GO:0002032

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Name desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Categary Process
Go Slim No
Go Link GO:0002032
Unique Molecular Interactions 51
Total Molecular Interactions 70
Total Single Events 710
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for desensitization of G-protein coupled receptor protein signaling pathway by arrestin. They are ordered first by their pain relevance and then by number of times they were reported for desensitization of G-protein coupled receptor protein signaling pathway by arrestin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
2 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
3 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
4 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
5 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
6 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
7 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
8 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
9 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
10 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
11 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
12 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
13 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
14 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
15 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
16 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
17 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
18 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
19 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
20 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
21 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
22 INT70663 Adrb3 Regulation of Cck 1 0.14 0 0.4
23 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
24 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
25 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
26 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
27 INT153924 Msr1 Regulation of Adrb3 1 0.02 0.24 0.32
28 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
29 INT84607 Oprl1 Regulation of Adrb3 1 0.19 0.25 0.24
30 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
31 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
32 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
33 INT40819 Binding of ADRB3 and AGPAT1 1 0.24 0 0.18
34 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
35 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
36 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
37 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
38 INT174892 Binding of ADRB3 and ENPP3 1 0.04 0.4 0.14
39 INT50533 Binding of ADRB3 and Positive_regulation of Gene_expression of CA3 1 0.11 0.61 0.1
40 INT94411 Positive_regulation of ADRB3 Negative_regulation of Gene_expression of TNF 1 0.19 0.15 0.09
41 INT33806 IL2 Regulation of ADRB3 1 0.28 0.08 0.09
42 INT233526 Tlr4 Regulation of Adrb2 1 0.03 0.07 0
43 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for desensitization of G-protein coupled receptor protein signaling pathway by arrestin. They are ordered first by their pain relevance and then by number of times they were reported in desensitization of G-protein coupled receptor protein signaling pathway by arrestin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
2 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
3 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
4 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
5 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
6 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
7 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
8 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
9 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
10 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
11 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
12 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
13 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
14 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
15 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
16 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
17 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
18 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
19 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
20 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
21 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
22 INT109 Binding of ADRB3 17 0.47 3.02 3.84
23 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
24 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
25 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
26 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
27 INT27100 Binding of Adrb3 10 0.47 3.44 3.07
28 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
29 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
30 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
31 INT80880 Gene_expression of ARRB2 4 0.65 3.51 2.71
32 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
33 INT18202 Localization of Adrb3 7 0.80 2.76 2.44
34 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33
35 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
36 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
37 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
38 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
39 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
40 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
41 INT80885 Positive_regulation of Gene_expression of ARRB2 3 0.49 1.36 1.82
42 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
43 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
44 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
45 INT158184 Localization of ARRB2 2 0.52 1.3 1.47
46 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
47 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
48 INT158183 Positive_regulation of Negative_regulation of ARRB2 1 0.35 1.13 1.33
49 INT68471 Negative_regulation of Positive_regulation of Adrb3 1 0.42 0.14 1.29
50 INT116537 Binding of ARRB2 1 0.34 0.3 1.19
51 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
52 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
53 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
54 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
55 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
56 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
57 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
58 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
59 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
60 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
61 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
62 INT1852 Localization of ADRB3 3 0.75 1.02 0.79
63 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
64 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
65 INT9980 Positive_regulation of Positive_regulation of Adrb3 2 0.43 0.91 0.71
66 INT18201 Positive_regulation of Localization of Adrb3 2 0.11 1.2 0.69
67 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
68 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
69 INT94412 Negative_regulation of Positive_regulation of ADRB3 3 0.38 0.52 0.55
70 INT153922 Transcription of Adrb3 1 0.52 0.34 0.52
71 INT12836 Positive_regulation of Negative_regulation of Adrb3 2 0.54 0.53 0.44
72 INT124786 Localization of Adrb2 1 0.04 0.07 0.44
73 INT13884 Positive_regulation of Positive_regulation of Adrb2 1 0.34 0 0.42
74 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
75 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
76 INT209145 Negative_regulation of Gene_expression of ADRB3 2 0.43 0.76 0.38
77 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
78 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
79 INT513 Transcription of Adrb2 2 0.06 0.55 0.37
80 INT84606 Negative_regulation of Regulation of Adrb3 1 0.29 0 0.31
81 INT36290 Protein_catabolism of Adrb3 2 0.82 0.36 0.29
82 INT354015 Positive_regulation of Gene_expression of ADRB3 1 0.44 0.76 0.27
83 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
84 INT61837 Regulation of Regulation of ADRB3 1 0.26 0.06 0.24
85 INT115874 Negative_regulation of Positive_regulation of Adrb2 1 0.20 0 0.21
86 INT224095 Phosphorylation of ARRB2 1 0.61 0.13 0.19
87 INT209149 Regulation of Gene_expression of ADRB3 1 0.54 0 0.18
88 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17
89 INT44087 Regulation of Negative_regulation of Adrb3 1 0.31 0.28 0.15
90 INT81943 Regulation of Regulation of Adrb2 1 0.29 0 0.12
91 INT81944 Regulation of Positive_regulation of Adrb2 1 0.18 0 0.12
92 INT115419 Positive_regulation of Gene_expression of Adrb3 1 0.37 0.77 0.11
93 INT36289 Regulation of Protein_catabolism of Adrb3 1 0.42 0.36 0.1
94 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
95 INT163263 Transcription of ADRB3 2 0.53 0 0.06
96 INT209148 Transcription of ADRB2 1 0.53 0 0.06
97 INT90474 Positive_regulation of Positive_regulation of ADRB3 1 0.42 0.25 0.06
98 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
99 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
100 INT9763 Negative_regulation of Gene_expression of Adrb3 1 0.42 0 0
101 INT230388 Localization of Adrb2 1 0.51 0.71 0
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