GO:0002020

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Name protease binding
Categary Function
Go Slim No
Go Link GO:0002020
Unique Molecular Interactions 2847
Total Molecular Interactions 3932
Total Single Events 39922
Pain Genes Associated 109

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protease binding. They are ordered first by their pain relevance and then by number of times they were reported for protease binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
3 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
4 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
5 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
6 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
7 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
8 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
9 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
10 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
11 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
12 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
13 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
14 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
15 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
16 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
17 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
18 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
19 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
20 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
21 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
22 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
23 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
24 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
25 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
26 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
27 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
28 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
29 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
30 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
31 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
32 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
33 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
34 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
35 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
36 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
37 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
38 INT49083 Mbp Positive_regulation of Eae1 1 0.02 2.96 1.71
39 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
40 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
41 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
42 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
43 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
44 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
45 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
46 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
47 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
48 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
49 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
50 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
51 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
52 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
53 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
54 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
55 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
56 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
57 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
58 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5
59 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
60 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
61 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
62 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
63 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
64 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
65 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
66 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
67 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
68 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
69 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
70 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
71 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
72 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
73 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
74 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
75 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27
76 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
77 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
78 INT18324 Sst Negative_regulation of Localization of Ins1 2 0.46 1.09 1.24
79 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
80 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
81 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
82 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
83 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
84 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
85 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
86 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
87 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
88 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
89 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
90 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
91 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
92 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
93 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
94 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
95 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
96 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
97 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
98 INT121362 Trpv1 Regulation of Localization of Ins1 1 0.51 0.17 1.12
99 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
100 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
101 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
102 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
103 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
104 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
105 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
106 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
107 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
108 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
109 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
110 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
111 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
112 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
113 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
114 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
115 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
116 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
117 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
118 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
119 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
120 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
121 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
122 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
123 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
124 INT12138 Ins1 Negative_regulation of Chat 1 0.27 0.71 1.01
125 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
126 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
127 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
128 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
129 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
130 INT103928 Binding of Cd28 and Trav6-3 3 0.03 0.55 0.98
131 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
132 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
133 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
134 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
135 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
136 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
137 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
138 INT37308 Ins1 Regulation of Localization of Gast 1 0.20 0 0.97
139 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
140 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
141 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
142 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
143 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
144 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
145 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
146 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
147 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
148 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
149 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
150 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
151 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
152 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
153 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93
154 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
155 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
156 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91
157 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
158 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
159 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
160 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
161 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
162 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
163 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
164 INT54854 Sorbs1 Regulation of Ins1 1 0.34 0.23 0.9
165 INT12766 Ins1 Positive_regulation of Prkcg 3 0.53 0.07 0.89
166 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
167 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
168 INT26991 Pomc Negative_regulation of Localization of Ins1 1 0.38 0 0.89
169 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
170 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
171 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
172 INT18325 Grem2 Positive_regulation of Ins1 1 0.02 0.9 0.88
173 INT26987 Pomc Regulation of Ins1 1 0.40 0 0.87
174 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
175 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
176 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
177 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
178 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
179 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
180 INT91992 IGKV1-22 Negative_regulation of Sell 1 0.40 0.31 0.86
181 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
182 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
183 INT114546 Ins1 Positive_regulation of Positive_regulation of Trpv1 1 0.39 0.19 0.86
184 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
185 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
186 INT30422 Penk Regulation of Ins1 1 0.06 0 0.85
187 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
188 INT115655 Glp1r Positive_regulation of Ins1 1 0.42 0 0.84
189 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
190 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
191 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
192 INT12142 Ins1 Regulation of Chat 1 0.24 0.69 0.84
193 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
194 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84
195 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
196 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
197 INT48384 CSF2 Regulation of Gene_expression of SELL 1 0.17 0.4 0.83
198 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
199 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
200 INT48380 CSF3 Regulation of Gene_expression of SELL 1 0.41 0.4 0.83

