GO:0002029

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Name desensitization of G-protein coupled receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0002029
Unique Molecular Interactions 129
Total Molecular Interactions 158
Total Single Events 1276
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for desensitization of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for desensitization of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
2 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
3 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
4 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
5 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
6 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
7 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
8 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
9 INT146496 Snta1 Positive_regulation of Gene_expression of Adrbk1 1 0.13 0.73 1.05
10 INT162250 Binding of TRPV1 and Grm5 1 0.01 0.8 1.03
11 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
12 INT123052 Gpbar1 Regulation of Phosphorylation of Grk4 1 0.37 0 0.94
13 INT123049 Grk4 Regulation of Phosphorylation of Gpbar1 1 0.37 0 0.94
14 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
15 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
16 INT146495 Snta1 Positive_regulation of Adrbk1 1 0.14 0.68 0.85
17 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
18 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75
19 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
20 INT104110 Negative_regulation of Adrbk2 Negative_regulation of Oprm1 1 0.00 0 0.71
21 INT104102 Negative_regulation of Adrbk2 Negative_regulation of Oprl1 1 0.06 0 0.7
22 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69
23 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
24 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
25 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
26 INT107523 Negative_regulation of Grm5 Negative_regulation of Gene_expression of Fos 1 0.37 0.09 0.58
27 INT166300 Adrbk1 Positive_regulation of Negative_regulation of Gpbar1 1 0.39 0.63 0.58
28 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
29 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
30 INT151222 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Adrbk1 1 0.00 0.13 0.51
31 INT151223 Negative_regulation of SIGMAR1 Negative_regulation of Adrbk1 1 0.00 0.13 0.51
32 INT159774 Binding of GRM5 and TRPV1 1 0.40 0.5 0.51
33 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
34 INT8181 Grm5 Positive_regulation of Gh 1 0.00 0 0.44
35 INT343640 Positive_regulation of Grm5 Positive_regulation of Adp 1 0.01 0 0.4
36 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
37 INT150196 Grm5 Regulation of Grin2b 1 0.45 0 0.36
38 INT265145 Calm2 Negative_regulation of Phosphorylation of Adrbk1 1 0.05 0.07 0.35
39 INT106397 Positive_regulation of OPRL1 Positive_regulation of ADRBK1 1 0.46 0.09 0.31
40 INT102976 Binding of ADRBK1 and Rbm39 1 0.00 0 0.31
41 INT265138 Adrbk1 Positive_regulation of Localization of Chrm1 1 0.07 0 0.31
42 INT116680 Binding of ADRBK1 and Oxtr 1 0.18 0.14 0.3
43 INT102955 OPRK1 Positive_regulation of Localization of ADRBK1 1 0.13 0 0.3
44 INT83569 Grk5 Regulation of Oprk1 1 0.02 0 0.29
45 INT83568 Adrbk2 Regulation of Oprk1 1 0.02 0 0.29
46 INT170727 Binding of Grm5 and Calm2 1 0.01 0.13 0.28
47 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
48 INT264841 NAMPT Positive_regulation of GRM5 1 0.01 0.72 0.27
49 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
50 INT343641 Grm5 Positive_regulation of Adp 1 0.01 0 0.19
51 INT343644 Grm5 Positive_regulation of Cav2 1 0.05 0 0.19
52 INT247507 Grk6 Regulation of LTB4R 1 0.02 0.2 0.18
53 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
54 INT224092 Adrbk1 Regulation of Grk5 1 0.08 0 0.16
55 INT102975 ADRBK1 Regulation of Localization of Rbm39 1 0.00 0 0.15
56 INT102954 Binding of ADRBK1 and OPRK1 1 0.11 0 0.14
57 INT224127 Grk5 Positive_regulation of Phosphorylation of Adora3 1 0.06 0 0.13
58 INT224125 Adrbk2 Positive_regulation of Phosphorylation of Adora3 1 0.04 0 0.13
59 INT224090 Binding of Grk6 and Grk4 1 0.06 0 0.12
60 INT224088 Binding of Grk5 and Grk4 1 0.07 0 0.12
61 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
