GO:0002063

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Name chondrocyte development
Categary Process
Go Slim No
Go Link GO:0002063
Unique Molecular Interactions 41
Total Molecular Interactions 44
Total Single Events 607
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chondrocyte development. They are ordered first by their pain relevance and then by number of times they were reported for chondrocyte development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
2 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
3 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
4 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
5 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
6 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
7 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
8 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
9 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
10 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
11 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
12 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
13 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
14 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
15 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
16 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
17 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
18 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
19 INT5608 Gnl3 Regulation of Eif2ak3 1 0.05 0 0.04
20 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04
21 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04
22 INT346283 Binding of COL11A1 and ELANE 1 0.01 0.08 0.04
23 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
24 INT312346 FUT1 Positive_regulation of Gene_expression of COL11A1 1 0.17 1.02 0.03
25 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
26 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
27 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
28 INT244454 Binding of EIF2AK3 and SIL1 1 0.05 0.41 0
29 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
30 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
31 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
32 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0
33 INT346285 Binding of COL11A1 and MR1 1 0.00 0.63 0
34 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
35 INT244466 EIF2AK3 Positive_regulation of Localization of SIL1 1 0.06 0.47 0
36 INT292504 Mlph Regulation of EIF2AK3 1 0.00 0.21 0
37 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0
38 INT244465 Binding of EIF2AK3 and ATF6 1 0.14 0.69 0
39 INT130851 Acan Positive_regulation of Gene_expression of Bgn 1 0.02 0.07 0
40 INT183134 Binding of SULF1 and Panc1 1 0.03 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chondrocyte development. They are ordered first by their pain relevance and then by number of times they were reported in chondrocyte development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
2 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
3 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
4 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
5 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
6 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
7 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
8 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
9 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
10 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
11 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
12 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
13 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
14 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
15 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
16 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
17 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
18 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
19 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
20 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
21 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
22 INT183127 Localization of SULF1 1 0.77 3.45 1.13
23 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
24 INT84235 Positive_regulation of Col11a1 2 0.01 0.09 1.03
25 INT43484 Binding of Runx2 7 0.37 3.22 0.95
26 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
27 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
28 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
29 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
30 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
31 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
32 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
33 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
34 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
35 INT3503 Localization of COL11A1 3 0.65 2.17 0.63
36 INT183133 Negative_regulation of Localization of SULF1 1 0.41 1.34 0.59
37 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
38 INT71274 Gene_expression of Acan 3 0.12 0.99 0.5
39 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
40 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
41 INT3504 Binding of COL11A1 1 0.32 0 0.4
42 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
43 INT147700 Positive_regulation of Gene_expression of Col11a1 1 0.01 0 0.39
44 INT183114 Positive_regulation of Gene_expression of SULF1 1 0.48 7.61 0.37
45 INT183116 Positive_regulation of SULF1 1 0.67 3.22 0.34
46 INT15697 Negative_regulation of EIF2AK3 1 0.41 0 0.33
47 INT15698 Transcription of EIF2AK3 1 0.52 0 0.32
48 INT127902 Negative_regulation of Gene_expression of EIF2AK3 1 0.42 0.47 0.3
49 INT277061 Positive_regulation of COL11A1 2 0.43 1.56 0.28
50 INT71271 Positive_regulation of Acan 2 0.09 0.55 0.27
51 INT71275 Positive_regulation of Localization of Acan 1 0.05 0.48 0.27
52 INT71272 Localization of Acan 1 0.08 0.48 0.26
53 INT185908 Gene_expression of COL11A1 4 0.71 6.18 0.25
54 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
55 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
56 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19
57 INT130849 Transcription of Acan 1 0.10 0.46 0.19
58 INT312356 Regulation of COL11A1 1 0.22 1.55 0.19
59 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17
60 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16
61 INT97186 Regulation of Col11a1 1 0.01 0.74 0.16
62 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13
63 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
64 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
65 INT183124 Regulation of Gene_expression of SULF1 1 0.59 1.92 0.1
66 INT211942 Transcription of Runx2 3 0.69 2.46 0.08
67 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
68 INT8906 Negative_regulation of Col11a1 1 0.01 0 0.07
69 INT284837 Localization of Col11a1 1 0.01 0 0.07
70 INT183129 Negative_regulation of Gene_expression of SULF1 1 0.56 5.19 0.07
71 INT67143 Binding of Acan 1 0.36 0 0.07
72 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
73 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
74 INT183122 Regulation of SULF1 1 0.59 1.53 0.06
75 INT268298 Gene_expression of Fgf18 1 0.22 0.44 0.05
76 INT268307 Positive_regulation of Fgf18 1 0.25 0.44 0.05
77 INT225365 Binding of Sox9 2 0.28 0.48 0.03
78 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
79 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
80 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
81 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
82 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0
83 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
84 INT211944 Regulation of Transcription of Runx2 1 0.34 0.32 0
85 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
86 INT312355 Transcription of COL11A1 1 0.63 0.69 0
87 INT220772 Transcription of Msx2 1 0.46 0.08 0
88 INT244533 Negative_regulation of Phosphorylation of EIF2AK3 1 0.20 0.39 0
89 INT211943 Transcription of Sox9 1 0.50 0.3 0
90 INT312361 Regulation of Gene_expression of COL11A1 1 0.42 1.04 0
91 INT322886 Transcription of Sox9 1 0.50 0.25 0
92 INT114719 Binding of Col11a1 1 0.19 0 0
93 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
94 INT130844 Positive_regulation of Gene_expression of Acan 1 0.09 0 0
95 INT265814 Localization of Runx2 1 0.75 0.84 0
96 INT277589 Regulation of Negative_regulation of Runx2 1 0.36 0.78 0
97 INT183128 Transcription of SULF1 1 0.66 0.17 0
98 INT271085 Positive_regulation of Regulation of Eif2ak3 1 0.03 0.66 0
99 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0
100 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
101 INT171613 Positive_regulation of Positive_regulation of Runx2 1 0.01 0 0
102 INT130848 Positive_regulation of Transcription of Acan 1 0.09 0 0
103 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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