GO:0002076

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Name osteoblast development
Categary Process
Go Slim No
Go Link GO:0002076
Unique Molecular Interactions 422
Total Molecular Interactions 592
Total Single Events 5354
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for osteoblast development. They are ordered first by their pain relevance and then by number of times they were reported for osteoblast development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
2 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
3 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
4 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
5 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
6 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
7 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87
8 INT113250 Olr1259 Negative_regulation of Ache 1 0.01 0.38 0.83
9 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
10 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
11 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
12 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
13 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
14 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
15 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
16 INT101716 JUND Regulation of Regulation of OPRM1 1 0.09 0.06 0.65
17 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59
18 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
19 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
20 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
21 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
22 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
23 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49
24 INT352031 Binding of NR3C1 and JUND 1 0.10 2.87 0.48
25 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
26 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
27 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
28 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
29 INT87603 Binding of FOS and Jund 1 0.03 0.77 0.39
30 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
31 INT57219 Binding of ATF3 and JUND 1 0.31 0.39 0.38
32 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
33 INT296306 Binding of BGLAP and SPIN1 1 0.05 1.69 0.37
34 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
35 INT83348 GSR Negative_regulation of JUND 1 0.20 0.72 0.33
36 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
37 INT51630 Binding of ACHE and OPRM1 1 0.11 0 0.33
38 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
39 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
40 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
41 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
42 INT158734 Esr1 Regulation of Esrrb 1 0.00 0.28 0.29
43 INT301277 Il6 Positive_regulation of Positive_regulation of Clec5a 1 0.16 0.37 0.29
44 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29
45 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
46 INT301289 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Atp6v0d2 1 0.02 1.01 0.28
47 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
48 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
49 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
50 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
51 INT233781 Binding of PTH1R and SCT 1 0.18 0 0.27
52 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
53 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27
54 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
55 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
56 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
57 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25
58 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
59 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
60 INT23626 Ache Regulation of Mir343 1 0.17 0 0.24
61 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
62 INT214412 CASQ1 Regulation of JUND 1 0.02 0.46 0.24
63 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
64 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
65 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
66 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
67 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
68 INT207456 LGALS3 Negative_regulation of Gene_expression of BGLAP 1 0.13 0.5 0.22
69 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
70 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
71 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
72 INT244299 FFAR1 Positive_regulation of PTH1R 1 0.00 0.4 0.2
73 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
74 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
75 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
76 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
77 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
78 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
79 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
80 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
81 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
82 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
83 INT111152 Pthlh Positive_regulation of Localization of Avp 1 0.53 0.26 0.18
84 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
85 INT355307 Use1 Positive_regulation of Gene_expression of Clec5a 1 0.02 2.97 0.17
86 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
87 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
88 INT19045 ESR1 Positive_regulation of Salpa1 1 0.02 0.6 0.17
89 INT355303 Use1 Positive_regulation of Clec5a 1 0.02 2.97 0.17
90 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
91 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
92 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
93 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
94 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
95 INT57218 Binding of JUND and PENK 1 0.11 0.16 0.15
96 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
97 INT107889 Binding of Pthlh and Pth1r 1 0.06 0 0.14
