GO:0002088

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Name lens development in camera-type eye
Categary Process
Go Slim No
Go Link GO:0002088
Unique Molecular Interactions 82
Total Molecular Interactions 131
Total Single Events 817
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lens development in camera-type eye. They are ordered first by their pain relevance and then by number of times they were reported for lens development in camera-type eye. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
2 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
3 INT334131 Acsm3 Positive_regulation of Mip 1 0.13 3.12 1.48
4 INT209409 Binding of CALM1 and NHS 2 0.27 0.58 1.32
5 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
6 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99
7 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
8 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
9 INT334130 Negative_regulation of Acsm3 Positive_regulation of Mip 1 0.12 1.48 0.81
10 INT334134 Acsm3 Positive_regulation of Gene_expression of Mip 1 0.13 1.4 0.77
11 INT98572 Binding of ABAT and CRYGS 1 0.01 0 0.75
12 INT199395 Mip Positive_regulation of Positive_regulation of Trpv1 1 0.01 0.86 0.69
13 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
14 INT109256 PDYN Positive_regulation of Binding of CRYGS 1 0.00 0.1 0.61
15 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 0.04 0 0.49
16 INT86089 Foxm1 Regulation of Binding of Crygs 1 0.02 0 0.49
17 INT79624 CDC42BPG Positive_regulation of Binding of CRYGS 1 0.02 0.25 0.46
18 INT335996 Mmp8 Regulation of Protein_catabolism of MIP 1 0.44 1.06 0.43
19 INT127543 Gria1 Positive_regulation of Gene_expression of Cryge 1 0.00 0.35 0.42
20 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
21 INT20974 SLC26A2 Negative_regulation of Binding of CRYGS 1 0.00 0 0.39
22 INT70836 Positive_regulation of OPRK1 Positive_regulation of Binding of CRYGS 1 0.03 0.09 0.36
23 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33
24 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
25 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29
26 INT128541 Pnoc Positive_regulation of Crygb 1 0.21 0 0.29
27 INT109711 Mip Positive_regulation of Rtcd1 1 0.00 0 0.29
28 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28
29 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28
30 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
31 INT268768 Mip Regulation of Positive_regulation of Ccr1 1 0.44 0.83 0.23
32 INT217349 Mip Positive_regulation of IL8 1 0.05 1.28 0.22
33 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
34 INT81833 Negative_regulation of Binding of ADRA2C and CRYGS 1 0.06 0 0.19
35 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
36 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
37 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
38 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
39 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
40 INT261630 Binding of CPD and NHS 1 0.02 0.69 0.15
41 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
42 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
43 INT81831 Positive_regulation of Binding of ADRA2C and CRYGS 1 0.07 0 0.14
44 INT213749 NHS Positive_regulation of Localization of CALM1 1 0.28 0.58 0.14
45 INT353011 GJA8 Regulation of USE1 1 0.00 0.35 0.13
46 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
47 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
48 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
49 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
50 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
51 INT267214 Hspb8 Negative_regulation of Cryab 1 0.32 1.56 0.06
52 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
53 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
54 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05
55 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05
56 INT226534 Binding of IL4 and Maf 1 0.02 0.21 0.04
57 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
58 INT226506 Maf Positive_regulation of Positive_regulation of Il2ra 1 0.02 0.22 0.04
59 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04
60 INT286885 Nhs Positive_regulation of Mir488 1 0.00 0 0.03
61 INT195638 Ccw Positive_regulation of Gene_expression of SEPP1 1 0.16 0 0.03
62 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
63 INT287653 Binding of C4bp and Nhs 1 0.11 1.19 0
64 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
65 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0
66 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
67 INT263737 Binding of Dlg1 and Neto1 1 0.07 0 0
68 INT234985 Binding of Dsg3 and Pitx3 1 0.00 0.3 0
69 INT270316 Binding of AMBP and NHS 1 0.20 0.91 0
70 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
71 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