62 INT347802 Grm5 Positive_regulation of Oss1 1 0.12 0.67 0.11
63 INT72849 RT1-EC2 Positive_regulation of Adrbk1 1 0.01 0.33 0.1
64 INT72848 RT1-EC2 Positive_regulation of Adrbk2 1 0.00 0.33 0.1
65 INT72847 Adrbk2 Positive_regulation of Adrbk1 1 0.02 0.33 0.1
66 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
67 INT223039 Gene_expression of TFPI Positive_regulation of Gene_expression of ADRBK1 1 0.11 0 0.07
68 INT223041 Binding of ADRBK1 and TFPI 1 0.08 0 0.03
69 INT223037 SLURP1 Positive_regulation of Gene_expression of ADRBK1 1 0.02 0 0
70 INT343645 Positive_regulation of Grm5 Positive_regulation of Localization of Car2 1 0.03 0 0
71 INT170726 Negative_regulation of Binding of Grm5 and Calm2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for desensitization of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in desensitization of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
2 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
3 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
4 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
5 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
6 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
7 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82
8 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
9 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
10 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
11 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51
12 INT105839 Positive_regulation of Grk5 5 0.70 0.35 9.2
13 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
14 INT123040 Phosphorylation of Grk4 12 0.60 0.31 9.14
15 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
16 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
17 INT98856 Negative_regulation of Gene_expression of Adrbk1 5 0.56 0.43 7.29
18 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
19 INT147498 Gene_expression of GRM5 10 0.75 3.16 7.12
20 INT54713 Gene_expression of Adrbk2 12 0.65 0.08 5.92
21 INT119132 Regulation of Grm5 8 0.48 2.66 5.46
22 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
23 INT107390 Negative_regulation of Grm5 11 0.45 6 4.42
24 INT74815 Binding of Grm5 11 0.36 3.62 4.25
25 INT95784 Positive_regulation of Positive_regulation of Grm5 8 0.11 3.48 4.01
26 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
27 INT99593 Gene_expression of Grk6 3 0.78 3.19 3.52
28 INT122438 Transcription of Grk5 1 0.72 0 3.46
29 INT83565 Gene_expression of Grk5 5 0.55 0.16 3.39
30 INT122441 Regulation of Grk5 1 0.62 0 3.13
31 INT54709 Positive_regulation of Gene_expression of Adrbk1 6 0.49 0.18 3.12
32 INT105840 Regulation of Gene_expression of Adrbk1 2 0.44 0.16 3.09
33 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
34 INT99592 Regulation of Adrbk1 3 0.61 1.46 2.84
35 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
36 INT105837 Regulation of Gene_expression of Grk5 1 0.44 0.16 2.68
37 INT140206 Binding of GRM5 6 0.36 1.85 2.52
38 INT94978 Negative_regulation of Adrbk1 6 0.38 0.13 2.47
39 INT181219 Positive_regulation of Phosphorylation of Grk4 4 0.30 0.05 2.42
40 INT123713 Binding of Grm5 7 0.31 2.96 2.38
41 INT107656 Regulation of Gene_expression of Grm5 4 0.26 0.84 2.38
42 INT105838 Negative_regulation of Grk5 2 0.43 0.1 2.37
43 INT94984 Regulation of Grk6 1 0.42 0 2.34
44 INT72842 Phosphorylation of Adrbk1 5 0.47 0.58 2.16
45 INT146491 Binding of Adrbk1 3 0.48 1.58 2.09
46 INT102966 Gene_expression of Grk4 4 0.75 1.51 2.07
47 INT157529 Positive_regulation of GRM5 3 0.48 0.59 2.07
48 INT152025 Negative_regulation of Positive_regulation of Grm5 4 0.14 2.21 2.06
49 INT101945 Regulation of Gene_expression of Grm5 2 0.48 0.96 1.98
50 INT51603 Localization of Grm5 5 0.73 0.33 1.87
51 INT102970 Localization of ADRBK1 4 0.66 0.45 1.85
52 INT73870 Positive_regulation of Regulation of Adrbk1 1 0.47 0.17 1.66
53 INT147384 Regulation of Positive_regulation of Grm5 2 0.11 0.41 1.65
54 INT153869 Positive_regulation of Grk6 1 0.47 1.7 1.61
55 INT83563 Positive_regulation of Gene_expression of Adrbk2 2 0.58 0 1.57
56 INT54711 Regulation of Adrbk2 1 0.59 0 1.57
57 INT117607 Localization of Grm5 12 0.50 1.31 1.56
58 INT104106 Localization of Adrbk2 3 0.19 0.35 1.53
59 INT94965 Transcription of Adrbk1 2 0.22 0.13 1.52
60 INT100523 Regulation of GRM5 2 0.26 0.49 1.51