Single Events

The table below shows the top 100 pain related interactions that have been reported for protease binding. They are ordered first by their pain relevance and then by number of times they were reported in protease binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT1114 Localization of Ins1 748 0.80 192.95 165.48
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
13 INT10166 Localization of Tnf 237 0.81 153.95 88.64
14 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36
15 INT3214 Localization of Ins1 527 0.80 196.9 79.26
16 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76
17 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
18 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
19 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
20 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37
21 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
22 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
23 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14
24 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
25 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
26 INT2276 Regulation of Ins1 234 0.61 103.78 54.05
27 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32
28 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
29 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
30 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
31 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94
32 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
33 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07
34 INT13354 Transcription of TNF 108 0.72 85.81 42.32
35 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
36 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63
37 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
38 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15
39 INT35406 Localization of Tnf 94 0.81 64.63 31.65
40 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
41 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
42 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
43 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
44 INT3217 Regulation of Ins1 154 0.62 87.11 27.29
45 INT2609 Localization of ELANE 111 0.81 50.22 26.63
46 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
47 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
48 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
49 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
50 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04
51 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
52 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59
53 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
54 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
55 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
56 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
57 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
58 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
59 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
60 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
61 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
62 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
63 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
64 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13
65 INT67975 Gene_expression of Bdkrb2 38 0.68 21.69 17.94
66 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71
67 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
68 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
69 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36
70 INT7580 Positive_regulation of Mbp 54 0.70 23.37 17.14
71 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
72 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
73 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
74 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
75 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43
76 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
77 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11
78 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07
79 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
80 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
81 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
82 INT10173 Binding of Tnf 45 0.48 35.6 14.32
83 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
84 INT37803 Positive_regulation of Bdkrb2 18 0.68 14.21 13.99
85 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
86 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67
87 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
88 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
89 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
90 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27
91 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
92 INT2578 Binding of Ins1 74 0.48 33.57 12.92
93 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
94 INT85510 Positive_regulation of Bdkrb2 23 0.70 12.08 12.68
95 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61
96 INT21160 Gene_expression of Sell 28 0.64 19.37 12.18
97 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
98 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
99 INT88223 Gene_expression of Bdkrb2 17 0.69 13.94 11.44
100 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
101 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
102 INT73504 Binding of CD28 35 0.45 15.99 10.04
103 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
104 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
105 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
106 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
107 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
108 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
109 INT4929 Binding of Mbp 25 0.48 18.01 9.41
110 INT71494 Positive_regulation of Hspa1b 14 0.67 8.5 9.19
111 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13
112 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
113 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82
114 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
115 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
116 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
117 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
118 INT87434 Gene_expression of Sell 38 0.77 21.95 8.51
119 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
120 INT9573 Regulation of Bdkrb2 9 0.43 6.04 8.41
121 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
122 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35
123 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
124 INT12762 Negative_regulation of Positive_regulation of Ins1 24 0.59 8.51 8.28
125 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
126 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26
127 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15
128 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
129 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
130 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
131 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79
132 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75
133 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
134 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
135 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
136 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
137 INT68299 Binding of Tnf 17 0.39 12.55 7.49
138 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
139 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
140 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32
141 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
142 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
143 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
144 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
145 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
146 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
147 INT21161 Positive_regulation of Sell 11 0.58 8.64 6.57
148 INT65295 Negative_regulation of Bdkrb2 9 0.37 6.36 6.49
149 INT7464 Regulation of Mbp 25 0.62 6.62 6.43
150 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
151 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
152 INT2217 Positive_regulation of Positive_regulation of Ins1 21 0.69 7.66 6.32
153 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
154 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
155 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
156 INT14486 Localization of Mbp 23 0.74 11.24 6.14
157 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
158 INT73179 Gene_expression of Hspa1b 10 0.73 6.24 6.04
159 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02
160 INT677 Positive_regulation of CST3 20 0.67 17.47 6
161 INT116420 Localization of Elane 16 0.14 7.8 6
162 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
163 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
164 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
165 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
166 INT18677 Gene_expression of F3 50 0.65 30.86 5.86
167 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
168 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77
169 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75
170 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
171 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74
172 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
173 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
174 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
175 INT17425 Regulation of Gene_expression of Ins1 23 0.45 18.99 5.61
176 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
177 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56
178 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
179 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
180 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39
181 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37
182 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
183 INT60585 Regulation of TP53 59 0.59 54.55 5.21
184 INT10888 Binding of Vwf 32 0.46 22.87 5.21
185 INT10100 Binding of ELANE 22 0.47 15.32 5.19
186 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16
187 INT2579 Protein_catabolism of Ins1 43 0.99 9.91 5.14
188 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
189 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05
190 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
191 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98
192 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95
193 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
194 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89
195 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
196 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85
197 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8
198 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77
199 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
200 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
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