GO:0002021

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Name response to dietary excess
Categary Process
Go Slim No
Go Link GO:0002021
Unique Molecular Interactions 502
Total Molecular Interactions 709
Total Single Events 4800
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to dietary excess. They are ordered first by their pain relevance and then by number of times they were reported for response to dietary excess. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
4 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
5 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
6 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
7 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
8 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
9 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
10 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
11 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
12 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
13 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
14 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
15 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
16 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
17 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
18 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
19 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
20 INT257717 Binding of Bdnf and Vgf 1 0.25 0.86 0.61
21 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
22 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
23 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
24 INT257715 Bdnf Positive_regulation of Transcription of Vgf 1 0.35 0.66 0.57
25 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
26 INT257713 Ngf Positive_regulation of Transcription of Vgf 1 0.41 0.66 0.57
27 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
28 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
29 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
30 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
31 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
32 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
33 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
34 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
35 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
36 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
37 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
38 INT257720 Bdnf Regulation of Vgf 1 0.19 0.64 0.49
39 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
40 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
41 INT257719 Ngf Regulation of Vgf 1 0.22 0.64 0.48
42 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
43 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
44 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
45 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
46 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
47 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
48 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
49 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
50 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
51 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
52 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
53 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
54 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
55 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
56 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
57 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
58 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
59 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
60 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
61 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
62 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
63 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
64 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
65 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
66 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
67 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
68 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
69 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
70 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
71 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
72 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
73 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
74 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
75 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
76 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
77 INT85791 Prlh Regulation of Localization of Prl 1 0.23 0 0.26
78 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
79 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
80 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
81 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
82 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
83 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
84 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
85 INT85792 Prlh Positive_regulation of Localization of Prl 1 0.39 0 0.24
86 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
87 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
88 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
89 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
90 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
91 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
92 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
93 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
94 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
95 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
96 INT257728 Binding of Pbx2 and Vgf 1 0.42 0.18 0.21
97 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
98 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
99 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
100 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
101 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
102 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
103 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
104 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
105 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
106 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
107 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
108 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
109 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
110 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
111 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
112 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
113 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
114 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
115 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
116 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
117 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
118 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
119 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
120 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
121 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
122 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
123 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
124 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
125 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
126 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
127 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
128 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
129 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
130 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
131 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13
132 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
133 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
134 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
135 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
136 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
137 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
138 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
139 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
140 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
141 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
142 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
143 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
144 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
145 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
146 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
147 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
148 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
149 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
150 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 0.45 0.1 0.09
151 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09
152 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
153 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09
154 INT213482 Lep Positive_regulation of Mapk1 1 0.06 0.08 0.09
155 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
156 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
157 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
158 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08
159 INT123866 Lep Negative_regulation of Olfr544 1 0.00 0.09 0.08
160 INT303999 Lep Positive_regulation of Gene_expression of ITGA2 1 0.06 0.29 0.08
161 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
162 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
163 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
164 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08
165 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
166 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
167 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
168 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
169 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
170 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
171 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
172 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
173 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
174 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
175 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
176 INT214153 Lep Regulation of Transcription of Nucb2 1 0.35 0.15 0.06
177 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
178 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
179 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
180 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
181 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05
182 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05
183 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
184 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
185 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