61 INT128391 Positive_regulation of Regulation of Grm5 1 0.37 0 1.49
62 INT153870 Negative_regulation of Gene_expression of Grk6 1 0.43 1.53 1.47
63 INT94987 Negative_regulation of Grk6 2 0.40 0 1.45
64 INT168906 Positive_regulation of Gene_expression of Grm5 4 0.39 1.75 1.38
65 INT211740 Negative_regulation of Phosphorylation of Grk4 1 0.26 0.14 1.37
66 INT54712 Positive_regulation of Adrbk2 3 0.66 0.34 1.35
67 INT211742 Regulation of Phosphorylation of Grk4 1 0.27 0.14 1.34
68 INT94982 Gene_expression of Grk6 2 0.56 0 1.32
69 INT151216 Positive_regulation of Adrbk1 2 0.46 0.9 1.3
70 INT94967 Localization of Adrbk1 2 0.26 0.33 1.21
71 INT94977 Positive_regulation of Grk6 1 0.47 0 1.17
72 INT107658 Regulation of Positive_regulation of Grm5 1 0.26 0.84 1.17
73 INT112931 Negative_regulation of Localization of Adrbk1 1 0.37 0 1.13
74 INT112932 Localization of Adrbk1 1 0.69 0 1.12
75 INT106404 Positive_regulation of Positive_regulation of ADRBK1 2 0.41 0.31 1.08
76 INT98849 Binding of Adrbk1 3 0.36 0.18 1.04
77 INT98855 Negative_regulation of Binding of Adrbk1 2 0.41 0.18 1.04
78 INT83566 Negative_regulation of Adrbk2 2 0.23 0 1.03
79 INT127016 Regulation of Grk4 3 0.60 2.59 1
80 INT146492 Positive_regulation of Negative_regulation of Adrbk1 1 0.50 0.74 1
81 INT157528 Regulation of Gene_expression of GRM5 1 0.43 0 0.96
82 INT122439 Positive_regulation of Transcription of Grk5 1 0.70 0 0.94
83 INT111883 Negative_regulation of Transcription of Adrbk1 1 0.33 0 0.93
84 INT111887 Transcription of Adrbk1 1 0.56 0 0.92
85 INT223653 Transcription of Grm5 4 0.69 1.4 0.83
86 INT110511 Regulation of ADRBK1 1 0.22 0.22 0.76
87 INT110505 Positive_regulation of Negative_regulation of ADRBK1 1 0.38 0.22 0.76
88 INT157526 Regulation of Binding of GRM5 1 0.43 0 0.73
89 INT104103 Positive_regulation of Localization of Adrbk2 1 0.08 0 0.69
90 INT54710 Regulation of Regulation of Adrbk1 1 0.37 0 0.69
91 INT168907 Negative_regulation of Negative_regulation of Grm5 1 0.14 1.01 0.65
92 INT122440 Regulation of Transcription of Grk5 1 0.24 0 0.63
93 INT224102 Negative_regulation of Localization of Adrbk1 1 0.19 0.44 0.61
94 INT99591 Positive_regulation of Gene_expression of Grk6 1 0.59 0.14 0.59
95 INT137480 Positive_regulation of Positive_regulation of Adrbk1 1 0.44 0.06 0.55
96 INT126960 Phosphorylation of ADRBK1 2 0.66 0.06 0.52
97 INT116677 Binding of ADRBK1 6 0.44 0.65 0.5
98 INT210972 Positive_regulation of Localization of Grm5 3 0.06 0.24 0.48
99 INT163205 Transcription of Grm5 1 0.00 0.73 0.47
100 INT224110 Positive_regulation of Phosphorylation of Adrbk1 2 0.28 0 0.45
101 INT86728 Negative_regulation of Positive_regulation of Adrbk1 1 0.38 0 0.45
102 INT128595 Negative_regulation of Gene_expression of Grm5 2 0.38 0.51 0.43
103 INT347792 Regulation of Regulation of Grm5 1 0.35 0.12 0.42
104 INT83561 Negative_regulation of Negative_regulation of Adrbk2 1 0.23 0 0.34
105 INT147500 Positive_regulation of Gene_expression of GRM5 1 0.67 0.25 0.33
106 INT102965 Positive_regulation of Gene_expression of Grk4 1 0.45 0 0.32
107 INT224119 Gene_expression of Grk4 1 0.29 0 0.32
108 INT224121 Negative_regulation of Gene_expression of Grk4 1 0.16 0 0.32
109 INT83559 Positive_regulation of Gene_expression of Grk5 1 0.32 0 0.3
110 INT147499 Negative_regulation of Gene_expression of GRM5 1 0.41 0.29 0.26
111 INT181221 Binding of Grk4 1 0.09 0 0.24
112 INT116676 Negative_regulation of Binding of ADRBK1 2 0.53 0.33 0.23
113 INT269441 Positive_regulation of Grk4 1 0.05 0 0.2
114 INT224104 Regulation of Phosphorylation of Adrbk1 1 0.14 0.07 0.17
115 INT224123 Transcription of Adrbk2 1 0.24 0 0.15
116 INT181222 Phosphorylation of Adrbk1 1 0.16 0 0.14
117 INT72844 Phosphorylation of Adrbk2 1 0.16 0.33 0.12
118 INT223056 Regulation of Gene_expression of ADRBK1 1 0.22 0 0.12
119 INT170678 Negative_regulation of Gene_expression of Grm5 1 0.41 0.07 0.09
120 INT223648 Negative_regulation of Transcription of Grm5 1 0.41 0.65 0.08
121 INT347712 Positive_regulation of Binding of Grm5 1 0.13 0 0.05
122 INT170708 Protein_catabolism of Grm5 1 0.02 0.08 0
123 INT223046 Positive_regulation of Localization of ADRBK1 1 0.24 0 0
124 INT170703 Positive_regulation of Regulation of Grm5 1 0.01 0 0
125 INT181220 Negative_regulation of Binding of Adrbk1 1 0.11 0 0
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