72 INT267215 Binding of Cryab and Hspb1 1 0.25 7.19 0
73 INT177286 Binding of CXADR and MED1 1 0.27 0 0
74 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
75 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
76 INT267216 Binding of Cryab and Hspb8 1 0.36 9.29 0
77 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
78 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lens development in camera-type eye. They are ordered first by their pain relevance and then by number of times they were reported in lens development in camera-type eye. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71995 Binding of Crygs 54 0.11 10.03 39.31
2 INT20976 Binding of CRYGS 39 0.46 5.4 20.09
3 INT89740 Positive_regulation of Binding of Crygs 21 0.13 2.7 14.6
4 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38
5 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14
6 INT122080 Positive_regulation of Crygb 10 0.45 4.32 7.14
7 INT110520 Negative_regulation of Crygb 6 0.31 2.32 4.71
8 INT70837 Positive_regulation of Binding of CRYGS 10 0.45 0.63 4.64
9 INT122078 Gene_expression of Crygb 7 0.76 1.25 4.34
10 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
11 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
12 INT131308 Gene_expression of Pitx3 11 0.74 3.69 3.5
13 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28
14 INT77177 Negative_regulation of Binding of Crygs 5 0.13 1.94 3.1
15 INT204122 Gene_expression of GJA8 13 0.47 22.98 3.04
16 INT110521 Regulation of Crygb 5 0.28 1.42 2.92
17 INT82885 Gene_expression of Mip 7 0.65 7.89 2.76
18 INT86713 Positive_regulation of Mip 10 0.67 6.44 2.63
19 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
20 INT122332 Binding of Crygb 2 0.48 0 2.55
21 INT119210 Positive_regulation of Cryge 1 0.02 0.16 2.29
22 INT83294 Regulation of MIP 4 0.60 3.91 2.21
23 INT83293 Negative_regulation of MIP 2 0.41 4.12 2.02
24 INT82886 Positive_regulation of Mip 7 0.49 3.61 1.89
25 INT122077 Positive_regulation of Gene_expression of Crygb 1 0.32 0.09 1.87
26 INT112971 Positive_regulation of Gene_expression of MIP 3 0.49 5.24 1.82
27 INT91336 Localization of MIP 5 0.78 2.97 1.79
28 INT83291 Regulation of Gene_expression of MIP 2 0.60 2 1.79
29 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68
30 INT108383 Positive_regulation of Crygs 1 0.04 0 1.65
31 INT160283 Localization of NHS 7 0.65 2.48 1.52
32 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
33 INT213750 Positive_regulation of NHS 14 0.59 2.17 1.43
34 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
35 INT45390 Negative_regulation of Mip 2 0.20 0.21 1.41
36 INT116008 Binding of Gata3 2 0.34 1.37 1.41
37 INT161276 Regulation of NHS 7 0.38 1.43 1.4
38 INT69863 Binding of Mip 7 0.36 4.54 1.33
39 INT32101 Regulation of Mip 3 0.26 0.89 1.31
40 INT79626 Negative_regulation of Binding of CRYGS 3 0.42 0.36 1.28
41 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
42 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
43 INT289973 Negative_regulation of Gene_expression of MIP 2 0.41 2.69 1.15
44 INT119208 Positive_regulation of Positive_regulation of Cryge 1 0.01 0.08 1.15
45 INT268763 Negative_regulation of Mip 3 0.41 2.61 1.12
46 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
47 INT135122 Binding of GJA8 3 0.11 2.08 0.97
48 INT101050 Localization of Mip 4 0.78 1.9 0.93
49 INT351296 Regulation of Maf 1 0.01 0.9 0.88
50 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
51 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
52 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
53 INT173794 Gene_expression of Maf 3 0.12 1.39 0.68
54 INT334126 Positive_regulation of Positive_regulation of Mip 1 0.20 1.65 0.67
55 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
56 INT204120 Positive_regulation of GJA8 2 0.30 1.51 0.63
57 INT91332 Regulation of Localization of MIP 1 0.44 0.75 0.6
58 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
59 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
60 INT137858 Binding of NHS 14 0.32 2.94 0.57
61 INT210075 Positive_regulation of MIP 3 0.67 0.98 0.56
62 INT77176 Negative_regulation of Crygs 1 0.03 0 0.53
63 INT77175 Regulation of Binding of Crygs 1 0.02 0 0.52
64 INT268755 Negative_regulation of Gene_expression of Mip 1 0.41 1.73 0.51
65 INT225762 Positive_regulation of Npp 1 0.32 2.61 0.47
66 INT183187 Transcription of Mip 2 0.69 0.69 0.43
67 INT335992 Protein_catabolism of MIP 1 0.86 1.04 0.42
68 INT127539 Positive_regulation of Gene_expression of Cryge 1 0.00 0.35 0.42
69 INT91568 Gene_expression of CRYGS 1 0.03 0 0.42
70 INT268751 Positive_regulation of Binding of Mip 1 0.49 0.91 0.4
71 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
72 INT138976 Binding of Mip 3 0.30 0.17 0.39
73 INT267196 Gene_expression of Cryab 17 0.64 22.5 0.38
74 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