98 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
99 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
100 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
101 INT27393 Tha1 Negative_regulation of Ache 1 0.15 0.24 0.14
102 INT107892 Binding of Pthlh and PTH2 1 0.27 0 0.14
103 INT42772 Penk Negative_regulation of Ache 1 0.06 0 0.14
104 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
105 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
106 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13
107 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13
108 INT86429 Binding of Hspb1 and Esr1 1 0.19 0.26 0.13
109 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
110 INT128281 Binding of JUND and NFKB1 1 0.36 0.39 0.13
111 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
112 INT346530 Binding of PTH1R and TFIP11 1 0.15 0 0.11
113 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
114 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11
115 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
116 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
117 INT34497 Binding of Oprl1 and Ache 1 0.40 0 0.1
118 INT301288 Clec5a Regulation of Nfatc1 1 0.21 0.25 0.1
119 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
120 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1
121 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1
122 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1
123 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09
124 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
125 INT77726 Ptger2 Regulation of Jund 1 0.08 0 0.09
126 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
127 INT75564 Binding of Jund and Penk 1 0.32 0 0.08
128 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
129 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
130 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08
131 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
132 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08
133 INT75571 Binding of Jund and Pigm 1 0.02 0 0.08
134 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08
135 INT220916 Positive_regulation of Binding of JUN and JUND 2 0.18 0.53 0.07
136 INT220911 Binding of JUN and JUND 2 0.14 1.08 0.07
137 INT38188 PGR Positive_regulation of Gene_expression of ESR1 1 0.42 0.22 0.07
138 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
139 INT224293 AR Positive_regulation of Protein_catabolism of ESR1 1 0.24 0.4 0.07
140 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
141 INT57216 JUND Positive_regulation of Gene_expression of PENK 1 0.10 0.07 0.07
142 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07
143 INT272388 Esr1 Regulation of Transcription of Trpv6 1 0.03 0.13 0.06
144 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
145 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
146 INT197594 Esr1 Regulation of Esr2 1 0.04 0 0.06
147 INT207463 Negative_regulation of LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
148 INT207458 LGALS3 Negative_regulation of Negative_regulation of BGLAP 1 0.12 0.18 0.06
149 INT207468 LGALS3 Regulation of Gene_expression of BGLAP 1 0.11 0.13 0.06
150 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
151 INT187845 Binding of ESR1 and Esr2 1 0.01 0.17 0.06
152 INT207467 LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
153 INT197592 Esr2 Regulation of Esr1 1 0.04 0 0.06
154 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
155 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05
156 INT251803 PTH1R Positive_regulation of PTH 1 0.08 0.06 0.05
157 INT346529 Binding of PTH1R and TACR1 1 0.00 0 0.05
158 INT107891 Binding of Pth1r and PTH2 1 0.08 0 0.05
159 INT346523 Binding of PTH1R and RHO 1 0.01 0 0.05
160 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05
161 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
162 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
163 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
164 INT206853 ESR1 Positive_regulation of Gene_expression of PCP4 1 0.08 1.39 0.04
165 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
166 INT197646 DPH1 Negative_regulation of Localization of BGLAP 1 0.01 0.26 0.04
167 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04
168 INT206851 NR4A1 Regulation of Gene_expression of ESR1 1 0.08 0.9 0.04
169 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
170 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04
171 INT206847 ESR1 Negative_regulation of Gene_expression of PTGER3 1 0.08 1.52 0.04
172 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
173 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
174 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04
175 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
176 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
177 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
178 INT206849 ESR1 Regulation of Gene_expression of ALDH1A1 1 0.11 2.26 0.04
179 INT217106 Binding of Hoxa2 and Hoxb2 1 0.34 0.08 0.04
180 INT206852 ESR1 Regulation of Gene_expression of CRABP2 1 0.08 1.52 0.04
181 INT183614 Binding of ESR1 and TMED4 2 0.02 0.13 0.03
182 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
183 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
184 INT217111 Binding of Egr2 and Hoxa2 1 0.35 0.21 0.03
185 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
186 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
187 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
188 INT330875 PLDN Negative_regulation of Gene_expression of Ache 1 0.01 0.85 0.03
189 INT278289 Binding of DBP and ESR1 1 0.03 0.82 0.03
190 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
191 INT300179 Binding of BGLAP and INCENP 1 0.02 0.08 0.03
192 INT245075 Binding of ESR1 and NR4A1 1 0.01 1.08 0.03
193 INT207457 LGALS3 Positive_regulation of Gene_expression of BGLAP 1 0.12 0.1 0.03
194 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
195 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
196 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
