of Gene_expression of Ren1 2 0.34 1.9 0.21
163 INT247022 Transcription of Agtr1a 2 0.46 1.47 0.21
164 INT230802 Positive_regulation of Positive_regulation of Agt 2 0.40 0.41 0.2
165 INT31926 Negative_regulation of Negative_regulation of Agtr2 1 0.00 0.19 0.2
166 INT230740 Regulation of Agtr1a 2 0.15 3.5 0.19
167 INT99724 Transcription of Ren1 2 0.36 0.14 0.18
168 INT41621 Negative_regulation of Positive_regulation of Ren1 2 0.43 0.6 0.18
169 INT17822 Regulation of Gene_expression of Agtr2 1 0.05 0.1 0.18
170 INT1770 Positive_regulation of Negative_regulation of Agt 2 0.49 1.09 0.17
171 INT268208 Transcription of Agtr2 1 0.05 3.15 0.17
172 INT256015 Negative_regulation of Regulation of Agt 1 0.18 0.16 0.17
173 INT142511 Regulation of Binding of Ren 1 0.45 0.81 0.17
174 INT79914 Positive_regulation of Negative_regulation of Agt 1 0.50 0.19 0.17
175 INT316364 Regulation of Negative_regulation of Ren1 1 0.25 0.53 0.16
176 INT10584 Regulation of Regulation of REN 2 0.18 0.26 0.15
177 INT236359 Negative_regulation of Positive_regulation of Agtr2 2 0.07 1.61 0.15
178 INT209796 Positive_regulation of Agtr1a 1 0.15 0.56 0.15
179 INT241008 Phosphorylation of Agtr2 1 0.09 0.13 0.14
180 INT288916 Negative_regulation of Positive_regulation of AGTR1 2 0.44 1.2 0.13
181 INT256004 Negative_regulation of Gene_expression of Agt 2 0.34 8.07 0.13
182 INT239214 Positive_regulation of Localization of Agt 2 0.55 1.89 0.13
183 INT26755 Positive_regulation of Regulation of REN 1 0.16 0.19 0.13
184 INT355657 Negative_regulation of Transcription of Agtr1a 1 0.38 1.17 0.13
185 INT355655 Regulation of Transcription of Agtr1a 1 0.29 1.15 0.13
186 INT119156 Positive_regulation of Protein_catabolism of Agt 1 0.49 0 0.13
187 INT214619 Positive_regulation of Negative_regulation of AGT 1 0.04 0.98 0.13
188 INT99725 Negative_regulation of Agtr1a 5 0.57 1.03 0.12
189 INT3532 Transcription of REN 2 0.60 1.06 0.12
190 INT229356 Negative_regulation of Binding of Agtr1a 1 0.36 0.89 0.12
191 INT3329 Protein_catabolism of REN 5 1.00 0.95 0.11
192 INT256008 Regulation of Gene_expression of Agt 4 0.36 5.03 0.11
193 INT37403 Negative_regulation of Regulation of REN 1 0.43 0.35 0.11
194 INT356371 Localization of Agtr2 1 0.04 0.74 0.11
195 INT25423 Regulation of Transcription of Ren 1 0.11 0.1 0.1
196 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1
197 INT242222 Positive_regulation of Negative_regulation of AGTR1 1 0.35 1.77 0.1
198 INT247024 Positive_regulation of Transcription of Agtr1a 1 0.19 0.33 0.09
199 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08
200 INT230801 Positive_regulation of Negative_regulation of Ren1 2 0.28 1.12 0.08
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