75 INT127540 Gene_expression of Cryge 1 0.01 0.35 0.38
76 INT131311 Negative_regulation of Pitx3 1 0.56 0.5 0.34
77 INT225759 Gene_expression of Npp 1 0.36 1.41 0.33
78 INT124634 Binding of MIP 2 0.35 0.46 0.31
79 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
80 INT319280 Positive_regulation of Dlg1 1 0.45 0.42 0.28
81 INT328583 Transcription of Pitx3 1 0.21 0.49 0.27
82 INT173787 Positive_regulation of Maf 1 0.10 0.06 0.26
83 INT204128 Negative_regulation of GJA8 2 0.26 2.73 0.24
84 INT209224 Binding of Dlg1 3 0.13 0.22 0.23
85 INT268762 Positive_regulation of Localization of Mip 1 0.49 0.83 0.23
86 INT328588 Negative_regulation of Gene_expression of Pitx3 1 0.12 0 0.23
87 INT204121 Regulation of GJA8 1 0.27 3.52 0.21
88 INT183186 Regulation of Mip 4 0.26 1.26 0.2
89 INT174581 Negative_regulation of Gene_expression of NHS 3 0.32 1.16 0.2
90 INT268749 Regulation of Gene_expression of Mip 1 0.44 0.41 0.2
91 INT268758 Regulation of Positive_regulation of Mip 1 0.44 0.83 0.18
92 INT328585 Regulation of Pitx3 1 0.13 0.16 0.18
93 INT267193 Positive_regulation of Gene_expression of Cryab 6 0.41 5.71 0.17
94 INT268756 Negative_regulation of Positive_regulation of Mip 1 0.41 0.83 0.17
95 INT285900 Positive_regulation of Localization of MIP 1 0.49 1.09 0.17
96 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
97 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
98 INT122708 Localization of Mip 2 0.61 0.17 0.16
99 INT225764 Positive_regulation of Binding of Npp 1 0.20 0.59 0.13
100 INT204125 Positive_regulation of Negative_regulation of GJA8 1 0.30 2.4 0.13
101 INT267198 Positive_regulation of Cryab 1 0.46 6.69 0.13
102 INT225766 Binding of Npp 1 0.15 0.59 0.13
103 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
104 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
105 INT204126 Localization of GJA8 1 0.45 2.36 0.12
106 INT101051 Regulation of Localization of Mip 1 0.19 0.09 0.11
107 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
108 INT268748 Phosphorylation of Mip 1 0.79 0.08 0.08
109 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
110 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
111 INT256975 Binding of Dlg1 7 0.36 0 0.06
112 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
113 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
114 INT174891 Negative_regulation of NHS 6 0.36 1.16 0
115 INT307189 Localization of Med1 3 0.53 0.32 0
116 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
117 INT267203 Negative_regulation of Cryab 2 0.29 3.98 0
118 INT234879 Binding of Pitx3 2 0.11 1.21 0
119 INT243714 Gene_expression of Nhs 2 0.18 1.18 0
120 INT291889 Negative_regulation of Pax6 2 0.45 0.39 0
121 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
122 INT256961 Regulation of Gene_expression of Dlg1 1 0.33 0 0
123 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
124 INT276270 Positive_regulation of Binding of MIP 1 0.16 0 0
125 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
126 INT282644 Transcription of NHS 1 0.34 0.18 0
127 INT256978 Positive_regulation of Dlg1 1 0.34 0 0
128 INT293028 Regulation of Regulation of NHS 1 0.03 0.25 0
129 INT307188 Transcription of Med1 1 0.48 0.7 0
130 INT340876 Positive_regulation of Negative_regulation of Cryab 1 0.20 0.62 0
131 INT256952 Localization of Dlg1 1 0.55 0 0
132 INT328584 Positive_regulation of Gene_expression of Pitx3 1 0.13 0.06 0
133 INT299204 Transcription of Mip 1 0.21 0.62 0
134 INT324196 Positive_regulation of Gene_expression of Pax6 1 0.36 0 0
135 INT249611 Regulation of Npp 1 0.02 0.32 0
136 INT291888 Regulation of Gene_expression of Pax6 1 0.33 0 0
137 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
138 INT177320 Binding of MED1 1 0.25 0 0
139 INT260865 Positive_regulation of Positive_regulation of NHS 1 0.41 0 0
140 INT225457 Binding of Med1 1 0.35 0.28 0
141 INT267200 Regulation of Gene_expression of Cryab 1 0.30 1.27 0
142 INT336416 Binding of Pax6 1 0.28 0 0
143 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
144 INT282643 Regulation of Gene_expression of NHS 1 0.22 0.19 0
145 INT336420 Positive_regulation of Binding of Pax6 1 0.38 0 0
146 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
147 INT283676 Regulation of Cryab 1 0.09 0.82 0
148 INT291885 Regulation of Pax6 1 0.15 0 0
149 INT195636 Gene_expression of Ccw 1 0.26 0 0
150 INT256974 Gene_expression of Dlg1 1 0.50 0.08 0
151 INT204129 Positive_regulation of Gene_expression of GJA8 1 0.30 0.85 0
152 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
153 INT200852 Positive_regulation of Pax6 1 0.11 0 0
154 INT208927 Localization of Pax6 1 0.11 0 0
155 INT267184 Negative_regulation of Gene_expression of Cryab 1 0.29 1.5 0
156 INT263679 Transcription of Dlg1 1 0.12 0.07 0
157 INT234878 Localization of Pitx3 1 0.01 0.25 0
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