197 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
198 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03
199 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
200 INT278294 Binding of ESR1 and SHBG 1 0.01 0.82 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for osteoblast development. They are ordered first by their pain relevance and then by number of times they were reported in osteoblast development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
3 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
4 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28
5 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89
6 INT20462 Binding of ESR1 210 0.44 102.7 26.34
7 INT276 Regulation of Ache 83 0.62 16.75 25.99
8 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
9 INT19071 Localization of Ache 66 0.81 5.1 16.27
10 INT92354 Localization of ESR1 77 0.75 33.04 15.51
11 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
12 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
13 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
14 INT1252 Binding of Ache 46 0.48 9.94 10.25
15 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
16 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
17 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62
18 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
19 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
20 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
21 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
22 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
23 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
24 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
25 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29
26 INT9480 Gene_expression of Jund 14 0.77 3.58 5.25
27 INT301263 Gene_expression of Clec5a 22 0.77 14.64 5.18
28 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
29 INT20059 Protein_catabolism of Ache 15 0.98 3.73 4.87
30 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
31 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
32 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
33 INT11946 Transcription of Ache 18 0.69 2.62 4.13
34 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
35 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
36 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
37 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
38 INT20461 Binding of Esr1 34 0.48 9.58 3.66
39 INT61028 Negative_regulation of Gene_expression of Jund 3 0.54 0 3.58
40 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
41 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
42 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
43 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
44 INT28009 Positive_regulation of Gene_expression of Ache 15 0.70 5.46 3.26
45 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26
46 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
47 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
48 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
49 INT301272 Positive_regulation of Clec5a 1 0.69 6.17 2.92
50 INT22069 Positive_regulation of Localization of Ache 9 0.70 0.61 2.9
51 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
52 INT15757 Gene_expression of JUND 11 0.75 2.47 2.86
53 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
54 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
55 INT11892 Gene_expression of ACHE 10 0.68 1.32 2.63
56 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
57 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5
58 INT27338 Regulation of ACHE 6 0.62 1.25 2.38
59 INT14890 Localization of ACHE 5 0.80 0.47 2.21
60 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18
61 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
62 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14
63 INT186893 Binding of BGLAP 10 0.37 6.19 2.02
64 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
65 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
66 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
67 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
68 INT38201 Negative_regulation of Localization of Ache 8 0.59 2.35 1.82
69 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
70 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
71 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
72 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
73 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
74 INT8757 Binding of ACHE 10 0.48 5.84 1.72
75 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
76 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
77 INT2847 Positive_regulation of Negative_regulation of Ache 8 0.49 1.09 1.65
78 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
79 INT14891 Positive_regulation of ACHE 10 0.70 5.37 1.64
80 INT75559 Negative_regulation of Jund 2 0.54 0.25 1.57
81 INT15758 Positive_regulation of Gene_expression of JUND 5 0.23 0.99 1.53
82 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
83 INT8511 Localization of Esr1 6 0.80 3.27 1.26
84 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
85 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
86 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
87 INT29772 Positive_regulation of Positive_regulation of Ache 3 0.50 0.09 1.18
88 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
89 INT27366 Negative_regulation of Negative_regulation of Ache 4 0.43 0.29 1.12
90 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
91 INT233816 Negative_regulation of PTH1R 2 0.58 4.08 1.07
92 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
93 INT70667 Regulation of JUND 3 0.33 2.36 1.05
94 INT301262 Negative_regulation of Gene_expression of Clec5a 1 0.43 3.01 1.02
95 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
96 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
97 INT119674 Localization of GLI2 6 0.52 2.84 0.99
98 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
99 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
100 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