186 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
187 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
188 INT303986 Lep Positive_regulation of Gene_expression of TNF 1 0.49 0.29 0.04
189 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
190 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
191 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
192 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
193 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
194 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04
195 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
196 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
197 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
198 INT303965 Lep Positive_regulation of Gene_expression of Il6 1 0.07 0.29 0.04
199 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03
200 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to dietary excess. They are ordered first by their pain relevance and then by number of times they were reported in response to dietary excess. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
3 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
4 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
5 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
6 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
7 INT75908 Regulation of LEP 77 0.60 60.16 15.19
8 INT73641 Regulation of Lep 45 0.62 26.2 12.59
9 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
10 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
11 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
12 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
13 INT82082 Localization of Lep 63 0.81 26.41 8.56
14 INT75907 Binding of LEP 53 0.46 46.65 8.44
15 INT197493 Localization of Apoe 61 0.79 27.48 7.06
16 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
17 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
18 INT50328 Positive_regulation of Vgf 8 0.70 13.98 6.37
19 INT63042 Binding of Apoe 59 0.48 31.23 5.88
20 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
21 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
22 INT85789 Gene_expression of Prlh 10 0.78 4.5 5.47
23 INT65356 Localization of LEP 46 0.79 41.17 5.43
24 INT91338 Binding of Lep 31 0.48 26.86 5.39
25 INT102935 Regulation of Lep 31 0.60 18.47 5.24
26 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
27 INT97391 Binding of Lep 18 0.48 8.97 4.47
28 INT163581 Localization of Lep 27 0.79 18.99 4.08
29 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
30 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
31 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
32 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
33 INT17379 Positive_regulation of Prlh 6 0.64 0.58 3.68
34 INT8781 Regulation of Prlh 6 0.45 0.67 3.58
35 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
36 INT257727 Transcription of Vgf 1 0.72 7.38 3.52
37 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
38 INT72141 Binding of Apoe 11 0.37 10.91 3.27
39 INT50326 Gene_expression of Vgf 11 0.78 4.41 3.2
40 INT97710 Localization of Apoe 1 0.79 7.18 3.2
41 INT85787 Transcription of Prlh 4 0.53 1.77 2.7
42 INT50080 Binding of APOE 38 0.45 29.61 2.67
43 INT127552 Gene_expression of Pcsk1n 8 0.78 1.11 2.66
44 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
45 INT50325 Regulation of Vgf 2 0.62 4.4 2.58
46 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
47 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
48 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
49 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
50 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
51 INT123588 Localization of Vgf 3 0.81 2.35 2.07
52 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
53 INT83392 Transcription of Lep 6 0.54 5.07 2.04
54 INT68522 Localization of Pcsk1n 2 0.56 1.19 1.85
55 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
56 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
57 INT85786 Localization of Prlh 3 0.75 0.87 1.57
58 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
59 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
60 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
61 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
62 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
63 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
64 INT213465 Transcription of Lep 4 0.68 2.11 1.15
65 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
66 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
67 INT85788 Negative_regulation of Prlh 5 0.54 0.95 1.09
68 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
69 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
70 INT330142 Positive_regulation of Pcsk1n 1 0.28 0.3 0.95
71 INT123589 Positive_regulation of Positive_regulation of Vgf 7 0.50 2.92 0.88
72 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
73 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
74 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
75 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
76 INT50329 Positive_regulation of Gene_expression of Vgf 2 0.70 3.45 0.75
77 INT156533 Transcription of LEP 9 0.69 4.35 0.74
78 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
79 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
80 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
81 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
82 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
83 INT257721 Regulation of Gene_expression of Vgf 1 0.27 0.79 0.67
84 INT175580 Localization of APOE 10 0.76 18.84 0.65
85 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
86 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
87 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
88 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
89 INT257724 Positive_regulation of Localization of Vgf 1 0.70 0.64 0.59
90 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
91 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
92 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
93 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
94 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
95 INT96816 Regulation of APOE 8 0.45 6.62 0.44
96 INT330154 Regulation of Pcsk1n 1 0.25 0.45 0.44
97 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
98 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
99 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
100 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
101 INT68523 Negative_regulation of Pcsk1n 2 0.35 0 0.36
102 INT330146 Binding of Pcsk1n 1 0.27 0 0.34
103 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
104 INT50327 Negative_regulation of Vgf 2 0.43 0.48 0.33
105 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
106 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
107 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
108 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
109 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
110 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
111 INT330151 Negative_regulation of Gene_expression of Pcsk1n 1 0.24 0 0.29
112 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
113 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
114 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
115 INT85790 Positive_regulation of Transcription of Prlh 1 0.43 0 0.25
116 INT85785 Negative_regulation of Transcription of Prlh 1 0.40 0 0.25
117 INT172687 Binding of Vgf 2 0.37 0.46 0.24
118 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
119 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
120 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
121 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
122 INT330152 Positive_regulation of Positive_regulation of Pcsk1n 1 0.28 0 0.21
123 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
124 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
125 INT257722 Positive_regulation of Transcription of Vgf 1 0.50 0.89 0.17
126 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
127 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
128 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
129 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
130 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
131 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
132 INT330143 Positive_regulation of Localization of Pcsk1n 1 0.28 0.26 0.16
133 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
134 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
135 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
136 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
137 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
138 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
139 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
140 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
141 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
142 INT330149 Transcription of Pcsk1n 1 0.39 0 0.12
143 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
144 INT85784 Binding of Prlh 1 0.34 0 0.11
145 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
146 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
147 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
148 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
149 INT330145 Regulation of Binding of Pcsk1n 1 0.25 0 0.08
150 INT330147 Negative_regulation of Regulation of Pcsk1n 1 0.24 0 0.08
151 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
152 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07
153 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
154 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
155 INT213466 Negative_regulation of Regulation of Lep 1 0.41 0 0.06
156 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
157 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
158 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
159 INT191285 Positive_regulation of Localization of APOE 3 0.66 3.06 0
160 INT326073 Transcription of APOE 2 0.51 1.94 0
161 INT50081 Positive_regulation of Positive_regulation of APOE 2 0.49 0.18 0
162 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
163 INT150408 Regulation of Regulation of Lep 1 0.27 0 0
164 INT305226 Negative_regulation of Phosphorylation of Lep 1 0.42 1.89 0
165 INT330153 Positive_regulation of Gene_expression of Pcsk1n 1 0.28 0 0
166 INT305239 Positive_regulation of Phosphorylation of Lep 1 0.43 1.09 0
167 INT330148 Negative_regulation of Localization of Pcsk1n 1 0.24 0.11 0
168 INT332954 Regulation of Transcription of Lep 1 0.11 1.4 0
169 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
170 INT174279 Positive_regulation of Negative_regulation of Lep 1 0.46 0.16 0
171 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
172 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
173 INT299888 Negative_regulation of Gene_expression of Prlh 1 0.35 0 0
174 INT326524 Negative_regulation of Transcription of APOE 1 0.30 1.71 0
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