101 INT43484 Binding of Runx2 7 0.37 3.22 0.95
102 INT9479 Positive_regulation of Jund 12 0.69 1.57 0.94
103 INT49658 Positive_regulation of Jund 1 0.02 0.51 0.93
104 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
105 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
106 INT112520 Negative_regulation of Regulation of Ache 2 0.28 1.02 0.87
107 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
108 INT309781 Positive_regulation of Gene_expression of PTH1R 2 0.46 1.88 0.87
109 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85
110 INT19070 Regulation of Localization of Ache 5 0.62 0.39 0.84
111 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84
112 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
113 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
114 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
115 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
116 INT48481 Negative_regulation of Binding of Ache 4 0.36 1.76 0.76
117 INT312011 Negative_regulation of Binding of BGLAP 1 0.11 1.04 0.76
118 INT83350 Negative_regulation of JUND 4 0.52 1.68 0.75
119 INT11944 Positive_regulation of Transcription of Ache 3 0.48 1.68 0.75
120 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
121 INT101722 Binding of JUND 12 0.31 2.21 0.73
122 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
123 INT60826 Negative_regulation of Positive_regulation of Ache 3 0.50 0.68 0.73
124 INT104840 Binding of GLI2 6 0.08 1.89 0.72
125 INT217098 Gene_expression of Hoxa2 1 0.77 2.23 0.72
126 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7
127 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
128 INT244300 Localization of PTH1R 2 0.74 2.03 0.67
129 INT301261 Negative_regulation of Clec5a 3 0.58 1.68 0.66
130 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
131 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
132 INT197832 Localization of MEN1 1 0.80 11.01 0.63
133 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
134 INT235398 Regulation of Gene_expression of BGLAP 3 0.27 1.03 0.61
135 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
136 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
137 INT144394 Protein_catabolism of ACHE 1 0.89 0.24 0.53
138 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
139 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
140 INT4387 Phosphorylation of Ache 3 0.79 1.15 0.5
141 INT101720 Localization of JUND 1 0.39 0.09 0.5
142 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
143 INT333910 Positive_regulation of Gene_expression of HDAC4 2 0.07 1.5 0.49
144 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49
145 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48
146 INT301265 Regulation of Clec5a 1 0.45 0.9 0.47
147 INT206484 Localization of Shh 2 0.75 1.14 0.46
148 INT301269 Positive_regulation of Positive_regulation of Clec5a 1 0.50 1.28 0.45
149 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
150 INT224428 Positive_regulation of Localization of BGLAP 5 0.30 2.34 0.44
151 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43
152 INT349695 Positive_regulation of Gene_expression of Jund 1 0.54 0 0.43
153 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
154 INT86052 Regulation of Transcription of Ache 1 0.12 0 0.41
155 INT86053 Positive_regulation of Binding of Ache 2 0.43 0 0.4
156 INT110258 Negative_regulation of PTHLH 6 0.56 5.42 0.39
157 INT140982 Negative_regulation of Gene_expression of Pthlh 1 0.30 0.39 0.39
158 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
159 INT268930 Regulation of Regulation of Esr1 2 0.41 0.48 0.38
160 INT94218 Positive_regulation of Regulation of Ache 2 0.40 0 0.38
161 INT277579 Binding of Hdac4 1 0.37 3.84 0.38
162 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
163 INT57118 Transcription of BGLAP 4 0.56 1.65 0.37
164 INT277604 Negative_regulation of Hdac4 4 0.51 2.89 0.36
165 INT277598 Regulation of Gene_expression of Hdac4 1 0.45 0.91 0.36
166 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
167 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
168 INT301267 Binding of Clec5a 2 0.37 1.17 0.35
169 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
170 INT346533 Protein_catabolism of PTH1R 1 0.52 0.47 0.32
171 INT301271 Localization of Clec5a 1 0.70 0.62 0.32
172 INT183916 Negative_regulation of Binding of Esr1 1 0.06 0.91 0.32
173 INT171995 Binding of PTH1R 8 0.35 1.16 0.31
174 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
175 INT73915 Negative_regulation of Negative_regulation of Esr1 1 0.40 0.06 0.31
176 INT82118 Positive_regulation of Pthlh 3 0.47 2.46 0.3
177 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
178 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
179 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
180 INT309782 Regulation of PTH1R 1 0.45 0.88 0.28
181 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
182 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
183 INT124568 Regulation of HDAC4 5 0.24 3.03 0.27
184 INT301270 Positive_regulation of Gene_expression of Clec5a 1 0.50 0.59 0.27
185 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
186 INT273924 Gene_expression of Jund 2 0.39 0.5 0.26
187 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
188 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
189 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
190 INT255780 Negative_regulation of Negative_regulation of ACHE 2 0.43 1.28 0.24
191 INT128285 Negative_regulation of Binding of JUND 2 0.38 0.39 0.23
192 INT143954 Regulation of Gene_expression of JUND 1 0.20 0.48 0.23
193 INT173655 Binding of LRP5 10 0.39 3.06 0.22
194 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
195 INT62070 Transcription of PTHLH 3 0.72 1.57 0.22
196 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
197 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
198 INT96972 Positive_regulation of Binding of Esr1 4 0.22 1.35 0.21
199 INT277584 Negative_regulation of Gene_expression of Hdac4 1 0.43 0.85 0.21
200 INT195061 Phosphorylation of PTHLH 1 0.35 0.46 0.21
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